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Angiogenesis

List of -TEMs -PEMs -NEMs

TEMs TEM1 TEM2 TEM3 TEM4 TEM5 TEM6 TEM7 TEM8 TEM9 TEM10 TEM11 TEM12 TEM13 TEM14 TEM15 TEM16 TEM17 TEM18 TEM19 TEM20 TEM21_1 TEM21_2 TEM22 TEM23 TEM24 TEM25 TEM26 TEM27 TEM28 TEM29 TEM30 TEM31_1 TEM31_2 TEM32 TEM33 TEM34 TEM35 TEM36 TEM37 TEM38 TEM39 TEM40 TEM41 TEM42 TEM43 TEM44 TEM45 TEM46

Summary -Overview of TEMs -extracellular TEMs -intrac. & membrane TEMs -TEM tissue distribution

Supplementary -SAGE -Seq.analysis Methods

FAQ

Tumor Endothelial Marker Report: TEM19 (partial sequence)

	TEM domain structure

	TEM Sequence Analysis

name	from	to	source/E	description
unknown	1	78
	10	26	SEG25	LCR(SR)
VWA	78	249	Pfam, E=2.3e-07	Impala - Y. Wolf SCOP: Integrin A (or I) domain: E=9e-13 coil 124-148 The extracellular matrix is the predominant site of expression of type A modules. The proteins that incorporate type A modules participate in numerous biological events such as cell adhesion, migration, homing, pattern formation, and signal transduction after interaction with a large array of ligands. The VWA domains have been shown to bind a variety of ligands, including collagen, laminin, and the glycosaminoglycans heparin and hyaluronan.
unknown	249	598		The region is LCR rich with a high proline content. The region might be an artificial translate as it is not confirmed by homologies.
	332	352		apolar, toppred2 (1.038)
TM	356	376	toppred2 = 2.6	If the sequence extending outside of the VWA domain is real, this region would be a transmembrane region. No homologues are found in this segment making the analysis unreliable.
	386	410	SEG25	LCR(PE)
	538	598	SEG25	LCR(P)
598

	Remarks

• RELIABILITY: The protein sequence is incomplete (particularly at the N-terminus) and potentially partially incorrect. The partial protein sequence has been deduced from the cDNA sequence and, therefore, moderately reliable. An elongation of the mRNA sequence has been obtained by EST clustering starting from the proposed TEM8 mRNA (as the protein has been named by Croix et al) which is visualized in the Blastn gegen nr of the prospective TEM19 mRNA.

• DOMAIN ARCHITECTURE & FUNCTION: The VWA domain is a domain present in many molecules that are involved in cell-cell, cell-matrix, and matrix-matrix interactions. The VWA domain is found in plasma proteins such as von Willebrand factor, transmembrane proteins such as the subunits of seven integrins, in which it is also called the I domain, and ECM proteins such as the microfibrillar collagen type VI, the anchoring fiber collagen type VII, the fibril-associated collagens type XII and type XIV, and the matrilin family. A Psi-Blast against nr of the complete sequence shows the relation of the VWA domain to several matrix and adhesion related transmembrane proteins. Out of these homologues, C-terminal VWA domains that are not followed by further known domains can be found in collagen alpha 1(XII)(Q91145) and in matrilins (O08746). TEM19 is either a VWA domain-containing transmembrane receptor or a extracelluar protein (if the C-terminus is not real).

	Sequence Information

TEM	TEM19
Reliability of Gen2Tag mapping	Cid->tag (Hs.8966) frequency: tem19: CATG-CTATAGGAGA=1/2 (cDNA) tem19: CATG-CTATAGGAGA=45/56 (EST oriented)
Analysis	BlastP against nr Output Created by a Suite of Single Sequence Analysis Techniques
Protein Description	hypothetical, deduced from cDNA
Protein Sequence	RTREEGPADGASLRVVASSRSVGRSGPCSPRAAGHGHGGAESPRHRLPVALTATLVLIC AGQGGRREDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIV FSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTAS VIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVN DGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKI NDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDG SILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPPAEESEEEDDDGLPKKKWPTVD ASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMR RPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNNQPAKYPL NNAYHTSSPPPAPIYTPPPPAPHCPPPPPSAPTPPIPSPPSTLPPPPQAPPPNRAPPPS RPPPRPSV
SAGE-Tag	CATG-CTATAGGAGACC
EST/cluster Description	UNIGEN CLUSTER: UniGene Cluster Hs.8966 TEM8 SEQ.SOURCE: ref|NM_018153.1| Homo sapiens FLJ10601 (FLJ10601) dbj|AK025429.1|AK025429 Homo sapiens FLJ21776 fis gi|9857405|gb|AF279145.1|AF279145 Homo sapiens TEM8, 3 UTR MARKINGS: TEM19 Tag in red first Poly-A-signal following the Tag in bold REMARKS: contig (blastn gegen nr) contains no alu-hits that could lead to wrong clustering
EST/cluster Sequence	AATTGCTTCCGGGGAGTTGCGAGGGAGCGAGGGGGAATAAAGGACCCGCGAGGAAGGGCCCG CGGATGGCGCGTCCCTGAGGGTCGTGGCGAGTTCGCGGAGCGTGGGAAGGAGCGGACCCTGC TCTCCCCGGGCTGCGGGCCATGGCCACGGCGGAGCGGAGAGCCCTCGGCATCGGCTTCCAGT GGCTCTCACGGCCACTCTGGTGCTCATCTGCGCCGGGCAAGGGGGACGCAGGGAGGATGGGG GTCCAGCCTGCTACGGCGGATTTGACCTGTACTTCATTTTGGACAAATCAGGAAGTGTGCTG CACCACTGGAATGAAATCTATTACTTTGTGGAACAGTTGGCTCACAAATTCATCAGCCCACA GTTGAGAATGTCCTTTATTGTTTTCTCCACCCGAGGAACAACCTTAATGAAACTGACAGAAG ACAGAGAACAAATCCGTCAAGGCCTAGAAGAACTCCAGAAAGTTCTGCCAGGAGGAGACACT TACATGCATGAAGGATTTGAAAGGGCCAGTGAGCAGATTTATTATGAAAACAGACAAGGGTA CAGGACAGCTAGCGTCATCATTGCTTTGACTGATGGAGAACTCCATGAAGATCTCTTTTTCT ATTCAGAGAGGGAGGCTAATAGGTCTCGAGATCTTGGTGCAATTGTTTACTGTGTTGGTGTG AAAGATTTCAATGAGACACAGCTGGCCCGGATTGCGGACAGTAAGGATCATGTGTTTCCCGT GAATGACGGCTTTCAGGCTCTGCAAGGCATCATCCACTCAATTTTGAAGAAGTCCTGCATCG AAATTCTAGCAGCTGAACCATCCACCATATGTGCAGGAGAGTCATTTCAAGTTGTCGTGAGA GGAAACGGCTTCCGACATGCCCGCAACGTGGACAGGGTCCTCTGCAGCTTCAAGATCAATGA CTCGGTCACACTCAATGAGAAGCCCTTTTCTGTGGAAGATACTTATTTACTGTGTCCAGCGC CTATCTTAAAAGAAGTTGGCATGAAAGCTGCACTCCAGGTCAGCATGAACGATGGCCTCTCT TTTATCTCCAGTTCTGTCATCATCACCACCACACACTGTTCTGACGGTTCCATCCTGGCCAT CGCCCTGCTGATCCTGTTCCTGCTCCTAGCCCTGGCTCTCCTCTGGTGGTTCTGGCCCCTCT GCTGCACTGTGATTATCAAGGAGGTCCCTCCACCCCCTGCCGAGGAGAGTGAGGAAGAAGAT GATGATGGTCTGCCTAAGAAAAAGTGGCCAACGGTAGACGCCTCTTATTATGGTGGGAGAGG CGTTGGAGGCATTAAAAGAATGGAGGTTCGTTGGGGAGAAAAGGGCTCCACAGAAGAAGGTG CTAAGTTGGAAAAGGCAAAGAATGCAAGAGTCAAGATGCCGGAGCAGGAATATGAATTCCCT GAGCCGCGAAATCTCAACAACAATATGCGTCGGCCTTCTTCCCCCCGGAAGTGGTACTCTCC AATCAAGGGAAAACTCGATGCCTTGTGGGTCCTACTGAGGAAAGGATATGATCGTGTGTCTG TGATGCGTCCACAGCCAGGAGACACGGGGCGCTGCATCAACTTCACCAGGGTCAAGAACAAC CAGCCAGCCAAGTATCCACTCAACAACGCCTACCACACCTCCTCGCCGCCTCCTGCCCCCAT CTACACTCCCCCACCTCCTGCGCCCCACTGCCCTCCCCCGCCCCCCAGCGCCCCTACCCCTC CCATCCCGTCCCCACCTTCCACCCTTCCCCCTCCTCCCCAGGCTCCACCTCCCAACAGGGCA CCTCCTCCCTCCCGCCCTCCTCCAAGGCCTTCTGTCTAGAGCCCAAAGTTCCTGCTCTGGGC TCTCTCAGAAACTTCAGGAGATGTTAGAACAAGTCTTTCCAGTTAGAGAAGAGGAGTGGTGA TAAAGCCCACTGACCTTCACACATTCTAAAAATTGGTTGGCAATGCCAGTATACCAACAATC ATGATCAGCTGAAAGAAACAGATATTTTAAATTGCCAGAAAACAAATGATGAGGCAACTACA GTCAGATTTATAGCCAGCCATCTATCACCTCTAGAAGGTTCCAGAGACAGTGAAACTGCAAG ATGCTCTCAACAGGATTATGTCTCATGGAGACCAGTAAGAAAATCATTTATCTGAAGGTGAA ATGCAGAGTTGGATAAGAAATACATTGCTGGGTTTCTAAAATGCTGCCTTCCTGCCTCTACT CCACCTCCATCCCTGGACTTTGGACCCTTGGCCTAGGAGCCTAAGGACCTTCACCCCTGTGC ACCACCCAAGAAAGAGGAAAACTTTGCCTACAACTTTGGAAATGCTGGGGTCCCTGGTGTGG TAAGAAACTCAACATCAGACGGGTATGCAGAAGGATGTTCTTCTGGGATTTGCAGGTACATA AAAAATGTATGGCATCTTTTCCTTGCAAATTCTTCCAGTTTCCAAGTGAGAAGGGGAGCAGG TGTTTACTGATGGAAAAGGTATGTTGCTATGTTGATGTGTAAGTGAAATCAGTTGTGTGCAA TAGACAGGGGCGTATTCATGGGAGCATCAGCCAGTTTCTAAAACCCACAGGCCATCAGCAGC TAGAGGTGGCTGGCTTTGGCCAGACATGGACCCTAAATCAACAGACAATGGCATTGTCGAAG AGCAACCTGTTAATGAATCATGTTAAAAATCAAGGTTTGGCTTCAGTTTAAATCACTTGAGG TATGAAGTTTATCCTGTTTTCCAGAGATAAACATAAGTTGATCTTCCCAAAATACCATCATT AGGACCTATCACACAATATCACTAGTTTTTTTTGTTTGTTTGTTTTTTGTTTTTTTTCTTGG TAAAGCCATGCACCACAGACTTCTGGGCAGAGCTGAGAGACAATGGTCCTGACATAATAAGG ATCTTTGATTAACCCCCATAAGGCATGTGTGTGTATACAAATATACTTCTCTTTGGCTTTTC GACATAGAACCTCAGCTGTTAACCAAGGGGAAATACATCAGATCTGCAACACAGAAATGCTC TGCCTGAAATTTCCACCATGCCTAGGACTCACCCCATTTATCCAGGTCTTTCTGGATCTGTT TAATCAATAAGCCCTATAATCACTTGCTAAACACTGGGCTTCATCACCCAGGGATAAAAACA GAGATCATTGTCTTGGACCTCCTGCATCAGCCTATTCAAAATTATCTCTCTCTCTAGCTTTC CACAAATCCTAAAATTCCTGTCCCAAGCCACCCAAATTCTCAGATCTTTTCTGGAACAAGGC AGAATATAAAATAAATATACATTTAGTGGCTTGGGCTATGGTCTCCAAAGATCCTTCAAAAA TACATCAAGCCAGCTTCATTCACTCACTTTACTTAGAACAGAGATATAAGGGCCTGGGATGC ATTTATTTTATCAATACCAATTTTTGTGGCCATGGCAGACATTGCTAATCAATCACAGCACT ATTTCCTATTAAGCCCACTGATTTCTTCACAATCCTTCTCAAATTACAATTCCAAAGAGCCG CCACTCAACAGTCAGATGAACCCAACAGTCAGATGAGAGAAATGAACCCTACTTGCTATCTC TATCTTAGAAAGCAAAAACAAACAGGAGTTTCCAGGGAGAATGGGAAAGCCAGGGGGCATAA AAGGTACAGTCAGGGGAAAATAGATCTAGGCAGAGTGCCTTAGTCAGGGACCACGGGCGCTG AATCTGCAGTGCCAACACCAAACTGACACATCTCCAGGTGTACCTCCAACCCTAGCCTTCTC CCACAGCTGCCTACAACAGAGTCTCCCAGCCTTCTCAGAGAGCTAAAACCAGAAATTTCCAG ACTCATGAAAGCAACCCCCCAGCCTCTCCCCAACCCTGCCGCATTGTCTAATTTTTAGAACA CTAGGCTTCTTCTTTCATGTAGTTCCTCATAAGCAGGGGCCAGAATATCTCAGCCACCTGCA GTGACATTGCTGGACCCCTGAAAACCATTCCATAGGAGAATGGGTTCCCCAGGCTCACAGTG TAGAGACATTGAGCCCATCACAACTGTTTTGACTGCTGGCAGTCTAAAACAGTCCACCCACC CCATGGCACTGCCGCGTGATTCCCGCGGCCATTCAGAAGTTCAAGCCGAGATGCTGACGTTG CTGAGCAACGAGATGGTGAGCATCAGTGCAAATGCACCATTCAGCACATCAGTCATATGCCC AGTGCAGTTACAAGATGTTGTTTCGGCAAAGCATTTTGATGGAATAGGGAACTGCAAATGTA TGATGATTTTGAAAAGGCTCAGCAGGATTTGTTCTTAAACCGACTCAGTGTGTCATCCCCGG TTATTTAGAATTACAGTTAAGAAGGAGAAACTTCTATAAGACTGTATGAACAAGGTGATATC TTCATAGTGGGCTATTACAGGCAGGAAAATGTTTTAACTGGTTTACAAAATCCATCAATACT TGTGTCATTCCCTGTAAAAGGCAGGAGACATGTGATTATGATCAGGAAACTGCACAAAATTA TTGTTTTCAGCCCCCGTGTTATTGTCCTTTTGAACTGTTTTTTTTTTATTAAAGCCAAATTT GTGTTGTATATATTCGTATTCCATGTGTTAGATGGAAGCATTTCCTATCCAGTGTGAATAAA AAGAACAGTTGTAGTAAATTATTATAAAGCCGATGATATTTCATGGCAGGTTATTCTACCAA GCTGTGCTTGTTGGTTTTTCCCATGACTGTATTGCTTTTATAAATGTACAAATAGTTACTGA AATGACGAGACCCTTGTTTGCACAGCATTAATAAGAACCTTGATAAGAACCATATTCTGTTG ACAGCCAGCTCACAGTTTCTTGCCTGAAGCTTGGTGCACCCTCCAGTGAGACACAAGATCTC TCTTTTACCAAAGTTGAGAACAGAGCTGGTGGATTAATTAATAGTCTTCGATATCTGGCCAT GGGTAACCTCATTGTAACTATCATCAGAATGGGCAGAGATGATCTTGAAGTGTCACATACAC TAAAGTCCAAACACTATGTCAGATGGGGGTAAAATCCATTAAAGAACAGGAAAAAATAATTA TAAGATGATAAGCAAATGTTTCAGCCCAATGTCAACCCAGTTAAAAAAAAAATTAATGCTGT GTAAAATGGTTGAATTAGTTTGCAAACTATATAAAGACATATGCAGTAAAAAGTCTGTTAAT GCACATCCTGTGGGAATGGAGTGTTCTAACCAATTGCCTTTTCTTGTTATCTGAGCTCTCCT ATATTATCATACTCAGATAACCAAATTAAAAGAATTAGAATATGATTTTTAATACACTTAAC ATTAAACTCTTCTAACTTTCTTCTTTCTGTGATAATTCAGAAGATAGTTATGGATCTTCAAT GCCTCTGAGTCATTGTTATAAAAAATCAGTTATCACTATACCATGCTATAGGAGACTGGGCA AAACCTGTACAATGACAACCCTGGAAGTTGCTTTTTTTAAAAAAATAATAAATTTCTTAAAT CAAAAAAAAAAAAAAAAAAAA
Genomic Sequence Description
Genomic Sequence

	Literature

PubMed:94018965

Type A modules: interacting domains found in several non-fibrillar collagens and in other extracellular matrix proteins. Colombatti A, Bonaldo P, Doliana R. Matrix 1993 Jul;13(4):297-306.