CLUSTAL W(1.60) multiple sequence alignment Scc1_Hs_HR21spA_KIA0078 mfyahFVLSKRGP-LAKIWLAAHWDK-----------------------KLTK-A--HVF Rec8_Hs_HR21spB mfyypNVLQRHTGCFATIWLAATRGS-----------------------RLVK-R--EYL Scc1_Dm mfyehIILAKKGP-LARIWLAAHWDK-----------------------KITK-A--HVF Rec8_Dm_Mei-910 safgqLNRNEIAD-VDVVACCKQITE-----------------------LIEE-N--ALR Scc1_Ce_A_K08A8_3 mfyadFVLSKKGP-LSKVWLAAHWEK-----------------------KLSK-A--QIF Rec8_Ce_B_W02A2_6 aevirKDAVFHVA----WILGTGDSK-----------------------KLSR-R--EIL Scc1_Sp_Rad21 mfyseAILSKKGP-LAKVWLAAHWEK-----------------------KLSK-V--QTL Rec8_Sp fynqdVLTKEKGG-MGVIWLAATLGSkh------------------slrKLHK-K--DIM Scc1_Sc_YDL003w rltvlRLATNKGP-LAQIWLASNMS------------------------NIPR-G--SVI Rec8_Sc_YPR007c_Spo69 lslnfKDDKKYKG-LTTVWLLSALGNsivkesnnyysnksnstgnisssTVKK-K--DIV Scc1_Leishmania mffstYVLTKKGP-LAKVWLAAHWDK-----------------------RLTR-H--EVK Scc1_At_A mfyshTLLARKGP-LGTVWCAAHVHQ-----------------------RLKK-S--QYT Rec8_At_SYN1 mfyshQLLARKAP-LGQIWMAATLHA-----------------------KINR-K--KLD Scc1_E_cuniculi mskamGALCLANP-QDVLFKAIFVER-----------------------RLSR-H--HLK Ctds1_Hs ~~~~~~MEDVEARFAHLLQ---PIR------------------------DLTKNW--EVD Ctds1_At ~mtshGGGEVRGERIHTVQ---PER------------------------DLVANW--EVD Ctds1_Dm_CG14685-PB vakciRAYDEQQDLASLVVLLEELS------------------------KNTD-Y--STD Ctds1_Ce_C29E4_2 aimtrNAPPGQES-TDLAWLVTPAK------------------------DLVENF--SID Ctds1_Plasm_falc ~~~~mSTTDELNLLIQNLQ---KCN------------------------NTNECI--NFD Ctds1_Cryptosporidium_1 ~~~meNI-----PLLKSV----ENK------------------------DPSLNW--NID scpA_B_subtilis eeyqvKIDTFEGP-LDLLLHLINRL------------------------EIDI-Y--DIP scpA_Thermotoga mdlvfKLPVFEGP-LDLLLYLVRKK------------------------KVDI-R--EIP DHFR_scpA_Mycoplasma lsfnvFLEDYNGT-LPNLLELLIDK------------------------KFNL-H--QVD scpA_Pseudomonas ~~mevFLEAFEGP-LDLLLYLIRKQ------------------------NIDI-L--DIP scpA_Chloroflexus mpyavTLPEFTGP-LDLLLRLIERA------------------------ELDI-T--TIA scpA_Pyrococcus ~~~meRFEPEVTP-VDILLQLVKMG------------------------KVDP-W--NID scpA_Methanococcus ~~midSNFDIVLW-VRMIKEGIEKK------------------------NLNP-W--DVN scpA_Thermosynechococcus ppvmsQSFADTA--IDILIELAERG------------------------EIDP-W--DIQ scpA_Cytophaga asfeiQLPLFAGP-FDLLLFFIERD------------------------ELDI-Y--DIP scpA_Mycobacterium agfrvRLTNFEGP-FDLLLQLIFAH------------------------QLDV-T--EVA scpA_Treponema pvqefKLSQFEGP-LDLLLFLIKKN------------------------ELSI-Y--DIP scpA_Aquifex ~~mkyFHFTEEHP-FSLVLPLIEEG------------------------KLDP-W--EVD scpA_Fusobacterium eevvvKLNNFEGP-FDLLLNLIEKN------------------------KMKI-S--DIN scpA_Thermoplasma mridrSVDPVKSI-ILEILSLCSDG------------------------RIDP-W--DVD scpA_Prochlorococcus lnrgaDSGARLA--IRLLQDAAERG------------------------ELDP-W--DVD scpA_Archaeoglobus ~~~~~MA---------------KRG------------------------EIDP-W--NID scpA_Rhodospirillum ~~~~~~~~~~~~~~~~MLLTLARSQ------------------------KVDL-T--KLS Barren_Encepha ~~~~mSN-----DDLGTWLKAAAEN------------------------KITTKNTWKST Barren_At esdpcFDKQQILELFQNCIKLASEN------------------------KINQKNTWELN Barren_Dm_B hrsstLESIEDNETIKNCLELYNGN------------------------KVSKDNAWNLM Barren_Plasm_f nkydkNKVKEINDVFKNCMVALSHNK-----------------------ICTR-NAFDIH Barren_Hs atipkFTNTQITEHYSTCIKLSTEN------------------------KITTKNAFGLH Barren_Sc ~~~~~MM-----ANFEEWIKMATDN------------------------KINSRNSWNFA Barren_Sp spfnsSHQVPVLSNFEEWIKLATDN------------------------KINSTNTWNFA Scc1_Hs_HR21spA_KIA0078 ECNLESSVESIISPKV------------------------------KMALRTSGHLLLGV Rec8_Hs_HR21spB RVNVVKTCEEILNYVLVRvQppq-----------------pglpRPRFSLYLSAQLQIGV Scc1_Dm ETNIEKSVEGILQPKV------------------------------KLALRTSGHLLLGV Rec8_Dm_Mei-910 KRQKRSNVLAARNRQ-------------------------------NVIFKDISRLVFGV Scc1_Ce_A_K08A8_3 ETDVDEAVNEIMQPSQ------------------------------KLALRTTGHLLLGI Rec8_Ce_B_W02A2_6 DQNLPELCHSIIEMVPERhRg----------------------sATKTGLYLLSLLTYGT Scc1_Sp_Rad21 HTSIEQSVHAIVTEET-----------------------------APMALRLSGQLMLGV Rec8_Sp SVDIDEACDFVAFSPE------------------------------PLALRLSSNLMIGV Scc1_Sc_YDL003w QTHIAESAKEIAKASGCDdEs---------------------gdNEYITLRTSGELLQGI Rec8_Sc_YPR007c_Spo69 NISIPKTCDEIQNFEN------------------------------DFSLRYISNLLYGV Scc1_Leishmania VVDLSQTILHIVRPVV------------------------------PIALRTSGELLVGV Scc1_At_A SINIPDTVDNIMFPEV------------------------------PLALRTSSHLLVGV Rec8_At_SYN1 KLDIIQICEEILNPSV------------------------------PMALRLSGILMGGV Scc1_E_cuniculi EVSISAIILRVMEEN--------------------------------ISVKDGGLIALGL Ctds1_Hs VAAQLGEYLEELDQICISfDe----------------------gKTTMNFIEAALLIQGS Ctds1_At LSEKLEEYLLKICSGEITgNee--------------------dgQIPVNFAEAALLLQGS Ctds1_Dm_CG14685-PB LRISLGYYIEELLRHCLGrNd----------------------vSRRSAIVAAGSALQYC Ctds1_Ce_C29E4_2 VLKALAGYLEVIRQESEDtDnqvd----------------aattYRLFDFQRACRIIQGS Ctds1_Plasm_falc LSSTIQGFLNCLDRNVLEnIdkglg-------------eneyekEVVDNFTSAAIFVENC Ctds1_Cryptosporidium_1 VSAELEKYLSAIELLDEDmNysqsteangygynnenitsnngsyMQMFNFVEAALIIQNS scpA_B_subtilis VAKITEQYLLYVHTMR------------------------------VLELDIASEYLVMA scpA_Thermotoga ISQLADEFVEYLEHMK------------------------------KLDMKITSDFLEMA DHFR_scpA_Mycoplasma IAKITTQYLHLINTNL-----------------------------NKQAIEPITDYLVIT scpA_Pseudomonas VAEITRQYMGYVELMK------------------------------AVRLELAAEYLVMA scpA_Chloroflexus LASVADQYLAHVRTLE------------------------------EVEPRELAEFVSMA scpA_Pyrococcus IVDLTEKYIKMLREMQ------------------------------ELDLRISARAILAA scpA_Methanococcus IAEIADYYIQKIKELK------------------------------KFDIRLSADVILVA scpA_Thermosynechococcus VVDVCDRCLAELARRG------------------------------EPNLSESGQAFLYA scpA_Cytophaga ISKITNDFLEYIHRLE------------------------------KMNVDIASEFILVA scpA_Mycobacterium LHQVTDDFIAYTKAIG-----------------------------ARLELEETTAFLVIA scpA_Treponema ICEITAQYLQYVDQTV------------------------------SPDLRGLTEFYAMA scpA_Aquifex IVELANLYMEELKKLE------------------------------VLDLRVPARAILAA scpA_Fusobacterium ISQLIDEYLEVLRVSK------------------------------RENIEIKSDFIIIA scpA_Thermoplasma LLKFAEIMNSFFGNS-------------------------------FIDFQFAGKAIADA scpA_Prochlorococcus VIAVVDGFLDQLRQRIEVpQqvaaq-------------vqrqggSYEQDLADSSEAFLAA scpA_Archaeoglobus VVDVTDRFLKRIEDAK------------------------------KLDLRVSGRVLLYA scpA_Rhodospirillum ILRLAEQYLAFVARAR------------------------------QIHLELAGDYLVMA Barren_Encepha LIDHFTNIDEFRERQ-------------------------------GINFQKASCTLDGC Barren_At LIDHLCEIIKVEDENN-----------------------------TETNFQKASCTLEAG Barren_Dm_B LIDSLANLLDHHHKR-------------------------------MSNFKMAGSSLEAS Barren_Plasm_f IIEHLEDLINLNDEE-IPeElnde---------------miengEFNLSFTRASKAIEGA Barren_Hs LIDFMSEILKQKDTE-------------------------------PTNFKVAAGTLDAS Barren_Sc LIDYFYDLDVLKDGEN------------------------------NINFQKASATLDGC Barren_Sp LIDYFHDMSLLRDGE-------------------------------DINFQKASCTLDGC Scc1_Hs_HR21spA_KIA0078 VRIYHRKAKYLLadcneafikikmafrpgv Rec8_Hs_HR21spB IRVYSQQCQYLVediqhilerlhraqlqir Scc1_Dm VRIYSRKAKYLLadcneafvkikmafrpgm Rec8_Dm_Mei-910 ADIFRCQVDLLLgdtkvlldqctrtnldyv Scc1_Ce_A_K08A8_3 CRVYSRKTKYLLadcneaflkiklvfrsga Rec8_Ce_B_W02A2_6 VLIHQVQVDFLKrdveklkelmkkksfill Scc1_Sp_Rad21 VRIYSRKARYLLedctealmrlkmsfqpgq Rec8_Sp TRVWAHQYSFFHsqvstlhlrvrkeldhft Scc1_Sc_YDL003w VRVYSKQATFLLtdikdtltkismlfktsq Rec8_Sc_YPR007c_Spo69 TICYNKKTEYVLndlnhllvqlqkndvyaf Scc1_Leishmania VRIYALKVKHLLkeateatlflrvttlatk Scc1_At_A VRIYSKKVDYLYndwnllntwvakafvstq Rec8_At_SYN1 VIVYERKVKLLFddvnrflveingawrtks Scc1_E_cuniculi SRILIRKLRYLLdecnevvhkicrkdmdre Ctds1_Hs ACVYSKKVEYLYslvyqaldfisgkrrakq Ctds1_At VQVYSKKVEYLYnlvlrtleflskqrdqeq Ctds1_Dm_CG14685-PB GKIYGDRVEYLCqvvehqiealltselqke Ctds1_Ce_C29E4_2 CAVYGRKVDHVYeltisvvdlvenkgqddg Ctds1_Plasm_falc VKIFSQKIEHLHnlahntlyniykenkhns Ctds1_Cryptosporidium_1 TSLYSKKIEHLHslvfdafhllstgksqln scpA_B_subtilis ATLLSIKSRMLLpkqeeelfedelleeedp scpA_Thermotoga STLMELKSKMLIprvreeekesidrkkeel DHFR_scpA_Mycoplasma SRIVEQKANNLLqindialdsdfldnklrd scpA_Pseudomonas AMLAEIKSRMLLprsaeaeeeeedpraeli scpA_Chloroflexus ARLILIKSRALLprspttpaeagdedagql scpA_Pyrococcus SILVRMKSEALLredeerneeekeerirve scpA_Methanococcus GILLRMKSEALYdeckveeeedydycddyy scpA_Thermosynechococcus AMLVLLKSDRLVavtepsppaegeeppeia scpA_Cytophaga ATLMRIKAKTLLprpdidpqgneidpreel scpA_Mycobacterium ATLLDLKAARLLpagqvddeedlallevrd scpA_Treponema AVLLYIKSCMLLpmeldldgediedprqsl scpA_Aquifex SFLLRKKIETIFpkpprkytkrkytlqeiv scpA_Fusobacterium SELIEIKTLNLLnldkdkeketnlrrrlee scpA_Thermoplasma WRVLRIKSDMSPkeqdrqmndigceepedt scpA_Prochlorococcus SVLVSLKAEVLEaqtfppeplfeegfeael scpA_Archaeoglobus AILVRMKAEAITlealggdeeeelemydyd scpA_Rhodospirillum AWLAYLKSRLLIpapkneqepsgedmaaal Barren_Encepha AKVYSTRVDDVSenamrllegsgreearkk Barren_At VKIYSMRVDSVHseaykvlggitraghddg Barren_Dm_B SKVYGLRVDSIYldamrisaglsartltdk Barren_Plasm_f TKVYGYRVEAIYdqtynfltnmnlakqfel Barren_Hs TKIYAVRVDAVHadvyrvlgglgkdapsle Barren_Sc IKIYSSRVDSVTtetgkllsglaqrktnga Barren_Sp VKIYTSRIDSVAtetgkllsglandskvlq