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GPI Anchor Biosynthesis Report: PIG-M family

Molecular Function: Mannosyltransferase I (MT I)
Complex: PIG-L, PIG-M in T.brucei and L.major, not in mammalia
Cellular Localization:ER membrane, ER lumen
Domain Architecture:(cytosol) N --|TM|-----globular Domain-----|multiple TM regions|-- C (?)

Protein Organism Sequence Length GenBank Entry
CAC34506.1 Arabidopsis thaliana 417 gi|13374872|
T18769 Caenorhabditis elegans 417 gi|7494962|
orf6.7880.prot Candida albicans 398  
AAF46748.1 Drosophila melanogaster 466 gi|7291318|
BAB18567.1 Homo sapiens 423 gi|11414879|
BAB31275.1 Mus musculus 423 gi|12858324|
NP_077058.1 Rattus norvegicus 423 gi|13162329|
NP_012547.1 Saccharomyces cerevisiae 305(403) gi|6322473|
CAB89880.1 Schizosaccharomyces pombe 815(411) gi|7688325|
BAB20994.1 Trypanosoma brucei 430 gi|12246834|

Fasta-File of the Family-Members

Alignments PIG-M: - MView
- Clustal
PIG-M, PIG-B, SMP3 - Alignment MView
- Alignment Clustal
- Tree

PubMed: 11226175 PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER.
EMBO J 2001 Jan 15;20(1-2):250-61
PubMed: 11102867 Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis.
Curr Opin Chem Biol 2000 Dec;4(6):632-8

Author: on internet.
Last modified: 24th January 2003