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GPI Anchor Biosynthesis Report: GPAA1 family

Molecular Function: part of the transamidase complex
Cellular Localization:ER membrane
Domain Architecture: (cytosol) N --|TM|-----globular Domain(s)-----|-6 TM regions-|-- C

Protein Organism Sequence Length GenBank Entry
EAA07058.1 Anopheles gambiae str. PEST 647 gi|21294913|
NP_197414.1 Arabidopsis thaliana 696 gi|15239657|
AN3715.1 Aspergillus nidulans 633 (916)  
NP_491700.1 Caenorhabditis elegans 670 gi|17507119|
orf6.4571.prot Candida albicans 567  
AAF46094.1 Drosophila melanogaster 674 gi|7290645|
NP_003792.1 Homo sapiens 621 gi|4504079|
CAB86709.1 Leishmania major 464 gi|7530128|
NP_034461.1 Mus musculus 621 gi|6754046|
XP_331144.1 Neurospora crassa 454 gi|32421401|
BAC01259.1 Oryza sativa (japonica cultivar-group) 718 gi|21644703|
XP_235447.1 Rattus norvegicus 671 gi|27662166|
NP_013189.1 Saccharomyces cerevisiae 614 gi|6323117|
CAB65611.1 Schizosaccharomyces pombe 581 gi|6689268|
EMBL:AC087702 Trypanosoma brucei 461  

Fasta-File of the Family-Members

Alignments GPAA1: - MView
- Clustal
OMIM: Entry 603048

PubMed: 11598210 The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p, and Gpi16p.
Mol Biol Cell 2001 Oct;12(10):3295-306
PubMed: 11483512 PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8.
EMBO J 2001 Aug 1;20(15):4088-98
PubMed: 11298746 Endoplasmic reticulum proteins involved in glycosylphosphatidylinositol-anchor attachment: photocrosslinking studies in a cell-free system.
Eur J Biochem 2001 Apr;268(8):2290-300
PubMed: 10793132 Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins.
Mol Biol Cell 2000 May;11(5):1523-33
PubMed: 9828142 Assignment of the human GPAA1 gene, which encodes a product required for the attachment of glycosylphosphatidylinositols to proteins, at 8q24.
Genomics 1998 Dec 1;54(2):354-5
PubMed: 9468317 Molecular cloning of human homolog of yeast GAA1 which is required for attachment of glycosylphosphatidylinositols to proteins.
FEBS Lett 1998 Jan 16;421(3):252-8
PubMed: 7730400 Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins.
J Cell Biol 1995 May;129(3):629-39

Author: on internet.
Last modified: 5th November 2003