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GPI Biosynthesis Report< | |
| GPI Biosynthesis Main Page | GPI Site Motif | GPI Site Prediction | Home Page B.E. |
| Molecular Function: | part of the UDP-GlcNAc transferase complex |
|---|---|
| Complex: | PIG-A/ GPI3, PIG-H/ GPI15, PIG-C/ GPI2, PIG-Q/ GPI1, PIG-P/ YDR437W, DPM2 |
| Cellular Localization: | ER membrane, cytosol |
| Domain Architecture: | (cytosol) N ------|TM|-|TM|-|TM|-|TM|-|TM|-|TM|-|TM|-|TM|---- C (cytosol) |
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Orthologues |  |
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| Protein | Organism | Sequence Length | GenBank Entry |
| NP_181043.1 | Arabidopsis thaliana | 303 | gi|15226871| |
| T25032 | Caenorhabditis elegans | 282 | gi|7508045| |
| orf6.6750.prot | Candida albicans | 304 | |
| AAF47758.1 | Drosophila melanogaster | 256 | gi|7292351| |
| PIGC_HUMAN | Homo sapiens | 297 | gi|14916629| |
| BAB29152.1 | Mus musculus | 297 | gi|12851751| |
| NP_015249.1 | Saccharomyces cerevisiae | 280 | gi|6325181| |
| T41379 | Schizosaccharomyces pombe | 324 | gi|7492813| |
| TRYP10.0.001875_6 | Trypanosoma brucei | 342 |
Fasta-File of the Family-Members
| Alignments: |
- MView - Clustal |
|---|---|
| OMIM: | Entry 601730 |
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Literature | |
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| PubMed: 9463366 | The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1. EMBO J 1998 Feb 16;17(4):877-85 |
| PubMed: 9325057 | Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1. Genomics 1997 Sep 15;44(3):347-9 |
| PubMed: 8806613 | PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2. Biochem Biophys Res Commun 1996 Sep 4;226(1):193-9 |
| PubMed: 7768896 | Temperature-sensitive yeast GPI anchoring mutants gpi2 and gpi3 are defective in the synthesis of N-acetylglucosaminyl phosphatidylinositol. Cloning of the GPI2 gene.
Biol Chem 1995 Jun 2;270(22):13029-35 |
Author: Birgit.Eisenhaber@nt.imp.univie.ac.at on internet.