This page supplies supplementary material for the manuscript
"The Brix domain protein family - a key to the ribosomal biogenesis pathway"
by Frank Eisenhaber, Christian Wechselberger, Guenther Kreil
Acknowledgements to:
M. Breitenbach, F.M. Jantsch, G. Lepperdinger
for sharing experimental data with respect to Brix and yol077c with us prior to publication, for discussion of
the sequence analysis results and for carefully reading the manuscript.
On this page, you will find
the method for collecting the whole superfamily
the method for collecting each of the six families individually and their nearest neighbors
the graph of qualitative familiy relationships rooted at the Archaea/Eukarya division
Brix from X. laevis is a sequence almost at the center of the superfamily in the sequence space. A PSIBLAST search does collect all six families and almost the whole superfamily (except of a few archaean sequences and one alternative human sequence from the Peter Pan clade - AAH00535.1, group II). This automatic, standard search with the command-line version concluded after six iteration with convergence.
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