lig PIG-N
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GPI Anchor Biosynthesis Report: PIG-N family



Molecular Function: Phosphoethanolamine Transferase I
Complex: -
Cellular Localization:ER membrane, ER lumen
Domain Architecture:(cytosol) N --|TM|-----globular Domain(s)-----|multiple TM regions|-- C (?)


Orthologues
Protein Organism Sequence Length GenBank Entry
NP_186787.1 Arabidopsis thaliana 921 gi|15232100|
AAF59557.2 Caenorhabditis elegans 929 gi|16950509|
AAF56048.1 Drosophila melanogaster 919 gi|7300908|
NP_036459.1 Homo sapiens 931 gi|6912500|
NP_038812.1 Mus musculus 931 gi|7305383|
NP_012756.1 Saccharomyces cerevisiae 919 gi|6322683|
T40715 Schizosaccharomyces pombe 935 gi|7491747|

Fasta-File of the Family-Members

Alignments PIG-N: - MView
- Clustal
OMIM: Entry 606097
PIG-N, GPI7, PIG-O - Alignment MView
- Alignment Clustal
- Tree

Literature
PubMed: 11746679 Conserved core structure and active site residues in alkaline phosphatase superfamily enzymes.
Proteins 2001 Dec 1;45(4):318-24
PubMed: 11297516 Its8, a fission yeast homolog of Mcd4 and Pig-n, is involved in GPI anchor synthesis and shares an essential function with calcineurin in cytokinesis.
J Biol Chem 2001 Apr 27;276(17):13579-86
PubMed: 10574991 Pig-n, a mammalian homologue of yeast Mcd4p, is involved in transferring phosphoethanolamine to the first mannose of the glycosylphosphatidylinositol.
J Biol Chem 1999 Dec 3;274(49):35099-106
PubMed: 10069808 MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast.
Mol Biol Cell 1999 Mar;10(3):627-48
PubMed: 9576863 Saccharomyces cerevisiae GPI10, the functional homologue of human PIG-B, is required for glycosylphosphatidylinositol-anchor synthesis.
Biochem J 1998 May 15;332 ( Pt 1):153-9


Author: Birgit.Eisenhaber@nt.imp.univie.ac.at on internet.
Last modified: 24th January 2003