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GPI Biosynthesis Report< | |
| GPI Biosynthesis Main Page | GPI Site Motif | GPI Site Prediction | Home Page B.E. |
| Molecular Function: | Phosphoethanolamine Transferase III |
|---|---|
| Complex: | PIG-O/GPI13, PIG-F/GPI11 |
| Cellular Localization: | ER membrane, ER lumen |
| Domain Architecture: | (cytosol) N --|TM|-----globular Domain(s)-----|multiple TM regions|-- C (?) |
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Orthologues |  |
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| Protein | Organism | Sequence Length | GenBank Entry |
| NP_197227.1 | Arabidopsis thaliana | 884 | gi|15237937| |
| AAB93646.1 | Caenorhabditis elegans | 905 | gi|2734088| |
| AAF57689.1 | Drosophila melanogaster | 1077 | gi|7302608| |
| T02245 | Homo sapiens | 880 | gi|7513075| |
| NP_064419 | Mus musculus | 1101 | gi|9910492| |
| NP_013069.1 | Saccharomyces cerevisiae | 1017 | gi|6322997| |
| T40030 | Schizosaccharomyces pombe | 918 | gi|7491546| |
Fasta-File of the Family-Members
| Alignments PIG-O: |
- MView - Clustal |
|---|---|
| PIG-N, GPI7, PIG-O |
- Alignment MView - Alignment Clustal - Tree |
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Literature | |
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| PubMed: 11746679 | Conserved core structure and active site residues in alkaline phosphatase superfamily enzymes. Proteins 2001 Dec 1;45(4):318-24 |
| PubMed: 10823837 | YLL031c belongs to a novel family of membrane proteins involved in the transfer of ethanolaminephosphate onto the core structure of glycosylphosphatidylinositol anchors in yeast. J Biol Chem 2000 Aug 11;275(32):24458-65 |
| PubMed: 10781593 | Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol. J Biol Chem 2000 Jul 7;275(27):20911-9 |
| PubMed: 10793139 | Glycosylphosphatidylinositol biosynthesis defects in Gpi11p- and Gpi13p-deficient yeast suggest a branched pathway and implicate gpi13p in phosphoethanolamine transfer to the third mannose. Mol Biol Cell 2000 May;11(5):1611-30 |
Author: Birgit.Eisenhaber@nt.imp.univie.ac.at on internet.