- a general introduction on the molecular understanding of angiogenesis
- a table of differentially expressed TEMs (derived from the SAGEnet homepage) linked to the analysis of the individual tags;
a table of differentially expressed PEMs (derived from the SAGEnet homepage), which have been confirmed and further described. - a discussion of the results obtained giving a summary of the gene expression modes upon angiogenesis
and a summary of the gene expression modes as derived from general EST databases - supplementary information
- a list of on-line sites of the applied sequence analysis techniques
- a short overview on the sage technique
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| In-depth Sequence-analysis Study of Proteins Differentially Expressed in Tumor Endothelium versus Normal Endothelium |
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The SAGE expression data used in this study are derived from the homepage of the SAGEnet Angiogenesis project and are described here and in:
St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW. Science. 2000 Aug 18;289(5482):1197-202. |
The TEM project @ IMP bioinformatics
Maria Novatchkova & Frank Eisenhaber
Relying on the data published by Croix et al, the goal of the present report is a detailed functional characterization of the published tumor endothelial markers (TEMs) from their sequences. As a result of our study a common model emerges, describing the functional relationship between gene expression and
altered behavior of tumor-associated endothelium. The majority of the TEMs have a function in the context of extracellular matrix and cytoskeleton
modifications, and are thus consistently clustering in migration
associated processes.
Follow the links on the left to obtain ...
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