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The conserved Eco1 domain is related to the GCN5-Acetyltransferase Superfamily

supplementary material for the manuscript:

Ivanov, D., Schleiffer, A., Eisenhaber, F., Mechtler, K., Haering, C., Nasmyth, K. (2001): Eco1 is a novel acetyltransferase which can acetylate proteins involved in cohesion. Curr Biol. 2002 Feb 19;12(4):323-328

Cover figure for this article in Current Biology
Biological Background
The conserved yeast protein Eco1p is required for establishment of sister chromatid cohesion during S-phase but not for its further maintenance during G2 or M phases or for loading the cohesin complex onto DNA. (more)
Eco1 protein family
Fasta file with all Eco1 sequences used in this publication
Multiple sequence alignment of all Eco1 sequences used in this publication
MSF-format Clustal-format PDF-format
Fasta file with fragments of other Eco1 genes in Homo sapiens (pseudogenes?)

Eco1 domain structure
Zinc finger - like motif
In all Eco1 proteins despite for the protozoa Trypanosoma brucei and Leishmania major, a Zinc finger-like motif is found adjacent to the N-terminus of the Eco1 domain with the following consensus:

C X2 C X3 Y X10 H X2 (F/Y/H) H
Alignment of C2H2 Zn finger domain
MSF-format Clustal-format PDF-format
The Eco1 Acetyltransferase domain
Alignment of Eco1 Acetyltransferase domain (extended version)
MSF-format Clustal-format PDF-format
HMMs of the Eco1 domain
global HMM local HMM