Here we list (domains of unknown function) DUFs with suggested similarity to other Pfam domains sorted by D-score (significant rps-blast similarities of a DUF to known domains are not included).
 
For this analysis the initial DUF sequence set was derived from Pfam18 database, made 80 percent non-redundant, and TM and coiled-coil regions have been masked. This sequence set included 34400 DUF proteins in 1462 families, of which 28 have a fam size below 2 (not suitable for DOUT analysis). The sequence set was analyzed by rps-blast against Pfam and sub-significant hits (E > 0.005, C > 40) have been further evaluated using DOUTfinder.
 
Similarities with a D-score > 24 are listed in warm colors, sim. with D-score > 13 are listed in cold colors.
 
As support for a correct assignment we list the Pfam19 CLANS assignment and distant similarities defined using psi-blast against a nr95 supplemented with PFAM18 sequences were applicable.
Out of 86 probable domain similarities defined by DOUT 19 are also supported by a psi-blast hit, 32 are supported by CLANs defined similarity.