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GPI Anchor Biosynthesis Report: PIG-C family

Molecular Function: part of the UDP-GlcNAc transferase complex
Complex: PIG-A/ GPI3, PIG-H/ GPI15, PIG-C/ GPI2, PIG-Q/ GPI1, PIG-P/ YDR437W, DPM2
Cellular Localization:ER membrane, cytosol
Domain Architecture:(cytosol) N ------|TM|-|TM|-|TM|-|TM|-|TM|-|TM|-|TM|-|TM|---- C (cytosol)

Protein Organism Sequence Length GenBank Entry
NP_181043.1 Arabidopsis thaliana 303 gi|15226871|
T25032 Caenorhabditis elegans 282 gi|7508045|
orf6.6750.prot Candida albicans 304  
AAF47758.1 Drosophila melanogaster 256 gi|7292351|
PIGC_HUMAN Homo sapiens 297 gi|14916629|
BAB29152.1 Mus musculus 297 gi|12851751|
NP_015249.1 Saccharomyces cerevisiae 280 gi|6325181|
T41379 Schizosaccharomyces pombe 324 gi|7492813|
TRYP10.0.001875_6 Trypanosoma brucei 342  

Fasta-File of the Family-Members

Alignments: - MView
- Clustal
OMIM: Entry 601730

PubMed: 9463366 The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1.
EMBO J 1998 Feb 16;17(4):877-85
PubMed: 9325057 Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1.
Genomics 1997 Sep 15;44(3):347-9
PubMed: 8806613 PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2.
Biochem Biophys Res Commun 1996 Sep 4;226(1):193-9
PubMed: 7768896 Temperature-sensitive yeast GPI anchoring mutants gpi2 and gpi3 are defective in the synthesis of N-acetylglucosaminyl phosphatidylinositol. Cloning of the GPI2 gene.
Biol Chem 1995 Jun 2;270(22):13029-35

Author: on internet.
Last modified: 24th January 2003