GPI Biosynthesis Report<

GPI Biosynthesis Main Page

Gene List DPM2 GAA1/ GAA1P GPI7 GPIdeAc PIG-A/ GPI3 PIG-B/ GPI10 PIG-C/ GPI2 PIG-F/ GPI11 PIG-H/ GPI15 PIG-K/ GPI8 PIG-L/ GPI12 PIG-M PIG-N/ MCD4 PIG-O/ GPI13 PIG-P PIG-Q/ GPI1 PIG-S/ GPI17 PIG-T/ GPI16 SMP3

GPI Site Motif

GPI Site Prediction

GPI Anchor Biosynthesis Report

Contact:
Birgit Eisenhaber
Sebastian Maurer-Stroh
Maria Novatchkova
Georg Schneider
Frank Eisenhaber

Reference:
Eisenhaber B, Maurer-Stroh S, Novatchkova M, Schneider G, Eisenhaber F
Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins.
Bioessays. 2003 Apr;25(4):367-85.
PMID: 12655644

GPI Biosynthesis Enzymes and Auxiliary Factors:

• The UDP-GlcNAc:PI alpha 1-6 N-acetylglucosaminyltransferase complex:
  
• DPM2
• PIG-A/ GPI3
• PIG-C/ GPI2
• PIG-H/ GPI15
• PIG-P
• PIG-Q/ GPI1
• The GlcNAc:PI de-N-acetylase PIG-L/GPI12
  
• The GlcN-PI mannosyltransferases:
  
• PIG-M
• PIG-B/ GPI10
• SMP3
• The GPI lipid anchor phosphoethanolamine transferase complexes:
  
• PIG-N/MCD4
• GPI7
• PIG-O/GPI13
• PIG-F/GPI11
• The transamidase complex:
  
• GPAA1/GAA1
• PIG-K/ GPI8
• PIG-S/ GPI17
• PIG-T/ GPI16
• The GPI inositol deacylase GPIdeAc
  

	Literature

PubMed: 11102867	Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis. Curr Opin Chem Biol 2000 Dec;4(6):632-8
PubMed: 10444375	The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research. J Cell Sci 1999 Sep;112 ( Pt 17):2799-809

Last modified: 27th May 2002