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GPI Anchor Biosynthesis Report: SMP3 family

Molecular Function: Mannosyltransferase IV (MT IV)
Complex: -
Cellular Localization:ER membrane, ER lumen
Domain Architecture: N --|TM|-----globular Domain-----|multiple TM regions|-- C

Protein Organism Sequence Length GenBank Entry
orf6.6626.prot Candida albicans 498  
AAF47201.1 Drosophila melanogaster 830 gi|7291781|
NP_079439.1 Homo sapiens 579 gi|13376765|
SMP3_YEAST Saccharomyces cerevisiae 516 gi|2507131|
YADC_SCHPO Schizosaccharomyces pombe 533 gi|1351602|

Fasta-File of the Family-Members

Alignments SMP3: - MView
- Clustal
PIG-M, PIG-B, SMP3 - Alignment MView
- Alignment Clustal
- Tree

PubMed: 11356840 The essential Smp3 protein is required for addition of the side-branching fourth mannose during assembly of yeast glycosylphosphatidylinositols.
J Biol Chem 2001 Jul 20;276(29):27731-9
PubMed: 11102867 Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis.
Curr Opin Chem Biol 2000 Dec;4(6):632-8

Author: on internet.
Last modified: 24th January 2003