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Tumor Endothelial Marker Report: TEM5 (scaffold + Rho GEF)

TEM domain structure

site-guide


TEM Sequence Analysis
name from to source/E description
unknown 1 517 BLASTP without filtering No known domain matches this region. It is LCR-rich (P) and 8 potential SH3 binding motif sequences (PXXP) cluster in the region. A potential 14-3-3-binding motif (RSXSXP) is found at position 179-184. The actin-binding protein profilin binds polyproline rich sequence tracts containing two or more ZPPX motifs in a stretch of no more than 100 residues (Z- P G A or charged, X- preferentially hydrophobic). The N-terminal of TEM5old4 contains 7 ZPPX motifs (64, 102, 343, 422, 428, 483, 490), 4 with a hydrophobic amino-acid at motif-position 4 (64, 102, 342, 421, 427). The function of the proline-rich N-terminal region remains unknown, although a partially sequence-similar proline-rich region in FGD1 was shown to mediate subcellular localization to the actin cytoskeleton.
  9 20 SEG LCR(SL)
  30 55 predator HELIX
  57 68 SEG LCR(DPG)
  162 176 SEG LCR(GS)
  277 344 SEG25 LCR(PSGE)
  478 502 SEG LCR(PA)
DH/RhoGEF 517 700 PFAM, E=7.5e-43 This region contains a potential GEF-domain for Rho/Rac/Cdc42-like GTPases.
DH domains are found to function not only as GEFs, but additionally to recruit GTPases to targets and locations.
The DH-domain of TEM5 shows closest homology to bcr, ect2, pbl (the latter two are Rho-specific).
PH 718 930 IMPALA1.1, E=3.3 (722-822) The hit is not reliable, but as PH domains are invariably found C-terminally to DH domains it can be considered. The assignment is based additionaly on a Psi-Blast search of the region 700-1000 with the inclusion condition E=0.002 collecting the PH domain of human bcr.
While the DH domain is responsible for catalytic activity, the PH domain has proposed functions in proper localization or full catalytic activity of the DH domain.
unknown 930 1012 44% identity in CG7397 This region of unknown function contains a motif of potential significance due to its 100% preserved sequence compared to CG7397: VWVCNSDGYVGQVC
  1012 1048 SEG No known domain matches this region. It is LCR enriched in proline and alanine.
  1083 1134 SEG No known domain matches this region. It is LCR enriched in serine and contains a predicted high scoring PEST domain.
apolar region 1135 1155 TOPPREDM(1.22) The following 7bladedbeta-propeler domain seems to be bordered by two apolar, unstructured regions.
7 bladed beta-propeler 1191 1362 IMPALA-SCOP, E= 1e-06 The region is predicted to form a 7 bladed beta-propeler, which is a structure frequently involved in multiple protein-interaction formation.
The secondary structures adopted in this region can be described are predicted as follows: alpha-helix (1251-1239) & 7predicted beta-str (1239-1362).
The region shows homology to the last 400 aa of JNK/SAPK-associated protein-1 (see below).
apolar region 1380 1394 TOPPREDM(1.539) The preceeding 7bladedbeta-propeler domain seems to be bordered by two apolar, unstructured regions.
unknown 1394 1493 blastp This region shows homology to CG7397 and JNK/SAPK-associated protein-1, the later of the two being more indicative on its potential function as it is studied. Seven potential SH3 binding motif sequences (PXXP) cluster in this region.
1510        

Remarks



Sequence Information
TEM TEM5
Reliability of Gen2Tag mapping
Cid->tag (Hs.45180) frequency:
tem5: CATG-TATTAACTCT=31/36 (EST: oriented)
tem5: CATG-TATTAACTCT=2/2 (cDNA)
Analysis
  • BlastP against nr

  • Output Created by a Suite of Single Sequence Analysis Techniques
  • Protein Description
    SEQ.SOURCE: gi|2224615|dbj|BAA20795.1| KIAA0337 [Homo sapiens]
    Protein Sequence
    MARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFEKIQRMGAQQDDGSDAPPGSPDWA
    GDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSSSSAQTNHHGPGTEDSLGGWA
    LVSPETPPTPGALRRRRKVPPSGSGGSEFSNGEAGEAYRSLSDPIPQRHRAATSEEPTGFSVDSNLLGSL
    SPKTGLPATSAMDEGLTSGHSDWSVGSEESKGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSR
    RGELAGPGFEGPGGEPIREVEPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNF
    HLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPE
    PPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLAAPPSAEAKPP
    EAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEI
    FDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARP
    AFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINK
    GVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRK
    SGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKL
    SESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATRPEGTDSYIFEFPHPDARLGFE
    QAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFSCAAPTLNSCPEPSPEVWVCNSDGYVGQVCLLSL
    RAEPDVEACIAVCSARILCIGAVPGLQPRCHREPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPG
    PQPCLHISIAGSGLEMTPGLGEGDPRPELVPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSK
    EATAETTSSEEEQEPGFLPLSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSSVWL
    GTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVT
    LGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHV
    CLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTV
    SCPRAPLSPTGLGQGHTGHVRFLAAVQLPDGFNLLCPTPPPPPDTGPEKLPSLEHRDSPWHRGPAPARPK
    MLVISGGDGYEDFRLSSGGGSSSETVGRDDSTNHLLLWRV
    SAGE-Tag CATG-TATTAACTCTC
    EST/cluster Description
    UNIGEN CLUSTER: Hs.45180 : KIAA0337 gene product
    SEQ.SOURCE:gi|2224614|dbj|AB002335.1|AB002335 Human mRNA for KIAA0337 gene
    MARKINGS: TEM5 Tag in red
    first Poly-A-signal following the Tag in bold
    EST/cluster Sequence
    ACGACCTATGGTCTAGTAGGGGTTCTGGGGGCTGGGGCGTGTACCGCTCCCCTAGCTTTGGAGCTGGGGA
    AGGGCTCCTGCGGTCCCAGGCTCGAACCCGTGCCAAAGGACCTGGAGGCACCTCTAGGGCATTGAGGGAT
    GGAGGATTTGAGCCTGAAAGAGTCGACAGCGGAAGTCCCTGTCAAATCCAGATATCGCCTCAGAGACCCT
    GACGCTTCTCAGTTTCCTGCGCTCAGACCTTTCAGAGCTGAGGGTCCGAAAACCTGGTGGGAGCTCCGGG
    GACCGTGGAAGCAACCCCCTAGATGGCAGAGACTCACCATCCGCAGGTGGCCCTGTGGGGCAACTTGAAC
    CCATACCCATCCCAGCCCCAGCATCACCTGGCACGCGCCCCACACTCAAGGACTTGACAGCCACTCTGCG
    GAGAGCAAAGTCATTCACCTGCTCTGAGAAGCCCATGGCCCGCCGCCTGCCCCGCACCAGTGCTCTGAAG
    TCCAGCTCCTCCGAGCTCCTGCTCACAGGCCCTGGTGCCGAGGAGGATCCGCTGCCCCTCATCGTCCAGG
    ACCAATATGTGCAGGAGGCCCGCCAGGTTTTTGAGAAGATCCAGCGCATGGGTGCCCAACAAGATGATGG
    AAGCGATGCCCCCCCTGGAAGCCCTGACTGGGCAGGGGATGTGACCCGAGGGCAGCGGTCCCAGGAGGAG
    CTCTCAGGCCCTGAGTCCAGTCTGACAGATGAAGGCATTGGGGCAGACCCTGAGCCTCCTGTTGCAGCAT
    TTTGCGGCCTGGGTACCACAGGGATGTGGCGACCTCTTTCCTCATCCTCGGCCCAGACGAACCACCATGG
    CCCTGGGACTGAGGACAGTCTGGGCGGGTGGGCCCTGGTGTCGCCTGAGACCCCTCCCACACCAGGTGCC
    CTCCGCCGACGACGCAAAGTCCCACCTTCAGGTTCTGGTGGGAGCGAATTTAGCAATGGGGAGGCAGGGG
    AGGCCTACAGGTCCCTGAGTGACCCAATTCCTCAGCGCCACCGGGCTGCCACCTCTGAAGAGCCTACTGG
    GTTCTCTGTGGACAGCAACCTCCTGGGCTCACTGAGCCCCAAGACAGGGCTCCCTGCCACCTCAGCCATG
    GATGAGGGCTTGACCAGTGGTCACAGTGACTGGTCTGTGGGCAGTGAAGAGAGCAAGGGATATCAGGAGG
    TTATTCAGAGCATAGTTCAGGGGCCTGGCACCCTGGGGCGTGTGGTGGACGACAGGATTGCTGGCAAAGC
    CCCCAAGAAGAAATCCCTGAGTGACCCCAGCCGCCGTGGGGAGCTGGCTGGGCCTGGATTCGAGGGCCCT
    GGAGGGGAGCCCATCCGAGAAGTTGAGCCCATGCTGCCTCCATCCAGCAGCGAGCCCATCCTTGTAGAGC
    AGCGGGCAGAGCCAGAAGAACCTGGTGCCACCAGGAGCCGGGCACAGTCTGAAAGGGCCCTACCTGAGGC
    TCTGCCTCCCCCTGCCACTGCCCACCGAAACTTTCACCTTGACCCCAAGCTGGCTGACATTCTGTCCCCG
    AGGCTAATCCGCCGAGGCTCCAAGAAGCGCCCAGCTCGGAGTAGTCACCAGGAGCTTCGGAGAGACGAGG
    GCAGTCAGGACCAGACTGGCAGCCTGTCTCGGGCCCGGCCCTCCTCCAGACACGTTCGCCATGCCAGTGT
    GCCCGCCACATTTATGCCTATTGTGGTGCCTGAGCCACCAACTTCTGTTGGTCCCCCTGTGGCTGTGCCA
    GAACCCATAGGCTTCCCTACCCGAGCCCATCCCACGTTGCAGGCACCATCGCTCGAGGACGTCACCAAGC
    AGTACATGCTGAACCTGCACTCCGGTGAGGTCCCTGCCCCAGTGCCAGTGGACATGCCCTGCTTGCCTCT
    GGCTGCACCGCCCTCTGCTGAGGCCAAGCCCCCTGAGGCAGCTCGGCCTGCAGATGAGCCTACCCCTGCC
    AGCAAGTGCTGCAGCAAGCCACAGGTGGACATGCGGAAGCACGTGGCCATGACCCTGCTGGACACAGAGC
    AGTCGTATGTGGAGTCGCTGCGCACCCTGATGCAGGGCTACATGCAGCCGCTGAAGCAGCCAGAGAACTC
    CGTGCTCTGTGACCCTTCACTGGTGGACGAGATCTTCGACCAGATCCCCGAGCTCCTGGAGCACCACGAG
    CAATTCCTGGAGCAGGTTCGGCACTGCATGCAGACCTGGCATGCCCAGCAGAAGGTGGGAGCCCTGCTCG
    TCCAGTCGTTCTCCAAGGATGTCCTAGTAAACATCTATTCTGCCTATATCGATAACTTCCTCAATGCAAA
    GGATGCTGTGCGTGTGGCCAAGGAGGCGAGGCCTGCCTTTCTCAAGTTCCTAGAGCAAAGCATGCGTGAG
    AACAAGGAGAAGCAGGCGCTGTCTGACCTCATGATCAAGCCTGTGCAGCGGATCCCACGCTACGAGCTTC
    TGGTGAAGGACCTCCTGAAGCATACACCTGAGGACCACCCGGACCATCCACTCCTGCTGGAGGCGCAGCG
    GAACATCAAGCAGGTGGCTGAGCGCATCAACAAGGGTGTGCGGAGTGCCGAGGAGGCGGAGCGCCATGCC
    CGTGTGCTGCAGGAGATAGAGGCTCACATCGAGGGCATGGAGGATCTCCAGGCCCCTCTGCGGCGGTTCC
    TGAGACAGGAGATGGTCATTGAAGTGAAGGCGATCGGTGGCAAGAAGGACCGGTCTCTCTTCCTGTTCAC
    GGACCTCATCGTCTGCACCACTCTGAAGCGAAAGTCAGGCTCCCTGCGGCGCAGCTCCATGAGCCTGTAC
    ACGGCAGCCAGTGTCATTGACACAGCCAGCAAGTACAAGATGCTGTGGAAGCTGCCGCTGGAAGACGCAG
    ACATCATCAAAGGGGCATCCCAAGCCACCAATCGGGAGAACATCCAGAAGGCCATCAGCCGCCTTGATGA
    GGACCTCACCACCCTGGGCCAAATGAGCAAGCTCTCTGAGAGCCTTGGTTTCCCCCACCAGAGCCTGGAC
    GATGCACTGCGGGACCTCTCAGCTGCCATGCACCGGGACCTGTCGGAGAAGCAGGCGCTGTGCTACGCGC
    TTTCCTTCCCGCCAACCAAGCTGGAGCTGTGCGCCACTCGGCCCGAGGGCACCGACTCCTACATTTTTGA
    GTTCCCTCACCCTGACGCCCGCCTTGGTTTTGAACAGGCCTTCGATGAGGCCAAGAGGAAGCTGGCATCC
    AGCAAAAGCTGTCTAGACCCTGAGTTCCTGAAGGCCATCCCCATCATGAAAACCCGCAGTGGCATGCAGT
    TCTCCTGTGCGGCTCCCACCCTGAACAGCTGCCCGGAGCCCTCGCCTGAGGTATGGGTCTGCAACAGCGA
    CGGCTACGTGGGCCAGGTGTGCCTGCTGAGCCTGCGCGCCGAGCCGGACGTGGAGGCCTGCATCGCCGTC
    TGTTCCGCCCGCATCCTCTGCATCGGGGCGGTGCCCGGGCTGCAGCCTCGCTGCCACCGGGAGCCTCCTC
    CGTCGCTGAGGAGTCCTCCAGAGACGGCACCGGAGCCCGCCGGGCCGGAGCTGGACGTCGAGGCCGCTGC
    AGACGAGGAAGCCGCGACGCTCGCGGAGCCGGGGCCGCAGCCCTGCCTTCACATCTCCATTGCAGGCTCG
    GGCTTGGAGATGACGCCGGGCCTCGGCGAGGGTGACCCCCGCCCAGAGCTGGTGCCCTTTGACAGTGACT
    CTGACGATGAGTCTTCGCCCAGCCCCTCGGGGACGCTGCAGAGCCAGGCCAGCCGGTCCACCATCTCCTC
    CAGCTTTGGCAATGAGGAGACCCCGAGTTCCAAGGAGGCCACGGCAGAGACCACCAGCTCAGAGGAGGAG
    CAGGAGCCAGGCTTCCTGCCACTGTCTGGCTCCTTTGGGCCTGGTGGTCCCTGCGGCACCAGCCCAATGG
    ATGGGAGAGCCCTTCGCCGCTCCAGCCACGGCTCCTTCACCCGGGGCAGCCTTGAGGACCTGCTGAGTGT
    CGACCCTGAGGCCTACCAGAGCTCCGTGTGGCTGGGCACTGAGGATGGCTGTGTCCACGTGTACCAGTCC
    TCCGACAGCATCCGTGACCGCAGGAACAGCATGAAGCTCCAGCATGCGGCCTCTGTGACCTGCATCTTGT
    ATCTGAATAACCAGGTGTTTGTGTCTCTGGCCAATGGAGAGCTTGTGGTCTACCAAAGGGAAGCAGGCCA
    TTTCTGGGACCCCCAGAACTTCAAATCAGTGACCTTGGGCACCCAGGGGAGCCCCATCACCAAGATGGTA
    TCTGTGGGTGGGCGGCTGTGGTGTGGCTGCCAGAACCGAGTCCTTGTCCTGAGCCCTGACACGCTGCAGC
    TGGAGCACATGTTTTACGTGGGTCAGGATTCAAGCCGCTGCGTGGCTTGCATGGTGGACTCCAGCCTGGG
    TGTGTGGGTGACATTGAAAGGTAGTGCCCACGTGTGTCTCTACCATCCAGACACCTTTGAGCAGCTGGCA
    GAAGTAGACGTCACTCCTCCCGTGCACAGGATGCTGGCAGGCTCGGATGCCATCATCCGGCAGCACAAGG
    CTGCCTGTCTGCGAATCACAGCGCTGCTGGTGTGTGAGGAGCTGCTGTGGGTGGGCACCAGTGCTGGTGT
    CGTCCTCACCATGCCCACTTCGCCCGGTACTGTCAGCTGCCCACGGGCACCACTCAGTCCCACAGGCCTC
    GGCCAGGGACACACCGGCCACGTCCGCTTCTTGGCTGCAGTCCAGCTGCCAGATGGCTTCAACCTGCTCT
    GCCCAACCCCACCACCTCCCCCAGACACAGGCCCCGAGAAGCTGCCATCACTGGAGCACCGGGACTCCCC
    TTGGCACCGAGGCCCCGCCCCTGCCAGGCCTAAAATGCTGGTTATCAGTGGAGGTGATGGCTATGAGGAC
    TTCCGACTCAGCAGTGGGGGCGGCAGCAGCAGTGAGACTGTGGGTCGAGACGACAGCACAAACCACCTCC
    TCCTGTGGAGGGTGTGACCCTGTCTGCCGTGGCCCAGGACTCGCCCGCCCACCTGCCTTCAGCCTGCTTG
    CCTCTCCCTAGCCCACACGCAGACTTTGACCAGGAGTATCCAGCCAGGGGCACACATGTGCCTGCGTGGG
    CTCTGCCTTGTCTTCGCGGAAGCATTCCTGATGGAACACCCACTGGCCAGCCAGGCCATGGCTTCTCCCG
    ACCCTCTGGCTGCCCCGGTGCTTCCAGTCATGATCGGGTGGGGGACATGTGGGCTGACCAGGACCTCTGA
    CCCTGGAGCTTCTACCAAAGACACAGCTGGGTCTGGACCCCACGGGGCTGGGGAGGGCCATGTGCAATAT
    TTGGAGGGTTTTCTGGAGGGCAGCAGGAAGGCTGGGGAATTCCCCATGTACAGTATTTATGTTTCTTTTT
    AGATGTGTACCTTCCCAAGCACTTATTTATGCAGTGACCTGGTCACCTGGGGTGGGGGTGATTTGAGGAA
    ATGACATGAGGAAAAGAAACCTATTCCTGCCCTGGGGACCACCCTGGGACTCTAACCAAGCCTTCCTGGA
    GGGACCCATGCGCCCCTGAGCCCCATTCCATTCATACAGACACACACGTACGCACACTGCATGTCCAAGG
    CCCTAAACATTGCCCGTTGACATAAACTTTCCAGGGCCCCAGCCTGATGGGGCTGCCCTCAGTCCTCTAG
    ATCAAGATGCTGACTATTAGGGGGCAGTGATTGCCATCTGGGGACCTGTCAGGCTTTGTCATTTCCCAGT
    TTGTTGGTGGTGCCTTTAGTGGTTCCCTAATTTGGGAACACTGATGGGGCCTTGGACAGGGCTTTCTCTC
    AGGTAGGAGAAATGGGCCCATGATCTCCTCACAGTCGCCCCCAGTCCTTGGCCCTGCTTCCCTGTGTCTC
    ATGCACTGGCACATATGGTCACCTTGGAGGGCAGACCTAGGAGCCCCTCTGACCACTGAATCCGTCTCCA
    CACCCCTTCTGCCAAGGGAAGCCCCTTCAGGAAGGACCCCCCAAAGCTGAGGGGCTGAATGTAGCCTTTT
    CAACAGAGAAGGCTCCCACTTGAGAGCAGCCTCTACCTGACCCCCTGGACCACAGAGAGCCACTCTGACC
    CTCAGCCCCCTCGCTTCTTCAGCTAAAACTCCAAAGGTTTGGTTTCAGATGGGGTTTGTTTTGTTCTGTT
    TGGTTTTGGTTTTGTTTGGGGTGGGTGGGTCATTGCGGTCTTAGATTATGTTTCTCTTGCTACCAAACAG
    TCATGTATTAACTCTCTTTGGATGATGAAGTTTAAAGAGTCAATAAATAGAAACACCAG
    Genomic Sequence Description  
    Genomic Sequence
    
          


    Literature

    PubMed:11106729 Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein.
    Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS.
    Cell. 2000 Nov 10;103(4):583-94.
    PubMed:8601312 Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine.
    Muslin AJ, Tanner JW, Allen PM, Shaw AS.
    Cell. 1996 Mar 22;84(6):889-97
    PubMed: 8791419 The Dbl family of oncogenes.
    Cerione RA, Zheng Y
    Curr Opin Cell Biol 1996 Apr;8(2):216-22
    PubMed: 10523642 JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway.
    Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI
    Mol Cell Biol 1999 Nov;19(11):7539-48
    PubMed:11181572 Fgd1, the Cdc42 guanine nucleotide exchange factor responsible for faciogenital dysplasia, is localized to the subcortical actin cytoskeleton and Golgi membrane.
    Estrada L, Caron E, Gorski J.
    Hum Mol Genet. 2001 Mar 1;10(5):485-95.
    PubMed:9463375 In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly.
    Witke W, Podtelejnikov AV, Di Nardo A, Sutherland JD, Gurniak CB, Dotti C, Mann M
    EMBO J. 1998 Feb 16;17(4):967-76


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