Tumor Endothelial Marker Report: TEM17/TEM3

TEM domain structure

	TEM domain structure

TEM Sequence Analysis

name from to source/E description

SignalP 1 18 SEG LCR(LAR)

unknown 18 143 BlastP This region has in part similarity to Drosophila and C. elegans proteins.

NIDO 143 290 SMART, E = 8.27e-01 Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins.

Plexin_repeat
PS (Plexin_Semaphorin) 303 349 Pfam, E = 0.021 Low cystein spacing.
Plexin like cysteine-rich repeats are found in several different extracellular receptors (plexins, semaphorins and integrins). The function of the repeat is unknown.

unknown 349 427 A LCR (S,T-; possibly mucin-like) is predicted for residues 365-400 by SEG25. Seven (out of 10) O-glycosylation site predictions cluster in the region 366-384.

TM 427 447 toppred2 = 2.4, SEG

cytoplasmic 447 502 Prosite, TYR_PHOSPHO_SITE A potential tyrosine phosphorylation site can be found by Prosite at position 475: RSHPDHSTY. It has to be noted that second tyrosine phosphorylation site is predicted at position 83 and is assumed to be false-positive. No homologues can be found in this region.

502

	TEM Sequence Analysis

name	from	to	source/E	description
SignalP	1	18	SEG	LCR(LAR)
unknown	18	143	BlastP	This region has in part similarity to Drosophila and C. elegans proteins.
NIDO	143	290	SMART, E = 8.27e-01	Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins.
Plexin_repeat PS (Plexin_Semaphorin)	303	349	Pfam, E = 0.021	Low cystein spacing. Plexin like cysteine-rich repeats are found in several different extracellular receptors (plexins, semaphorins and integrins). The function of the repeat is unknown.
unknown	349	427		A LCR (S,T-; possibly mucin-like) is predicted for residues 365-400 by SEG25. Seven (out of 10) O-glycosylation site predictions cluster in the region 366-384.
TM	427	447	toppred2 = 2.4, SEG
cytoplasmic	447	502	Prosite, TYR_PHOSPHO_SITE	A potential tyrosine phosphorylation site can be found by Prosite at position 475: RSHPDHSTY. It has to be noted that second tyrosine phosphorylation site is predicted at position 83 and is assumed to be false-positive. No homologues can be found in this region.
502

Remarks

	Remarks

CLASSIFICATION: The protein is predicted to be a type I membrane protein, but this assignment has to be considered with caution as the protein sequence is not very reliable in all its parts.
HOMOLOGUES: The sequence is not confirmed by full-length homologues in other species. The middle sequence part contains extracellular domains (PSI, NIDO) the organization of which is shared by the two major homologous proteins (Drosophila protein CG2221 (Identity= 43% in 87-352 of TEM17); C.elegans- C36E8.3 (Identity= 40% in 78-342 of TEM17)).
DOMAIN ARCHITECTURE: TEM17 is a potential type I membrane protein. In its extracellular domain, Tem17 shares regions of homology with two other protein-families which have been implicated in axon migration:
1. a more N-terminal region similar to parts of the G1 domain of nidogen
2. a 100aa region with homology to Plexins (Tessier-Lavigne et al, 1999).
A Psi-BLAST iteration(E=0.01) performed with the extracellular 420aa shows homologies clustering independently in the PSI and nido domains, with only two proteins (Drosophila CG2221 and C.elegans- C36E8.3) showing a similar domain-structure (CG2221 and C36E8.3 were excluded from all iterations.
The short cytoplasmic domain shows no similarity to known proteins.
FUNCTION: The NIDO domain is found in several non-collagenous human glycoproteins as alpha-tectorin, nidogen. A Psi-BLAST analysis was performed with this domain. No explicit function can be proposed for the NIDO domain.
The ~ 100 aa region with homology to PLEXINs contains a short cysteine-rich motif, termed Met-related sequences (MRS), whose minimal consensus is: C-X(5-6)-C-X(2)-C-X(6-8)-C-X(2)-C-X(3-5)-C (Maestrini, 1996; Tamagnone, 1997). Semaphorins, the plexin family of semaphorin receptors, and scatter factor receptors share evolutionarily conserved protein modules, as the semaphorin domain and Met Related Sequences (MRS)(Winberg, 1998). All these proteins also have in common a role in mediating cell guidance cues. PlexinC1/VESPR, a divergent member of the Plexin family known to bind GPI linked semaphorin, shows closest similarity to the TEM17 plexin-like region. No explicit function can be proposed for the MRS domain.

Sequence Information

TEM TEM17

Reliability of Gen2Tag mapping

Cid->tag (Hs.125036) frequency:
tem17: CATG-ACAGACTGTTA= 12/14 (EST oriented)

Analysis
BlastP against nr

Output Created by a Suite of Single Sequence Analysis Techniques

Protein Description

SEQ.SOURCE: gi|9857404|gb|AAG00869.1|AF279144_1 tumor endothelial marker 7

Protein Sequence

MRGELWLLVLVLREAARALSPQPGAGHDEGPGSGWAAKGTVRGWNRRARESPGHVSEPDRTQLSQDLGGG TLAMDTLPDNRTRVVEDNHSYYVSRLYGPSEPHSRELWVDVAEANRSQVKIHTILSNTHRQASRVVLSFD FPFYGHPLRQITIATGGFIFMGDVIHRMLTATQYVAPLMANFNPGYSDNSTVVYFDNGTVFVVQWDHVYL QGWEDKGSFTFQAALHHDGRIVFAYKEIPMSVPEISSSQHPVKTGLSDAFMILNPSPDVPESRRRSIFEY HRIELDPSKVTSMSAVEFTPLPTCLQHRSCDACMSSDLTFNCSWCHVLQRCSSGFDRYRQEWDGTMGCAQ EAEGQDVRGLPGMRTTTSASPDTSFSPYDGDLTTTSSSLFIDSLTTEDDTKLNPYAGGDGLQNNLSPKTK GTPVHLGTIVGIVLAVLLVAAIILAGIYINGHPTSNAALFFIERRPHHWPAMKFRSHPDHSTYAEVEPSG HEKEGFMEAEQC

SAGE-Tag CATG-ACAGACTGTTA

EST/cluster Description

UNIGEN CLUSTER: Hs.125036 : tumor endothelial marker 7 precursor

SEQ.SOURCE: ugc|Hs.125036.2|Hs.125036 GENE=TEM7 PROTSIM=PID:g3924708 tumor endothelial marker 7 precursor

MARKINGS: tem17 Tag in red
first Poly-A-signal following the Tag in bold

EST/cluster Sequence

1 GCGGCCGCAGCCTGAGCCAGGGCCCCCTCCCTCGTCAGGACCGGGGCAGCAAGCAGGCCG 61 GGGGCAGGTCCGGGCACCCACCATGCGAGGCGAGCTCTGGCTCCTGGTGCTGGTGCTCAG 121 GGAGGCTGCCCGGGCGCTGAGCCCCCAGCCCGGAGCAGGTCACGATGAGGGCCCAGGCTC 181 TGGATGGGCTGCCAAAGGGACCGTGCGGGGCTGGAACCGGAGAGCCCGAGAGAGCCCTGG 241 GCATGTGTCAGAGCCGGACAGGACCCAGCTGAGCCAGGACCTGGGTGGGGGCACCCTGGC 301 CATGGACACGCTGCCAGATAACAGGACCAGGGTGGTGGAGGACAACCACAGCTATTATGT 361 GTCCCGTCTCTATGGCCCCAGCGAGCCCCACAGCCGGGAACTGTGGGTAGATGTGGCCGA 421 GGCCAACCGGAGCCAAGTGAAGATCCACACAATACTCTCCAACACCCACCGGCAGGCTTC 481 GAGAGTGGTCTTGTCCTTTGATTTCCCTTTCTACGGGCATCCTCTGCGGCAGATCACCAT 541 AGCAACTGGAGGCTTCATCTTCATGGGGGACGTGATCCATCGGATGCTCACAGCTACTCA 601 GTATGTGGCGCCCCTGATGGCCAACTTCAACCCTGGCTACTCCGACAACTCCACAGTTGT 661 TTACTTTGACAATGGGACAGTCTTTGTGGTTCAGTGGGACCACGTTTATCTCCAAGGCTG 721 GGAAGACAAGGGCAGTTTCACCTTCCAGGCAGCTCTGCACCATGACGGCCGCATTGTCTT 781 TGCCTATAAAGAGATCCCTATGTCTGTCCCGGAAATCAGCTCCTCCCAGCATCCTGTCAA 841 AACCGGCCTATCGGATGCCTTCATGATTCTCAATCCATCCCCGGATGTGCCAGAATCTCG 901 GCGAAGGAGCATCTTTGAATACCACCGCATAGAGCTGGACCCCAGCAAGGTCACCAGCAT 961 GTCGGCCGTGGAGTTCACCCCATTGCCGACCTGCCTGCAGCATAGGAGCTGTGACGCCTG 1021 CATGTCCTCAGACCTGACCTTCAACTGCAGCTGGTGCCATGTCCTCCAGAGATGCTCCAG 1081 TGGCTTTGACCGCTATCGCCAGGAGTGGATGGACTATGGGCTGTGCACAGGAGGCAGAGG 1141 GCAGGATGTGCGAGGACTTCCAGGATGAGGACCACGACTCAGCCTCCCCTGACACTTCCT 1201 TCAGCCCCTATGATGGAGACCTCACCACTACCTCCTCCTCCCTCTTCATCGACAGCCTCA 1261 CCACAGAAGATGACACCAAGTTGAATCCCTATGCAGGAGGAGACGGCCTTCAGAACAACC 1321 TGTCCCCCAAGACAAAGGGCACTCCTGTGCACCTGGGCACCATCGTGGGCATCGTGCTGG 1381 CAGTCCTCCTCGTGGCGGCCATCATCCTGGCTGGAATTTACATCAATGGCCACCCCACAT 1441 CCAATGCTGCGCTCTTCTTCATCGAGCGTAGACCTCACCACTGGCCAGCCATGAAGTTTC 1501 GCAGCCACCCTGACCATTCCACCTATGCGGAGGTGGAGCCCTCGGGCCATGAGAAGGAGG 1561 GCTTCATGGAGGCTGAGCAGTGCTGAGAACACCAAGTCTCCCCTTTGAAGACTTTGAGGC 1621 CACAGAAAAGACAGTTAAAGCAAAGAAGAGAAGTGACTTTTCCTGGCCTCTCCCAGCATG 1681 CCCTGGGCTGAGATGAGATGGTGGTTTATGGCTCCAGAGGTGCTGCTCGCTTCGTCAGCA 1741 CACCCCGAATATTGAAGAGGGGGCCAAAAAACAACCACATGGATTTTTTATAGGAACAAC 1801 AACCTAATCTCATCCTGTTTTGATGCAAGGGTTCTCTTCTGTGTCTTGTAACCATGAAAC 1861 AGCAGAAGAACTAACATAACTAACTCCATTTTTGTTTAAGGGGCCTTTACCTATTCCTGC 1921 ACCTAGGCTAGGATAACTTTAGAGCACTGACATAAAACGCAAAAACAGGAATCATGCCGT 1981 TTGCAAAACTAACTCTGGGATTAAAGGGGAAGCATGTAAACAGCTAACTGTTTTTGTTAA 2041 AGATTTATAGGAATGAGGAGGTTTGGCTATTGTCACATGACAGACTGTTAGCCAAGGACA 2101 AAGAAGTTCTGCAAACCTCCCCTGGACCCTTGCTGGTGTCCAGATGTCTGCGGTTGTCAG 2161 CCCCTTCCTTTCCCCCGACCTAAACATAAAAGACAAGGCAAAGCCCGCATAATTTTAAGA 2221 CGGTTCTTTAGGACATTAGTCCACCATCTTCTTGGTTTGCTGGCTCTCCGAAATAAAGTC 2281 CCTTTCCTTGCTCCAAAAAAAAAAAAAAAAAAAAACTCGTGACTAGTTC

Genomic Sequence Description

SEQ.SOURCE: gi|5867254|ref|NT_000793.1|Hs17_1495 Homo sapiens chr.17 sequence
only 5 region of the gen included

ANALYSIS: PROMOTOR ANALYSIS

MARKINGS: transcribed regions displayed bold

Genomic Sequence

1 GAGAGGATCGGTGAGCCCTGTCTGTACTACACAGCTGGTAGGTACAGAAAGTGGGTCGCC 61 TGGGGTTTTGCTTCAGTCTAGTGCCCTAGACATGGCACTCAGAGGAGGGAGAGCTGGGAT 121 CCGGTTCCGCGCGCAGTGCTGAGTCTCCCCTGATTTGCGGTAGTGGAGCAGTCCACCCGG 181 AGAACTCAGGAGTTTTCGCAGGGCGAGGGGGAGGGCTGGAGCCTGGAACCCCCATATTCC 241 TTGCACCTCTTGGGCCCGGGACAGGCAGCCCTTAGTCACTGGGGTGTCCATAGTGCCCAC 301 GAAGGGCCAGCGTCCCAGAGGGTTCCCAGGTCAGGTTGGTGACGTGTGGGGCTTCCCTAA 361 CTTCGTAGGCAAAATCTGCCAGACCCTCCCGGGGGAGCGGAGCTCCGAATACCAGGGCCG 421 ACTCCGCTCCTGAGGCCGCTGAGCCCTCCTGCACCTGTCCGGCCCGGGAAGTGCCATGGG 481 ACAGCTGATCGCCAAGTTAATGAGCATCTTCGGGAACCAGGGTAAGGGGCGCACAGGGCA 541 TCCAAGCGAGCGCTTTGATCTCGCCCTCTTCTGGGACTCCTCTGATCTGTGGTCGGACGC 601 ACGGGGGGACCTCGGGCTCCGAGGGTCGTATATGGGCGCTCCTCGACTGCCCCGCGGCCT 661 CCCCTGCCCCCGTCCCTGCCTGCTCCTCTTGGGTCCCGGCGCTTCGGTGCGCCCCAGGAC 721 GCAAAGCTGGGCGACCCTCCTTTCTCCCCGCTAAACGGAGCCAGCGGCGGGGATGGGGGG 781 CTGCTGCGAGTTTCCTGCGATTGTGACTTCGCGTTATGCTCTTTCTCTAAACACCGTCTC 841 TTGGCAAGCCCCGAAGCGCCCCGGGCCTTTCAGACACTTTTCTGGAATGTGAAGGGAGGT 901 GGGGGCTCAGCTGTCTTTTCCACCGTCCCGGAGTGGGGCAGGTGTCGGAGCTGGGTGGGA 961 AGCAGACGCGGTACGGTGGGCAGAGGTCCCCAGCCTGCGGGGAGCGCTATCTCCTTCCTG 1021 GGAGGTCTGGTGGGGGCACACAGTCCCTTGGTCTTCGGGTTTGGCCCTGACGCTGCCCTT 1081 CCTCCGACGCTTCCAGAGCACACGGTCATCATCGTGGGACTGGACAATGAAGGAAAGACC 1141 ACCATTCTCTACCGGTTGTAAGTGACTCTCGGGCGGGGAGGGTAGAGAGCTGGGCCTCCC 1201 ACCAGACTGACAGGCAGGGGGACCAATCACTGGAGCTCTTCCCTGGGTTCCCGGGCTCCT 1261 CTGTAGTCCGGAGGAGCGATTGGGCACGCTGCTTGGACCTTCCTAGTACTGCGGCTCCTC 1321 GGTCTGGCATTCAAATCCTGCACCGTACAGGCAACCCTAGCTCCCACTGCTTTCCTCCAT 1381 CTTCCCGGGGGCCCTGCCAAACCCAGCTCCAGGCCTGCCAAGTGTCCCAAACTGCCTCCC 1441 TGCTCTTCGCTCCCTCTAGCGGCAGGTCCCTCCTTTCTCACCCCTGTCCCCTCTGCCAGT 1501 TAACTTTCTTCCCCTTCTTCAAACCCAAAGGCTCACTGAGGCTCTGTAGCTCCTGGTCTA 1561 GCAAGCCTGGCACATATGGGTGGTGCTGAGTAAATACCGATCGCAGCTTTCCCCGATATT 1621 CGCTCTCTGGATGGCACCTCTCCCATTTTACAGCCTCCAAAGTACTTTACTTAGGAGAAG 1681 CTTTTCCATGAAAAAGTAATACATGTAATGATTTTAAAAAATTATAAAGGAAAATTTCAA 1741 ACAATGGAGGAATACACGGTGAAAAGTAAGTTTCCTTCTTGCCTCTGGCTCCTAGTTTTC 1801 CTCCTATTGTAACTTTGCGTAACTTTTCAGAAGCATTATTTACATATAAAAGCATGTGTA 1861 TATTTTCTATGTCACTTTAAACAAAGCACCTCTCTGATGTCCCTCACTGTGTCTGTCTCA 1921 TTTTTCTAAACTCTTGCTCCTCAAAGTGTGGTCTACAGACCAGTCACACAGGCATCACCT 1981 GAAAGCTTATTAGGAATGCAAAACCATGGCCGGGCGCTGTTGCTCTCAAAGTGCCTGTAA 2041 TCGCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACCTGAGATCAGGAGTTCAAGAGCAG 2101 CCTGGCCAACATGGTGAAACCTCGTCTCTACTAAAAATACAACAACAACAACAACAACAA 2161 CAACAAAGGGCTGAGCAAGGTGGCTCACGCCTGTAATCCCAGCACTTTGAGAGGCTGAAG 2221 TGGGTGGATCTACCTGAGGACAGGAGTTCGAGACCAGCCTGGCCAACATGGCGAAACCCC 2281 ATCTCTACTAAAAAAATATAAAAATTAGCTGGGCGTGGTGGCACATGCCTGTAATCCCAC 2341 CTACTCTGGAGGCTGAGGAAGGAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTGAG 2401 CTGAGACTGCGCCACTGTACTCCAGCCTGGGCGACAAAGGGAGGCGGAGGTTGCAGTGAG 2461 CTGAGATTGTGCCACTGCACTCCAACCTGGGCGACAGAGAGAGACTACATCTCAAGGAAA 2521 AAAAAAAAAAAAAAGCAAAACTGTGGCCGGATGCGGTGGCTCATGCCTGTAATCCCAGCA 2581 CTTTGGGAGTCCAAGGTGGATGGATCACTTGAGGTCAGGAGTTCGAGACTCGCCCAGCCA 2641 ACATGGCGAAACCCCGTTTCTACAAAAATACAAAAATAAGCCTGGCGTGGGGGTGTGCTC 2701 CTGTAATCCCAGCTACTCAGGAGGCCGAGGCGGGAGAATTGCTTGAACCTGGGAGACATG 2761 ATCGTACCTACACTCCAGACTGGGCGACAGAGTGAGACTCTGTGAAAGAAAGAAAGAGAG 2821 AGAGAGAAGGAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAA 2881 AGAAAGAAAGGCAAAAGCCTGGACCCCTGCCCAGACTCACTGGGTCAGAATCTGCATTTT 2941 GACAAAACTCTCAGGTCATTCAACTGCATATTAAAGTTTGAGGAGGCTGGGCTCTGTGGC 3001 TCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGAGGATCTCTTGACAGGAGCC 3061 CAAGGTCAGGAGTTCAAGGTAAGCCTGGGCAACACAGTGAGACCCTGTTTCTATAAAAAG 3121 AAAAAAAGAGATAAAGTTTGAGGAGCCTCCTCTAAGATGTTTCCCTTCTCTGGGGTCCAA 3181 GCCAGGGCAGGGCTTAGTCTCACTCCTGTCTTCATTCCCCAGGGCCCAGCACGGGGCCTG 3241 GCTCCGAGCAGGTGTTTGGTGAACCTGGGTGGACTTGTTCTGAGTTAGATTCAGACTGCT 3301 TTGGGAGTAGAGCATTTGGGGGCCAGAGTTGGGAGTAGGCTGGACTGAGCTCTTGGTGCC 3361 CACTCCTACCTCCCCAGCTTGACCAATGAGGTGGTCCATATGTGTCCCACCATTGGCAGC 3421 AACGTGGAGGAGATCATTCTGCCGAAGACCCACTTCTTCATGTGGGACATAGTGAGACCT 3481 GAGGCTCTGAGCTTTATCTGGAACACATACTACTCCAACACTGAGGTGAGGAGGGCACCA 3541 GGGCTGAAGGGTCTCCAAGGCAGGCGTGTGATATCAGACTGTCATGTAACCTTTCTGAGC 3601 CTTGGTTCCCCAACTTGTGAAATAGAGATTATAATGGTCGGTTCCTGTGGCTCACACCTG 3661 TAATCCCAGCACTTTGGGAGTCCAAGGCGGGTGGATCACCTGAGGTCAAGAGTTCGAAAC 3721 CAGCCTGGCCAACATGGCAAAACCCCACCTCTACTGAAAATACAAAAATTAGCTGGGCAT 3781 GGTGTCAGGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGACAGGAGAACTGCTTGAAC 3841 CTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCACGCCATTGCAACTCCAGCCTGGGCAAC 3901 AGAGCAAGACTCTGTCTCAAAAAAAAAGTTTTATATATACATATATATAATGATCTCCCT 3961 AAGTTGTTGTGAAAATTAAATAACAAACCAATATGTAATGCATATATGTCAGATACTCAA 4021 CACAGTGCAGTGCCTGCCTGTTAACGTGTTTGAATACTTCCTGGCAGCTGCTGGCAGCTT 4081 TCTGTTTGATGCACTGGATGGGTAGGCCCCTTCTCTCTAGGGGCCTTACTTTCTTACTCC 4141 AGCAGGAGTAGAATTCAGTGGTATAATTCCTGGACCGAGACAGAGCTGGGTTCCATTTCC 4201 AGCACTGCTACTCACCAGCTGTGTGGTCAAGAGCAAGATACATAGCCTCACTGAGCCTCA 4261 GTCTCTTCATTTGTAAAATGGGGATACTAACAGTACCAAGTCCACAGCGTTGTGGTAAGG 4321 CCTAAATGGAGTCATGAACACCCAATGCTTATGTAGCACAGCCTCTGCCACACAGTCAGA 4381 GGTGTGCTATTCCCATGTCTGGATAGAAAAGACAATTACAGGCCAGGTGTGGCAGCACAC 4441 CTGGTGGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATGACCTGAGATCAGGAGT 4501 TTGAGACCATCCTGGCCAACATGGCGAAACCCCGTCTCTACTAAAAATACAAAAATTAGC 4561 CGGGTGTGGTGGCACGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGTGGGAGAATCG 4621 CTTGAACTAAGGAGGCAGAAGTTGGAGTGAACCAAGATTGCGCCACTGCACTCCAGCCTG 4681 GATGACAGAGCGAGACTCCGCCTCAAAAAAAAAAAAAAAGACAATTATAATGGAAGCAGG 4741 GTGGTGAAATCTTGAGGCTGCATGCTTTCATTTCTCTGGGGCTGACATCTGGGCAGTGCA 4801 GAGACCAGTGGGGAAAGAAAGAGGGCAGGAAACACATTTACCAAAGAGAAAGCCTGTCTC 4861 TCACGGCTCCCCTCTGCTGCCCAGTTTATCATCCTTGTGATTGACAGCACGGACCGGGAT 4921 CGGCTGCTGACCACTCGGGAGGAGCTATATAAAATGCTGGCCCATGAGGTAAGCCCCCTG 4981 CAGTTGGGAGAGGGCCCAGTGGTACTAGCTGTGTGCCCTCAGGCTGGTCACTTAGCTTCT 5041 CTGAGATTCGTTCCTGCTGTCCCAGTTTCTGAGAGCCTCTATACCAGCAGCATGAGGAGG 5101 GCTGGTTTGTGCCTGATGAAGGGCATCAGTACCCTCAGTGCAATTGACTATAGAAGCCAG 5161 AGTTGCTGGTTCAAGTTCTAACTCCATCTTTCATTCACTGTAGGACTTTGGACAAGTGAC 5221 TTCACCTCTCTAATCCTCAGTTTCCCCAAGTATAAAATGAGGAGGATCATCAATTCCCAC 5281 CTATGGGATTGTCATAAAGAGGCTTTCCTTGAGCTGCTGATGTTATTTGATACGGTTGCT 5341 ACCATTGTGGCAGGGCCCCCATCTCTGCCCCATCCAGGCATGGGCCTCTCTTCCTGGGAC 5401 AGCTGGAGAGGGAGCCAGAGAGCGCCTGTGAGGCAGTAGGAAGGAAGGCTGGGCACTAGC 5461 AGGCTGACTGGGGCTGGGCTCCTCTGTCCACAGGCTCTACAGGATGCTTCAGTCCTGATA 5521 TTTGCCAATAAGCAGGACGTGAAGGACTCCATGAGGATGGTGGAGATCTCCCATTTCCTT 5581 ACTCTCAGCACCATCAAAGACCACTCGTGGCATATACAAGGCTGCTGTGCCCTCACCAGG 5641 GAAGGGTTAGTGGCTGCCCTACCTGGATCTCTAGGGCCTGGCTGAACCAATGGATGACTG 5701 ACCATCAGAACCCTTCTCCTGCCTCTCTCCTGTGAGAATCTGGTTCACAGTTGGCTCCTG 5761 GGCCAAGCCAATTTGGCATCTCCCCACAGGTGAGATGTGGTGGGTAAGCCACAAGCAGAC 5821 AGCATCCCTGCTCTCAGGGGCTTGTTCTAGTGGAGAAAGAGGTAGCACTCCGCCTAAATG 5881 CAATAATCTCTCTCTCTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTTTGTTGCCCAG 5941 GCTGGAGTGCAATGGCATGACCTCAGCTCACTGTAACCTCCGCCTCCCAGGTTCAAGCAA 6001 TTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGATTACAGGTACCCGCCACCACGCCTGGCT 6061 AATTTTTATATTTTTAGTAAAGATGGGGTTGGCCAGGCTGGTCTTGAACTCCTGACCACA 6121 GGTGGTCCACCGGCCTCGGCCTTCCAAAGTGTTGGGATTACAGGCATGAGCCACTGCACC 6181 TGGCCGCAATAATCTTAGGTGCTGAGAAGTGATGTGAAGAATCCCACTGGTTACCAGAAA 6241 TGGAAGGGAGAAGGATAGGTCTGATTTAGTTCTGGTGGTCAGGGCTGGCCTCTCTTAAGA 6301 GATGACTTTTGAGCTGAGACCTGAGTGAAGAGTAGGAGACAGCCATGGGGAGACCTGGGG 6361 AACAAGCCTTCCAGGCAGAAATCATTGACTCACTCTGACTTCAGTTTCTTAACTGTAAGG 6421 AAGAGGATCATTATACCTCCTAGAGTTTCTGTAGAGTAAATGACACCATTCAGTACACAA 6481 ATCTTTCTTGAGCACCTCCTTTGTGCCAGGTACTGTTCTAGGCACTGGAGAAACAGCAGC 6541 GAGCAAAACAGACAAAAATCCCTGCCCTCACGGAGCTTACTTTCCGGTAGGGGAGGCAGA 6601 TGATAAACAAGAAAAATATATAGTCAGTTAGAAAATGATGGCGGGGCGCGGTGGCTCATG 6661 CCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCAGATCACCCAAGGTCGGGAGTTCG 6721 AGACCAGCCTGACCAACATGGAGGAACCCCGTCTCTACTAAAAATACAAAAATTAGCCGG 6781 GTGTGGTGGCAGATGCCTGTAATCCCAGGTACTTGGGAGGGTGAGGCAGGAGAAGCGCTT 6841 GAACCCAGGAGGCGGAGGTTGCGGTGAGTCAAGATCATACCATTGCACTCCAGCCTGGGC 6901 AACAAGAGCGAAGCACCATCTCAAAAAAAAAAAAAAAAGAAAGAAAGAAAATGGTAAACG 6961 GCTTGAGGCCAGGAGTTTGAGAAAAGCCTTGGCAACAGAGCGAGACTCTGTCTTTACAAA 7021 AAAAAAAAAAAAAAAAAACCGCTGGATGTGGTGGCACACACCTGTATTCCTAACTGCTCA 7081 TGAGGTTGAGGCAGGAAAATCACTTGAGCCCAGGAGTTCCAGGCTGCACTGAGCTCTGAC 7141 CATGTTGCTGCACTCCAGTCTGGGTGACATAGCAAGATCCTGTCTCAAAAAAAAAAAAAA 7201 AAAAAAAAAAAAACAAGTGATAAATGATAAGGTGAATAAAGAGTAAGAAACAGAGATTGG 7261 GCCAGCATGGTGGTTCATGCCTGTAGTTCTAGCTACTGGAGAGTCTGAGGCAGGAGGATG 7321 GCTTGGGGCCAGGAGTTGGAGTCCAGCCTGGGCAACATATCCAGACCCCCATTTCCAAAA 7381 GCAAAAACAAAGAAAAGAAAAGGGAGAGTGGAAGTGTGTGGAGGGAATGTTGCAATTTTA 7441 GGTAAGTTATCTGACAAGGGACACTAAGCAGGTAGATATTGAGTAATCACCTGGAGGATT 7501 TTAAGGAGCTGGGCCACGTAGAAAGGGCCTTACATCAGGCCTGGAAAACTTCCCTTTCGT 7561 CTTACCTGTCAAGTGGAATCATGGCAGGCTGGGCACACAGGTATCTTTTTTTTTTTTTTT 7621 GAGGCAGGGTCTCCCTCTGTCACCCCCCAGGCTGGAGTACAGTTGTGCAAACATGGCTTA 7681 CTGCAGCTTCAACCTCTTGGGCTCAAGCGATCCTCCCACCTCAGCCTCCCTAGTAGCTGG 7741 GACTACAGGCGCACACCACCATGCCCTGGTAATTTTTGTATTTTTGTAGAGACAAGGTTT 7801 TGCCACGTTGCCCATGGCTGGTGTCAAACACCTGAGCTCAAATGATCTTCCTGCCTTGGC 7861 CTCCCCAAGTGTTGGGATTACATGAGTGAGCTACCACGCCTGGCGCAGATGTGTTTTTTG 7921 AAGAAGGGGAGACTTTAGGCAAGTCAGTCCAAGGGACCACACGTTTCTAGCAGTGTCCTT 7981 GCCACCCGCTGGGTCAGGAGAACCCTCTTCCACAACCCACAGTCAGTTCAATCAGCATTT 8041 TCCCTCCCTTCTTTCCCTCCCTCCCTCCCTCACTTCCTCCCTCTCTTCCTTCCTTCCTTC 8101 CTTCCTCCCTCCCTCCCTCCCTCCCTCCTTCCCTTTCTTCGACGGCCACTTGCTCTGTTG 8161 CCCAGGCTGGAGCGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCTGCCTCCCAGGTTCA 8221 CGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCCGGGATTACAGGCGTGAGCCACCACGCC 8281 CGGTTAATTTTTTTTTTTGTATTTTTAGTAGAGACGGTGTTTCATGGTGTTAGCCAGGAT 8341 GGTCTCGATCTCCTGACCTCATGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTAC 8401 AGGCGTGAGCCACTGTGCCCGGCCACTTTTTTCTTTTTTTTTTTTTGAGTGGAGTTTCAC 8461 TCTTGTTGCCCAGGCTGGAGTGCAATAGCATGATCTCAGCTCACTGCAACCTCCGTCTCC 8521 CGGGTTCAAGGGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGAGATTACAGGCATGCGCC 8581 AACATGCCCAGTTGATTTTTGTATTTCTAGTAGAGACGGGCTTTCTCCATGTTGGTCAGG 8641 CTGGTCTCGAATTCCCGACCTCAGGTGATCCACCCGCCTCCGCCTCCCTAAGTGCTGGGA 8701 TTAAAGGCGTGAGCCACTGCGCCTGGCCCAATCAGCATTTTCTAAGTACCCCCCATGTTC 8761 CCTGTGCGGTGCCAGACCAAGGCTGAGGATGATACAGAGATGACCAAGACTCCACCCATG 8821 CGCCGGAGTTGCTTACAATCTAATGGGGGAACTTGCGTAGGGAACCTCTTTCTGGCACAG 8881 ATCACCGTGAAGAATCCTTGCCCAGAGACACAGCTAAGGGGCCCAGCAAGGTGAGTCTCC 8941 AGGCTCCTTCCTCAGAGAAGCCCTCCCTGACTCTCAGGCATCCAGAGGCCTCTGTATATT 9001 TCCTTTATCACAGTATGTAATTACAGAATTATGTGTCTGACCATTTATTTAGTATCCATC 9061 TCTTCTACTAGACAGTAAGCCTCAGGGGCATGTCTGCATTTTCACCAGTAACTCCAGAGC 9121 CTTGCACAGTACCTGATGCACAGCAGATACTCAAGCCAGTTCATCTCTGTTAATTGAATT 9181 ATTGGATGTAACTTTGGTTCCTGCACCCAGTCCGATCTGGGCAAGGGCTGGAGACTTGAA 9241 GGCCATCATTCTCTTGGGTTAGGCTGACCCCTCCTGTTCCTTCCTCCCTGCAGGCTGCCT 9301 GCCAGACTTCAGTGGATGGAATCTCAGGCCGCTGCTAACTGATGTTCCAGTCTGAGGTCA 9361 ACCAGAAACTTTGGGGTTTTGCATGGTCAACATGGGTGGAAAATCAAGTGGCTATTTATT 9421 ACTTTTCTATGGTTCTCTAGTGGGAGCAGTGGCTGCTATGGACAGTGAGATTGACACCAT 9481 TCTCCCAACCCGTTGCTGAGAAGCTGGACTGCATACCTTGGATTCCTGCAGACAGCACAG 9541 CAGAAGAAGCTGCTCCTCACTCCATGGCCGCAGGCATCCTTCTTGGAGACGTCAGGGAAA 9601 TGTTGGATATGTTGCAGATTTAGTGAGTGGAACTCTCTCCCTCTCCTCAGCCCTCAGTCT 9661 CTCCGTAGGAATAATGTGTGTGTGTGTTGGGGGGGCAGATTAAGAGACCCCTGAGGCTGG 9721 GCGCGGTGGTTTACGCCTATAATCCAGCACTTTGGGAGGCTGAGGCAAGAGGATCACTTG 9781 AGGTCAGGAGTTGGAGACCAGCATGGCTAACACGGTGAAACCCTGTCTCTACTAAAAATA 9841 TAAAAATTAGCTTGGTGGTGGTGCACGCCTGTAGTCCCAGCTACTCGGGTGGCTGAGGCA 9901 GAAGAATTGCTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATTGTGCCATTGCAC 9961 TCCAGCTTGGGTGACAGAGCGAGACACCGTCTCAAACAAAACAAAGCAAAATACAAAAAT 10021 TAGCCGGACGTGGTGGCGGGCGTCTGTAATCCTAGCTACTCGGGAGGCTGAGACAGGAGA 10081 ATCCTTTGAACCTGGGAGGCGGAGGTTGCAGTGAGTTGAGATCGGGTCACTGTACTCCAG 10141 CCTGGGCGACAGAGAGAGACTCCGACTCAAAAAAAAACAAAAACAAAAACAAAAAACCCT 10201 GGAATTGCTCTTCATTTCCTCAAACCTCCTTCCACCCTCAGGCTTTTTAGCCCCTCAGCC 10261 ATTTTTGTCCCATTCCCTTTGGGCAAAGGAGATTCTAGCAAGGTGAAGAAGGTGGGCTCA 10321 AGGGGAGGAGGGCAGAGGCAAAAACTGGAAGGGGAAATGGAGGAGGACAGGACGTCCCAG 10381 ATAGGGACAGCCCTTTGCACTGCAGGGATTCCACTTCTCCTCGTCTTCCCATTCCCTCTG 10441 AGATGCTGACTCTGACCACAGCTCTTGGACTTTAAGCCACCCCACAGCATCCCCTTTACT 10501 TCTAGTGTCCTTCCAATTTGAATCCCACTCCTCCCAAATATACCAGATTCCTAAAGGGGC 10561 TGCTTGTTTGTCTTTGTGTAATGATTTTTGTTGTTGTTGTTATTGTTGGAGTCTCGCTCT 10621 ACCGCCCAGGCTGGAGAGCAGTAGTGGCGCGATCTCGGCTCACTGCAACCTCCGCTTCCC 10681 GGGTTCAAGCGATTGTCCTGCCCCAGCCTCTCGAGTAGCTGGGACTATAAGCGCGCACCA 10741 CCACGCCCTGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAG 10801 GATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGAT 10861 TACAGGCGCGAGCCACCGCGCCCGGCCAGGATTTTAAAAAAAATACTGTATTAGGATTTT 10921 TATAAGGCTGTAGTAAATGCTATTGAAAAATGCTTACCTCTTATTTCAGCCTTCTCCTCT 10981 GTCTGTTCCTCAAACTGGCTTTTGGTTTGAGAGAAGGGGAGGAGCGACCCTGGGGTTGGA 11041 AAAGCCCAGGAGACAAGATGGAGATCCAGTCTGTTCATCTGTACATCCCTGGACCTGGGG 11101 CGGTCCTGGGGACAGTCCTTTTCTCAAGCCAGTCAGTGGACATTTGGGGGAGAGTCTAGG 11161 CACGGATATAGAGGACCCAATATTCCTTTTTTTTTGAGACAGAGTCTCGCTCTGTTGCCC 11221 AGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCAGGGTTCACGC 11281 CATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACCACACCCGG 11341 CTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGAGGTCTCGATG 11401 TCCTGACCTTGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGC 11461 CACCGCTCTCGGCCCAAGATTCCTTAATCTAGTTGGTTTTCCGAAAGCGTGGCTATGAAG 11521 GAAGAACTCAGGAGTTCTAGCCATTCCCATTGTATTTTGTGTTTTTTTCAGTAGGTATCC 11581 CGACGCAACCCTCAGATTAAAACTTTAAGGGAAAATGAAGACCACACCCCTATTCCATAG 11641 AAATTAACTCTAATGACAACGTAGTGGCGTGGCGGGGGTATAGCTCAGTGGTAGAGCATT 11701 TGACTGCAGATCAAGAGGTCCCCGGTTCAAATCCGGGTGCCCCCTCTGTGCTCCGGAGTT 11761 ACCTCGTTTTGTTGGTCTCCGGAGGTCCTCTAAAGAGTTCCCGCACAGATGGAATGGGAG 11821 GGAGTCTCGAGCCCTGCCACCCTTTTTGCTTTCGCAGGCGAGTGAGGATGGAGTCCTGGC 11881 CCCTGCCAGTGGCTCAGCCTGTGTGTGTACCCAGGGTAGAATGCAATGCGAGTGAGGGCG 11941 AGGAGCTCCGGGCTGACCCTTGGAACACGGTACGGGTGGCTCAACCTCGCAATGGCAGGG 12001 CGGAGGCGAGCGCACCCCCAGGTCAGCCTGGCTCTTTCTTGGCGGGAAGGAGGCTGAGTT 12061 TCTAAGGGCTGGGCTGGGGAAGACAGGTCGGGAGAAGCCGCGTGAGCATGTGGGAGGGAG 12121 AAAGAAGCTCCGAGACGTGGCAAGGGGTCTTCTGCAGGGCAGGAGAGTGGGACGCCCCCG 12181 AAGTGAAATATTTCGAGAGACTTCTCCTTCCACACCCCAGGAATATATTTTCTTATACTG 12241 CCAGTGGGGATCTTCAGCTCAGAGCTTCAGGGAACAACCCCTGCTTCCAAGTGAGTAATT 12301 CTTCTGGGAGTTGTATTTTTTCCATCTCTTGTAAACGTCTTACCCCACTTCCACTTCCCT 12361 TCGGGAACGCCACACAGCGCCTGCGCAGCAATACCACTAAACGACTACGTGCGGTCGGTT 12421 TGCCGGCAGAGGGGGTATAGCTCAGTGGTAGAGCATTTGACTGCAGATCAAGAGGTCCCC 12481 GGTTCAAATCCGGGTGCCCCCTCTTTGGCCTTTTCGAGATACTGTTTTTGTCCTGGGTGT 12541 CGATTTTTCCTAAGCTGTTTGCTTTTACTCCTACTGGCAGACGAGGAGCAGTGAGGGACT 12601 GAAAGGAACTGGGGATTCAACAGCAGTGGCTCTCAAAATGTGGTCCTGGGACCAGCAGCA 12661 TTACCTGGGTACGCTCGGGCCTCATCCCAGACCTAATGAATTAGAAACTTGAGGGTGGAG 12721 TCCAGAAATCTGTGTTTTCATATACGCTCCCCATCGCTTGAGTCCAGGAGTTGGAAGCTG 12781 CAGTGAGCTATGATCGCAGCACTGCACTCCAGCCTAGGCAACGTGCGAGAACCTGTCTCA 12841 AAAAACAAACAAAATACACACACACACACACACACACACACACACACACACACACACACA 12901 CCCTGCAGGTGATTACGATCTCAAGTTCTAGAGGCTTACGTTAAAATTTACACATTTGCT 12961 TCTACTATTTACAAGTTTATGTTTCAGCCTGAGCTCTTCTTGTAAGACAGACCACGAGGT 13021 ACCCCAGATGGAGGAATGTGCAAAGACGCCGGGGCTGGAGCTGGAATCCGTCCCGAGACT 13081 TCTCACCTTGACCTCGAGGAAGGCAGGAGGTCGGAGACAGGGGGTGGGCAGGCTGGGGAA 13141 AGAGGAAACCCGCAGGACAAGAGGGTTGTGGCTCGTCACGTGGCCACTTGAGGGCAGCAA 13201 GTAGCTGCAGCTGGAGGTAGCTGCCTATCTGATTCTGTTTGAGAGTCCGCCAAGTTGGGA 13261 TTTAAATTAGACATCAAGAAGAATTTACAGACCGGCCTTGCCTTGTTCCACGGTAAGGGG 13321 ACATTGGGTTTAGGGCTGGAGGAGGTAGTCTCTGGGACTCTGGGCCCGGCGGAAGGAGGA 13381 ACCGGCGTTCTAAGAGATTAGAGAGCCTTTAGTTGTTTCCTTTCTTAGGTGTTTTTTTTT 13441 CTTTTCTTTTCTTTTTTTTTTTTTTAACCTCAGTGCCACGGAATCCGTCTCTTCCAGCCC 13501 ACAGTGTACCTTCTCCTGTCCCCGCCCATATCCCTCCTCCTGGAAAATTTCTCCAATGGC 13561 GCTCAGCGTTCGCACCCTTCCTCTCCGCGGTTTTCTAGTCCCTAGGCCCCAGCCCACTAG 13621 AAGCCAGGATGCCCCCTCACCCCGTCTCCCACTCTCCAGCGCCCCAGCTCCTTGCCGTCA 13681 CAAGAACGAAGTAGGTCAGGGGAGGGAAGAGGCATCTTCGTGTCCTGACCTGATTCCTTG 13741 CCGTCTATTAAATATCCTACATTGCGGGTATTTTTATTCTGTCCTGGAAGAAAAAATAAA 13801 AAGATTATCTATCCCCAGAGCCTGTCAGAAGGTGGTGACAGGTGGGGTGAGCCATTTCCT 13861 CGTCTGGGGCTGGCTCTGAAGATTGATTGGGTCTGGCCCTGAGTAGGCCTGGAGGCCCCA 13921 GAGAGGCAGGAGGCCTGGGTTACCTACTCGTGGGGAGGGGTCCAGACTGTTGCAGAGTAA 13981 GGGGTAGCCAGGCCCCCTCCACCCTCACGTCTGCTAGGCTTGGGGGGCAAATCGGTGCTG 14041 GAAATGGGGGGTGGAGGGATAAGGTGGAGTCATGGAAGGGGGGTGGGATTCAGGCCCCTC 14101 TTGGGGAGAAAAGCTGGGGGTCTTTGCTGCAGGGGGAGATTTCTGGGGGTGGGGGCTGGA 14161 GGACAAAGCATCAGAGACGCACAGAATTCCGAAGAACAGCTCAGGAAGTCGCAGAGCTTG 14221 GAGGAGCTGGGGGCGGGGAACAGTCAGGGGCCCGTGACCCAGGGATGGGGCGCCTGTCCC 14281 TTCCAGGGGTCCAGTCCTCGGGCCTTCTCTCTGCAGCTTTCCCGGCGGAACGGAGGAGGG 14341 AAAGGGAGCCAGGAGCTCAGTGAGGAGCGCGGGGCGGCTGATGCTTCTAGGGGTTCTCTC 14401 AGCCCGAGGGGCTCCCGCCCTGTCCCCTACTCTGCACCCCTTGCCTTGGGAGCGGCTGCA 14461 GAGCTCTAGGGGAGCGCTCCGTTAGGGCTGAGGGCAGGCGCCGGGAGAGCCCCCAACGAC 14521 GCCGCGCCCCCCGCCCCGCCCCCTGCCCCAGCTCCCCCCCACCCCCACCGACCCAGCGGC 14581 CCCCCCAGCTCCCCGCCTGCTCCCGGAGGCCGCAGCCTCCAGCTCCGCTCGCGCTCTCGC 14641 CGCTCCTGCCGGCTCGCCCGGCCCCGCGCTCCGCCGTCTCCTCGCCGCCCGCCCCTCCGC 14701 CAGCCCCGGGGACCGCGCGGCCGCAGCCTGAGCCAGGGCCCCCTCCCTCGTCAGGACCGG 14761 GGCAGCAAGCAGGCCGGGGGCAGGTCCGGGCACCCACCATGCGAGGCGAGCTCTGGCTCC 14821 TGGTGCTGGTGCTCAGGGAGGCTGCCCGGGCGCTGAGCCCCCAGCCCGGAGCAGGTAGGA 14881 CTGGCGGGAGCCGGCCCGGGTGGGCCGGGGGCGGGGAGGGACGGGCAGTCAGGTGTGGGC 14941 ATGGGCAGGTGTGGACGGCCTGGCGATGTCCGCGAGGGGGGCATTGTCCGCAGGAGGCCA 15001 GGAGAGCTGTGGGCTGTGGGCAGGTGGATAGGGACCCCACTTTCCCAAACACATAGGGTG 15061 TGTGAGTGACGGTGGAGACACCGATGCCCGGACCTCTCCTTCTCTCCTGGAAGGATACTG 15121 GAGGGACCTTAGGAGAGGGGGCTCTATGTGGCCATGGGCTCTGAAAGGGGACAGCGGGAG 15181 AGTCATCAGGACCCCTGATCACCCCAGGCAAGGCTGAATTCTGATGAGATGGGAGCCTGG 15241 GGAGGCCCCTGCCCCAGCCATGCCTTCTTTTCCTCTTCTCTGCCACACCCCCGACCCCAA 15301 AGCTGATCCAGGCTAGGGATAGGTGGGAGCAGCCAGGGGGATGGTGGGGACACAGCGTCT 15361 CTGCCTGGGAAGGCAGCAGCCATTCGGTCACCTTCCCTTGCCTATTTGGTGTCAGTAGAG 15421 AGGCAGTGGGCCCAGGAAGAAGCAACTTGCTGCTTCTGCACCCCCAGCCTCAAGAGTCCC 15481 CCTCCTCACACCTGCTCCCATTTGCCCTGGCAGCCTTTGGCTTTCAGCTACTCTGGCTCT 15541 AGATGGGGCACTGGGGTAGGGGGTGGAGGGAGGCGTCCCATTCTGCACACTCCTCTTCCC 15601 CCCTACCAGTTCTCCAAACTCATCTCTCCCACCTGGAAGTCCTTTCTGAGATCTACCTGG 15661 AATCCCTCATGGTATAATTTTCATAGTCTCTGTTCTCCCCTAAGCACCTAGACTTTCTCT 15721 GGGGTTGGGGAGATGGGTAATTTGCAGCCTGGCCCCTCAGCAGAGATGATTAAGAAGATA 15781 GATACCTGTGCATCATTGGCATGGGTGCCCCTCAGGTGGGGTGAGGGAGGCGCTGTTGAG 15841 GTGAGTGCTGTGGTTGACCTGCTGTGTCTCAGGAGTGTGCTGGCACCAGGCACAGTGTCA 15901 GTGGCAATGTTCTTGACTTTAATGGTCCCAGCATGTAGCTGAGACAGACCTGGGTCCCTA 15961 TTGAGAAGAAGAGTATGTTGGGGGTGGGAGGGGAAGGAGGCTGACAGTGGGAAGTATGGG 16021 CAGAGGGCAGTGGAGCTGACGAACCGAGAAGCTGCTGGTGAGAACCACCAATTTTCAGGG 16081 AGACCACACAGAGGGTGGCCAGAGACGTGGCTTCTAGTCCCGCCATCTCACTTGCTGTGT 16141 GACTTTAGACAAGTTACTTTCTCTCTCTGGACCTATTTTTGCATTTATAAAGTGAGGCTG 16201 TTGGCAAAATCTTTGACTCTTGTGCGTGGAATAATGAAGGATCTTTTATAATTGCCTTTC 16261 CTTTTCATATTTGTTAGGGTCTTTATGGGTAACTGATACTTTAAAAAAATCAAGGTAAAC 16321 AGGAGAGAGTTGGATATGTTATGAATAATTTCTGGGCTCCTTTGAATCCTCAACCTGGTG 16381 TGATCTTCTGAACTCTGGGTGTAACAGAGTTTATGAGGGGAGGATCTGAACCTTTGGCTG 16441 GATTGTGTGAACCACGGAGAGGGCTGGGGAAGGGGGAATTGGGAGGTAACAAGGATGGGC 16501 TGGGAGATAGTGGCCAGACCCGGGCCTGGCTGAGGGCGGCCCCTTCAGAGTAGGGTTGGG 16561 GTAGTAGACGGTTGAGGAGACCAGGAAGAGTGGGGCAGGCAGAGACTTGAATCACTTCTC 16621 TAAGTAGAGGCTATCCTGTCTTCTTGGCTTTGACAGAGATTGAGCCAGGAGAAATGCACT 16681 TTTTCTGCAGCAGGAGGGATAGAGGTTAGACTTAAGGAATCTGTAAGAAGCCAGAGGCGG 16741 CAGCTGTTGACTCCCAGTCCGGTGCCCTTTTCACAGGCCAGGTGGGATTTCACAGGCAGG 16801 AGGACCTATGAGGAGGAAGCGGGTGTCTGGGGAGGCCAGATGTAGGAGAAGGACGTTCTG 16861 GGGGAGAGTTGCTAAGGAGGGGCAGCCTGACCTGATTGATGGCGGAGTTGTTGTGACCAG 16921 TGGAAGGGCAGCTGGGAGCAGGACCTGAAGAGATGCTAGCATCCTTCCCCAAGGCTCTGG 16981 GTTTGTGGGGCTGGTGGGGGGCCTTGGGAAGTAGCTGAGATCTCCCCTCGCTCCTGATGG 17041 ACAGGCTTGTTTGGTAGAGCCTTGAAACCTCATCTATCATTAGAACAGCAGCAGCAGAGA 17101 GATGAGTGGCCCAAAGACAGAGTCAGACAGCAGGGGAGACCAGGATGACAGACAGGAAAA 17161 TGGCCTTGGGGTGCAGAGCAGGGGCCCAGGGAACTGACAGTCTGGTCAGATGGAACCAGA 17221 GGTGCATATGACAGATAAAGAAGAGGCAGCGAGAGTTGGCATCCTGGCCTGGGAGTCCTG 17281 CAGGAGGCCAGGCTCAATACCAACTACTGGTGACCCTGACAGCTTCCTCCTTTCTCTGAG 17341 GAAGGTTTCCCCGTCTATAAAATGGGGGCTTGCACCAGTCACGGTGGCTCATGCTTGTGA 17401 TCCTAACACTTTGGGAGGCTGAGGTGGGAGGATAGCTTTAGACCAGGAGTTTGAGACCAG 17461 CCTGGGCAAAATAGTGAGACCCCATGTCTATAAATGATTTAGGCCAGGCAGGGTGGCTCA 17521 TGCCTGTAATCCCAGCACTCTGGGAGGCCGAGGCCGGCGGATCACCTGAGGTCAGGAGTT 17581 TGAGACCAGCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAATATACAAAAATTAGTA 17641 TATTTAGTATTGTTATTAATATTATTAATATTAGTATATTAGTAAAAATTAGCCAGGCGT 17701 GGTGGTGCATGCCTGTAATCTCAGTTACTCAGGAAGCTGAGGCAGGAGAATAGCTTGAAC 17761 CCGAGAGGCAGAGGTTATAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGGGCAACA 17821 GAGTAAGACTCTGTCAAAAAAAAAAATTAAAATTAAAATAAAAAATTAGCTGGGCATGGC 17881 GGTGTGCGCCTGTAGTCCCAGGTACTCGGAAGGCTGAGGCAGGAGGATCGTTTGAGCCCA 17941 GGAACTGGAGGCTGCAGTGAGCTATGATCATGCCACATAGTGAGGGCAGCATAACGAGGT 18001 CCCATCTTTTTTTAAAAAAAGGAGGGAAGGAGGTTGGACCAGATTGTCTCTAGGGCTCCA 18061 ACAACCTGAGACTAAAATGCGAACTTATGGAGGTCAGGCAGCCCCTCCCTCATCCCACCA 18121 TCTTCTCTAGCTCTCCCCAGATTCACCCCTTAACCCACTCCAGCTGCCGTCCCCTCCGAT 18181 CGACAGATAACTAACTGGCTTCTTCTCATTCAGGTCTTAATCAGCTCAAGGGGACCCTCC 18241 TCAGAGAGCCCCACCTCATGGCTCTGTGTAGAGTAGCAACAACCCCAACCCTTTCCTCTG 18301 TCTGATTTTCTTCATAGCCCTTACCAAATGATTCATTTTGTATGTCTCCATGAAGAAAAC 18361 TAGACTCTTCCTGGGTACAGGGCTTGTGTCCCCCCAGCACCCAGCACAGTGCCTGCGACT 18421 CAATAAAAGTGTATTGAATGAATGAGTGAGTGACTGAGTGAGTATATCAGAGGTGGCACA 18481 GATCCCAGACTCTCCCCTCAAGGGACACACATAGAGAGCTGAACTCTTCTTGCTGTCCCT 18541 CCCTTCCCCTCCCCTCCCCTTCCCTCCCTCCCTCTTCCCTTCTGCTACCTGGTGGTCCCT 18601 CCCTGCACTTCCTTTGACTCCTTCCCTCTCCCCAGGTGAGGGTCCTCAGTGGGTCCCTAC 18661 CTGCCAGAGGAAAGGGAGAGGGTATGGTTAGGGGCTTTGTAACTTGGAGGCAGGATTTCA 18721 GTTTAGGGTTTGGAGCCTTCCCTGGCCCCTCTGAAAGCTGGTCCTGTGACCCTAACTGGT 18781 GTGTTGCCCAAGGTGCAGCAAGTTGACACACCAACACCGAGGGGGCAGCAGAGAAAGAGT 18841 TTCATCATCGTGGGGCAGCATTTGGGGCTAGAGGTTTTATGGGGTTTGGGGTGGGGTGGC 18901 CAACGTGTGGGAATTGTTAATTGGTTGAAGAGTGCATGAAGAAATAAAGAAACTGCATTC 18961 TCATGTTAAATCAGTTCCTCGGCTGGGCGCGGTGGCCCGCGCCTGTAATCCCAGCACTTT 19021 GGGAGGTCGAGGTGGGTGGATCACAAGGTCAGGAGTTCGAGACCAGCCTGCCCAATATGG 19081 TGAAACCCTGTCTCTACTAAAAACACAAGAAAATTAGCTGGGCGTGGTGGTACATGCCTG 19141 TAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAATCCGGGAGGCAGAGGT 19201 TGCAGTGAGCCGAGATCGTGCCACTACACTCCAGCCTGGGTGACAGAGCGAGACTCCGTC 19261 TCAAAAAAAAAAAAAAAAAAAAAAAAATCATTTCCTGTCTGAGGGTCTTCGAATTGGCCC 19321 TTCTGCTGGAATTCAGGATCCGAAAACCATCTTAATCCTTCTTTTTTTTTTTTCTTTTTT 19381 GAGACAGGGTCTCACTCTGTTGTTCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTG 19441 CTGCCTCAACTTCCTGGGCTCAAGTGATCCTCCTGCCTCTGCTTCCTGAGTAGCTGGGAC 19501 TGCAGGCATGCACCACCACATCTGGCTAATTTTTTAAAATTTATTATTAATAATAAATTA 19561 AATTTTATAATACCTTTTTTTATTATAAAAAAGACAAGGTCTTGCCATGTTGCCCAGGCT 19621 GATCTCCAACTCCTGGGCTCAGGTAATCCTCCTGTCTTGGCCTTCCAAAGTGCTGGGACT 19681 ACAGGCATGAGCCACCATGTCCAGACTTTAAAAAAAATTTTAGTAGAGATGGGGTCTTGC 19741 TATGTTGTCCAGTCTGGTCTCGAACTCCTGGACTCAAGTGATCCCACCACCTCACCCTCC 19801 CAAAGTGTTGGGATTATAGGCATGAGCCACTGCACCTGGCCTTAAACAATTCTTAAATAA 19861 AAGCTGGCCAGGCGTGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCAAGGCGG 19921 GAGCATCATTTGAGGTCAGGAGCTCAAGACTAGCCTGGCCAACATGGTGAAACCCCATCT 19981 CTGCTAAAAATATAAAAATTAGCTGGGTGTGGTGGCGCACTCCTGTAGTCCCAGCTACTT 20041 GGGATGGTGAGGCAGGAGAATTGCTTGAACCCGAGAGGTGGAGGTTGCAGGGAGCTGAGA 20101 TCACACCAATGTACTCCAGCCTGGGTGACATATCGAGATTCCCTCTCAAAAAAAAAAAAA 20161 AAAAAGGAATGGGCCGAAGTGCAGCCTGATTAATGCTTAATTACTCCTATACTTCTGCCC 20221 AGAACCCGGCATGTAATTCTTGTTAACCCTGAGAAGACGGTTTCAGTCCTCATGTGAAAC 20281 CCAGGGAAGGCAGGGCGACTTGCTGGGTGCTCTGTGTATATGATTTTGTTAAAGTGTCAA 20341 ACCTACCAAGTTTATGTTTTATCAGCCCCATCTCACAGATGAGGAAACTGAGTCTTAGAG 20401 AGTGTGTGTAATTTGTCCAATGTTGTAGTTAGTAGGTGGTAGATTCAGGGTTCAGTGTCT 20461 AGCTTGTCTGATTCCAAACCTGTGTTGTTTTACTGCTCTGATACTACAATGAAGTTCCAA 20521 GGGAAGGGTGTTTCCAGTTCGGTGTATCTCAGGTACTCAGGGCATTTAAAGATGCTCTCC 20581 CTTCCCTCCCCTCCCCTCGCCTCCTTTCTCTTCTCCTCTTTTTCTCAGCCTGTGGGACAG 20641 GATGAGCCAGGGACAGGTGAGCTGGAAGCCGGAGAGAGATGGAATCAAGTTCACCCTCTA 20701 GGTGGCTTGTCCTGGCTATGGTGGGGGAGATTAGCTCTAGGGCATTAAGGGTGGAGGCTG 20761 ACCCAGGATAGAGGCTGTGGTAACCTGAGCTATGGGGTGGCCCAGGGCTGGGATGCCAAG 20821 TTTGGGTGTTGGGTGAGATGAGGATGGCTTGGCCCAGGCTCTGGGGCCGCACAACCTGGC 20881 CTCCTGAGGTCAGCCCCATTCCCCCTTGCCCTGAAATGGGACCAGTGCCAGCTGAGGGGA 20941 CTGGGACGCTACTGCTGGGCTGTACCCTGCATGCTGGGGGACACAGTCTCCCAGGGAAGC 21001 TCTCAGGTTCAGGCCCAATGGCAGCCTGAGTAGGGCCCTCCAAGAACCTAGCCCACATGC 21061 CAGCCCCACCCCGGGGCTGCCCCTGCACCCTGGGAAACAGTGGGGATTGTCGGTCACTTT 21121 TTACTGCACTTTCTGTGGTTCTGAGTAGGCTCTGGAGCCAGCCTGCCTGAGTTCAGATCC 21181 TGCCATGGACTGGTTCTGTGACCTTGGGAGGTTCCTTAACGTCTTTGTGCCTCAGTTTCT 21241 CCATTTGTAAAATGGATTTTAAACTAGTAACTATTTCATGGGATTATTGTGGGGATTAAG 21301 GGGGTGGATGTGTTTAAAGCCCCTGGAATAGTGCTAGCACAGAGCAGCATTCTCTGAAAG 21361 TCAGCTATCATTTTTATTACTAGGGTGATTATTATGGCATCCCACTGGACTGCACACTAC 21421 TTGGGGCCATGAGTGAGTGAATCAATGAATGAACAGCTTGTGTTCCGGAAGCTCCTTGGC 21481 AACACATGCAGGCGGGGAACGGGTCCAGGGAAAATGGAGCTCTCTCCAGTGGAAGGCAGG 21541 TGGGGTGAGGAGTGGCTGAGGGTTGGGCAGGTGTCCAACTTGTGTGTGAGCACATACGGG 21601 AAGGCCGAGGCTTTCAGGAAAGTCTTTGTGGGCATGTGCACAGGCACGTGGGCCCCTGCA 21661 CATACACGTGAGCAACCAGCTGTGTTGGCTTCTTTCATGAGTCGTGGGGATGACGTCCTG 21721 TCCCAGGCAACAGGGAAGGAAGGGTGGCCAGGAAACAGATGTAGTATGGGTTGGAAGAGT 21781 AAGATTCAGGGCTAGGCCAGGGTAGGCCAGGGTCCTGGTCAAGCTCCCTCTCCATCCCTC 21841 GCCCTGCCCTCTTTCATGGACTCTTTACCTCTTACCCTGGCCTGAGCTCTCTATAAAACC 21901 TCATTTGTGTTTCTCACTTGACGCTTATGGCAGCCTGTACTGTGGGCACCATCGTCAAAT 21961 CCATTTGAGTCACTAGGGAGCTGAGGATTAGAGAGGAAAACTGATGGGGCTAAGGTCCCA 22021 TAACTTGTGAGTGGCAAGACTGGGTGTGGAGGTCAACCCAGTGTCTCTTCCCTGGCCACC 22081 CCCAGCTGGGCCCCCTCCCTGTCCTTCCCCGGGCTGCAGGCCTCCACCATCCCGCCTCCT 22141 GTCTCGGCTCCAGGTTTGTGAATCCTGAAGATCCCCAACACTCCTCTCTGGGCCGCTGAG 22201 CCCCTCCACTTGTTCACTACCCGCTCTATCCTGTTCTGGCTCCTGCCCAGGCCCCAGGGC 22261 TGCTTGCAGGAAGACCTGGGGAGCTGGGCAGACCAGCCCAGCACAAACAGCTCTGTCTCC 22321 AGAAGCAGCTGTGGGCCCCACCCAAGAGAGACCAGACAGCCCTGGCTTGGGCCTGGGCAG 22381 TGGGCAGGCTGCCTTCCCAGCCCTGGACTCATGTCCATCTGTGGGCAGCCAGTGGGCATC 22441 TTGGGGAAGGGGTCTGGGGACTGCCCTCCTCCCCACGTGCTCCAGCAGCATCTGGTTGCT 22501 ATTAGGGGCAGAGAAGTGAGAGGGGGCCGGCAAGGGTCCAGTAGGCGCCAGCAGCCAAGA 22561 ATGACTTAATTGGATACAATGTCTAATGACAAAGCAGGGCCCCACAGCGGAGTTCTGGCC 22621 TCAGCCCCAGGCCTGGGCCTGGCCAAGCCTGGTCTCAACCTCTGTCCTTGCTGGCTCCCA 22681 GGAGCTACCCTATGCACTGCGTCCTCAATTCTGCAGTGATGGAGCACCTGCTGTTTGCTG 22741 GACATGCCAAATTTGAAGAAGGTGGAGAGAATCCTGGGGGAACTCAAATCTACCAGGGAG 22801 ATAGGCACATAGTCGCACACGTAGGTGCTCTAGGAGAGGGAGAGCCACATCCAGGAGCTC 22861 TGGGGAGTGGGCTGGGGGAAGGCAGAGGTTGAGACAGGTATCTGACACAGGGTGGGCCTG 22921 AAATGGAAGAGGGTCATAGGTGGGGAATGTCAGATCCACCTATCTGATGGTCTGTTCTCA 22981 TATATACATCCATAGTAGGTGTGACCATTAGAATGACAATAAAAGCCACAGCTTTGGGGG 23041 GCATAAATCTTTTTGAAGTGGAAAAGGATGGTTTTTGTGTTGTTTATTTATTTATTTGGA 23101 GAAGGAGTTTCGCTTTTTTGTCCAGGCTGGAGTACAGTGGCGCAATCTCGGCTCACTGCA 23161 ACCTCTGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTA 23221 TGGGTGCCCGCCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCGTC 23281 ATGTTGGCCAGGCTGGTCTCGAATTCCTGACCTCAGGTGATCCACCCACCTCAGCCTCCC 23341 AAAGTGCTAGGATTATAGGTGTGAGCCACCACGCCCGGCCTTTTGTTAGAACTAATTTAA 23401 CAGACCTGGTGCAGTGGCTCACGCTTATAATCCCACCACTTTGGGAGGCCAAGGTGGAAG 23461 GACCGCTAGAGCCCAGGAGTTCAAGGCCAGTGTAGGCAACATGGTGAAACCCAGCCTCTA 23521 CGAAAAATACAAAATAAAATAATAATAACTAGCCGGGTGTGGTGGCATGCAACTGTAGTA 23581 CCAGCTACTCAGAAGGCTGAGGTGGGAGGATTGCTTGAGCCTGAGAGGTCAAGCGTACAG 23641 TGAGCTGTGATTGTGCCACTGCACTCCAGCCTGCATGCTAGAGTGAGACCCTGTCTCAAA 23701 AAAAGCATGCATTTAACAACCTAGAGGGAACTGGAGAGGAGATCATGGAACCTAAAGCCA 23761 TTTCGCAACCTCCAGAAATGGAGGTTCGCATGGCCGCGAAATGGCCTGTGTGTAGTCACT 23821 TTCCAATCCTGTGCCCATGGCAGACATTGCTTATTGATCTTCACAGTCCTTCCTGCTAAA 23881 TACAAGAGGAGCCTTTGCATTCTCAGTTGGAGTGCCTCTGGCTGTCACGAATGGATTGCA 23941 GATGGCATGTGATATGAAACCTATTTGCCATCCTAGACAGTATCTAGGTAGTGATAGGAG 24001 TAAAACAGTAAAAAATTACCCCTCCCTCAATGGGGCAAGGGGGGGTTAATTTTATTCCCC 24061 AGGGGATATTTGGCAATGTTTGGAGACGTTTTTCATTGTCACAGCTTGGGATGGGGAGGA 24121 GCGTGGTGCTACTGGCATTTAGTGAGCAGGGGCCAAGGCTGCGGCTGCTAAACATCTTAC 24181 AGAGCACTGGACAGTTCCCGCATAACAATGAATTATCCAGTCCAACCAACAATCCAATTT 24241 AAAAACAGGAAAAAGACTTAAATAGACATTTCTCCAAAGAAGATATACAAATGGCCCACA 24301 AGCATATGAAAAGATGTTCGGCATCACTAATCATCAGGGAAATGCCAATTTATAAAAACG 24361 ATGAGATATAACCTCATACCTGTTAGGATGGCTACTATAAAAAAAACAGAAAATAACAAG 24421 TATTGGCAAGAATGTGGAGAGATTGGAACCCATGTGCACGGTTGGTGGGAATGTAAAATG 24481 GTCCAGTCATTTTACATGGAAAACATTTTATATGGAAAACAGTATGACAATTCCTCAAAA 24541 AATTAGAAATAGAATTACCATACAATCCAGCAATTCCGCTTCTGGGTATATACCCAAAAG 24601 AATTGAAGGCCAGGTCTCAAAGAGATATTTGTACACCCATGTTTGTAGCAGCATTGTTCA 24661 CAATAGCTAAAACGTGGAAGCAAAACAGACATCCATTGATAGTTGAGTGGGTTAGCAAAA 24721 TGTGGTATATCCACACAATGGAATATTATTCAGCCTTCAAAAGGAAGTCAATTCTGCCAT 24781 ATGCTACGACATGAATGAACCTTGAATTTATTATGCTAAGTGAAATAAGCCAATCACAAA 24841 AAGACAAATATAGTATGATGCCATTTATATGAGATACTTAGAGTAGTCAAAATCATAGAT 24901 ACAGGCTGCGCGCTGTGGCTCATATCTGTAATCCCAGCACCTTGGGAGCCAAGGCAGGAA 24961 AATTGCTTGAGACCAGGAATTCAAGACCAACCACCCTGAACAAAATAGTGAGACCCTGTC 25021 TCTATAAAAAGTAAAAAGATTAGCTGGGCATGGTGGCGCATGCCTATAGTCCCAGCTACT 25081 TAGGAAGCTGAGGTGGGAGGATCGCATGAGCCCAGCAGTTGGAGGCTGCAGTGAGCTATG 25141 ATCGCACCACTACTCCCCAGCCTGGGTGACAGAGCAAGGCCCCATCTCTTAAATAAAATA 25201 AAATAACAGGGGTGAATAGGGAGTTATTATTTAACGGGTACAGAATTTTAGTTTTACAAG 25261 GTGAAAAGAGTTATGCAGATAGATGGTGGTGATGGTCATACAACATTAGGAATGTATTTA 25321 ATGTTACTGAATTGTACACTTGGAAATGGTTAGATGGCAAATTTTGTTATGTGTATTTTG 25381 CCACAATAAAAAAATTGGAAAAGGAATTATCCAGTCCAAATGTCAATAGTACCGAGGTTG 25441 AGAAGCCCTGAACGAAAAGAACTCTGGCTTCTAGTCCCCTGACCCCACTGGGAAATAGGA 25501 TTATGTGCCATTTCTGCCAGAGAAATAAGAAACTGGTTTGGAAGGCTCAACGGCAATGGT 25561 TCTCACCCTTGCCTGCAGAGTTAAGTCCAAGACTCCTCAAAATCTCCCCTGAGGCTCTTT 25621 TAAGAAATCGAGGCTAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCG 25681 AGACGGGTGGATCACGAGGTCAGGAGATTGAGACCATCCTGGCTAACACGGTGAAACCTC 25741 GTCTCTATTAAAAATACAAAAAATTAGCTGGGCGCGGTAGCGGGCGCCTGTAGTCCCAGC 25801 TACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCTGGAGGCGGAGCTTGCAGGGAGC 25861 GGAGCTCGGGCCACTGCACTCCAGCCTGGGTGACAGAGCGAGACTCCATTTCAAAAAAAG 25921 AAAAAGAAAAAGAAATTGAATGCCCAGGCTACACCATAGACCAGTTACAAGAGATCTCTA 25981 GGGTGGGACCCAGACATCAGGAACTTTTGAAGCTGTCCAGGTGACTCCAGTGTATAGCTG 26041 AGGTTGAGAATAATCACCCTTTGGAGGCAGATCAGCTTGGGTTTGAAACTTACCTGCATG 26101 CCTAACCCACTGCGTGACTTTTAACCTCTGAGCCTCTGATTCTTGTTTGCAAAATGGAGA 26161 ACATCCTAACTACTGCGGAGAGCTGGCATGAGGATTAAAAGGATATGTGCGAAGTGCTTG 26221 GCCTGGAGCTGGGCACGTGACTCTCAGTACACATTGGGTGTCTCCTGTCCTGGTAGTCAG 26281 TCAAGTGTCTGCAAATTCTACAGTGGCATGGTGTTGGGGCCCTTGCAGAATAACTGGGCT 26341 GGATTCCCCTCCTGATCTTCATTCCGGACTGCTGGCACTCAGGTTTCTGTCCCCTTCTCC 26401 CAGGTCACGATGAGGGCCCAGGCTCTGGATGGGCTGCCAAAGGGACCGTGCGGGGCTGGA 26461 ACCGGAGAGCCCGAGAGAGCCCTGGGCATGTGTCAGAGCCGGACAGGACCCAGCTGAGCC 26521 AGGACCTGGGTGGGGGCACCCTGGCCATGGACACGCTGCCAGATAACAGGACCAGGGTGG 26581 TGGTGAGTGCTGGAGGAACATGGAGGGGGAGCGAAGTGGGGGTGGGGGAGGTCTCACCAG 26641 CTGCCCCAGGTGTGCTTGTCCTACATGCAAATCACATATCATTTGGGGTTGGCCCCGGAG 26701 GACAGGGTGGAGAGAAGAATCCCCGGGGAGGGGATGGAAGCAGGGCCCAGACTGGGTCAT 26761 AAAATCACAGCATCTCAGCGTTTCATAGGCTGCCTACTCCCTCCTGGACCCAGAGACATC 26821 AAATGGATTGTATCAGGATGCACAGCCTGACCACAGCATTCCTGAAACTGGACTCTCCCA 26881 TGACTTAGGGAAGAAAAAGCTGACAGTGGCCTTATGAGTCACATCTCAGCTGCCAGATGG 26941 GGCCCTTCCCCACCCCATTTCTGCCCCATCTACAGACTGGGGCGCAAGAGGATTAATGGC 27001 TGCTTAGCCTAAGGGCTGGGCACTCAGCAGGGGGCTGAGTAGAGAAAGCAATTAGGGTGC 27061 AGCTCCTGGAGACAACCTCCTTGGCCTGGGGCAGTTCTGGGGTGCTGGCACAGGGAGGAG 27121 AGGCCTGGAGGGAGTGCTCTTCTCTCAGGGTTTCCGGGAGGCTCTTGGAAGCCTCGGTGT 27181 GTCTGGGGGTGAATCTATTAATATAATTGTGCGTTTCTGGGAATGGGTGTGTGTGTCATG 27241 GACGCTGGGTTCGCACCTGTGTCAGATGATTTTGTATATTATGTATGTGTACCTGTCTGT 27301 CACTGTGGGCTGTTTGTGGGTGTCTGTGATGAGCATGTGTAAGTGTGAGTGTGCCTGTGG 27361 CTGTGTGTGTAGGTGCCTGCGGCTGGGAGTGATGAGGGTGGATTCTTAGGACGCAAGAAG 27421 CAACAAGAGGACCTTCTTCTCAGTATAGATTTATTTTATATTTTAATAACTATTTTCTTA 27481 AATTAGTATGTGCTGACAGTTAAAAAAAAAAAAGGTTAAATAGTGCTAAAATCATAAAAC 27541 AAAACAGCAGTCCTGCCCCTCCTCTCCCCTGGGGCCTGCCCCCTTCCCTTTCTCAGAAGG 27601 CTCTGTCTGGGCTGTTTCCTCTGGAGTTTACTTCCATATTTCCAAGGGATTTGCTTATAC 27661 TGTACTGCTACCTCTCTGTGCACTGGTTTTAGGCCGTACCTATTCATGGCCTGCTGCGGC 27721 TCAGGGAGATTTGGCTTTTGTATACTCCCGCTGAGCAACCTTTCACCCTGCCGCCCAATC 27781 TTCCTGTTCAATCCGTGTGCTCGGTTGTGGATTGTGACGATCATGTACATAGTGTTCACT 27841 TCTAATCCAGGCAGGGTCATAACATTGTTTCTTTTCTTGTATGATTTTGGCTCTTCCTGG 27901 ATCCTGGCCCCCTCTCCTGCCCTTGCTTACTTAGTTTTCTGTGCCTACCGTAGCTACATT 27961 TTCCTACACGTCCCCTAGCCTCAAATGTAATTCCAGTGTGGGCTGGGCATGGTGGCCCAC 28021 ACCTGTAATCCTAGCACTTTGGGAGGCCCAGACGGGTGGATCGCTTGAGCTCAGGAGTTC 28081 CAGAATAGCCTAAGCAACATAGTGAGACCCACGTCTCTAAAAAATTAAAACAAAAATTAT 28141 CTGGATGTGGTGGTTTGCCCCTGTAGTCCCAGCTACTTGGGAGGCTAAGGCTGGAGGATT 28201 GCTTGAGCCTGGGCGGTCAAGGCTGTGCTGAGCTGTGACCTCACCAGCCTGGGAAAAAGA 28261 AGAAGACTCTGTCTCCGAAAAAATATAAAAGAAAGAAAATAAGATAATTCAGGGTGGTCA 28321 AACCTGTCAGTTCCTTTATCCCCCCGAGAAACTTCTCTCCTGTCCTGCACTCCAATCCCG 28381 CCCAGCCACTCGCCTGCTGGTACCACGGGTGCCATCCTGGGGCCTCCCTTTCTGTTCGTC 28441 CTGGGAACCCCTTTGTCTCCCTCCTGTGTTGGATCCCCTGTTCCCTTGACCCTGTGTCTT

	Sequence Information

Literature

	Literature

PubMed: 20217227 Positioning of longitudinal nerves in C. elegans by nidogen.
Kim S, Wadsworth WG
Science 2000 Apr 7;288(5463):150-4.

PubMed: 10520995 Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.
Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM.
Cell. 1999 Oct 1;99(1):71-80.

PubMed: 9875845 Plexin A is a neuronal semaphorin receptor that controls axon guidance.
Winberg ML, Noordermeer JN, Tamagnone L, Comoglio PM, Spriggs MK, Tessier-Lavigne M, Goodman CS
Cell 1998 Dec 23;95(7):903-16

PubMed: 9733643 Nidogen-2: a new basement membrane protein with diverse binding properties.
Kohfeldt E, Sasaki T, Gohring W, Timpl R.
J Mol Biol 1998 Sep 11;282(1):99-109

PubMed: 9586637 A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR.
Comeau MR, Johnson R, DuBose RF, Petersen M, Gearing P, VandenBos T, Park L, Farrah T, Buller RM, Cohen JI, Strockbine LD, Rauch C, Spriggs MK
Immunity 1998 Apr;8(4):473-82

FAQ

PubMed: 20217227	Positioning of longitudinal nerves in C. elegans by nidogen. Kim S, Wadsworth WG Science 2000 Apr 7;288(5463):150-4.
PubMed: 10520995	Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM. Cell. 1999 Oct 1;99(1):71-80.
PubMed: 9875845	Plexin A is a neuronal semaphorin receptor that controls axon guidance. Winberg ML, Noordermeer JN, Tamagnone L, Comoglio PM, Spriggs MK, Tessier-Lavigne M, Goodman CS Cell 1998 Dec 23;95(7):903-16
PubMed: 9733643	Nidogen-2: a new basement membrane protein with diverse binding properties. Kohfeldt E, Sasaki T, Gohring W, Timpl R. J Mol Biol 1998 Sep 11;282(1):99-109
PubMed: 9586637	A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR. Comeau MR, Johnson R, DuBose RF, Petersen M, Gearing P, VandenBos T, Park L, Farrah T, Buller RM, Cohen JI, Strockbine LD, Rauch C, Spriggs MK Immunity 1998 Apr;8(4):473-82