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GPI Biosynthesis Report< | |
| GPI Biosynthesis Main Page | GPI Site Motif | GPI Site Prediction | Home Page B.E. |
| Molecular Function: | part of the transamidase complex |
|---|---|
| Complex: | GPAA1/GAA1, PIG-K/GPI8, PIG-S/GPI17, PIG-T/GPI16 |
| Cellular Localization: | ER membrane |
| Domain Architecture: | (cytosol) N --|TM|-----globular Domain(s)-----|-6 TM regions-|-- C |
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Orthologues |  |
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| Protein | Organism | Sequence Length | GenBank Entry |
| EAA07058.1 | Anopheles gambiae str. PEST | 647 | gi|21294913| |
| NP_197414.1 | Arabidopsis thaliana | 696 | gi|15239657| |
| AN3715.1 | Aspergillus nidulans | 633 (916) | |
| NP_491700.1 | Caenorhabditis elegans | 670 | gi|17507119| |
| orf6.4571.prot | Candida albicans | 567 | |
| AAF46094.1 | Drosophila melanogaster | 674 | gi|7290645| |
| NP_003792.1 | Homo sapiens | 621 | gi|4504079| |
| CAB86709.1 | Leishmania major | 464 | gi|7530128| |
| NP_034461.1 | Mus musculus | 621 | gi|6754046| |
| XP_331144.1 | Neurospora crassa | 454 | gi|32421401| |
| BAC01259.1 | Oryza sativa (japonica cultivar-group) | 718 | gi|21644703| |
| XP_235447.1 | Rattus norvegicus | 671 | gi|27662166| |
| NP_013189.1 | Saccharomyces cerevisiae | 614 | gi|6323117| |
| CAB65611.1 | Schizosaccharomyces pombe | 581 | gi|6689268| |
| EMBL:AC087702 | Trypanosoma brucei | 461 |
Fasta-File of the Family-Members
| Alignments GPAA1: |
- MView - Clustal |
|---|---|
| OMIM: | Entry 603048 |
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Literature | |
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| PubMed: 11598210 | The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p, and Gpi16p. Mol Biol Cell 2001 Oct;12(10):3295-306 |
| PubMed: 11483512 | PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8. EMBO J 2001 Aug 1;20(15):4088-98 |
| PubMed: 11298746 | Endoplasmic reticulum proteins involved in glycosylphosphatidylinositol-anchor attachment: photocrosslinking studies in a cell-free system. Eur J Biochem 2001 Apr;268(8):2290-300 |
| PubMed: 10793132 | Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins. Mol Biol Cell 2000 May;11(5):1523-33 |
| PubMed: 9828142 | Assignment of the human GPAA1 gene, which encodes a product required for the attachment of glycosylphosphatidylinositols to proteins, at 8q24. Genomics 1998 Dec 1;54(2):354-5 |
| PubMed: 9468317 | Molecular cloning of human homolog of yeast GAA1 which is required for attachment of glycosylphosphatidylinositols to proteins. FEBS Lett 1998 Jan 16;421(3):252-8 |
| PubMed: 7730400 | Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins. J Cell Biol 1995 May;129(3):629-39 |
Author: Birgit.Eisenhaber@nt.imp.univie.ac.at on internet.