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Angiogenesis

List of -TEMs -PEMs -NEMs

TEMs TEM1 TEM2 TEM3 TEM4 TEM5 TEM6 TEM7 TEM8 TEM9 TEM10 TEM11 TEM12 TEM13 TEM14 TEM15 TEM16 TEM17 TEM18 TEM19 TEM20 TEM21_1 TEM21_2 TEM22 TEM23 TEM24 TEM25 TEM26 TEM27 TEM28 TEM29 TEM30 TEM31_1 TEM31_2 TEM32 TEM33 TEM34 TEM35 TEM36 TEM37 TEM38 TEM39 TEM40 TEM41 TEM42 TEM43 TEM44 TEM45 TEM46

Summary -Overview of TEMs -extracellular TEMs -intrac. & membrane TEMs -TEM tissue distribution

Supplementary -SAGE -Seq.analysis Methods

FAQ

Functional Classification of intracellular & membrane associated TEM

	INVOLVEMENT OF INTRACELLULAR & MEMBRANE ASOCIATED TEMs IN POLICING STEPS OF ANGIOGENESIS
	general context signaling - G-protein signaling: Secretin family receptor (TEM9) RGS (PEM24= TEM42= RGS5) - small GTPases: Ras family small GTPases (TEM2)	TEM9 is a previously non-decribed seven-transmembrane domain protein belonging to the secretin receptor family. Proteins with closest similarity in their transmembrane region are involved in cytoskeletal rearrangments. RGS5 (TEM42) is a G-protein signaling regulator of unknown specificity that was shown to be expressed differentially in artery versus vein media. TEM2 is a ras superfamily and rap subfamily member. The likely rat orthologue Rhes shows thyroid hormone dependent expression, and thus, might show a functional and/or causal linkage with Dkk-3 (TEM4) expression.
	cell-cell communication Connexin45= TEM35	Connexin45 (TEM35) was recently and unexpectedly found to be essential for vascular development in a Cx45 deficiency study.
	transcriptional regulation Heyl= TEM8	HEYL (TEM8= PEM68) encodes a basic helix-loop-helix transcription factors related to the hairy/Enhancer of split genes. The protein TEM8 (HEYL) is likely to act by dimerizing with other bHLH proteins, potentially with members of the same family. A function for Hairy/E(SPL) transcription factors in angiogenesis is well established. HeyL transcription is potentially regulated by Notch.
	INVOLVEMENT OF INTRACELLULAR & MEMBRANE ASOCIATED TEMs IN EXECUTIVE STEPS OF ANGIOGENESIS AND THEIR REGULATION
	cytoskeletal remodeling & related signaling TEM5 TEM16 TEM24 TEM28 (TEM21_2) (Tropomyosin= TEM45)	TEM5 is a previously non-decribed RhoGEF could act upstream of Rho family members in regulating the behaviour of cytoskeletal and structural proteins. TEM5 might have an integrative function between Rho-GTPase signaling and MAPK-pathways (JNK and/or ERK-cascade), and might interact with SH3 domain containing and/or 14-3-3 proteins. TEM16 is highly similar to tensins. If it is assumed that TEM16 is a fragment of a complete tensin, functions typical for tensins might be hypothesized for the protein. TEM24, the recently cloned human tensin, has a proposed integrative function for signal transductions with the cytoskeleton. It localizes to the focal adhesion where it binds both actin filaments and tyrosine-phosphorylated proteins. The mechanism of a proposed JNK regulation remains unclear. A functional link between TEM5 and TEM24 is not excluded since 89% of the Unigen SAGE libraries with TEM24 upregulation show expression of TEM5 as well. TEM28 is a previously non-decribed RhoGAP that might act upstream of Rho family members. Via its N-terminal coiled-coil and a C-terminal SH3-domain binding proline-rich region, it could mediate signalling between membrane receptors, the cytoskeleton and the nucleus.
	adhesion Integrin alpha1= TEM30 Thy-1= TEM13 TEM17	Thy-1 (TEM13) is a GPI-anchored protein having a role in the regulation of cell-cell adhesion and differentiation. TEM17 is a potential type I membrane protein. In its extracellular domain, Tem17 shares regions of similarity to nidogen and plexins, two protein-families which have been implicated in axon migration. Integrin alpha1 (TEM30) binds collagens I, collagen IV, laminin and mediates migration on collagen. It is involved in regulating collagen and MMP synthesis.
	endo- and exocytosis Endosialin= TEM1 uPARAP= TEM22 Peanut-like= TEM46	Given the similarity of the receptor endosialin (TEM1) to C1qR and the existence of the WIGL motif, a function in internalization can be proposed. uPARAP (TEM22) is an endocytic recycling glycoprotein belonging to the macrophage mannose receptor family. The protein has been found to bind strongly to collagenV and participate in a tri-molecular complex with the urokinase receptor and pro-urokinase. It has been hypothesized that the protein might be involved in the uptake of highly glycosylated proteins in the course of matrix remodelling. Peanut-like 1 (TEM46) is a septin that associates with synaptic vesicles. It is hypothesized to have both a positive and a negative role in exocytosis.
	protein fragment of an extracellular domain containing protein (TEM19)	The partial sequence of TEM19 is hinting on a transmembrane or extracellular protein with relation to adhesion.
	undetermined protein sequences (TEM3, TEM18, TEM26, TEM29, TEM32, TEM33, TEM34, TEM43, TEM44)