This page supplies supplementary material for the manuscript
"The Brix domain protein family - a key to the ribosomal biogenesis pathway"
by Frank Eisenhaber, Christian Wechselberger, Guenther Kreil
M. Breitenbach, F.M. Jantsch, G. Lepperdinger
for sharing experimental data with respect to Brix and yol077c with us prior to publication, for discussion of the sequence analysis results and for carefully reading the manuscript.
On this page, you will find
the method for collecting the whole superfamily
the method for collecting each of the six families individually and their nearest neighbors
the graph of qualitative familiy relationships rooted at the Archaea/Eukarya division
Brix from X. laevis is a sequence almost at the center of the superfamily in the sequence space. A PSIBLAST search does collect all six families and almost the whole superfamily (except of a few archaean sequences and one alternative human sequence from the Peter Pan clade - AAH00535.1, group II). This automatic, standard search with the command-line version concluded after six iteration with convergence.
The following data allows to reconstruct the collection of the six families and the detection of their neighbor relationship to the other families.
Putative evolutionary relationship between Brix domain protein families
The relative position between between families in the sequence space can be found by the nature of the first
non-family hit in database searches started with one of the family members. The resulting graph of family connectivity
has been rooted at the division between Archaea and Eukaryota. This figure does not aim at quantifying evolutionary
distances but is solely an illustration of nearest neighbor relationships between these protein families.
Last modified: Feb 2001