|
Prokaryote kleisin - ScpA | CLUSTAL | |
Kleisin-α - Scc1/Rec8 | CLUSTAL | |
Kleisin-β | CLUSTAL | |
Kleisin-γ - Barren | CLUSTAL | |
selected kleisins - N-terminus | CLUSTAL | |
selected Kleisins - C-terminus | CLUSTAL |
Note on the kleisin proteins from Mycoplasma: |
The two Mycoplasma orthologues have an additional globular domain at the N-terminus. These first 160 residues of NP_072878.1 (Mycoplasma genitalium) and NP_109988.1 (Mycoplasma pneumonia) have low but non-random sequence similarity (E-value=0.007), but only the latter segment represents a dihydrofolate reductase (DHFR)-like domain (a CD search yields E-value=6.0e-17 with PF00186). Subject to verification of correct Mycoplasma genome assembly, the role of this domain remains to be clarified. |