Score E
Sequences producing significant alignments: (bits) Value
ref|NP_055386.1| hairy/enhancer-of-split related with YRPW ... 523 e-147
ref|NP_038933.1| hairy/enhancer-of-split related with YRPW ... 404 e-112
emb|CAB71347.1| (AJ271868) basic-helix-loop-helix protein [... 404 e-112
emb|CAB96791.1| (AJ401271) bHLH protein Hesr-1/Hey1 [Xenopu... 181 1e-44
emb|CAB51321.1| (AJ243895) basic-helix-loop-helix protein (... 173 2e-42
gb|AAF37297.1|AF232239_1 (AF232239) HES-related repressor p... 171 7e-42
ref|NP_036390.1| hairy/enhancer-of-split related with YRPW ... 171 7e-42
ref|NP_036391.1| hairy/enhancer-of-split related with YRPW ... 171 9e-42
gb|AAF44780.1|AF237948_1 (AF237948) Gridlock [Danio rerio] 171 1e-41
emb|CAB65543.1| (AJ388551) bHLH protein Hesr-1/Hey1 [Canis ... 171 1e-41
ref|NP_034553.1| hairy/enhancer-of-split related with YRPW ... 170 2e-41
ref|NP_038932.1| hairy/enhancer-of-split related with YRPW ... 168 6e-41
gb|AAF59152.1| (AE003839) Hey gene product [Drosophila mela... 111 8e-24
gb|AAD46771.1|AF151523_1 (AF151523) hairy and enhancer of s... 111 8e-24
ref|NP_066993.1| bHLH factor Hes4 [Homo sapiens] >gi|101211... 70 3e-11
gb|AAG23838.1|AF301264_1 (AF301264) bHLH-WRPW transcription... 70 4e-11
dbj|BAA76633.1| (AB019516) newt HES1 [Cynops pyrrhogaster] 70 4e-11
ref|NP_032261.1| hairy and enhancer of split 1, (Drosophila... 68 1e-10
sp|Q04666|HES1_RAT TRANSCRIPTION FACTOR HES-1 (HAIRY AND EN... 68 1e-10
pir||A48106 hairy-like gene RHL - rat >gi|204555|gb|AAA4130... 68 1e-10
ref|NP_005515.1| hairy (Drosophila)-homolog; transcription ... 68 1e-10
emb|CAA65998.1| (X97333) HER-6 protein [Danio rerio] 67 3e-10
sp|O57337|HES1_CHICK TRANSCRIPTION FACTOR HES-1 (C-HAIRY1) ... 66 4e-10
emb|CAB89491.1| (AJ252154) DNA-binding-protein hairy [Cupie... 66 6e-10
gb|AAA79185.1| (U36194) hairy1 [Xenopus laevis] 64 3e-09
gb|AAD01745.1| (AF022798) basic-helix-loop-helix transcript... 55 8e-07
gb|AAF59113.1| (AE003838) dpn gene product [Drosophila mela... 54 2e-06
pir||S29712 segmentation protein hairy - red flour beetle >... 54 2e-06
sp|Q26263|DPN_DROME DEADPAN PROTEIN >gi|423828|pir||A46231 ... 54 2e-06
ref|NP_034549.1| hairy and enhancer of split 5, (Drosophila... 52 7e-06
gb|AAF54527.1| (AE003687) stich1 gene product [Drosophila m... 51 2e-05
gb|AAF24476.1|AF203477_1 (AF203477) Sticky ch1 [Drosophila ... 51 2e-05
sp|Q03062|HES5_RAT TRANSCRIPTION FACTOR HES-5 (HAIRY AND EN... 49 6e-05
gb|AAF22960.1|AF146088_1 (AF146088) enhancer of split relat... 48 1e-04
gb|AAB63586.1| (AF009329) enhancer-of-split and hairy-relat... 48 2e-04
sp|P14003|HAIR_DROME HAIRY PROTEIN >gi|8053|emb|CAA34019.1|... 48 2e-04
pir||S06956 segmentation protein hairy - fruit fly (Drosoph... 48 2e-04
ref|NP_032262.1| hairy and enhancer of split 2 (Drosophila)... 46 4e-04
gb|AAG23292.1| (AY007991) transcription factor Her-8b [Dani... 46 7e-04
gb|AAG23291.1| (AY007990) transcription factor Her-8a [Dani... 46 7e-04
gb|AAF53741.1| (AE003661) CG10446 gene product [Drosophila ... 45 0.001
pir||A44443 basic helix-loop-helix transcription repressor ... 45 0.001
sp|P29303|HAIR_DROVI HAIRY PROTEIN >gi|157590|gb|AAA28602.1... 45 0.001
emb|CAB77019.1| (AJ276313) HLHmgamma protein [Drosophila hy... 45 0.002
emb|CAB46198.1| (AL031848) dJ202O8.2.1 (ortholog of rodent ... 43 0.005
pir||B46177 enhancer of split locus protein mB - fruit fly ... 43 0.005
pir||S29901 helix-loop-helix protein m-gamma - fruit fly (D... 43 0.005
gb|AAF56546.1| (AE003754) HLHmbeta gene product [Drosophila... 41 0.014
ref|NP_062109.1| hairy and enhancer of split 2 (Drosophila)... 41 0.014
pir||C46177 enhancer of split locus protein mA - fruit fly ... 41 0.014
>ref|NP_055386.1| hairy/enhancer-of-split related with YRPW motif-like [Homo sapiens]
emb|CAB75716.1| (AJ272215) HEYL protein [Homo sapiens]
Length = 328
Score = 523 bits (1332), Expect = e-147
Identities = 269/327 (82%), Positives = 269/327 (82%)
Query: 1 MKRPKEPSGSDGESDGPIDVGQEGQLSQMARPLSTPSSSQMQAXXXXXXXXXXXXXXXXN 60
MKRPKEPSGSDGESDGPIDVGQEGQLSQMARPLSTPSSSQMQA N
Sbjct: 1 MKRPKEPSGSDGESDGPIDVGQEGQLSQMARPLSTPSSSQMQARKKRRGIIEKRRRDRIN 60
Query: 61 SSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIG 120
SSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIG
Sbjct: 61 SSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIG 120
Query: 121 FRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFF 180
FRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFF
Sbjct: 121 FRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFF 180
Query: 181 HSCPGLPALSNQLAILGRXXXXXXXXXXXXAYPIPALRTAPLRRATGIILPARRNVLPSR 240
HSCPGLPALSNQLAILGR AYPIPALRTAPLRRATGIILPARRNVLPSR
Sbjct: 181 HSCPGLPALSNQLAILGRVPSPVLPGVSSPAYPIPALRTAPLRRATGIILPARRNVLPSR 240
Query: 241 GASSTRRARPLEXXXXXXXXXXXXXXXXXXHIAPLLQXXXXXXXXXXXXAAYVAVPTPNS 300
GASSTRRARPLE HIAPLLQ AAYVAVPTPNS
Sbjct: 241 GASSTRRARPLERPATPVPVAPSSRAARSSHIAPLLQSSSPTPPGPTGSAAYVAVPTPNS 300
Query: 301 SSPGPAGRPAGAMLYHSWVSEITEIGA 327
SSPGPAGRPAGAMLYHSWVSEITEIGA
Sbjct: 301 SSPGPAGRPAGAMLYHSWVSEITEIGA 327
>ref|NP_038933.1| hairy/enhancer-of-split related with YRPW motif-like; hairy-related
transcription factor 3 [Mus musculus]
gb|AAF14547.1|AF172288_1 (AF172288) hairy-related transcription factor 3 [Mus musculus]
Length = 326
Score = 404 bits (1028), Expect = e-112
Identities = 214/327 (65%), Positives = 229/327 (69%), Gaps = 2/327 (0%)
Query: 1 MKRPKEPSGSDGESDGPIDVGQEGQLSQMARPLSTPSSSQMQAXXXXXXXXXXXXXXXXN 60
MKRP+ PSGSDGESDGPIDVGQE LSQMARPL+TPS SQMQA N
Sbjct: 1 MKRPRAPSGSDGESDGPIDVGQENDLSQMARPLTTPSPSQMQARKKRRGIIEKRRRDRIN 60
Query: 61 SSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIG 120
SSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHA+GGTGFFDARALAVDFRSIG
Sbjct: 61 SSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHASGGTGFFDARALAVDFRSIG 120
Query: 121 FRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFF 180
FRECLTEVIRYLGVLEGPSS ADPVRIRLLSHL SYAAEMEPSPT T LAFP WPWSF
Sbjct: 121 FRECLTEVIRYLGVLEGPSSHADPVRIRLLSHLKSYAAEMEPSPTTTSALAFPVWPWSFL 180
Query: 181 HSCPGLPALSNQLAILGRXXXXXXXXXXXXAYPIPALRTAPLRRATGIILPARRNVLPSR 240
HSCPGLP+L++QLAILGR YPI ALR+AP+ R G I P RRN+LPSR
Sbjct: 181 HSCPGLPSLNSQLAILGRVPSPVLPSISSPPYPISALRSAPVHRPAGTIPPTRRNLLPSR 240
Query: 241 GASSTRRARPLEXXXXXXXXXXXXXXXXXXHIAPLLQXXXXXXXXXXXXAAYVAVPTPNS 300
G +ST+RA E I P+ V+ +
Sbjct: 241 GVTSTQRAHLPERPAAPPPTALDARAARS--IVPIPPCSPTTAPGAGKSDDNVSGSISSP 298
Query: 301 SSPGPAGRPAGAMLYHSWVSEITEIGA 327
GP GRPAGA+ YHSWVSEITEIGA
Sbjct: 299 CPSGPTGRPAGAVFYHSWVSEITEIGA 325
>emb|CAB71347.1| (AJ271868) basic-helix-loop-helix protein [Mus musculus]
Length = 326
Score = 404 bits (1027), Expect = e-112
Identities = 214/327 (65%), Positives = 229/327 (69%), Gaps = 2/327 (0%)
Query: 1 MKRPKEPSGSDGESDGPIDVGQEGQLSQMARPLSTPSSSQMQAXXXXXXXXXXXXXXXXN 60
MKRP+ PSGSDGESDGPIDVGQE LSQMARPL+TPS SQMQA N
Sbjct: 1 MKRPRAPSGSDGESDGPIDVGQENDLSQMARPLTTPSPSQMQARKKRRGIIEKRRRDRIN 60
Query: 61 SSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIG 120
SSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHA+GGTGFFDARALAVDFRSIG
Sbjct: 61 SSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHASGGTGFFDARALAVDFRSIG 120
Query: 121 FRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFF 180
FRECLTEVIRYLGVLEGPSS ADPVRIRLLSHL SYAAEMEPSPT T LAFP WPWSF
Sbjct: 121 FRECLTEVIRYLGVLEGPSSHADPVRIRLLSHLKSYAAEMEPSPTTTSALAFPVWPWSFL 180
Query: 181 HSCPGLPALSNQLAILGRXXXXXXXXXXXXAYPIPALRTAPLRRATGIILPARRNVLPSR 240
HSCPGLP+L++QLAILGR YPI ALR+AP+ R G I P RRN+LPSR
Sbjct: 181 HSCPGLPSLNSQLAILGRVPGPVLPSISSPPYPISALRSAPVHRPAGTIPPTRRNLLPSR 240
Query: 241 GASSTRRARPLEXXXXXXXXXXXXXXXXXXHIAPLLQXXXXXXXXXXXXAAYVAVPTPNS 300
G +ST+RA E I P+ V+ +
Sbjct: 241 GVTSTQRAHLPERPAAPPPTALDARAARS--IVPIPPCSPTTAPGAGKSDDNVSGSISSP 298
Query: 301 SSPGPAGRPAGAMLYHSWVSEITEIGA 327
GP GRPAGA+ YHSWVSEITEIGA
Sbjct: 299 CPSGPTGRPAGAVFYHSWVSEITEIGA 325
>emb|CAB96791.1| (AJ401271) bHLH protein Hesr-1/Hey1 [Xenopus laevis]
Length = 294
Score = 181 bits (454), Expect = 1e-44
Identities = 123/330 (37%), Positives = 170/330 (51%), Gaps = 47/330 (14%)
Query: 1 MKRPKEPSGSDGESDGPIDVGQE-----GQLSQMARPLSTPSSSQMQAXXXXXXXXXXXX 55
MKR + S SD E D I+V +E G LS M S +SSQ+ A
Sbjct: 1 MKRGHDYSSSDSELDENIEVEKESADENGNLSSM----SPSTSSQILARKRRRGIIEKRR 56
Query: 56 XXXXNSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVD 115
N+SLSELRRLVP+AFEKQGS+KLEKAE+LQMTVDHLKMLH GG G+FDA ALA+D
Sbjct: 57 RDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMD 116
Query: 116 FRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAW 175
+RS+GFRECL EV RYL ++EG + ADP+R+RL+SHLN+YA++ E + T + W
Sbjct: 117 YRSLGFRECLAEVARYLSIIEGMET-ADPLRVRLVSHLNNYASQREAASTAHTSIGHIPW 175
Query: 176 PWSFFHSCPGLPALSNQLAILGRXXXXXXXXXXXXAYPIPALRTAPLRRATGIILPARRN 235
+F H P LS+ L +L + A+ LR +P ++ + + N
Sbjct: 176 GGTFAHH----PHLSHPL-LLAQTAHTNSTSSSTEAHHHNRLRGSPHAESSSLRVAPNGN 230
Query: 236 VLPSRGASSTRRARPLEXXXXXXXXXXXXXXXXXXHIAPLLQXXXXXXXXXXXXAAYVAV 295
+ ++ + P PLL ++ +
Sbjct: 231 IASVLPVVASSKLSP-----------------------PLLSSMASLSAFPFSFGSFHLL 267
Query: 296 PTPNS---SSPGPAGRPAGAMLYHSWVSEI 322
+PNS ++P P+G+P Y W +EI
Sbjct: 268 -SPNSLSPTTPTPSGKP-----YRPWGTEI 291
>emb|CAB51321.1| (AJ243895) basic-helix-loop-helix protein (bHLH) [Mus musculus]
gb|AAD51750.1|AF176423_1 (AF176423) cardiovascular helix-loop-helix factor 2 [Mus musculus]
gb|AAF14545.1|AF172286_1 (AF172286) hairy-related transcription factor 1 [Mus musculus]
gb|AAF37299.1|AF232241_1 (AF232241) HES-related repressor protein 2 HERP2 [Mus musculus]
dbj|BAA95073.1| (AB041590) unnamed protein product [Mus musculus]
Length = 299
Score = 173 bits (434), Expect = 2e-42
Identities = 94/179 (52%), Positives = 119/179 (65%), Gaps = 6/179 (3%)
Query: 8 SGSDGESDGPIDVGQE-----GQLSQMARPLSTPSSSQMQAXXXXXXXXXXXXXXXXNSS 62
S SD E D I+V +E G LS +S +SSQ+ A N+S
Sbjct: 9 SSSDSELDETIEVEKESADENGNLSSALCSMSPTTSSQVLARKRRRGIIEKRRRDRINNS 68
Query: 63 LSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIGFR 122
LSELRRLVP+AFEKQGS+KLEKAE+LQMTVDHLKMLH GG G+FDA ALA+D+RS+GFR
Sbjct: 69 LSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFR 128
Query: 123 ECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFFH 181
ECL EV RYL ++EG + +DP+R+RL+SHLN+YA++ E + G L W +F H
Sbjct: 129 ECLAEVARYLSIIEGLDA-SDPLRVRLVSHLNNYASQREAASGAHGGLGHIPWGSAFGH 186
>gb|AAF37297.1|AF232239_1 (AF232239) HES-related repressor protein 2 HERP2 [Homo sapiens]
Length = 304
Score = 171 bits (430), Expect = 7e-42
Identities = 97/187 (51%), Positives = 121/187 (63%), Gaps = 7/187 (3%)
Query: 1 MKRPK-EPSGSDGESDGPIDVGQE-----GQLSQMARPLSTPSSSQMQAXXXXXXXXXXX 54
MKR E S SD E D I+V +E G LS +S +SSQ+ A
Sbjct: 1 MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR 60
Query: 55 XXXXXNSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAV 114
N+SLSELRRLVP+AFEKQGS+KLEKAE+LQMTVDHLKMLH GG G+FDA ALA+
Sbjct: 61 RRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAM 120
Query: 115 DFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPA 174
D+RS+GFRECL EV RYL ++EG + +DP+R+RL+SHLN+YA++ E + L
Sbjct: 121 DYRSLGFRECLAEVARYLSIIEGLDA-SDPLRVRLVSHLNNYASQREAASGAHAGLGHIP 179
Query: 175 WPWSFFH 181
W F H
Sbjct: 180 WGTVFGH 186
>ref|NP_036390.1| hairy/enhancer-of-split related with YRPW motif 1; hairy and
enhancer of split related-1 [Homo sapiens]
gb|AAD38967.1|AF151522_1 (AF151522) hairy and enhancer of split related-1 [Homo sapiens]
gb|AAD51749.1|AF176422_1 (AF176422) cardiovascular helix-loop-helix factor 2 [Homo sapiens]
emb|CAB75715.1| (AJ272214) HEY1 protein [Homo sapiens]
Length = 304
Score = 171 bits (430), Expect = 7e-42
Identities = 97/187 (51%), Positives = 121/187 (63%), Gaps = 7/187 (3%)
Query: 1 MKRPK-EPSGSDGESDGPIDVGQE-----GQLSQMARPLSTPSSSQMQAXXXXXXXXXXX 54
MKR E S SD E D I+V +E G LS +S +SSQ+ A
Sbjct: 1 MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR 60
Query: 55 XXXXXNSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAV 114
N+SLSELRRLVP+AFEKQGS+KLEKAE+LQMTVDHLKMLH GG G+FDA ALA+
Sbjct: 61 RRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAM 120
Query: 115 DFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPA 174
D+RS+GFRECL EV RYL ++EG + +DP+R+RL+SHLN+YA++ E + L
Sbjct: 121 DYRSLGFRECLAEVARYLSIIEGLDA-SDPLRVRLVSHLNNYASQREAASGAHAGLGHIP 179
Query: 175 WPWSFFH 181
W F H
Sbjct: 180 WGTVFGH 186
>ref|NP_036391.1| hairy/enhancer-of-split related with YRPW motif 2; gridlock [Homo
sapiens]
emb|CAB56839.1| (AJ249545) basic-helix-loop-helix protein, bHLH [Homo sapiens]
gb|AAF20173.1|AF173901_1 (AF173901) basic helix-loop-helix factor 1 [Homo sapiens]
gb|AAF37296.1|AF232238_1 (AF232238) HES-related repressor protein 1 HERP1 [Homo sapiens]
gb|AAF44781.1|AF237949_1 (AF237949) GRIDLOCK [Homo sapiens]
emb|CAB87581.1| (AL078594) dJ293L8.1 (hairy/enhancer-of-split related with YRPW
motif 2 (cardiovascular basic helix-loop-helix factor 1,
CHF1)) [Homo sapiens]
dbj|BAA96781.1| (AB044755) basic-helix-loop-helix protein [Homo sapiens]
Length = 337
Score = 171 bits (429), Expect = 9e-42
Identities = 100/192 (52%), Positives = 125/192 (65%), Gaps = 12/192 (6%)
Query: 1 MKRPKEPSGSDGESDGPIDVGQE----GQLSQMARPLSTPSS-SQMQAXXXXXXXXXXXX 55
MKRP E + S+ + D IDVG E GQ + L++P++ SQ+ A
Sbjct: 1 MKRPCEETTSESDMDETIDVGSENNYSGQSTSSVIRLNSPTTTSQIMARKKRRGIIEKRR 60
Query: 56 XXXXNSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVD 115
N+SLSELRRLVPTAFEKQGS+KLEKAE+LQMTVDHLKML ATGG G+FDA ALA+D
Sbjct: 61 RDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMD 120
Query: 116 FRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTG------P 169
F SIGFRECLTEV RYL +EG S +DP+R+RL+SHL++ A + E + + P
Sbjct: 121 FMSIGFRECLTEVARYLSSVEGLDS-SDPLRVRLVSHLSTCATQREAAAMTSSMAHHHHP 179
Query: 170 LAFPAWPWSFFH 181
L W +F H
Sbjct: 180 LHPHHWAAAFHH 191
>gb|AAF44780.1|AF237948_1 (AF237948) Gridlock [Danio rerio]
Length = 324
Score = 171 bits (428), Expect = 1e-41
Identities = 96/172 (55%), Positives = 117/172 (67%), Gaps = 6/172 (3%)
Query: 1 MKRPKEPSGSDGESDGPIDVGQEGQLSQMA-----RPLSTPSSSQMQAXXXXXXXXXXXX 55
MKRP E S SD + D IDVG + S + R S ++SQ+ A
Sbjct: 1 MKRPCEDSTSDSDMDETIDVGSQNNYSGQSNGSFIRCGSPTTTSQVMARKKRRGIIEKRR 60
Query: 56 XXXXNSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVD 115
N+SLSELRRLVPTAFEKQGS+KLEKAE+LQMTVDHLKML ATGG G+FDA +LA+D
Sbjct: 61 RDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHSLAMD 120
Query: 116 FRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPT 167
F SIGFRECLTEV RYL +EG S +DP+R+RL+SHL+S A++ E + T
Sbjct: 121 FLSIGFRECLTEVARYLSSVEGLDS-SDPLRVRLVSHLSSCASQREAAAMTT 171
>emb|CAB65543.1| (AJ388551) bHLH protein Hesr-1/Hey1 [Canis familiaris]
Length = 304
Score = 171 bits (428), Expect = 1e-41
Identities = 92/179 (51%), Positives = 118/179 (65%), Gaps = 6/179 (3%)
Query: 8 SGSDGESDGPIDVGQE-----GQLSQMARPLSTPSSSQMQAXXXXXXXXXXXXXXXXNSS 62
S SD E D ++V +E G LS +S +SSQ+ A N+S
Sbjct: 9 SSSDSELDETVEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNS 68
Query: 63 LSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIGFR 122
LSELRRLVP+AFEKQGS+KLEKAE+LQMTVDHLKMLH GG G+FDA ALA+D+RS+GFR
Sbjct: 69 LSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFR 128
Query: 123 ECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFFH 181
ECL EV RYL ++EG + +DP+R+RL+SHLN+YA++ E + L W +F H
Sbjct: 129 ECLAEVARYLSIIEGLDA-SDPLRVRLVSHLNNYASQREAASGAHAGLGHLPWGSAFGH 186
>ref|NP_034553.1| hairy/enhancer-of-split related with YRPW motif 1;
Hairy/E(spl)-related with YRPW motif 1 [Mus musculus]
gb|AAD38966.1|AF151521_1 (AF151521) hairy and enhancer of split related-1 [Mus musculus]
Length = 299
Score = 170 bits (427), Expect = 2e-41
Identities = 93/179 (51%), Positives = 118/179 (64%), Gaps = 6/179 (3%)
Query: 8 SGSDGESDGPIDVGQE-----GQLSQMARPLSTPSSSQMQAXXXXXXXXXXXXXXXXNSS 62
S SD E D I+V +E G LS +S +SSQ+ A N+S
Sbjct: 9 SSSDSELDETIEVEKESADENGNLSSALCSMSPTTSSQVLARKRRRGIIEKRRRDRINNS 68
Query: 63 LSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIGFR 122
LSELRRLVP+AFEKQGS+KLEKAE+LQMTVDHLKMLH GG G+FDA ALA+D+RS+GFR
Sbjct: 69 LSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFR 128
Query: 123 ECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFFH 181
ECL EV RYL ++EG + +DP+ +RL+SHLN+YA++ E + G L W +F H
Sbjct: 129 ECLAEVARYLSIIEGLDA-SDPLLVRLVSHLNNYASQREAASGAHGGLGHIPWGSAFGH 186
>ref|NP_038932.1| hairy/enhancer-of-split related with YRPW motif 2;
Hairy-E(spl)-related with YRPW motif 2; hairy-related
transcription factor 2 [Mus musculus]
gb|AAF14546.1|AF172287_1 (AF172287) hairy-related transcription factor 2 [Mus musculus]
gb|AAF20174.1|AF173902_1 (AF173902) basic helix-loop-helix factor 1 [Mus musculus]
emb|CAB71346.1| (AJ271867) basic-helix-loop-helix protein [Mus musculus]
gb|AAF37298.1|AF232240_1 (AF232240) HES-related repressor protein 1 HERP1 [Mus musculus]
Length = 339
Score = 168 bits (422), Expect = 6e-41
Identities = 98/192 (51%), Positives = 121/192 (62%), Gaps = 12/192 (6%)
Query: 1 MKRPKEPSGSDGESDGPIDVGQEGQL-----SQMARPLSTPSSSQMQAXXXXXXXXXXXX 55
MKRP E + S+ + D IDVG E S + R S ++SQ+ A
Sbjct: 1 MKRPCEETTSESDLDETIDVGSENNYPGHATSSVMRSNSPTTTSQIMARKKRRGIIEKRR 60
Query: 56 XXXXNSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVD 115
N+SLSELRRLVPTAFEKQGS+KLEKAE+LQMTVDHLKML ATGG G+FDA ALA D
Sbjct: 61 RDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALATD 120
Query: 116 FRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTG------P 169
F SIGFRECLTEV RYL +EG +DP+R+RL+SHL++ A++ E + + P
Sbjct: 121 FMSIGFRECLTEVARYLSSVEG-LDPSDPLRVRLVSHLSTCASQREAAVMTSSMAHHHHP 179
Query: 170 LAFPAWPWSFFH 181
L W +F H
Sbjct: 180 LHPHHWAAAFHH 191
>gb|AAF59152.1| (AE003839) Hey gene product [Drosophila melanogaster]
Length = 421
Score = 111 bits (276), Expect = 8e-24
Identities = 73/187 (39%), Positives = 101/187 (53%), Gaps = 27/187 (14%)
Query: 34 STPSSSQMQAXXXXXXXXXXXXXXXXNSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVD 93
S P S Q+ + NSSL+EL+RLVP+A+EKQGS+KLEKAE+LQ+TV+
Sbjct: 87 SEPGSCQLMSRKKRRGVIEKKRRDRINSSLTELKRLVPSAYEKQGSAKLEKAEILQLTVE 146
Query: 94 HLKMLHA-TGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSH 152
HLK L + T + +D + +A+D+ IGFREC EV RYL +EG + DP+R+RL+SH
Sbjct: 147 HLKSLQSKTLDSLSYDPQRVAMDYHIIGFRECAAEVARYLVTIEGMDIQ-DPLRLRLMSH 205
Query: 153 LNSYAAEMEPSP---------TPTGP----------------LAFPAWPWSFFHSCPGLP 187
L + + E S +P P A PA P ++ S P L
Sbjct: 206 LQYFVQQRELSAKSCASPGGWSPAAPSSSGYQPNCAAAPYQSYAAPANPGAYVSSYPTLS 265
Query: 188 ALSNQLA 194
A +Q A
Sbjct: 266 ASPSQQA 272
>gb|AAD46771.1|AF151523_1 (AF151523) hairy and enhancer of split related protein 1
[Drosophila melanogaster]
Length = 425
Score = 111 bits (276), Expect = 8e-24
Identities = 73/187 (39%), Positives = 101/187 (53%), Gaps = 27/187 (14%)
Query: 34 STPSSSQMQAXXXXXXXXXXXXXXXXNSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVD 93
S P S Q+ + NSSL+EL+RLVP+A+EKQGS+KLEKAE+LQ+TV+
Sbjct: 91 SEPGSCQLMSRKKRRGVIEKKRRDRINSSLTELKRLVPSAYEKQGSAKLEKAEILQLTVE 150
Query: 94 HLKMLHA-TGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSH 152
HLK L + T + +D + +A+D+ IGFREC EV RYL +EG + DP+R+RL+SH
Sbjct: 151 HLKSLQSKTLDSLSYDPQRVAMDYHIIGFRECAAEVARYLVTIEGMDIQ-DPLRLRLMSH 209
Query: 153 LNSYAAEMEPSP---------TPTGP----------------LAFPAWPWSFFHSCPGLP 187
L + + E S +P P A PA P ++ S P L
Sbjct: 210 LQYFVQQRELSAKSCASPGGWSPAAPSSSGYQPNCAAAPYQSYAAPANPGAYVSSYPTLS 269
Query: 188 ALSNQLA 194
A +Q A
Sbjct: 270 ASPSQQA 276
>ref|NP_066993.1| bHLH factor Hes4 [Homo sapiens]
dbj|BAB13510.1| (AB048791) bHLH factor Hes4 [Homo sapiens]
Length = 221
Score = 70.2 bits (169), Expect = 3e-11
Identities = 52/144 (36%), Positives = 71/144 (49%), Gaps = 12/144 (8%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N SL++L+ L+ A K+ S SKLEKA++L+MTV HL+ L T A +
Sbjct: 51 NESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTAALSADPAVLGKY 110
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSP-----TPTGPLAF 172
GF ECL EV R+L EG + VR RLL HL + ++ PS +P P
Sbjct: 111 RAGFHECLAEVNRFLAGCEGVPA---DVRSRLLGHLAACLRQLGPSRRPASLSPAAPAEA 167
Query: 173 PAWPWSFFHSCPGLPALSNQLAIL 196
PA + P LP+L +L
Sbjct: 168 PA--PEVYAGRPLLPSLGGPFPLL 189
>gb|AAG23838.1|AF301264_1 (AF301264) bHLH-WRPW transcription factor [Danio rerio]
Length = 291
Score = 69.9 bits (168), Expect = 4e-11
Identities = 45/122 (36%), Positives = 64/122 (51%), Gaps = 11/122 (9%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N SL +L+ L+ A +K S SKLEKA++L+MTV HL+ L + A +
Sbjct: 51 NESLGQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRVQMSAALSADTNVLSKY 110
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEM------EPSPTPTGPLA 171
GF EC+ EV R+L EG ++ VR RLL+HL+ +M +P+P LA
Sbjct: 111 RAGFNECMNEVTRFLSTCEGVNTE---VRSRLLNHLSGCMGQMMAMNYPQPAPAQQAHLA 167
Query: 172 FP 173
P
Sbjct: 168 QP 169
>dbj|BAA76633.1| (AB019516) newt HES1 [Cynops pyrrhogaster]
Length = 251
Score = 69.9 bits (168), Expect = 4e-11
Identities = 44/118 (37%), Positives = 61/118 (51%), Gaps = 14/118 (11%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N SL +L+ L+ A +K S SKLEKA++L+MTV HL+ L T A +
Sbjct: 52 NESLGQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRVQMTAALSADPTVLGKY 111
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLN---------SYAAEMEPSPTP 166
GF EC+ EV R+L EG ++ VR RLL HL+ +Y ++P P P
Sbjct: 112 RAGFNECMNEVTRFLSTCEGVNTE---VRTRLLGHLSGCLGGMAAMNYPQHVQPGPGP 166
>ref|NP_032261.1| hairy and enhancer of split 1, (Drosophila) [Mus musculus]
sp|P35428|HES1_MOUSE TRANSCRIPTION FACTOR HES-1 (HAIRY AND ENHANCER OF SPLIT 1)
pir||A53336 transcription factor HES-1 - mouse
dbj|BAA03931.1| (D16464) helix-loop-helix factor HES-1 [Mus musculus]
Length = 282
Score = 68.3 bits (164), Expect = 1e-10
Identities = 46/127 (36%), Positives = 62/127 (48%), Gaps = 20/127 (15%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N SLS+L+ L+ A +K S SKLEKA++L+MTV HL+ L T +
Sbjct: 51 NESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKY 110
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSY---------------AAEMEP 162
GF EC+ EV R+L EG ++ VR RLL HL + A + P
Sbjct: 111 RAGFSECMNEVTRFLSTCEGVNTE---VRTRLLGHLANCMTQINAMTYPGQAHPALQAPP 167
Query: 163 SPTPTGP 169
P P+GP
Sbjct: 168 PPPPSGP 174
>sp|Q04666|HES1_RAT TRANSCRIPTION FACTOR HES-1 (HAIRY AND ENHANCER OF SPLIT 1)
(HAIRY-LIKE) (RHL)
pir||S36748 transcription factor HES-1 - rat
dbj|BAA02682.1| (D13417) HES-1 factor [Rattus norvegicus]
prf||1905315A HES-1 protein [Rattus norvegicus]
Length = 281
Score = 68.3 bits (164), Expect = 1e-10
Identities = 46/127 (36%), Positives = 62/127 (48%), Gaps = 20/127 (15%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N SLS+L+ L+ A +K S SKLEKA++L+MTV HL+ L T +
Sbjct: 51 NESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKY 110
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSY---------------AAEMEP 162
GF EC+ EV R+L EG ++ VR RLL HL + A + P
Sbjct: 111 RAGFSECMNEVTRFLSTCEGVNTE---VRTRLLGHLANCMTQINAMTYPGQAHPALQAPP 167
Query: 163 SPTPTGP 169
P P+GP
Sbjct: 168 PPPPSGP 174
>pir||A48106 hairy-like gene RHL - rat
gb|AAA41307.1| (L04527) hairy [Rattus norvegicus]
Length = 281
Score = 68.3 bits (164), Expect = 1e-10
Identities = 46/127 (36%), Positives = 63/127 (49%), Gaps = 20/127 (15%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N SLS+L+ L+ A +K S SKLEKA++L+MTV+HL+ L T +
Sbjct: 51 NESLSQLKTLILDALKKDSSRHSKLEKADILEMTVNHLRNLQWAQMTAALSTDPSVLGKY 110
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSY---------------AAEMEP 162
GF EC+ EV R+L EG ++ VR RLL HL + A + P
Sbjct: 111 RAGFSECMNEVTRFLSTCEGVNTE---VRTRLLGHLANCMTQINAMTYPGQAHPALQAPP 167
Query: 163 SPTPTGP 169
P P+GP
Sbjct: 168 PPPPSGP 174
>ref|NP_005515.1| hairy (Drosophila)-homolog; transcription factor HES-1 [Homo
sapiens]
sp|Q14469|HES1_HUMAN TRANSCRIPTION FACTOR HES-1 (HAIRY AND ENHANCER OF SPLIT 1)
(HAIRY-LIKE) (HHL) (HAIRY HOMOLOG)
pir||A53027 transcription factor HES-1 - human
gb|AAA65220.1| (L19314) also called HHL [Homo sapiens]
dbj|BAA91149.1| (AK000415) unnamed protein product [Homo sapiens]
gb|AAF73060.1| (AF264785) hairy [Homo sapiens]
Length = 280
Score = 67.9 bits (163), Expect = 1e-10
Identities = 46/126 (36%), Positives = 60/126 (47%), Gaps = 19/126 (15%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N SLS+L+ L+ A +K S SKLEKA++L+MTV HL+ L T +
Sbjct: 51 NESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKY 110
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHL--------------NSYAAEMEPS 163
GF EC+ EV R+L EG ++ VR RLL HL + A P
Sbjct: 111 RAGFSECMNEVTRFLSTCEGVNTE---VRTRLLGHLANCMTQINAMTYPGQPHPALQAPP 167
Query: 164 PTPTGP 169
P P GP
Sbjct: 168 PPPPGP 173
>emb|CAA65998.1| (X97333) HER-6 protein [Danio rerio]
Length = 334
Score = 67.1 bits (161), Expect = 3e-10
Identities = 41/110 (37%), Positives = 58/110 (52%), Gaps = 5/110 (4%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N SL +L+ L+ A +K S SKLEKA++L+MTV HL+ + T + +
Sbjct: 115 NESLGQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNMQRAQMTAALNTDPTVLGKY 174
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPT 167
GF EC+ EV R+L EG ++ VR RLL HL S ++ PT
Sbjct: 175 RAGFSECMNEVTRFLSTCEGVNTE---VRTRLLGHLASCMTQINAMNYPT 221
>sp|O57337|HES1_CHICK TRANSCRIPTION FACTOR HES-1 (C-HAIRY1)
gb|AAB88691.1| (AF032966) c-hairy1 [Gallus gallus]
Length = 290
Score = 66.3 bits (159), Expect = 4e-10
Identities = 45/123 (36%), Positives = 62/123 (49%), Gaps = 9/123 (7%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N SL +L+ L+ A +K S SKLEKA++L+MTV HL+ L A +
Sbjct: 52 NESLGQLKMLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMAAALSADPSVLGKY 111
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEP----SPTPTGPLAFP 173
GF EC+ EV R+L EG ++ VR RLL HL++ ++ P P G A
Sbjct: 112 RAGFNECMNEVTRFLSTCEGVNA---DVRARLLGHLSACLGQIVAMNYLPPPPAGQPAHL 168
Query: 174 AWP 176
A P
Sbjct: 169 AQP 171
>emb|CAB89491.1| (AJ252154) DNA-binding-protein hairy [Cupiennius salei]
Length = 335
Score = 66.0 bits (158), Expect = 6e-10
Identities = 46/115 (40%), Positives = 64/115 (55%), Gaps = 8/115 (6%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLH-ATGGTGFFDARALAVDF 116
N+SLSEL+ L+ A +K + SKLEKA++L+MTV HL+ L ++ F
Sbjct: 76 NNSLSELKNLILDALKKDNARHSKLEKADILEMTVKHLQNLQMQQQQQQLTPDPSMMAKF 135
Query: 117 RSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHL-NSYAAEMEPSPTPTGPL 170
R+ GF EC EV R++G +EG +R RLL+HL N P PTP P+
Sbjct: 136 RA-GFAECANEVNRFMGSMEGID---HTIRQRLLNHLANCLTGMSNPPPTPLPPV 186
>gb|AAA79185.1| (U36194) hairy1 [Xenopus laevis]
Length = 266
Score = 63.6 bits (152), Expect = 3e-09
Identities = 42/123 (34%), Positives = 62/123 (50%), Gaps = 10/123 (8%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N SL +L+ L+ A +K S SKLEKA++L+MTV HL+ L + +
Sbjct: 51 NESLGQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRVQMSAALSTDPSVLGKY 110
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEME-----PSPTPTGPLAF 172
GF EC+ EV R+L EG ++ VR RLL HL + ++ P+ P+
Sbjct: 111 RAGFSECMNEVTRFLSTCEGVNT---DVRTRLLGHLANCMNQINGMNYLPAQMPSAAAPH 167
Query: 173 PAW 175
PA+
Sbjct: 168 PAY 170
>gb|AAD01745.1| (AF022798) basic-helix-loop-helix transcription factor hairy2b
[Xenopus laevis]
Length = 274
Score = 55.4 bits (131), Expect = 8e-07
Identities = 32/76 (42%), Positives = 42/76 (55%), Gaps = 3/76 (3%)
Query: 80 SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPS 139
SKLEKA++L+MTV HL+ L T + + GF EC EV R+L EG +
Sbjct: 47 SKLEKADILEMTVKHLRNLQRVQMTAALTSDPSVLGKYRAGFNECTNEVTRFLSTCEGVN 106
Query: 140 SRADPVRIRLLSHLNS 155
+ VR RLL HL+S
Sbjct: 107 TE---VRTRLLGHLSS 119
>gb|AAF59113.1| (AE003838) dpn gene product [Drosophila melanogaster]
Length = 435
Score = 54.3 bits (128), Expect = 2e-06
Identities = 37/104 (35%), Positives = 55/104 (52%), Gaps = 5/104 (4%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N L+EL+ L+ A +K + +KLEKA++L+MTV HL+ + + V
Sbjct: 57 NHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQLNMAIQSDPSVVQKF 116
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEME 161
GF EC EV RY+ ++G + VR RL +HLN A +E
Sbjct: 117 KTGFVECAEEVNRYVSQMDGIDT---GVRQRLSAHLNQCANSLE 157
>pir||S29712 segmentation protein hairy - red flour beetle
prf||1907283A hairy gene [Tribolium castaneum]
Length = 218
Score = 54.3 bits (128), Expect = 2e-06
Identities = 40/108 (37%), Positives = 57/108 (52%), Gaps = 11/108 (10%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N+SL+EL+ L+ A +K + SKLEKA++L+MTV HL+ L + V
Sbjct: 15 NNSLNELKTLILDAMKKDPARHSKLEKADILEMTVKHLQNLQRQQAAMWQPTDPSVVSKF 74
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADP-VRIRLLSHLNSYAAEMEPSP 164
GF EC +EV R+ G+ DP V+ RLL HL S + + P
Sbjct: 75 RAGFSECASEVGRFPGL--------DPVVKRRLLQHLASCLNQGQKEP 114
>sp|Q26263|DPN_DROME DEADPAN PROTEIN
pir||A46231 helix-loop-helix protein Dpn - fruit fly (Drosophila sp.)
gb|AAB24149.1| (S48025) Dpn=helix-loop-helix protein [Drosophila, Peptide, 435 aa]
[Drosophila sp.]
Length = 435
Score = 54.3 bits (128), Expect = 2e-06
Identities = 37/104 (35%), Positives = 55/104 (52%), Gaps = 5/104 (4%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N L+EL+ L+ A +K + +KLEKA++L+MTV HL+ + + V
Sbjct: 57 NHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQLNMAIQSDPSVVQKF 116
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEME 161
GF EC EV RY+ ++G + VR RL +HLN A +E
Sbjct: 117 KTGFVECAEEVNRYVSQMDGIDT---GVRQRLSAHLNQCANSLE 157
>ref|NP_034549.1| hairy and enhancer of split 5, (Drosophila) [Mus musculus]
sp|P70120|HES5_MOUSE TRANSCRIPTION FACTOR HES-5 (HAIRY AND ENHANCER OF SPLIT 5)
pir||A55438 transcription factor HES-5 - mouse
dbj|BAA06858.1| (D32132) HES-5 [Mus musculus]
Length = 167
Score = 52.3 bits (123), Expect = 7e-06
Identities = 37/115 (32%), Positives = 60/115 (52%), Gaps = 9/115 (7%)
Query: 60 NSSLSELRRLVPTAFEK-QGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRS 118
NSS+ +L+ L+ F + Q +SKLEKA++L+M V +LK H+ ++L D+ S
Sbjct: 33 NSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLK--HSKAFAAAAGPKSLHQDY-S 89
Query: 119 IGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFP 173
G+ CL E +++L + A +++LL H A P+ P P A P
Sbjct: 90 EGYSWCLQEAVQFLTL-----HAASDTQMKLLYHFQRPPAPAAPAKEPPAPGAAP 139
>gb|AAF54527.1| (AE003687) stich1 gene product [Drosophila melanogaster]
Length = 621
Score = 50.8 bits (119), Expect = 2e-05
Identities = 23/73 (31%), Positives = 45/73 (61%), Gaps = 8/73 (10%)
Query: 60 NSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSI 119
NS L++L RL+P ++++G ++EK E+++M + HLK L + + + D+RS
Sbjct: 2 NSCLADLSRLIPPQYQRKGRGRIEKTEIIEMAIRHLKHLQS-------ECQQKESDYRS- 53
Query: 120 GFRECLTEVIRYL 132
G+ +C+ E ++L
Sbjct: 54 GYMDCMKEAAKFL 66
>gb|AAF24476.1|AF203477_1 (AF203477) Sticky ch1 [Drosophila melanogaster]
Length = 610
Score = 50.8 bits (119), Expect = 2e-05
Identities = 23/73 (31%), Positives = 45/73 (61%), Gaps = 8/73 (10%)
Query: 60 NSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSI 119
NS L++L RL+P ++++G ++EK E+++M + HLK L + + + D+RS
Sbjct: 79 NSCLADLSRLIPPQYQRKGRGRIEKTEIIEMAIRHLKHLQS-------ECQQKESDYRS- 130
Query: 120 GFRECLTEVIRYL 132
G+ +C+ E ++L
Sbjct: 131 GYMDCMKEAAKFL 143
>sp|Q03062|HES5_RAT TRANSCRIPTION FACTOR HES-5 (HAIRY AND ENHANCER OF SPLIT 5)
pir||A45119 basic helix-loop-helix negative regulatory factor HES-5 - rat
dbj|BAA02081.1| (D12516) HES-5 [Rattus norvegicus]
Length = 166
Score = 49.2 bits (115), Expect = 6e-05
Identities = 36/111 (32%), Positives = 62/111 (55%), Gaps = 12/111 (10%)
Query: 60 NSSLSELRRLVPTAFEK-QGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRS 118
NSS+ +L+ L+ F + Q +SKLEKA++L+M V +LK H+ ++L D+ S
Sbjct: 33 NSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLK--HSKAFAAAAGPKSLHQDY-S 89
Query: 119 IGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLN---SYAAEMEPSPTP 166
G+ CL E +++L + A +++LL H + AA ++ +PTP
Sbjct: 90 EGYSWCLQEAVQFLTL-----HAASDTQMKLLYHFQRPPAPAAPVKETPTP 135
>gb|AAF22960.1|AF146088_1 (AF146088) enhancer of split related protein-7 [Xenopus laevis]
Length = 158
Score = 48.4 bits (113), Expect = 1e-04
Identities = 31/100 (31%), Positives = 53/100 (53%), Gaps = 6/100 (6%)
Query: 60 NSSLSELRRLVPTAFEKQGSS-KLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRS 118
NSS+ +L+ L+ F KQ + KLEKA++L+MTV +L+ + + +D++
Sbjct: 35 NSSIEQLKVLLENVFHKQQPNVKLEKADILEMTVTYLRQQTLQLKSEIPHNNDIQMDYK- 93
Query: 119 IGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAA 158
+G+ C EVI +L + + +L+SH NS A
Sbjct: 94 VGYSRCFEEVIDFLSL----HQKQPETEAKLISHFNSKTA 129
>gb|AAB63586.1| (AF009329) enhancer-of-split and hairy-related protein 1 [Rattus
norvegicus]
Length = 253
Score = 47.6 bits (111), Expect = 2e-04
Identities = 38/121 (31%), Positives = 59/121 (48%), Gaps = 15/121 (12%)
Query: 60 NSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSI 119
N +++L+ L+P + LEKA VL++T+ HLK L A AL RS+
Sbjct: 61 NECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSL 120
Query: 120 -------------GFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAE-MEPSPT 165
GF+ C EV++YL E + R +P +L+SHL++ A + + P T
Sbjct: 121 KSPVQADLDAFHSGFQTCAKEVLQYLARFESWTPR-EPRCAQLVSHLHAVATQLLTPQVT 179
Query: 166 P 166
P
Sbjct: 180 P 180
>sp|P14003|HAIR_DROME HAIRY PROTEIN
emb|CAA34019.1| (X15905) hairy gene product (AA 1-337) [Drosophila melanogaster]
Length = 337
Score = 47.6 bits (111), Expect = 2e-04
Identities = 35/98 (35%), Positives = 53/98 (53%), Gaps = 9/98 (9%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N+ L+EL+ L+ A +K + SKLEKA++L+ TV HL+ L A V+
Sbjct: 48 NNCLNELKTLILDATKKDPARHSKLEKADILEKTVKHLQELQRQQAAMQQAADPKIVNKF 107
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNS 155
GF +C+ EV R+ G+ P+ R RLL HL++
Sbjct: 108 KAGFADCVNEVSRFPGI--EPAQRR-----RLLQHLSN 138
>pir||S06956 segmentation protein hairy - fruit fly (Drosophila melanogaster)
emb|CAA34018.1| (X15904) hairy [Drosophila melanogaster]
gb|AAF50378.1| (AE003554) h gene product [Drosophila melanogaster]
Length = 337
Score = 47.6 bits (111), Expect = 2e-04
Identities = 35/98 (35%), Positives = 53/98 (53%), Gaps = 9/98 (9%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N+ L+EL+ L+ A +K + SKLEKA++L+ TV HL+ L A V+
Sbjct: 48 NNCLNELKTLILDATKKDPARHSKLEKADILEKTVKHLQELQRQQAAMQQAADPKIVNKF 107
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNS 155
GF +C+ EV R+ G+ P+ R RLL HL++
Sbjct: 108 KAGFADCVNEVSRFPGI--EPAQRR-----RLLQHLSN 138
>ref|NP_032262.1| hairy and enhancer of split 2 (Drosophila) [Mus musculus]
sp|O54792|HES2_MOUSE TRANSCRIPTION FACTOR HES-2 (HAIRY AND ENHANCER OF SPLIT 2)
dbj|BAA24091.1| (AB009967) HES2 [Mus musculus]
Length = 157
Score = 46.5 bits (108), Expect = 4e-04
Identities = 45/134 (33%), Positives = 59/134 (43%), Gaps = 22/134 (16%)
Query: 60 NSSLSELRRLVPTAF--EKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N SLS+L+ LV E SSKLEKA++L+MTV + L T + A ++
Sbjct: 30 NESLSQLKGLVLPLLGAETSRSSKLEKADILEMTV---RFLQEQPATLYSSAAPGPLNSY 86
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLN---------SYAAEMEPSPTPTG 168
G+R CL + R VL S V RLL HL S P+P P+
Sbjct: 87 LEGYRACLARLAR---VLPACSVLEPAVSARLLEHLRQRTVSDDSPSLTLPPAPAPAPSP 143
Query: 169 PLAFPA----W-PW 177
P+ P W PW
Sbjct: 144 PVPPPGSSGLWRPW 157
>gb|AAG23292.1| (AY007991) transcription factor Her-8b [Danio rerio]
Length = 221
Score = 45.7 bits (106), Expect = 7e-04
Identities = 35/111 (31%), Positives = 55/111 (49%), Gaps = 7/111 (6%)
Query: 60 NSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR-- 117
NSSL +L+ ++ A+ SKLEKA+VL++TV H++ L G G ++ + R
Sbjct: 36 NSSLEQLKGIMVDAYNLD-QSKLEKADVLEITVQHMENLQRGHGQGGSNSPGTGFESRQR 94
Query: 118 -SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPT 167
S G+ +C+ EV L G + RLL+HL + P+ T
Sbjct: 95 YSSGYIQCMHEVHNLLLSCPGMDK---TLGARLLNHLLKSLPHISTEPSGT 142
>gb|AAG23291.1| (AY007990) transcription factor Her-8a [Danio rerio]
Length = 221
Score = 45.7 bits (106), Expect = 7e-04
Identities = 35/111 (31%), Positives = 55/111 (49%), Gaps = 7/111 (6%)
Query: 60 NSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR-- 117
NSSL +L+ ++ A+ SKLEKA+VL++TV H++ L G G ++ + R
Sbjct: 36 NSSLEQLKGIMVDAYNLD-QSKLEKADVLEITVQHMENLQRGHGQGGSNSPGTGFESRQR 94
Query: 118 -SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPT 167
S G+ +C+ EV L G + RLL+HL + P+ T
Sbjct: 95 YSSGYIQCMHEVHNLLLSCPGMDK---TLGARLLNHLLKSLPHISTEPSGT 142
>gb|AAF53741.1| (AE003661) CG10446 gene product [Drosophila melanogaster]
Length = 507
Score = 45.3 bits (105), Expect = 0.001
Identities = 39/134 (29%), Positives = 57/134 (42%), Gaps = 23/134 (17%)
Query: 60 NSSLSELRRLVPTAFEKQGS---------SKLEKAEVLQMTVDHLKMLHATGGTGFFDAR 110
N SL+ L+ L+ + + Q + +KLEKA++L++TV H + R
Sbjct: 67 NQSLAILKALILESTKTQNAKNGEGQAKHTKLEKADILELTVRHFQRHRNLDDPTVNKYR 126
Query: 111 ALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPV------RIRLLSHLNSYAAEMEPSP 164
A G+ +C EV RYL E P P + RLL HL+ AE++
Sbjct: 127 A--------GYTDCAREVARYLATPEPPPMGTMPTLAEPGSKARLLRHLDQCIAEIDVEI 178
Query: 165 TPTGPLAFPAWPWS 178
P AF P S
Sbjct: 179 CPHSTAAFAESPSS 192
>pir||A44443 basic helix-loop-helix transcription repressor H - fruit fly
(Drosophila virilis)
Length = 378
Score = 44.9 bits (104), Expect = 0.001
Identities = 33/98 (33%), Positives = 50/98 (50%), Gaps = 9/98 (9%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N+ L+EL+ L+ A +K + SKLEKA++L+ TV HL+ L A ++
Sbjct: 54 NNCLNELKTLILDATKKDPARHSKLEKADILEKTVKHLQELQRQQAAMQQAADPKIINKF 113
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNS 155
GF +C EV R+ G+ R RLL HL++
Sbjct: 114 KAGFADCANEVSRFPGL-------DSTQRRRLLQHLSN 144
>sp|P29303|HAIR_DROVI HAIRY PROTEIN
gb|AAA28602.1| (M87885) basic-helix-loop-helix protein [Drosophila virilis]
Length = 378
Score = 44.9 bits (104), Expect = 0.001
Identities = 33/98 (33%), Positives = 50/98 (50%), Gaps = 9/98 (9%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N+ L+EL+ L+ A +K + SKLEKA++L+ TV HL+ L A ++
Sbjct: 54 NNCLNELKTLILDATKKDPARHSKLEKADILEKTVKHLQELQRQQAAMQQAADPKIINKF 113
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNS 155
GF +C EV R+ G+ R RLL HL++
Sbjct: 114 KAGFADCANEVSRFPGL-------DSTQRRRLLQHLSN 144
>emb|CAB77019.1| (AJ276313) HLHmgamma protein [Drosophila hydei]
Length = 217
Score = 44.5 bits (103), Expect = 0.002
Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 16/123 (13%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKML-------HATGGTGFFDAR 110
N L EL+ L+ E +G ++LEKA++L++TV HL+ + A GG +
Sbjct: 32 NKCLDELKDLMVATLESEGEHVTRLEKADILELTVTHLQKMKQQRQQKRANGGA---ETL 88
Query: 111 ALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPL 170
A FRS G+ + EV R L L G + + L++HL +++P+ P+
Sbjct: 89 TPAEGFRS-GYIHAVNEVSRSLSQLPGMNV---SLGTELMTHLGQRLNQLQPAVKEVLPV 144
Query: 171 AFP 173
P
Sbjct: 145 TAP 147
>emb|CAB46198.1| (AL031848) dJ202O8.2.1 (ortholog of rodent HES2 (Hairy and Enhacer
of Split 2) (isoform 1)) [Homo sapiens]
Length = 173
Score = 43.0 bits (99), Expect = 0.005
Identities = 43/126 (34%), Positives = 58/126 (45%), Gaps = 19/126 (15%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFR 117
N SLS+L+ L+ ++ S SKLEKA+VL+MTV L+ L A + + A L D
Sbjct: 30 NQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQELPA---SSWPTAAPLPCDSY 86
Query: 118 SIGFRECLTEVIRYLGVLEGPSSRA--DPVRIRLLSHLNSYAAEME-------PSPTPTG 168
G+ C+ + R L P+ R V RLL HL AA S P+
Sbjct: 87 REGYSACVARLARVL-----PACRVLEPAVSARLLEHLWRRAASATLDGGRAGDSSGPSA 141
Query: 169 PLAFPA 174
P PA
Sbjct: 142 PAPAPA 147
>pir||B46177 enhancer of split locus protein mB - fruit fly (Drosophila
melanogaster)
gb|AAA28910.1| (M96167) split locus enhancer protein mB [Drosophila melanogaster]
emb|CAB77021.1| (AJ276315) HLHmgamma protein [Drosophila melanogaster]
gb|AAF56545.1| (AE003754) HLHmgamma gene product [Drosophila melanogaster]
Length = 205
Score = 43.0 bits (99), Expect = 0.005
Identities = 35/123 (28%), Positives = 59/123 (47%), Gaps = 17/123 (13%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKML-------HATGGTGFFDAR 110
N L EL+ L+ E +G ++LEKA++L++TV HL+ + A+G A
Sbjct: 32 NKCLDELKDLMVATLESEGEHVTRLEKADILELTVTHLQKMKQQRQHKRASGDESLTPAE 91
Query: 111 ALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPL 170
FRS G+ + EV R L L G + + +L++HL +++P+ P+
Sbjct: 92 G----FRS-GYIHAVNEVSRSLSQLPGMNV---SLGTQLMTHLGQRLNQIQPAEKEVLPV 143
Query: 171 AFP 173
P
Sbjct: 144 TAP 146
>pir||S29901 helix-loop-helix protein m-gamma - fruit fly (Drosophila
melanogaster)
emb|CAA47434.1| (X67049) helix-loop-helix protein [Drosophila melanogaster]
Length = 205
Score = 43.0 bits (99), Expect = 0.005
Identities = 35/123 (28%), Positives = 59/123 (47%), Gaps = 17/123 (13%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKML-------HATGGTGFFDAR 110
N L EL+ L+ E +G ++LEKA++L++TV HL+ + A+G A
Sbjct: 32 NKCLDELKDLMVATLESEGEHVTRLEKADILELTVTHLQKMKQQRQHKRASGDESLTPAE 91
Query: 111 ALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPL 170
FRS G+ + EV R L L G + + +L++HL +++P+ P+
Sbjct: 92 G----FRS-GYIHAVNEVSRSLSQLPGMNV---SLGTQLMTHLGQRLNQIQPAEKEVLPV 143
Query: 171 AFP 173
P
Sbjct: 144 TAP 146
>gb|AAF56546.1| (AE003754) HLHmbeta gene product [Drosophila melanogaster]
Length = 195
Score = 41.4 bits (95), Expect = 0.014
Identities = 37/127 (29%), Positives = 60/127 (47%), Gaps = 14/127 (11%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHA---------TGGTG-FF 107
N L EL+ ++ ++G ++LEKA++L++TV+H+K L A TGG
Sbjct: 30 NKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKLRAQKQLRLSSVTGGVSPSA 89
Query: 108 DAR-ALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTP 166
D + ++A FR+ G+ EV + L + G S + L H +Y + PS
Sbjct: 90 DPKLSIAESFRA-GYVHAANEVSKTLAAVPGVSVDLGTQLMSHLGHRLNYLQVVVPSLPI 148
Query: 167 TGPLAFP 173
PL P
Sbjct: 149 GVPLQAP 155
>ref|NP_062109.1| hairy and enhancer of split 2 (Drosophila) [Rattus norvegicus]
sp|P35429|HES2_RAT TRANSCRIPTION FACTOR HES-2 (HAIRY AND ENHANCER OF SPLIT 2)
pir||S35037 helix-loop-helix protein HES-2 - rat
dbj|BAA03118.1| (D14029) HES-2 [Rattus norvegicus]
Length = 157
Score = 41.4 bits (95), Expect = 0.014
Identities = 44/138 (31%), Positives = 60/138 (42%), Gaps = 30/138 (21%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLK----MLHATGGTGFFDARALA 113
N SLS+L+ LV + S SKLEKA++L+MTV L+ + +T G +
Sbjct: 30 NESLSQLKGLVLPLLGAETSRYSKLEKADILEMTVRFLREQPASVCSTEAPG-------S 82
Query: 114 VDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLN-------------SYAAEM 160
+D G+R CL + R VL S V RLL HL + A+
Sbjct: 83 LDSYLEGYRACLARLAR---VLPACSVLEPAVSARLLEHLRQRTVSGGPPSLTPASASAP 139
Query: 161 EPSPTPTGPLAFPAW-PW 177
PSP P + W PW
Sbjct: 140 APSPPVPPPSSLGLWRPW 157
>pir||C46177 enhancer of split locus protein mA - fruit fly (Drosophila
melanogaster)
gb|AAA28909.1| (M96166) split locus enhancer protein mA [Drosophila melanogaster]
Length = 195
Score = 41.4 bits (95), Expect = 0.014
Identities = 37/127 (29%), Positives = 60/127 (47%), Gaps = 14/127 (11%)
Query: 60 NSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHA---------TGGTG-FF 107
N L EL+ ++ ++G ++LEKA++L++TV+H+K L A TGG
Sbjct: 30 NKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKLRAQKQLRLSSVTGGVSPSA 89
Query: 108 DAR-ALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTP 166
D + ++A FR+ G+ EV + L + G S + L H +Y + PS
Sbjct: 90 DPKLSIAESFRA-GYVHAANEVSKTLAAVPGVSVDLGTQLMSHLGHRLNYLQVVVPSLPI 148
Query: 167 TGPLAFP 173
PL P
Sbjct: 149 GVPLQAP 155
Database: nr
Number of letters in database: 182,691,300
Number of sequences in database: 580,189
Lambda K H
0.316 0.133 0.393
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100378486
Number of Sequences: 580189
Number of extensions: 3561096
Number of successful extensions: 11111
Number of sequences better than 10.0: 94
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 65
Number of HSP's that attempted gapping in prelim test: 11039
Number of HSP's gapped (non-prelim): 103
length of query: 327
length of database: 182,691,300
effective HSP length: 57
effective length of query: 270
effective length of database: 149,620,527
effective search space: 40397542290
effective search space used: 40397542290
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 71 (32.1 bits)
