Rad60-Esc2-NIP45 (RENi)

Rad60-Esc2-NIP45 (RENi)
A protein family in the SUMO-HDAC tangency

Selected RENi proteins are summarized in the table below. Follow the links for:

sequence retrieval
full length BLAST

Ce
Cb
Dm
Ag
Xl
Mm
Hs

Sc
Sp
An
Mg
Nc
Gz
Yl

At
Os
Zm
Dd

Collecting animal RENi representatives

A PSI-Blast search started with region 220-424 of the Drosophila CG4449 (NP_651134) protein against nr collects its likely orthologs in A. gambiae, C. elegans, M. fascicularis, H. sapiens till round 2 (rounds 1 2 3).

Expanding the RENi family

HMMsearch with the conserved animal RENi C-terminus (containing 2 SUMO domains: SD1 and SD2) against various full proteomes
Sequence Alignment	clustal-format
Hidden Markov Model	HMM
HMMsearch versus plants	A thaliana, Oryza sativa
HMMsearch versus fungi	S cerevisiae, S pombe, Y lipolytica, A gossypii, C glabrata, K lactis
HMMsearch versus mycetozoa	D discoideum

Backconfirming the fungal RENi family members

- Independently collecting fungal homologous set:
BLASTP of the Candida glabrata homolog against Sc, Sp, Kl, Ca,Yl,Dh, An

HMMsearch with the conserved fungal RENi C-terminus (containing 2 SUMO domains: SD1 and SD2) against various full proteomes

Sequence Alignment clustal-format clustal-format_X (helix subst. with gap)

Hidden Markov Model HMM HMM_X

HMMsearch versus plants A thaliana, A thaliana_X

HMMsearch versus animals mouse, mouse_X
worm, worm_X

Backconfirming the plant RENi family members

    - Independently collecting plant homologous set:
      TBLASTN of the A. thaliana homolog against TIGR Gene Indices
      yields the following plant homologs

HMMsearch with the conserved plantal RENi C-terminus (containing 1 SUMO domains) against various full proteomes

Sequence Alignment clustal-format

Hidden Markov Model HMM

HMMsearch versus fungi Y. lipolytica, C glabrata

HMMsearch versus mycetozoa D discoideum

Reciprocal best genomic hit:

Sequence set used in the CLANS analysis:

fasta-file, CLANS-output: with names, with numbers