Tumor Endothelial Marker Report: TEM13 (Thy-1)

TEM domain structure

	TEM domain structure

TEM Sequence Analysis

name from to source/E description

SignalP 1 20

ig 31 106 Pfam, E = 9.5e-07 The domain might be involved in protein-protein and protein-ligand interactions.

GPI 130 130 Pv: 8.453277e-03 A GPI anchor attaches the mature protein to the outside of the cytoplasmic membrane, and allows later release by phospholipase.

130

Propeptide 131 161 The propeptide is removed in the mature form.

161

	TEM Sequence Analysis

name	from	to	source/E	description
SignalP	1	20
ig	31	106	Pfam, E = 9.5e-07	The domain might be involved in protein-protein and protein-ligand interactions.
GPI	130	130	Pv: 8.453277e-03	A GPI anchor attaches the mature protein to the outside of the cytoplasmic membrane, and allows later release by phospholipase.
130
Propeptide	131	161		The propeptide is removed in the mature form.
161

Remarks

	Remarks

CLASSIFICATION: Belongs to the Ig superfamily.
DOMAIN ARCHITECTURE: Thy-1 consists of a single variable-type immunoglobulin domain anchored to the external face of the plasma membrane via a glycophosphatidylinositol moiety.
REGULATION: Thy-1 is induced on human EC by phorbol esters, proinflammatory cytokines, e.g. TNF. Can act as a surface reporter of PKC activation.
FUNCTION: Thy-1 is a marker of adult but not embryonic angiogenesis.
The function of Thy-1 is not known.
Thy-1 is a cell surface glycoprotein expressed mainly on lymphoid tissue, brain and neurons after axonal growth is finished.
Thy-1 can play a role in the modulation of endothelial permeability in inflammation (Ishizu,1995). Thy-1 expression on the EC surface is upregulated by the proinflammatory cytokine TNF and that ligating EC Thy-1 with antibodies results in a transient calcium flux. Studies with other cell types have suggested that Thy-1 may also have an important role in the regulation of cell adhesion, growth, and differentiation.

Sequence Information

TEM TEM13 CD90=Thy-1 cell surface antigen

Reliability of Gen2Tag mapping

Cid->tag (Hs.125359) frequency:
tem13: CATG-GAGTGAGACC =100/127 (ESTs)

Analysis
BlastP against nr

Output Created by a Suite of Single Sequence Analysis Techniques

Protein Description

SEQ. SOURCE: sp|P04216|THY1_HUMAN THY-1 MEMBRANE GLYCOPROTEIN PRECURSOR
(THY-1 ANTIGEN) (CDW90) (CD90 ANTIGEN) - Homo sapiens (Human)

SIGNAL 1 19

CHAIN 20 130 THY-1 MEMBRANE

PROPEP 131 161 REMOVED IN MATURE FORM.

GPI 130 130

OTHER SOURCES: Prow annotation

LIGANDS FOR CD90 AND MOLECULES ASSOCIATED WITH CD90 MOLECULE
CD45 Associated molecule
required for activation of murine lymphocytes via CD90
lck Noncovalently associated
fyn Noncovalently associated
P100 Noncovalently associated

Protein Sequence

MNLAISIALLLTVLQVSRGQKVTSLTACLVDQSLRLDCRHENTSSSPIQYEFSLTRETKKHVLFGTVGVP EHTYRSRTNFTSKYHMKVLYLSAFTSKDEGTYTCALHHSGHSPPISSQNVTVLRDKLVKCEGISLLAQNT SWLLLLLLSLSLLQATDFMSL

SAGE-Tag CATG-GAGTGAGACCC

EST/cluster Description

UNIGEN CLUSTER: Hs.125359 : Thy-1 cell surface antigen

SEQ.SOURCE: gi|339682|gb|M11749.1|HUMTHY1A Human Thy-1 glycoprotein, complete cds

MARKINGS: tem13 Tag in red
first Poly-A-signal following the Tag in bold

EST/cluster Sequence

GGATCCAGGACTGAGATCCCAGAACCATGAACCTGGCCATCAGCATCGCTCTCCTGCTAACAGGTACCCG GCATGGGGCAGGACTGGGGCTCCAGGCGCCCTGGCTTCCTTCCCTCCAGAGAAGCAGCTTCTCCCTCACA GTCTCAGAAAAGCGCAGGTGACAAAGAGAGGGCTCTTTTTCATCCTGAAGTCAGCCGATCCACCGCGCTG ATATTCTGACGGCCTGAGGTGGTTTTTGGAAACACAGTTTGCTGAGCCCTCCTTCACACTATTGAACTAG AATCCCCAACTGAGAACCCAGGAACCAGCATCAACTCCCTAAGATCTCCTGTCCTTGAAACACATTGATA GGATCCAAGGCTCAAGCAGAGTGGGGAGGGAGGCTGGGGTCTGCAAAGGAGAAGTGGGATCCCTGGGGTG GGGAAAGGCACTCAGAGAGCAGACCCCGGTCCCCTCCCTAGCCAGGCCCATCTCTCCACTTCAGGTGGGT GGGAGGCCCCTGTGCCGCAGGCCCCTCCAGTTTGAAGGAGGCACTGCTGGTGCCAGTCTTGCAGGTCTCC CGAGGGCAGAAGGTGACCAGCCTAACGGCCTGCCTAGTGGACCAGAGCCTTCGTCTGGACTGCCGCCATG AGAATACCAGCAGTTCACCCATCCAGTACGAGTTCAGCCTGACCCGTGAGACAAAGAAGCACGTGCTCTT TGGCACTGTGGGGGTGCCTGAGCACACATACCGCTCCCGAACCAACTTCACCAGCAAATACCACATGAAG GTCCTCTACTTATCCGCCTTCACTAGCAAGGACGAGGGCACCTACACGTGTGCACTCCACCACTCTGGCC ATTCCCCACCCATCTCCTCCCAGAACGTCACAGTGCTCAGAGGTGAGACAAGCCCCTAACAAGGTCAAGT GAGCTGGGAGAGCCAGGCTCGGGGACAGCAGGCAGTTCCCTTGGCTGGACTAGAGAGGAGAATAGCCCCA TAACGCTCTCACCCTCTCCCAACTGCTGCCTGGTCAACTGGGGAACCATTGCCTTCGGTGTGAATGGGGT GAAGAGCTCAGGGCCAGACAGGCAGAGCAGTGTGGTTCCACCAGAACTGTGGGCAAGGCCTTTGGCCCCT AATCTTCCTTCTCCCAGCGGGAAACAGGGATGACACCACCTCCCTCAGCCAGTTTTCTTGTCATGATGTT TAGTAAGGTTTTCATAAGATGATATGTGTGCAAGAGATCAGTAATCTGCAAATGGGAAAGATGGCTGGTT CTGTGAGACCAGGCTGTTCCTGGTCCCAGCTAAGACATTGCAGTACCCACCTCCCAAAGGGAGTACACCC TTGCTTTGGGCCTGTGCCTGCCTGAGTCCTGATCCGTCTTCCTTCCTACCCTGCCCCCGGCCCCCTTCTC TTTCTGCAGACAAACTGGTCAAGTGTGAGGGCATCAGCCTGCTGGCTCAGAACACCTCGTGGCTGCTGCT GCTCCTGCTGTCCCTCTCCCTCCTCCAGGCCACGGATTTCATGTCCCTGTGACTGGTGGGGCCCATGGAG GAGACAGGAAGCCTCAAGTTCCAGTGCAGAGATCCTACTTCTCTGAGTCAGCTGACCCCCTCCCCCCAAT CCCTCAAACCTTGAGGAGAAGTGGGGACCCCACCCCTCATCAGGAGTTCCAGTGCTGCATGCGATTATCT ACCCACGTCCACGCGGCCACCTCACCCTCTCCGCACACCTCTGGCTGTCTTTTTGTACTTTTTGTTCCAG AGCTGCTTCTGTCTGGTTTATTTAGGTTTTATCCTTCCTTTTCTTTGAGAGTTCGTGAAGAGGGAAGCCA GGATTGGGGACCTGATGGAGAGTGAGAGCATGTGAGGGGTAGTGGGATGGTGGGGTACCAGCCACTGGAG GGGTCATCCTTGCCCATCGGGACCAGAAACCTGGGAGAGACTTGGATGAGGAGTGGTTGGGCTGTGCTGG GCCTAGCACGGACATGGTCTGTCCTGACAGCACTCCTCGGCAGGCATGGCTGGTGCCTGAAGACCCCAGA TGTGAGGGCACCACCAAGAATTTGTGGCCTACCTTGTGAGGGAGAGAACTGAGGATCTCCAGCATTCTCA GCCACAACCAAAAAAAAATAAAAAGGGCAGCCCTCCTTACCACTGTGGAAGTCCCTCAGAGGCCTTGGGG CATGACCCAGTGAAGATGCAGGTTTGACCAGGAAAGCAGCGCTAGTGGAGGGTTGGAGAAGGAGGTAAAG GATGAGGGTTCATCATCCCTCCCTGCCTAAGGAAGCTAAAAGCATGGCCCTGCTGCCCCTCCCTGCCTCC ACCCACAGTGGAGAGGGCTACAAAGGAGGACAAGACCCTCTCAGGCTGTCCCAAGCTCCCAAGAGCTTCC AGAGCTCTGACCCACAGCCTCCAAGTCAGGTGGGGTGGAGTCCCAGAGCTGCACAGGGTTTGGCCCAAGT TTCTAAGGGAGGCACTTCCTCCCCTCGCCCATCAGTGCCAGCCCCTGCTGGCTGGTGCCTGAGCCCCTCA GACAGCCCCCTGCCCCGCAGGCCTGCCTTCTCAGGGACTTCTGCGGGGCCTGAGGCAAGCCATGGAGTGA GACCCAGGAGCCGGACACTTCTCAGGAAATGGCTTTTCCCAACCCCCAGCCCCCACCCGGTGGTTCTTCC TGTTCTGTGACTGTGTATAGTGCCACCACAGCTTATGGCATCTCATTGAGGACAAAGAAAACTGCACAAT AAAACCAAGCCTCTGGAATCTGTCCTCGTGTCCACCTGGCCTTCGCTCCTCCAGCAGTGCCTGCCTGCCC CCGCTT

Genomic Sequence Description

SEQ.SOURCE: AC010762.00018, sanger center

MARKINGS: tem13 Tag in red
cDNA bold

Genomic Sequence

1 AGTAGAGACGGGGTTTCACTGTATTAACCAGGATGGTCTCGATCTCCTGACCTCATGATC 61 CGCCCACCTCAGCCTCCTAAAGTACTCAGATTACAGGCATGAGCCACCGCGCCCGGCCTA 121 GATGTCACCTCTTGATGAAGGAATGTCAAAGAATTTGTGTCCACATTTTAGAATCACCAC 181 GGTAGCCTTATCTGGGTGGCTCATTTCTCTTCTGTATGGCATCACTTGGAATTACACATG 241 CTTTTGTGGTCCCATGACAGGTCACATGCCTGTGTGGTCCCATGGCAGGTCACAGGCCTG 301 TGTGGTCCCATGGCAGGTCAACTGGGGGCTGGCAGATCCCAAATGGTGATTGATGTAAAC 361 TGAGATAGTTCAGACTCCCTCAAGTGGCAACTGAACTCCAAAAAAGCAAGCTCCAACGTA 421 CAAACATTTCACAAGCTTCTGCTTTCATCACATTTGCTGATGGCCCATTGGCCAAAGCAA 481 GGCACGTGGCCAAGCCCAGAATCAGCACGGAAGGGATTACACAAAAGCATGGACACCGGG 541 CGGGGGGGGGCATGACTCACTGGAGGCCATTGATGTGACAGTCTACCATACCTGGGCAAC 601 TCCCATTTATCTTTAAAAGCTCAGTTCATGCCTGGCCTCCAAGAAGCCCTCTCTGACAGA 661 TTGGGTCATCACCTGTCCCTCCTCTGGACTCCCACAGTACCCTTTACACGTCTCTACCTC 721 TGTGTCTACCCTCTTTTTTCTAATTATCTATGTATCATTTCTGTTTCCCCCATTGGAACA 781 AGCCTTTGAGATGGTGTTCTACTAATCTTTGTATACCTAGCGTCTAGCCCCGTGCCTTGG 841 AACATTATTGGTACCAATAATGTCTTAATTATTTGGTCAATTAAACCATCCATGAATAAA 901 GTTTTTAAAATAACTATCAAAGATTAAAGTGTCTCCATTGGTGCCTTCTCTCAACTTCTG 961 CCCTGCATTCCAAGAAATAATGTTTAGTTTGTATTTGTCACATTCTCCAACCAAATATGC 1021 AGTTCTTCAGGGAGCTGACCTTGCTCAGGAAGTTGACCTCGACTAGAGGTTAGGAGAGGT 1081 AGCGGAGTGTAGAGCAGCAGTTCCAAGATATTTTAATTTCATAGACTTAGTCACATTTCC 1141 AAAGAAGTGTGAGGGTTAACAGGAAGTTACCAATTTTCTTTTTTTTATATATAAAGTAGG 1201 ACATTAAAAACCACACATACACACATATCAATACCACCATCTCTTCAGAAAAATGGAAAG 1261 GTATAACCTTAGAATGAAAGTATAGGAAAGGCAGGTGTATAGTCTCAATTAGTCAAAGAT 1321 TAGAGCTCAGTATTATGGCTGCCTTGATATCAGGGAGACCTCAAATGGCCTAATTACAAG 1381 ATCCCCTCCCTACTTTGCTGATGAGGTCCCCCAGCCAAACCACCCTCCTTATTGTGGGGG 1441 CCAGGCACAATTTCTGCTTAACCCTGAGTACTGGGCTTCAGCACCCTGCCAGCCCACAGA 1501 ATTATGCAAACAGCCAATCACATTCTCTTACAGGAAACGGGGGCATTCCACCGTTTTGAC 1561 ATTACAAAGCCTGCCTCCCACAGCTCCTGGTAATACCTGTTTCTGAGTGCAACTCCCATG 1621 AAGCAGTTCATGGCGTGCAGTGTTATCCTCCCAGGTATGAGCATATGTGACTAATAAACT 1681 GCTATTGCTCTCATTCGTCCAGTGTTGAGGTCATGTGATCCCCCTAACTTTAGGGGATGG 1741 GAATCTCTCCCTCATCAACAGGGTGAAGAACATAAAATCAAAACAAGGTGATAACCTGAC 1801 AGCTATGTTCAGAGTACCCCGGACTGTCCTCGTTTTACTTATTTCACCGTGAACCAGGGA 1861 AATGAGTCTAGCAGAGATCTGAGGGTCCGCCCTGGGAGCACTGGAGAGCACAGTGGGAAC 1921 ATGGAGTCAGGAGACTTAAGATCTAATAGTCCAGACCATGCTTCAAAATATTTGTCTGAC 1981 CTTGACAAATCATTACCTTTCTCGGGCCTCAAGTCCCAGCTATAAAATAGTGGGGCAAGC 2041 CAGGTGCAGTGGCTCCCACCTGTAATCCCAGCATTTTGAGAGGCCAGGCGGGAGGATTAC 2101 TTGAGCCCAGGAGTTCAAGATCAGCCTGGGCAACATGGTGAGATCCCATCTCTACAAAAA 2161 AAAAAAAAAAAAATTAATTAGCTGGGCATAGTGTCAAGTGCCTATTGTCCCAGCTACTCA 2221 GGAGGCTGAGGTAGGAGGATCACTTGAGCCCAGGAGGTCAAAGCTTCAGTGAGTGGTGAT 2281 TGCACCACTGCACTCTAGCCTAGGCAACAGAGTGAGACCCTGGCTCAAAAATAAAATAAA 2341 ATAAAATTTAAAAGATGGGACCACTGTAGTCACCTCTGTGATTCTAGAAAGACAATCTGA 2401 TGAAATGAGGGAATGGCTGGCAGTCCCTAGGTCATGCTAAAGGACTGTGTGTTTTTAGAA 2461 GAGTTTTTATCCCCATATGTTTCTGGGTGGGAAAACAGGAGATGGTGGGAAAAGAGAGAT 2521 CTAAGAGACCAACAGGGCAGCCGCAGTCTTCTGGCAGGAAGTCTTGCCTTAGCTGGATTC 2581 CTCTAAAGCCTTGCTGGTTTCAGCACTCCGATCCTATCCACAGTAAATGGAGTTTTAAAA 2641 TCTCCTCCCTCCACCACCTTGTGCTCTATCCCCTGACCTCAGATGTCTAATCAGAGCCAT 2701 TAATTCCATCCAATCAGAGATCTTGCTTGGCAGACACAGAATTGCCACACCTTCTACAGT 2761 CTATACTCCCCTCCCCTGCCTAAAAGCAAGGTGCTTGGGGACCCAGAAATTAGGCCAGGT 2821 CCTCATAACCTTATCAAAATAGCAACTGCTAGGCCTTCCACCCAGCAACACTCAGAGACA 2881 GGGCCAAAGAGTGGGAAACGGAGCATCCAGGGCCTCAGCCAGCAGAGCCCAGATGCCTTC 2941 TGCAGTTAAGATCCCTGGACTCAGAATCAGAAAGCTGTTAAGCAGGAAGGAGTGCGCTGC 3001 CATGAAGAGGCAGACAGAAGCCAGAGCCAGTGTGTCTGGAATGCATCAGGTAGATGAATG 3061 GGAAGATGGCTGGGATGGAGTTGGAGGGAGGAGGGAAGTCAGCAGCCAGGGGCCAGGACA 3121 TTCATGGCCTTAAAAAGTATCCTACAAACAAGAAGCCAGGTTAGCTCACCTATGAAGAGG 3181 GACAGTCTTACCAGATCATGTGTTAGAGTCCCCAGATCCTGGGGAGCGTGAGAAAAGTGC 3241 AGACTCAGCTGGCTCTAGTACTAGATTAAGGAGGTCCTAGGTGGGCAAGGCCAGCTGCAT 3301 TTTTCATAAAATGCCCTAGAAACCTCTGCAGTTTACCAAAGTGAATAGCTCCTTTGGACT 3361 TAACCATCTGCAAGGCTCATTCCAGTTAGAGTGTTCCATCACCCTAAATGCTGGGAAACC 3421 AAGCGAATCTCCTCCCACTTGCAAGCTTCCAACAGTGGCTTCCAACAGTGCCACTGCAGT 3481 ATCAGAAACTGCAGGGAAGGTGCCAGGGCTGACTTCCATGAAGAAATAGGAGAACAGGCA 3541 GGCAGACATTGGGGAGGCCCACAGAATGTCGTGATCAGAATTCATAAAGAGGCTGGCAGG 3601 ATACAAATCAATCAAATAAACGTTAGTTCAAAAAAATTCACTACACCTGTGAGTGAGAGA 3661 AAGTCATCAGCACTGTCTCTAAAAATGAGCCTAGGGCTTCTGGTGACATCCAATCGGTGG 3721 GTTATCAGGAGTGCCCCAGGTGATCAGGAGTTGGCCTCGACTCAGTCCTTTTTGTGCTGT 3781 CTCCTCCTCTTTCCCAGAGTTCCTCTCTCTCTTCTCCCACTAGGCAGGGATGAGCAAGAG 3841 GAATGGCTCACCCTTGAGAGCTGGGGTCCATAGCCCAGGTCAGTTCTCCAGCTCTCCCAC 3901 TTACCAGCCAAGACAGGAGGTGAGGATTGAGATGGGATGAACCCAGCAGGCGGCCATGGG 3961 TTAAAGGTCGCCATGAATGTAATGTGCCCAGCACAGTGCCTGCTAAAAGGCAACACTCCC 4021 TTCCTGGTCTGAAGACCAAACAAGCAGACTGTACTCAGGAAAGCCAGAAGAACCTTCCAG 4081 CTGTCTGGACCAGAAGGTGCCAGCCCAGGGGCTGAAGAAGACGTAATGCCCAGAGCAAAA 4141 AGCGCCTGCAGCCCCCTGAAGGGCTGGGTGCTCTGGAATAGATGAGGGGGCGAAATGGGG 4201 CTGGGGACCAGGGACGGACAGGGTGGGTCCAGCACCTGCCTCGCTTCCGAAGGGCTGCTC 4261 CAACACTGAAAAACACCCAACCAGCTTCCTTTCAGAAAGACTGGAATATTCCAAAACTTC 4321 TCACTGGAGGCTCCGGAGGAGGTGGGCTCCAGCTGAAAAGGAAATGTGGAGGCGTGGGCG 4381 CTCCCGGCCTGCATCCTGCACCTCTTACACTTTGGTTTTCCCACAGACTCCTGAAGAATA 4441 GGTCAGAAGAAAGGGTTAAAGCCTTAAAAGGGGAACAACCATTGCGGGGCTCAGGGAGGA 4501 GGATAATGTTCTTTGGGCTGCCGCACCCTGATCCCCGGGGTCCCGAACCCTCCCGTCCCT 4561 GGCCAGGCCTGCCAGCCACAGGGTGAGGGCCCCCTTCCGCCGCAACCTGCCACTCTCACA 4621 CCAATGCGGGACCGCCTTCTCTTCCTTCCCCACCCCCCACCCCACCCTGCCGTCCTTTCT 4681 CCCCCAATCTCCGCCTCTGATTGGCTGAGCCCCCGGCTCCCCGCTCCCCCTCTCCTCCAT 4741 CCCCGGTGAAAACTGCGGGCTCCGAGCTGGGTGCAGCAACCGGAGGCGGCGGCGCGTCTG 4801 GAGGAGGCTGCAGCAGCGGAAGACCCCAGTCCAGGTGGGAACTGGAGCCGGTGGGACCTG 4861 GGGCTCGGGGACCGCCGTCAGGCGCCCATGCAAGACTTCCCAACACTAGGCTTCGGGCCA 4921 CGGTCCGAGGGCGCCCAGGGAAGAAGGGCGCAGAGCTTAGGGAGGGGCCTGCTTTCCAGG 4981 CAGGGGCGGGAGGGGGATGCTTCTGCAGGGCAGGGGCCGCGTGGCACCCTGATGTCTTTC 5041 GGGGAAGGCGCTCCCGGGCTTTCGCCCGCTGGGGGACTGGTGTCTGGGGCTGGGGCGCTG 5101 GAGAACAGGGAGGAAGGGCACCAAGGACAGCCTGTGGGTCTACATTCCACCCAGACGTCC 5161 CCAAACCCAGCTCGCAGAGGCGGGGAGGAGGACGGATGAAACTGCGGGGAGAGGATGGAG 5221 GATGGCGAGCTAGAGGGAATCTGCCGGGTGACCTCGCGGCGGGCTGGGTGCGGGGCACCG 5281 GAGGAGAAGGAAGCCGCAGTGCCGCAGGCGGGGACTGGGTGGAAGGCGGGCGGACGGGGG 5341 AGGGGAGAGCTGGAAAAGGATGAGAGAGGGGGAAGGGGGACTCATTTGGGAAAGGAGAGG 5401 ATTGGAATACGGAAATGGATTAAGGATGAGGCCCGCCGGGGGCTTGAGAGGGAGGAAGAG 5461 CAGACCTTCTCTGGGTCTGGAGCCGCCTGAGGACACAGACCAGAGGAAATGAATACAGAC 5521 TGCACCTCCCCAGCCGCTCTCCACCCCTCCCCTGGCTCTTCTACCCTCTCCAGCCCCAGA 5581 CCCATTTCTTCCCTTTCTTGCTCTGGCCATTGCTCCCCCTTCCCCTCCTAGATCCCAAGC 5641 CCGCACAACATCTCAAACAAGAGTCCTCGATTCAAAAGCCAGATGCCGACCCCCCTTCCT 5701 CCTGGATCTGGCTCAGGGCAGCAGCTCCACCCCGGGACAGAGAGAGCATTGATTGTAGCT 5761 GCAGCCGCCGCGGGATCCTAGCCTCACCCGTCAAGGGGCTGAGCGCCAGGGACCCTGAAC 5821 TCGTCTAGTGGTGCGCCCTGCGCACCCGGGCGCACTCAACCGAGGCAATGCCCTGCGCGC 5881 TCTCGCGGGTGCACGCCCCTTCTGTGGCCTCTCCTGGGCGAGCACTGCTCTGCAGATAGG 5941 CTAGACTACCGGCTCCGCGTCGCCTCGCCAAGGGTTGGTTCAGCCAAGGCTGCAAAAAAC 6001 AAAAAAAGACCAGGCAGACAGCCTATCCAGGGTGGCTATTGAAACTGGGCTGGAAAACTG 6061 CAGTCCCAGGAACTCCAGAGAGCTGGACATTGGGAAGCATCCTTGGCTCACATACAATCG 6121 GAGATCACTATGTCTTTCTCTCCTCCAGGAACACGATTAGCTTGTGTCCTATCCAGATAG 6181 GAATAGATGCTCCCTATCTGGGAGCATCCTTAGCTATGGTGAATGGTATCTAGCCATCCA 6241 CTGGGGATGGCGAGTGACTTAGGGATTTGTGTCTCACGTATATGAAGCAGTCATCGCCAG 6301 ATGTTGGTTGTTTTTCTTAACCCCCATCATAACCCGGTGGGTATGTAAGATTCAGAGAGA 6361 TTCATTCATTCATTCACAATAAATATCTTTGGAGTGTATGCTATATGCCAGTAATCTGCA 6421 AACGGAAACGGTTTTGAGCATTGGGGATTTTCTTCTGAACAGGAAATGGGAAGTCCCTAA 6481 ATGGGGAGTCTTTGTTTAACAGATACAGAGTTTTACTTTGAAAGACAAAAAGAGTTCCGG 6541 AGATGGGCTGCATAGCAACGTGAATGTATCCAGCACTGCTGAATATACTGAATTTAAGTA 6601 CTGAATTTAAATGGTTAAAATAGTAATTATTATGCTTTTTGTATTTTACCACGATTAAAT 6661 TTTTTTTTTAAATACGAAGCCTCAGCCCTCATAGGTCTTATATTACCATACACTATGTTA 6721 ATGTAAGAAGAGGAGAAAGAGTGGTAAAGTTACTTAAAGTCACCCAGCTAGTAAGTGCTC 6781 CATGGCCAAGCGCAGAAACACACCGTGACTGGGCTTGTTCTCCCTCCTTCCTTGCTTTCC 6841 CTGAGCAGGAAAGAGCCAGTGGCAGTATCATGTTCAGTGAGATGCAGGGACGAGAGGGGG 6901 AATGGAGAGAGGGACTTAGATGACTGCCATAGCCACTATGCCATGTTCCCAGGGACCCCC 6961 AGCCCTGGTGGTAAGTGTGGCACAGCTTGGCTGATTCCCATCCTGTTCCCACCCCAGATC 7021 CAGGACTGAGATCCCAGAACCATGAACCTGGCCATCAGCATCGCTCTCCTGCTAACAGGT 7081 ACCCGGCATGGGGCAGGACTGGGGCTCCAGGCGCCCTGGCTTCCTTCCCTCCAGAGAAGC 7141 AGCTTCTCCCTCACAGTCTCAGAAAAGCGCAGGTGACAAAGAGAGGGCTCTTTTTCATCC 7201 TGAAGTCAGCCAATCCACCGCGCTGATATTCTGACGGCCTGAGGTGGTTTTTGAAAACAC 7261 AGTTTGCTGAGCCCTCCTTCACACTATTGAACTAGAATCCCCAACTGAGAACCCGGAACC 7321 AGCATCAACTCCCTAAGATCTCCTGTCCTTGAAACACATTGATAGGATCCAAGGCTCAAG 7381 CAGAGTGGGGAGGGAGGCTGGGGTCTGCAAAGGAGAAGTGGGATCCCTGGGGTGGGGAAA 7441 GGCACTCAGAGAGCAGACCCCGGTCCCCTCCCTAGCCAGGCCCATCTCTCCACTTCAGGT 7501 GGGTGGGAGGCCCCTGTGCCGCAGGCCCCTCCAGTTTGAAGGAGGCACTGCTGGTGCCAG 7561 TCTTGCAGGTCTCCCGAGGGCAGAAGGTGACCAGCCTAACGGCCTGCCTAGTGGACCAGA 7621 GCCTTCGTCTGGACTGCCGCCATGAGAATACCAGCAGTTCACCCATCCAGTACGAGTTCA 7681 GCCTGACCCGTGAGACAAAGAAGCACGTGCTCTTTGGCACTGTGGGGGTGCCTGAGCACA 7741 CATACCGCTCCCGAACCAACTTCACCAGCAAATACAACATGAAGGTCCTCTACTTATCCG 7801 CCTTCACTAGCAAGGACGAGGGCACCTACACGTGTGCACTCCACCACTCTGGCCATTCCC 7861 CACCCATCTCCTCCCAGAACGTCACAGTGCTCAGAGGTGAGACAAGCCCCTAACAAGGTC 7921 AAGTGAGCTGGGAGAGCCAGGCTCGGGGACAGCAGGCAGTTCCCTTGGCTGGACTAGAGA 7981 GGAGAATAGCCCCATAACGCTCTCACCCTCTCCCAACTGCTGCCTGGTCAACTGGGGAAC 8041 CATTGCCTTCGGTGTGAATGGGGTGAAGAGCTCAGGGCCAGACAGGCAGAGCAGTGTGGT 8101 TCCACCAGAACTGTGGGCAAGGCCTTTGGCCTCCCTAATCTTCCTTCTCCCAGCGGGAAA 8161 ACAGGGATGACACCACCTCCCTCAGCCAGTTTTCTTGTCATGATGTTTAGTAAGGTTTTC 8221 ATAAGATGATATGTGTGCAAGAGATCAGTAATCTGCAAATGGGAAAGATGGCTGGTTCTG 8281 TGAGACCGGGCTGTTCCTGGTCCCAGCTAAGACATTGCAGTACCCACCTCCCAAAGGGAG 8341 TACACCCTTGCTTTGGGCCTGTGCCTGCCTGAGTCCTGATCCGTCTTCCTTCCTACCCTG 8401 CCCCCGGCCCCCTTCTCTTTCTGCAGACAAACTGGTCAAGTGTGAGGGCATCAGCCTGCT 8461 GGCTCAGAACACCTCGTGGCTGCTGCTGCTCCTGCTCTCCCTCTCCCTCCTCCAGGCCAC 8521 GGATTTCATGTCCCTGTGACTGGTGGGGCCCATGGAGGAGACAGGAAGCCTCAAGTTCCA 8581 GTGCAGAGATCCTACTTCTCTGAGTCAGCTGACCCCCTCCCCCCAATCCCTCAAACCTTG 8641 AGGAGAAGTGGGGACCCCACCCCTCATCAGGAGTTCCAGTGCTGCATGCGATTATCTACC 8701 CACGTCCACGCGGCCACCTCACCCTCTCCGCACACCTCTGGCTGTCTTTTTGTACTTTTT 8761 GTTCCAGAGCTGCTTCTGTCTGGTTTATTTAGGTTTTATCCTTCCTTTTCTTTGAGAGTT 8821 CGTGAAGAGGGAAGCCAGGATTGGGGACCTGATGGAGAGTGAGAGCATGTGAGGGGTAGT 8881 GGGATGGTGGGGTACCAGCCACTGGAGGGGTCATCCTTGCCCATCGGGACCAGAAACCTG 8941 GGAGAGACTTGGATGAGGAGTGGTTGGGCTGTGCCTGGGCCTAGCACGGACATGGTCTGT 9001 CCTGACAGCACTCCTCGGCAGGCATGGCTGGTGCCTGAAGACCCCAGATGTGAGGGCACC 9061 ACCAAGAATTTGTGGCCTACCTTGTGAGGGAGAGAACTGAGCATCTCCAGCATTCTCAGC 9121 CACAACCAAAAAAAAATAAAAAGGGCAGCCCTCCTTACCACTGTGGAAGTCCCTCAGAGG 9181 CCTTGGGGCATGACCCAGTGAAGATGCAGGTTTGACCAGGAAAGCAGCGCTAGTGGAGGG 9241 TTGGAGAAGGAGGTAAAGGATGAGGGTTCATCATCCCTCCCTGCCTAAGGAAGCTAAAAG 9301 CATGGCCCTGCTGCCCCTCCCTGCCTCCACCCACAGTGGAGAGGGCTACAAAGGAGGACA 9361 AGACCCTCTCAGGCTGTCCCAAGCTCCCAAGAGCTTCCAGAGCTCTGACCCACAGCCTCC 9421 AAGTCAGGTGGGGTGGAGTCCCAGAGCTGCACAGGGTTTGGCCCAAGTTTCTAAGGGAGG 9481 CACTTCCTCCCCTCGCCCATCAGTGCCAGCCCCTGCTGGCTGGTGCCTGAGCCCCTCAGA 9541 CAGCCCCCTGCCCCGCAGGCCTGCCTTCTCAGGGACTTCTGCGGGGCCTGAGGCAAGCCA 9601 TGGAGTGAGACCCAGGAGCCGGACACTTCTCAGGAAATGGCTTTTCCCAACCCCCAGCCC 9661 CCACCCGGTGGTTCTTCCTGTTCTGTGACTGTGTATAGTGCCACCACAGCTTATGGCATC 9721 TCATTGAGGACAAAGAAAACTGCACAATAAAACCAAGCCTCTGGAATCTGTCCTCGTGTC 9781 CACCTGGCCTTCGCTCCTCCAGCAGTGCCTGCCTGCCCCCGCTTCGCTGGGGTCTCCACG 9841 GGTGAGGCTGGGGAACGCCACCTCTTCCTCTTCCCTGACTTCTCCCCAACCACTTAGTAG 9901 CAACGCTACCCCAGGGGCTAATGACTGCACACTGGGCTTCTTTTCAGAATGACCCTAACG 9961 AGACACATTTGCCCAAATAAACGAACATCCCATGTCTGCTGACTCACCTGGCTGGAACAA 10021 CATGCTTACTGCCAACATGTGGGCCGAACCACATGGCCCTGGCTCTGGAATGCACAAGTG 10081 GCTTTGCGTGAATCTGCGCTAAGCTATGCAGTCTGCTTTTTCTTCTCAGCTCTGGTAGTT 10141 CTTCAGAAATGTACCCTCCAGGCACATCCACTATTGCGAGGGTGAGCACGAAGGGTGGGA 10201 GATGCCCATGTCCTCAAGGCATCACTTCCTAAATCCAAAAGCATCGGCAGGAGAAAGGAC 10261 TGGGGACAAATACTGTCCCTTCGGGAGTAGGGAGGGAACACTGAGGCCCATCCCTGGCTC 10321 CTTCCCTAAAAGTAGAGTAAAATGGAAGCGAGCATCCTGGGATTGGGGGCAAGAGGGGGA 10381 CCGCAGGGTAGCTGTGGGTTCCAACTGCTGTCAGAGTCAGAGAGGCAGCCCCAAGCCAGC 10441 CTCCCTGCTTTGCCAGGGAATTTGGGGGAGGAAGGTGACAGCTGCCCAGAGGCTGACTCA 10501 TCTGATATTTAGCACTGGGTAGGATGATTGTTTCTGAGCATTTTTCTTAAAGGCCTCAGA 10561 TCTAAATTATGCCACCGGCTCCCACTCTTGCTACCTCCCGTCAACTTCTCTGCCTTGCCT 10621 TCCACCCCTGTAGTTACCATACACAGAGGAGGAGGAGCTGTCCTTGTCCCAGGTTGGGAG 10681 GCTGACAACCCCTTAGCAAGATGCTGCCAGCCCAGAGCTCTCCAAGGGGAGGAACACCCC 10741 TGAGACTCAGGCCCCTCTCCTTCAGCCCTGCTTGGGCTGCAAGCGCCGTGCCAAGGAAAG 10801 GCATCTTGGTGAGAAGAGCTGCTGTGGGGGAAGGGAGATCAAATGCCAGAGAAATGTGGG 10861 GTGCCCCACCCTCAGGATAGTAAAAGAGTATGGAGGTATTTCTGGAAGGAAATGAGCGGC 10921 ACTGTGTGAAGCCTCGCACCTGTGTGACACTTCCTATGGGGTCTTTGTCACACTCTAGTA 10981 CTATGTCCCTGAAGAGTTTAGCAGCCACACTCTTAGAAGGGTGCTGGGAGATGGTGTTGC 11041 CCTCTGCAGCCATGTTTAGGGGAGCGGAACCTGAGGCCCACAGTGGGTGAGATTAGCTCA 11101 AGAAGCCACAGAGGCCACCAGAGGGCCACGGACTTCGGAAAGGAGAAGAGAAGAACAGGG 11161 CATCAGGCCTCACAACGCAAACCTACCCAGAGATGGGCACAGTGGCTCATGCCTGTAATC 11221 CCACCACTTTGGGAAGAGGCGGATCGCTTGAGGTCAGGAGTTCGAGACTAGCCTCGAAAC 11281 CCTATCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCCTGCGCCTGTAATCCCA 11341 GCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCGGAGGTTGCAGTGA 11401 GCCAAGATTGCACCACTGCACTCCAGCCTGGGAGATAGAGTGAGACTCCATCTCAAAAAA 11461 ATAAAAAATAAAATAAACCTACCCGGAATGACCATGCTGAGGACTGGGAGCCCGCAGACT 11521 TTCAGCCACAGGCCGCGACAGCCGTGGGTCCCTCCCTGGTCAAGTCAGCAGGCCTTGTGG 11581 AGGCTGTGGGGTATCTGTGGTGACTCAGGTAATTATAGAGGGCTGGCCCCCAGCCCTGGT 11641 TCCTGTACACATGCCCCAACCCCATCCCCATCCACTCCCTCGCCAGTCCTAACCTCTTTC 11701 CTGGGTCCCCCCCCTTCAGCACCTAAGTCCATACCTAGGGCCGTGGAATTCCCGCTCAAG 11761 AGCAACAGAAGCCCCTCTCTGCACCCCCATTTCTGGACTGGATTGTCCACTGAGACGCGC 11821 AATGTCTGCATCTCTGACATCTAGAGGCTTCCTCGGGAAGGGCATGGGGATCTCCGTGAG 11881 ATGTGGGGACTTTCACTGGCCAACCAAGAAATCTACACAGCGTCCGGGGACCTGTGACAC 11941 ACATCCCTCCCGCCTCCTCAACCTGATGTCCCTCTCTGAATCTGCAGCTTTCGTGCTGTG 12001 AAGGTGTCTTTACATGTGAAACAAACAAACCCAAGTCAAGAGTAAATCATCTCATTTACT 12061 AGTGAGAAAATGTTGGAGCTGGAGTCCTTCAGAGAGTCCTGGCCAGGCAAGAGGGCCATC 12121 AGCTCTCTTCTGCTCAACAGGGGCTCTCAGCCTCAGGACACTCTCAGGCCTGGAATGTCC 12181 CCAACACACTCAAGGAGAAACATGTCCTGTGCAGACCCACAGGAGGCATCTTTGCCCGGC 12241 ACAAAGAAGAGCTGGGGTCAGTGGGACCTGTGGATGTGGACACATCATATGGAGGGTGGG 12301 TAGGACCAATGTGGCAGCTTCATGGAGGCCAAGTGTGGCTCTGCACCAAGAAGGGGCTGC 12361 GACGGCTGGAGGTGCCCATCAGAGCACGCGGGGAGAGCCTGTCGGTGGCTCGGCCAGGTG 12421 GACGCCACCTGTCCAGTTTGC

	Sequence Information

Literature

	Literature

PubMed: 9357767
Am J Physiol: C1233 Human umbilical vein and dermal microvascular endothelial cells show heterogeneity in response to PKC activation.
Mason JC, Yarw.
Am J Physiol 1997 Oct;273(4 Pt 1):C1233-40.

PubMed: 8752941 Human Thy-1 is cytokine-inducible on vascular endothelial cells and is a signaling molecule regulated by protein kinase C.
Mason JC, Yarwood H, Tarnok A, Sugars K, Harrison AA, Robinson PJ, Haskard DO.
J Immunol. 1996 Jul 15;157(2):874-83.

PubMed: 1671083 Thy-1 supports adhesion of mouse thymocytes to thymic epithelial cells through a Ca2(+)-independent mechanism.
He HT, Naquet P, Caillol D, Pierres M.
J Exp Med. 1991 Feb 1;173(2):515-8.

PubMed: 1346926 Selective inhibition of neurite outgrowth on mature astrocytes by Thy-1 glycoprotein.
Tiveron MC, Barboni E, Pliego Rivero FB, Gormley AM, Seeley PJ, Grosveld F, Morris R.
Nature. 1992 Feb 20;355(6362):745-8.

PubMed: 9576104 Thy-1, a novel marker for angiogenesis upregulated by inflammatory cytokines.
Lee WS, Jain MK, Arkonac BM, Zhang D, Shaw SY, Kashiki S, Maemura K, Lee SL, Hollenberg NK, Lee ME, Haber E.
Circ Res 1998 May 4;82(8):845-51.

FAQ

PubMed: 9357767 Am J Physiol: C1233	Human umbilical vein and dermal microvascular endothelial cells show heterogeneity in response to PKC activation. Mason JC, Yarw. Am J Physiol 1997 Oct;273(4 Pt 1):C1233-40.
PubMed: 8752941	Human Thy-1 is cytokine-inducible on vascular endothelial cells and is a signaling molecule regulated by protein kinase C. Mason JC, Yarwood H, Tarnok A, Sugars K, Harrison AA, Robinson PJ, Haskard DO. J Immunol. 1996 Jul 15;157(2):874-83.
PubMed: 1671083	Thy-1 supports adhesion of mouse thymocytes to thymic epithelial cells through a Ca2(+)-independent mechanism. He HT, Naquet P, Caillol D, Pierres M. J Exp Med. 1991 Feb 1;173(2):515-8.
PubMed: 1346926	Selective inhibition of neurite outgrowth on mature astrocytes by Thy-1 glycoprotein. Tiveron MC, Barboni E, Pliego Rivero FB, Gormley AM, Seeley PJ, Grosveld F, Morris R. Nature. 1992 Feb 20;355(6362):745-8.
PubMed: 9576104	Thy-1, a novel marker for angiogenesis upregulated by inflammatory cytokines. Lee WS, Jain MK, Arkonac BM, Zhang D, Shaw SY, Kashiki S, Maemura K, Lee SL, Hollenberg NK, Lee ME, Haber E. Circ Res 1998 May 4;82(8):845-51.