NMT
MyristoylCoA:Protein N-Myristoyltransferase
Supplementary material to
N-terminal N-Myristoylation of Proteins:
I. Refinement of the Sequence Motif and its Taxon-specific Differences
II. Prediction of Substrate Proteins from Amino Acid Sequence

   

 

Compare the structures of fungal and human NMT

YEAST

HUMAN (MODEL)

Left click on molecule and move mouse to rotate the molecule. Right click on molecule for the menu (hold down for Macintosh users), e.g. to change the color or display mode. 

 Select All
 Select only Protein N-Myristoyltransferase
 Select only MyristoylCoA
 Select only Substrate (GLYASKLFSNL)
 Reset View
 Select All
 Select only Protein N-Myristoyltransferase
 Select only MyristoylCoA
 Select only Substrate (GLYASKLFSNL)
 Reset View

Below are some automatic scripts serving as a shortcut to subsequently combine useful commands from the menu (calculations might take some time).

 Map Electrostatic Potential to Calculated Surface
 Map Molecular Lipophilicity Potential to Calculated Surface
 Recommended Surface View
 Toggle Surface Transparency
 Map Electrostatic Potential to Calculated Surface
 Map Molecular Lipophilicity Potential to Calculated Surface
 Recommended Surface View
 Toggle Surface Transparency

Some tips:
Be aware of what is selected before calculating surfaces or you might not be able to see the binding pocket. When using the recommended surface view, take a look at the upper right corner of the molecule and you will see the different potential in this part of the binding pocket. 

Technical details:
For calculating and mapping the electrostatic potential to the molecule's surface a probe with radius 1.4 Angstroms will be used for the surface and CHARMM 1.9 charges are assigned to the amino acids.

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