Score E
Sequences producing significant alignments: (bits) Value
dbj|BAA87044.2| (AB035182) Dickkopf-3 [Homo sapiens] 606 e-172
ref|NP_037385.1| Dickkopf gene 3; RIG-like 7-1 [Homo sapien... 606 e-172
ref|NP_056629.1| dickkopf homolog 3 (Xenopus laevis) [Mus m... 530 e-149
gb|AAG15890.1|AF245040_1 (AF245040) substrate binding subun... 445 e-124
sp|Q90839|LFE4_CHICK UNKNOWN LENS FIBER PROTEIN CLFEST4 PRE... 370 e-101
ref|NP_056965.1| Dickkopf gene 3; RIG-like 7-1 [Homo sapien... 345 4e-94
ref|NP_055235.1| dickkopf (Xenopus laevis) homolog 4; Dickk... 73 6e-12
dbj|BAA33438.1| (AB017788) hdkk-4 [Homo sapiens] 71 1e-11
gb|AAC02427.1| (AF030434) Xdkk-1 [Xenopus laevis] 59 1e-07
ref|NP_055234.1| soggy-1 gene [Homo sapiens] >gi|6049612|gb... 57 4e-07
ref|NP_036374.1| dickkopf (Xenopus laevis) homolog 1; dickk... 57 4e-07
dbj|BAA82135.1| (AB023488) dickkopf1 [Danio rerio] 56 5e-07
gb|AAD22461.1|AF116852_1 (AF116852) dickkopf-1 [Danio rerio] 53 5e-06
ref|NP_034181.1| dickkopf homolog 1 (Xenopus laevis) [Mus m... 52 8e-06
gb|AAG21341.1|AF274313_1 (AF274313) soggy precursor [Mus mu... 52 1e-05
gb|AAG21340.1|AF274312_1 (AF274312) soggy precursor [Mus mu... 52 1e-05
ref|NP_055236.1| dickkopf (Xenopus laevis) homolog 2; Dickk... 51 2e-05
ref|NP_056604.1| soggy 1 [Mus musculus] >gi|6049614|gb|AAF0... 50 4e-05
dbj|BAA87056.1| (AB035181) Dickkopf-2 [Homo sapiens] 50 5e-05
sp|P18563|ITB6_CAVPO INTEGRIN BETA-6 >gi|112517|pir||B37057... 46 5e-04
ref|NP_067334.1| integrin beta 6 [Mus musculus] >gi|4324977... 43 0.007
ref|NP_000879.2| integrin, beta 6 [Homo sapiens] >gi|944640... 42 0.012
sp|P18564|ITB6_HUMAN INTEGRIN BETA-6 PRECURSOR >gi|106778|p... 42 0.012
pir||A53612 laminin B1k chain precursor - human >gi|510703|... 41 0.020
pir||T27283 hypothetical protein Y64G10A.f - Caenorhabditis... 41 0.027
gb|AAD45816.1|AF168790_1 (AF168790) Bv8 protein [Bombina va... 40 0.035
pir||I56985 kalinin B1 - mouse 40 0.035
ref|NP_032510.1| laminin, beta 3; nicein, 125kD [Mus muscul... 40 0.035
pir||JC2005 integrin beta-5 chain - baboon 40 0.035
sp|Q07441|ITB5_PAPCY INTEGRIN BETA-5 >gi|176590|gb|AAA16866... 40 0.035
pir||A38308 integrin beta-5 chain precursor - human >gi|186... 40 0.035
gb|AAF44692.1|AF239959_1 (AF239959) hybrid integrin beta 3 ... 40 0.046
gb|AAD51955.1|AF170529_1 (AF170529) glycoprotein IIIa; GPII... 40 0.046
gb|AAD51953.1|AF170527_1 (AF170527) glycoprotein IIIa; GPII... 40 0.046
gb|AAB71380.1| (U95204) platelet membrane glycoprotein IIIa... 40 0.046
gb|AAA67537.1| (M32686) glycoprotein IIIa [Homo sapiens] 40 0.046
pir||A60798 platelet glycoprotein IIIa beta chain (version ... 40 0.046
pir||I77349 plate glycoprotein IIIa (GPIIIa) - human >gi|30... 40 0.046
pir||B36268 platelet glycoprotein IIIa-II - human (fragment) 40 0.046
ref|NP_000203.1| integrin beta chain, beta 3 precursor; pla... 40 0.046
gb|AAA52600.1| (M57494) platelet glycoprotein IIIa [Homo sa... 40 0.046
sp|P05106|ITB3_HUMAN PLATELET MEMBRANE GLYCOPROTEIN IIIA PR... 40 0.046
gb|AAD49737.1|AF170525_1 (AF170525) glycoprotein GPIIIa [Ca... 39 0.060
pdb|1IMT| Mamba Intestinal Toxin 1, Nmr, 39 Structures 39 0.060
emb|CAB40149.1| (AL031316) dJ28O10.1(LAMB3 (laminin, beta 3... 39 0.060
gb|AAD13680.1| (AF116270) platelet glycoprotein IIIa [Canis... 39 0.060
ref|NP_000219.1| laminin subunit beta 3 precursor [Homo sap... 39 0.060
sp|Q13751|LMB3_HUMAN LAMININ BETA-3 CHAIN PRECURSOR (LAMINI... 39 0.060
ref|NP_002204.1| integrin, beta 5 [Homo sapiens] >gi|306894... 39 0.060
sp|P18084|ITB5_HUMAN INTEGRIN BETA-5 PRECURSOR >gi|33953|em... 39 0.060
>dbj|BAA87044.2| (AB035182) Dickkopf-3 [Homo sapiens]
Length = 350
Score = 606 bits (1546), Expect = e-172
Identities = 285/329 (86%), Positives = 285/329 (86%)
Query: 1 MQRLGXXXXXXXXXXXXXXXXXXXXXXXXXXVKPGPALSYPQEEATLNEMFREVEELMED 60
MQRLG VKPGPALSYPQEEATLNEMFREVEELMED
Sbjct: 1 MQRLGATLLCLLLAAAVPTAPAPAPTATSAPVKPGPALSYPQEEATLNEMFREVEELMED 60
Query: 61 TQHKLRXXXXXXXXXXXXXXXXXXVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITN 120
TQHKLR VNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITN
Sbjct: 61 TQHKLRSAVEEMEAEEAAAKASSEVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITN 120
Query: 121 NQTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTR 180
NQTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTR
Sbjct: 121 NQTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTR 180
Query: 181 DSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGEL 240
DSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGEL
Sbjct: 181 DSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGEL 240
Query: 241 CHDPASRLLDLITWELEPDGALDRCPCASGLLCQPHSHSLVYVCKPTFVGSRDQDGEILL 300
CHDPASRLLDLITWELEPDGALDRCPCASGLLCQPHSHSLVYVCKPTFVGSRDQDGEILL
Sbjct: 241 CHDPASRLLDLITWELEPDGALDRCPCASGLLCQPHSHSLVYVCKPTFVGSRDQDGEILL 300
Query: 301 PREVPDEYEVGSFMEEVRQELEDLERSLT 329
PREVPDEYEVGSFMEEVRQELEDLERSLT
Sbjct: 301 PREVPDEYEVGSFMEEVRQELEDLERSLT 329
>ref|NP_037385.1| Dickkopf gene 3; RIG-like 7-1 [Homo sapiens]
gb|AAF02676.1|AF177396_1 (AF177396) dickkopf-3 [Homo sapiens]
dbj|BAA85488.1| (AB033421) Dickkopf-3 [Homo sapiens]
dbj|BAA90548.1| (AB034203) REIC/Dkk-3 [Homo sapiens]
Length = 350
Score = 606 bits (1546), Expect = e-172
Identities = 285/329 (86%), Positives = 285/329 (86%)
Query: 1 MQRLGXXXXXXXXXXXXXXXXXXXXXXXXXXVKPGPALSYPQEEATLNEMFREVEELMED 60
MQRLG VKPGPALSYPQEEATLNEMFREVEELMED
Sbjct: 1 MQRLGATLLCLLLAAAVPTAPAPAPTATSAPVKPGPALSYPQEEATLNEMFREVEELMED 60
Query: 61 TQHKLRXXXXXXXXXXXXXXXXXXVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITN 120
TQHKLR VNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITN
Sbjct: 61 TQHKLRSAVEEMEAEEAAAKASSEVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITN 120
Query: 121 NQTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTR 180
NQTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTR
Sbjct: 121 NQTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTR 180
Query: 181 DSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGEL 240
DSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGEL
Sbjct: 181 DSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGEL 240
Query: 241 CHDPASRLLDLITWELEPDGALDRCPCASGLLCQPHSHSLVYVCKPTFVGSRDQDGEILL 300
CHDPASRLLDLITWELEPDGALDRCPCASGLLCQPHSHSLVYVCKPTFVGSRDQDGEILL
Sbjct: 241 CHDPASRLLDLITWELEPDGALDRCPCASGLLCQPHSHSLVYVCKPTFVGSRDQDGEILL 300
Query: 301 PREVPDEYEVGSFMEEVRQELEDLERSLT 329
PREVPDEYEVGSFMEEVRQELEDLERSLT
Sbjct: 301 PREVPDEYEVGSFMEEVRQELEDLERSLT 329
>ref|NP_056629.1| dickkopf homolog 3 (Xenopus laevis) [Mus musculus]
gb|AAF02680.1|AF177400_1 (AF177400) Dkk-3 protein [Mus musculus]
emb|CAB60111.1| (AJ243964) dickkopf-3 [Mus musculus]
Length = 349
Score = 530 bits (1350), Expect = e-149
Identities = 242/328 (73%), Positives = 265/328 (80%)
Query: 1 MQRLGXXXXXXXXXXXXXXXXXXXXXXXXXXVKPGPALSYPQEEATLNEMFREVEELMED 60
MQRLG +PGPAL+YPQEEATLNEMFREVEELMED
Sbjct: 1 MQRLGGILLCTLLAAAVPTAPAPSPTVTWTPAEPGPALNYPQEEATLNEMFREVEELMED 60
Query: 61 TQHKLRXXXXXXXXXXXXXXXXXXVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITN 120
TQHKLR VNLA+LPP+YHNET+T+T+VGNNT+HVH+E+HKITN
Sbjct: 61 TQHKLRSAVEEMEAEEAAAKTSSEVNLASLPPNYHNETSTETRVGNNTVHVHQEVHKITN 120
Query: 121 NQTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTR 180
NQ+GQ+VFSETVITSVGDEEG+RSHECIIDEDCGP+ YCQF+SF+YTCQPCR Q+MLCTR
Sbjct: 121 NQSGQVVFSETVITSVGDEEGKRSHECIIDEDCGPTRYCQFSSFKYTCQPCRDQQMLCTR 180
Query: 181 DSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGEL 240
DSECCGDQLC WGHCT+ AT+G NGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGEL
Sbjct: 181 DSECCGDQLCAWGHCTQKATKGGNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGEL 240
Query: 241 CHDPASRLLDLITWELEPDGALDRCPCASGLLCQPHSHSLVYVCKPTFVGSRDQDGEILL 300
CHDP S+LLDLITWELEP+GALDRCPCASGLLCQPHSHSLVY+CKP FVGS D E L
Sbjct: 241 CHDPTSQLLDLITWELEPEGALDRCPCASGLLCQPHSHSLVYMCKPAFVGSHDHSEESQL 300
Query: 301 PREVPDEYEVGSFMEEVRQELEDLERSL 328
PRE PDEYE F+ EVRQELEDLERSL
Sbjct: 301 PREAPDEYEDVGFIGEVRQELEDLERSL 328
>gb|AAG15890.1|AF245040_1 (AF245040) substrate binding subunit of type II 5'-deiodinase D2p29
[Rattus norvegicus]
Length = 277
Score = 445 bits (1133), Expect = e-124
Identities = 197/244 (80%), Positives = 220/244 (89%)
Query: 85 VNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITNNQTGQMVFSETVITSVGDEEGRRS 144
V L++LP +YHNETNT+T++ NNT HVHRE+HKITNNQ+GQ VFSETVITSV D EG++S
Sbjct: 14 VTLSSLPANYHNETNTETRMENNTAHVHREVHKITNNQSGQTVFSETVITSVEDGEGKKS 73
Query: 145 HECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHCTKMATRGSN 204
HECIIDEDCGP+ YCQF+SF+YTCQPCR Q+MLCTRDSECCGDQLC WGHCT+ AT+GSN
Sbjct: 74 HECIIDEDCGPTRYCQFSSFKYTCQPCRDQQMLCTRDSECCGDQLCAWGHCTQKATKGSN 133
Query: 205 GTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDR 264
GTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDP S++LDLITWELEP+GALDR
Sbjct: 134 GTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPTSQMLDLITWELEPEGALDR 193
Query: 265 CPCASGLLCQPHSHSLVYVCKPTFVGSRDQDGEILLPREVPDEYEVGSFMEEVRQELEDL 324
CPCASGLLCQPHSHSLVY+CKP FVGS D + E LPRE D+YE F+ EVRQELEDL
Sbjct: 194 CPCASGLLCQPHSHSLVYMCKPAFVGSHDHNEESQLPREALDDYEDVGFIGEVRQELEDL 253
Query: 325 ERSL 328
ERSL
Sbjct: 254 ERSL 257
>sp|Q90839|LFE4_CHICK UNKNOWN LENS FIBER PROTEIN CLFEST4 PRECURSOR
dbj|BAA05373.1| (D26311) unknown protein [Gallus gallus]
Length = 350
Score = 370 bits (939), Expect = e-101
Identities = 168/293 (57%), Positives = 208/293 (70%), Gaps = 12/293 (4%)
Query: 45 ATLNEMFREVEELMEDTQHKLRXXXXXXXXXXXXXXXXXXVNLANLPPSYHNETNTDTKV 104
A+L EM REVE LMEDTQHKLR VN NLPP+YHNE+NT+T++
Sbjct: 37 ASLGEMLREVEALMEDTQHKLRNAVQEMEAEEEGAKKLSEVNFENLPPTYHNESNTETRI 96
Query: 105 GNNTIHVHREIHKITNNQTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQFASF 164
GN T+ H+EI K+T+N+TG +FSET+ITS+ E +R+HECIIDEDC YCQF++F
Sbjct: 97 GNKTVQTHQEIDKVTDNRTGSTIFSETIITSIKGGENKRNHECIIDEDCETGKYCQFSTF 156
Query: 165 QYTCQPCRGQRMLCTRDSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQR 224
+Y CQPC+ Q C+RD ECCGDQLCVWG C K +RG NGTIC+NQ DC PG CCAFQ+
Sbjct: 157 EYKCQPCKTQHTHCSRDVECCGDQLCVWGECRKATSRGENGTICENQHDCNPGTCCAFQK 216
Query: 225 GLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPCASGLLCQPH-SHSLVYV 283
LLFPVCTPLP EGE CHDP++RLL+LITWELEPDG L+RCPCASGL+CQP SHS V
Sbjct: 217 ELLFPVCTPLPEEGEPCHDPSNRLLNLITWELEPDGVLERCPCASGLICQPQSSHSTTSV 276
Query: 284 CKPTFVGSRDQDGE-----------ILLPREVPDEYEVGSFMEEVRQELEDLE 325
C+ + +R + E L+PR++ +YE S ++EVR+ELE LE
Sbjct: 277 CELSSNETRKNEKEDPLNMDEMPFISLIPRDILSDYEESSVIQEVRKELESLE 329
>ref|NP_056965.1| Dickkopf gene 3; RIG-like 7-1 [Homo sapiens]
gb|AAB92664.1| (AF034208) RIG-like 7-1 [Homo sapiens]
Length = 171
Score = 345 bits (876), Expect = 4e-94
Identities = 151/156 (96%), Positives = 154/156 (97%)
Query: 157 MYCQFASFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQP 216
MYCQFASFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQP
Sbjct: 1 MYCQFASFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQP 60
Query: 217 GLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPCASGLLCQPH 276
GLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPC SGLLCQPH
Sbjct: 61 GLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPCXSGLLCQPH 120
Query: 277 SHSLVYVCKPTFVGSRDQDGEILLPREVPDEYEVGS 312
SHSLVYVCKPTFVGSRDQDGEILLPREVPDEY++ +
Sbjct: 121 SHSLVYVCKPTFVGSRDQDGEILLPREVPDEYKLAA 156
>ref|NP_055235.1| dickkopf (Xenopus laevis) homolog 4; Dickkopf gene 4 [Homo sapiens]
dbj|BAA33475.1| (AB018005) hdkk-4 [Homo sapiens]
gb|AAF02677.1|AF177397_1 (AF177397) dickkopf-4 [Homo sapiens]
Length = 224
Score = 72.6 bits (175), Expect = 6e-12
Identities = 57/215 (26%), Positives = 78/215 (35%), Gaps = 65/215 (30%)
Query: 124 GQMVFSETVITSVGDEEG-RRSHECIIDEDCGPSMYC-QFASFQYTCQPCRGQRMLCTRD 181
G +V I S D G R+ +C+ D DC +C Q + C CRG R C RD
Sbjct: 17 GALVLDFNNIRSSADLHGARKGSQCLSDTDCNTRKFCLQPRDEKPFCATCRGLRRRCQRD 76
Query: 182 SECCGDQLCVWGHCTKM------------------------------------------A 199
+ CC LCV CT M
Sbjct: 77 AMCCPGTLCVNDVCTTMEDATPILERQLDEQDGTHAEGTTGHPVQENQPKRKPSIKKSQG 136
Query: 200 TRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELC----HDPASRLLDLITWE 255
+G G C DC PGLCCA R +C P+ +EG++C H ++ ++
Sbjct: 137 RKGQEGESCLRTFDCGPGLCCA--RHFWTKICKPVLLEGQVCSRRGHKDTAQAPEI---- 190
Query: 256 LEPDGALDRCPCASGLLCQP-----HSHSLVYVCK 285
RC C GLLC+ H+ + VC+
Sbjct: 191 ------FQRCDCGPGLLCRSQLTSNRQHARLRVCQ 219
>dbj|BAA33438.1| (AB017788) hdkk-4 [Homo sapiens]
Length = 224
Score = 71.4 bits (172), Expect = 1e-11
Identities = 56/215 (26%), Positives = 78/215 (36%), Gaps = 65/215 (30%)
Query: 124 GQMVFSETVITSVGDEEG-RRSHECIIDEDCGPSMYC-QFASFQYTCQPCRGQRMLCTRD 181
G +V I S D G R+ +C+ D DC +C Q + C CRG R C RD
Sbjct: 17 GALVLDFNNIRSSADLHGARKGSQCLSDTDCNTRKFCLQPRDEKPFCATCRGLRRRCQRD 76
Query: 182 SECCGDQLCVWGHCTKM------------------------------------------A 199
+ CC LCV CT +
Sbjct: 77 AMCCPGTLCVNDVCTTLEDATPILERQLDEQDGTHAEGTTGHPVQENQPKRKPSIKKSQG 136
Query: 200 TRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELC----HDPASRLLDLITWE 255
+G G C DC PGLCCA R +C P+ +EG++C H ++ ++
Sbjct: 137 RKGQEGESCLRTFDCGPGLCCA--RHFWTKICKPVLLEGQVCSRRGHKDTAQAPEI---- 190
Query: 256 LEPDGALDRCPCASGLLCQP-----HSHSLVYVCK 285
RC C GLLC+ H+ + VC+
Sbjct: 191 ------FQRCDCGPGLLCRSQLTSNRQHARLRVCQ 219
>gb|AAC02427.1| (AF030434) Xdkk-1 [Xenopus laevis]
Length = 259
Score = 58.6 bits (139), Expect = 1e-07
Identities = 44/178 (24%), Positives = 63/178 (34%), Gaps = 60/178 (33%)
Query: 145 HECIIDEDCGPSMYCQFA--SFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHC------- 195
+ C D+DC +C + C CR +R C RD+ CC C G C
Sbjct: 73 YSCTEDDDCALDEFCHSSRNGNSLVCLACRKRRKRCLRDAMCCTGNYCSNGICVPVEQDQ 132
Query: 196 ----------------------------TKMAT--------RGSNGTICDNQRDCQPGLC 219
+K+ T +G +G +C DC PGLC
Sbjct: 133 ERFQHQGYLEETILENYNNADHATMDTHSKLTTSPSGMQPFKGRDGDVCLRSTDCAPGLC 192
Query: 220 CAFQRGLLFPVCTPLPVEGELC---HDPASRLLDLITWELEPDGALDRCPCASGLLCQ 274
CA R +C P+ EG++C S L++ RC C +GL C+
Sbjct: 193 CA--RHFWSKICKPVLDEGQVCTKHRRKGSHGLEI----------FQRCHCGAGLSCR 238
Score = 40.2 bits (92), Expect = 0.035
Identities = 29/121 (23%), Positives = 44/121 (35%), Gaps = 29/121 (23%)
Query: 106 NNTIHVHREIH-KITNNQTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQFASF 164
NN H + H K+T + +G F +GR C+ DC P + C +
Sbjct: 150 NNADHATMDTHSKLTTSPSGMQPF-----------KGRDGDVCLRSTDCAPGLCCARHFW 198
Query: 165 QYTCQPCRGQRMLCTRDSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQR 224
C+P + + CTK +GS+G + C GL C Q+
Sbjct: 199 SKICKPVLDEGQV-----------------CTKHRRKGSHGLEIFQRCHCGAGLSCRLQK 241
Query: 225 G 225
G
Sbjct: 242 G 242
>ref|NP_055234.1| soggy-1 gene [Homo sapiens]
gb|AAF02678.1|AF177398_1 (AF177398) soggy-1 protein [Homo sapiens]
dbj|BAB12400.1| (AB047818) Soggy [Homo sapiens]
Length = 242
Score = 56.6 bits (134), Expect = 4e-07
Identities = 23/57 (40%), Positives = 39/57 (68%)
Query: 85 VNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITNNQTGQMVFSETVITSVGDEEG 141
++ LP +YH E N + ++GNNT+ H +I K+T+N+TG+++ SE V+ S+ EG
Sbjct: 76 MDFRGLPGNYHKEENQEHQLGNNTLSSHLQIDKMTDNKTGEVLISENVVASIQPAEG 132
>ref|NP_036374.1| dickkopf (Xenopus laevis) homolog 1; dickkopf-1 like [Homo sapiens]
dbj|BAA34651.1| (AB020315) homologue of mouse dkk-1 gene:Acc# AF030433 [Homo
sapiens]
gb|AAD21087.1| (AF127563) Sk/Dkk-1 protein precursor [Homo sapiens]
gb|AAF02674.1|AF177394_1 (AF177394) dickkopf-1 [Homo sapiens]
gb|AAG15544.1| (AF261158) dickkopf homolog 1 [Homo sapiens]
Length = 266
Score = 56.6 bits (134), Expect = 4e-07
Identities = 47/177 (26%), Positives = 62/177 (34%), Gaps = 60/177 (33%)
Query: 145 HECIIDEDCGPSMYCQF------ASFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHC--- 195
+ C DE+CG YC A Q C CR +R C R + CC C G C
Sbjct: 83 YPCAEDEECGTDEYCASPTRGGDAGVQI-CLACRKRRKRCMRHAMCCPGNYCKNGICVSS 141
Query: 196 ----------------------------------TKMA-TRGSNGTICDNQRDCQPGLCC 220
+KM T+G G++C DC GLCC
Sbjct: 142 DQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYHTKGQEGSVCLRSSDCASGLCC 201
Query: 221 AFQRGLLFPVCTPLPVEGELC---HDPASRLLDLITWELEPDGALDRCPCASGLLCQ 274
A R +C P+ EG++C S L++ RC C GL C+
Sbjct: 202 A--RHFWSKICKPVLKEGQVCTKHRRKGSHGLEI----------FQRCYCGEGLSCR 246
>dbj|BAA82135.1| (AB023488) dickkopf1 [Danio rerio]
Length = 240
Score = 56.2 bits (133), Expect = 5e-07
Identities = 47/165 (28%), Positives = 62/165 (37%), Gaps = 48/165 (29%)
Query: 147 CIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHC----------- 195
C DE+CG +C F S + C C+ +R C RD+ CC C G C
Sbjct: 68 CESDEECGGEEFC-FQS-RGVCLQCKKRRKRCIRDAMCCPGNHCSNGVCIPNDPDMIQQL 125
Query: 196 -----------------TKMATRGS---------NGTICDNQRDCQPGLCCAFQRGLLFP 229
K++T+GS G C DC GLCCA R
Sbjct: 126 GMEEFVSIAHENSTALMPKVSTQGSPQNQMLKGLEGENCLRSSDCAEGLCCA--RHFWSK 183
Query: 230 VCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPCASGLLCQ 274
+C P+ EG++C + T LE RC C GL C+
Sbjct: 184 ICKPVLKEGQVCTKHKRK----GTHGLE---IFQRCDCGEGLSCR 221
Score = 33.6 bits (75), Expect = 3.5
Identities = 19/86 (22%), Positives = 31/86 (35%), Gaps = 17/86 (19%)
Query: 140 EGRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHCTKMA 199
+G C+ DC + C + C+P + +CT+
Sbjct: 157 KGLEGENCLRSSDCAEGLCCARHFWSKICKPVLKEGQVCTKHKR---------------- 200
Query: 200 TRGSNGTICDNQRDCQPGLCCAFQRG 225
+G++G + DC GL C QRG
Sbjct: 201 -KGTHGLEIFQRCDCGEGLSCRTQRG 225
>gb|AAD22461.1|AF116852_1 (AF116852) dickkopf-1 [Danio rerio]
Length = 241
Score = 53.1 bits (125), Expect = 5e-06
Identities = 46/165 (27%), Positives = 61/165 (36%), Gaps = 48/165 (29%)
Query: 147 CIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHC----------- 195
C DE+CG +C F S + C C+ +R C RD+ CC C G C
Sbjct: 69 CESDEECGGEEFC-FQS-RGVCLQCKKRRKRCIRDAMCCPGNHCSNGVCIPNDPDIIQQL 126
Query: 196 -----------------TKMATRGS---------NGTICDNQRDCQPGLCCAFQRGLLFP 229
K++T+GS G C DC LCCA R
Sbjct: 127 GMEEFVSIAHENSTALMPKVSTQGSPQNQMLKGLEGENCLRSSDCAETLCCA--RHFWSK 184
Query: 230 VCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPCASGLLCQ 274
+C P+ EG++C + T LE RC C GL C+
Sbjct: 185 ICKPVLKEGQVCTKHKRK----GTHGLE---IFQRCDCGEGLSCR 222
Score = 34.0 bits (76), Expect = 2.6
Identities = 19/86 (22%), Positives = 32/86 (37%), Gaps = 17/86 (19%)
Query: 140 EGRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHCTKMA 199
+G C+ DC ++ C + C+P + +CT+
Sbjct: 158 KGLEGENCLRSSDCAETLCCARHFWSKICKPVLKEGQVCTKHKR---------------- 201
Query: 200 TRGSNGTICDNQRDCQPGLCCAFQRG 225
+G++G + DC GL C QRG
Sbjct: 202 -KGTHGLEIFQRCDCGEGLSCRTQRG 226
>ref|NP_034181.1| dickkopf homolog 1 (Xenopus laevis) [Mus musculus]
gb|AAC02426.1| (AF030433) mdkk-1 [Mus musculus]
Length = 272
Score = 52.3 bits (123), Expect = 8e-06
Identities = 43/181 (23%), Positives = 57/181 (30%), Gaps = 63/181 (34%)
Query: 145 HECIIDEDCGPSMYCQFASFQYT-------CQPCRGQRMLCTRDSECCGDQLCVWGHCTK 197
+ C DE+CG YC S C CR +R C + CC C G C
Sbjct: 84 YPCAEDEECGSDEYCSSPSRGAAGVGGVQICLACRKRRKRCMTHAMCCPGNYCKNGICMP 143
Query: 198 MA-----------------------------------------TRGSNGTICDNQRDCQP 216
T+G G++C DC
Sbjct: 144 SDHSHFPRGEIEESIIENLGNDHNAAAGDGYPRRTTLTSKIYHTKGQEGSVCLRSSDCAA 203
Query: 217 GLCCAFQRGLLFPVCTPLPVEGELC---HDPASRLLDLITWELEPDGALDRCPCASGLLC 273
GLCCA R +C P+ EG++C S L++ RC C GL C
Sbjct: 204 GLCCA--RHFWSKICKPVLKEGQVCTKHKRKGSHGLEI----------FQRCYCGEGLAC 251
Query: 274 Q 274
+
Sbjct: 252 R 252
>gb|AAG21341.1|AF274313_1 (AF274313) soggy precursor [Mus musculus]
Length = 128
Score = 51.5 bits (121), Expect = 1e-05
Identities = 21/55 (38%), Positives = 38/55 (68%)
Query: 85 VNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITNNQTGQMVFSETVITSVGDE 139
++ +LP ++H E N + ++GN+T+ H +I K+T+NQTG+++ SE V S+ E
Sbjct: 66 MDFRDLPRNFHQEENQEHRMGNHTLSSHLQIDKVTDNQTGEVLISEKVEASIEPE 120
>gb|AAG21340.1|AF274312_1 (AF274312) soggy precursor [Mus musculus]
Length = 230
Score = 51.5 bits (121), Expect = 1e-05
Identities = 21/55 (38%), Positives = 38/55 (68%)
Query: 85 VNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITNNQTGQMVFSETVITSVGDE 139
++ +LP ++H E N + ++GN+T+ H +I K+T+NQTG+++ SE V S+ E
Sbjct: 66 MDFRDLPRNFHQEENQEHRMGNHTLSSHLQIDKVTDNQTGEVLISEKVEASIEPE 120
>ref|NP_055236.1| dickkopf (Xenopus laevis) homolog 2; Dickkopf gene 2 [Homo sapiens]
gb|AAF02675.1|AF177395_1 (AF177395) dickkopf-2 [Homo sapiens]
dbj|BAA85465.1| (AB033208) Dickkopf-2 [Homo sapiens]
Length = 259
Score = 50.8 bits (119), Expect = 2e-05
Identities = 45/188 (23%), Positives = 64/188 (33%), Gaps = 62/188 (32%)
Query: 137 GDEEGR---RSHECIIDEDCGPSMYCQFA-SFQYTCQPCRGQRMLCTRDSECCGDQLCVW 192
G ++G+ +++ C D++C YC C CR ++ C RD CC C
Sbjct: 65 GSKKGKNLGQAYPCSSDKECEVGRYCHSPHQGSSACMVCRRKKKRCHRDGMCCPSTRCNN 124
Query: 193 GHC------------------------------------------TKMA-TRGSNGTICD 209
G C TKM+ +G G C
Sbjct: 125 GICIPVTESILTPHIPALDGTRHRDRNHGHYSNHDLGWQNLGRPHTKMSHIKGHEGDPCL 184
Query: 210 NQRDCQPGLCCAFQRGLLFPVCTPLPVEGELC---HDPASRLLDLITWELEPDGALDRCP 266
DC G CCA R +C P+ +GE+C S L++ RC
Sbjct: 185 RSSDCIEGFCCA--RHFWTKICKPVLHQGEVCTKQRKKGSHGLEI----------FQRCD 232
Query: 267 CASGLLCQ 274
CA GL C+
Sbjct: 233 CAKGLSCK 240
>ref|NP_056604.1| soggy 1 [Mus musculus]
gb|AAF02679.1|AF177399_1 (AF177399) soggy-1 protein [Mus musculus]
Length = 230
Score = 50.0 bits (117), Expect = 4e-05
Identities = 21/55 (38%), Positives = 37/55 (67%)
Query: 85 VNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITNNQTGQMVFSETVITSVGDE 139
++ +LP ++H E N + ++GN+T+ H +I K+T+NQTG++ SE V S+ E
Sbjct: 66 MDFRDLPRNFHQEENQEHRMGNHTLSSHLQIDKVTDNQTGEVHISEKVEASIEPE 120
>dbj|BAA87056.1| (AB035181) Dickkopf-2 [Homo sapiens]
Length = 185
Score = 49.6 bits (116), Expect = 5e-05
Identities = 43/178 (24%), Positives = 58/178 (32%), Gaps = 59/178 (33%)
Query: 144 SHECIIDEDCGPSMYCQFA-SFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHC------- 195
++ C D++C YC C CR ++ C RD CC C G C
Sbjct: 1 AYPCSSDKECEVGRYCHSPHQGSSACMVCRRKKKRCHRDGMCCPSTRCNNGICIPVTESI 60
Query: 196 -----------------------------------TKMA-TRGSNGTICDNQRDCQPGLC 219
TKM+ +G G C DC G C
Sbjct: 61 LTPHIPALDGTRHRDRNHGHYSNHDLGWQNLGRPHTKMSHIKGHEGDPCLRSSDCIEGFC 120
Query: 220 CAFQRGLLFPVCTPLPVEGELC---HDPASRLLDLITWELEPDGALDRCPCASGLLCQ 274
CA R +C P+ +GE+C S L++ RC CA GL C+
Sbjct: 121 CA--RHFWTKICKPVLHQGEVCTKQRKKGSHGLEI----------FQRCDCAKGLSCK 166
>sp|P18563|ITB6_CAVPO INTEGRIN BETA-6
pir||B37057 integrin beta-6 chain - guinea pig (fragment)
gb|AAA37043.1| (M35197) integrin B-6 [Cavia sp.]
Length = 577
Score = 46.5 bits (108), Expect = 5e-04
Identities = 43/170 (25%), Positives = 64/170 (37%), Gaps = 38/170 (22%)
Query: 158 YCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCVWG------HCTKMATR--GSNGTIC 208
YCQ +F R + +LC + +C CG+ +C G +CT +GT+C
Sbjct: 395 YCQCDNFSCV----RHKGLLCGDNGDCECGECVCRSGWTGEYCNCTTSTDTCISEDGTLC 450
Query: 209 DNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDG-----ALD 263
+ DC G C G P C P C DP + I L DG +D
Sbjct: 451 SGRGDCVCGKCVCTNPGASGPTCERCPT----CSDPCNSKRSCIECHLSADGQPGEECVD 506
Query: 264 RCPCA-------------SGLLCQPHSHSLVYVCKPTFVGSRDQDGEILL 300
+C A S + C + C TF+ S D +G+ ++
Sbjct: 507 KCKLAGVTISKEADFSKDSSVSCSLQGEN---ECLITFLISTDNEGKTII 553
>ref|NP_067334.1| integrin beta 6 [Mus musculus]
gb|AAD17212.1| (AF115376) integrin beta-6 subunit [Mus musculus]
Length = 787
Score = 42.6 bits (98), Expect = 0.007
Identities = 41/166 (24%), Positives = 63/166 (37%), Gaps = 31/166 (18%)
Query: 158 YCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCVWG----HCTKMATRGS----NGTIC 208
YCQ +F +C +G +LC + +C CG+ +C G +C R S +G +C
Sbjct: 536 YCQCDNF--SCLRHKG--LLCGDNGDCDCGECVCRDGWTGEYCNCTTNRDSCTSEDGVLC 591
Query: 209 DNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDG-----ALD 263
+ DC G C G P C P C DP + I L DG D
Sbjct: 592 SGRGDCVCGKCVCRNPGASGPTCERCPT----CGDPCNSKRSCIECYLSADGQAQEECAD 647
Query: 264 RCPCASGLLCQPHSHSLVYV---------CKPTFVGSRDQDGEILL 300
+C + + V C TF+ + D +G+ ++
Sbjct: 648 KCKAIGATISEEDFSKDTSVSCSLQGENECLITFLITTDNEGKTII 693
>ref|NP_000879.2| integrin, beta 6 [Homo sapiens]
gb|AAA36122.2| (M35198) integrin beta-subunit [Homo sapiens]
Length = 788
Score = 41.8 bits (96), Expect = 0.012
Identities = 39/167 (23%), Positives = 61/167 (36%), Gaps = 32/167 (19%)
Query: 158 YCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCVWG------HCTKMATR--GSNGTIC 208
YCQ +F R + +LC + +C CG+ +C G +CT +G +C
Sbjct: 536 YCQCDNFSCV----RHKGLLCGGNGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLC 591
Query: 209 DNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDG-----ALD 263
+ DC G C G P C P C DP + I L G +D
Sbjct: 592 SGRGDCVCGKCVCTNPGASGPTCERCPT----CGDPCNSKRSCIECHLSAAGQAREECVD 647
Query: 264 RCPCASGLLCQPHSHSL----------VYVCKPTFVGSRDQDGEILL 300
+C A + + S C TF+ + D +G+ ++
Sbjct: 648 KCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTII 694
>sp|P18564|ITB6_HUMAN INTEGRIN BETA-6 PRECURSOR
pir||A37057 integrin beta-6 chain - human
Length = 788
Score = 41.8 bits (96), Expect = 0.012
Identities = 39/167 (23%), Positives = 61/167 (36%), Gaps = 32/167 (19%)
Query: 158 YCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCVWG------HCTKMATR--GSNGTIC 208
YCQ +F R + +LC + +C CG+ +C G +CT +G +C
Sbjct: 536 YCQCDNFSCV----RHKGLLCGGNGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLC 591
Query: 209 DNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDG-----ALD 263
+ DC G C G P C P C DP + I L G +D
Sbjct: 592 SGRGDCVCGKCVCTNPGASGPTCERCPT----CGDPCNSKRSCIECHLSAAGQAGEECVD 647
Query: 264 RCPCASGLLCQPHSHSL----------VYVCKPTFVGSRDQDGEILL 300
+C A + + S C TF+ + D +G+ ++
Sbjct: 648 KCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTII 694
>pir||A53612 laminin B1k chain precursor - human
gb|AAA61834.1| (L25541) laminin S B3 chain [Homo sapiens]
Length = 1170
Score = 41.0 bits (94), Expect = 0.020
Identities = 44/150 (29%), Positives = 58/150 (38%), Gaps = 27/150 (18%)
Query: 174 QRMLCTRDSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTP 233
QR C SE C V+ A++G+ G +CDN RD G C + F P
Sbjct: 313 QRCDCNGHSETCHFDPAVFA-----ASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRP 367
Query: 234 LPVEGELCHDPASRLLDLITWELEPDGALDRCPC---ASGLLCQPH-SHSLVYVCKPTFV 289
E C I+ E +PDGA+ PC +C+ H +CKP F
Sbjct: 368 GASIQETC----------ISCECDPDGAVAGAPCDPVTGQCVCKEHVQGERCDLCKPGFT 417
Query: 290 G--------SRDQDGEILLPREVPDEYEVG 311
G D IL RE+P + E G
Sbjct: 418 GLTYANPRRCHRCDCNILGSREMPCDEESG 447
>pir||T27283 hypothetical protein Y64G10A.f - Caenorhabditis elegans
Length = 1620
Score = 40.6 bits (93), Expect = 0.027
Identities = 53/201 (26%), Positives = 71/201 (34%), Gaps = 48/201 (23%)
Query: 137 GDEEGRRSHEC-IIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTRDSEC---CGDQLCVW 192
G E + + +C ID GPS+ C F F C QR C + C G C+
Sbjct: 1200 GGECNKENGDCECIDGWTGPSL-CPFGQFGRNC----AQRCNCKNGASCDRKTGRCECLP 1254
Query: 193 G----HCTKMATRGSNGTICDNQRDCQPG-LC------CAFQRGLLFPVCTPLPVEG--- 238
G HC K G G C+ +C+ G LC C+ Q G C ++G
Sbjct: 1255 GWSGEHCEKSCVSGHYGAKCEETCECENGALCDPISGHCSCQPGWRGKKCNRPCLKGYFG 1314
Query: 239 ----ELCHDPASRLLDLIT--------------WELEPDGAL-----DRCPCASGLLCQP 275
+ C S+ D I+ EL PDG +C C +C
Sbjct: 1315 RHCSQSCRCANSKSCDHISGRCQCPKGYAGHSCTELCPDGTFGESCSQKCDCGENSMCDA 1374
Query: 276 HSHSLVYVCKPTFVGSRDQDG 296
S CKP GS + G
Sbjct: 1375 ISGKC--FCKPGHSGSDCKSG 1393
>gb|AAD45816.1|AF168790_1 (AF168790) Bv8 protein [Bombina variegata]
Length = 96
Score = 40.2 bits (92), Expect = 0.035
Identities = 27/69 (39%), Positives = 30/69 (43%), Gaps = 11/69 (15%)
Query: 208 CDNQRDCQPGLCCA---FQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDR 264
CD C G CCA + R + F C PL GE CH PAS + L
Sbjct: 26 CDKDVQCGSGTCCAASAWSRNIRF--CIPLGNSGEDCH-PASHKVPYDGKRLS-----SL 77
Query: 265 CPCASGLLC 273
CPC SGL C
Sbjct: 78 CPCKSGLTC 86
>pir||I56985 kalinin B1 - mouse
Length = 1168
Score = 40.2 bits (92), Expect = 0.035
Identities = 36/127 (28%), Positives = 51/127 (39%), Gaps = 15/127 (11%)
Query: 169 QPCRGQRMLCTRDSECCGDQL-CVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLL 227
+P GQ + +C G L C + A++G+NG +CDN RD G C +
Sbjct: 300 RPAEGQDTHECQRCDCNGHSLTCHFDPAVFAASQGTNGGVCDNCRDHTEGKNCEPCQLHY 359
Query: 228 FPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPC---ASGLLCQPH-SHSLVYV 283
F P E C I E +PDGA+ PC +C+ + +
Sbjct: 360 FWNRRPSAPIHETC----------IPCECDPDGAVQGAPCDRLTGQCVCKEYVQGERCDL 409
Query: 284 CKPTFVG 290
CKP F G
Sbjct: 410 CKPGFTG 416
>ref|NP_032510.1| laminin, beta 3; nicein, 125kD [Mus musculus]
sp|Q61087|LMB3_MOUSE LAMININ BETA-3 CHAIN PRECURSOR (KALININ B1 CHAIN)
gb|AAA85255.1| (U43298) laminin beta3 chain [Mus musculus]
Length = 1168
Score = 40.2 bits (92), Expect = 0.035
Identities = 36/127 (28%), Positives = 51/127 (39%), Gaps = 15/127 (11%)
Query: 169 QPCRGQRMLCTRDSECCGDQL-CVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLL 227
+P GQ + +C G L C + A++G+NG +CDN RD G C +
Sbjct: 300 RPAEGQDTHECQRCDCNGHSLTCHFDPAVFAASQGTNGGVCDNCRDHTEGKNCEPCQLHY 359
Query: 228 FPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPC---ASGLLCQPH-SHSLVYV 283
F P E C I E +PDGA+ PC +C+ + +
Sbjct: 360 FWNRRPSAPIHETC----------IPCECDPDGAVQGAPCDRLTGQCVCKEYVQGERCDL 409
Query: 284 CKPTFVG 290
CKP F G
Sbjct: 410 CKPGFTG 416
>pir||JC2005 integrin beta-5 chain - baboon
Length = 656
Score = 40.2 bits (92), Expect = 0.035
Identities = 37/130 (28%), Positives = 52/130 (39%), Gaps = 21/130 (16%)
Query: 154 GPSMYCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCVWGHC-------TKMAT-RGSN 204
GP C ++C R + +LC+ EC CG+ C G+ T ++T RG +
Sbjct: 402 GPFCECD----NFSC--ARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDISTCRGRD 455
Query: 205 GTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDR 264
G IC + C G C + G +C P C D S D + L G D
Sbjct: 456 GQICSERGHCLCGQCQCTEPGAFGEMCEKCPT----CPDACSTKRDCVECPLLHSGKPDN 511
Query: 265 CPCASGLLCQ 274
C S LC+
Sbjct: 512 QTCHS--LCR 519
>sp|Q07441|ITB5_PAPCY INTEGRIN BETA-5
gb|AAA16866.1| (L12231) integrin beta 5 glycoprotein [Papio cynocephalus]
Length = 655
Score = 40.2 bits (92), Expect = 0.035
Identities = 37/130 (28%), Positives = 52/130 (39%), Gaps = 21/130 (16%)
Query: 154 GPSMYCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCVWGHC-------TKMAT-RGSN 204
GP C ++C R + +LC+ EC CG+ C G+ T ++T RG +
Sbjct: 401 GPFCECD----NFSC--ARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDISTCRGRD 454
Query: 205 GTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDR 264
G IC + C G C + G +C P C D S D + L G D
Sbjct: 455 GQICSERGHCLCGQCQCTEPGAFGEMCEKCPT----CPDACSTKRDCVECPLLHSGKPDN 510
Query: 265 CPCASGLLCQ 274
C S LC+
Sbjct: 511 QTCHS--LCR 518
>pir||A38308 integrin beta-5 chain precursor - human
gb|AAA59183.1| (J05633) integrin beta-5 subunit precursor [Homo sapiens]
Length = 799
Score = 40.2 bits (92), Expect = 0.035
Identities = 37/130 (28%), Positives = 52/130 (39%), Gaps = 21/130 (16%)
Query: 154 GPSMYCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCVWGHC-------TKMAT-RGSN 204
GP C ++C R + +LC+ EC CG+ C G+ T ++T RG +
Sbjct: 545 GPFCECD----NFSC--ARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDISTCRGRD 598
Query: 205 GTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDR 264
G IC + C G C + G +C P C D S D + L G D
Sbjct: 599 GQICSERGHCLCGQCQCTEPGAFGEMCEKCPT----CPDACSTKRDCVECPLLHSGKPDN 654
Query: 265 CPCASGLLCQ 274
C S LC+
Sbjct: 655 QTCHS--LCR 662
>gb|AAF44692.1|AF239959_1 (AF239959) hybrid integrin beta 3 subunit precursor [synthetic
construct]
Length = 788
Score = 39.9 bits (91), Expect = 0.046
Identities = 28/93 (30%), Positives = 40/93 (42%), Gaps = 13/93 (13%)
Query: 158 YCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCV--W-GHCTKMATR-----GSNGTIC 208
YC+ F +C +G+ +C+ +C CGD LC W G+ TR SNG +C
Sbjct: 546 YCECDDF--SCVRYKGE--MCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLC 601
Query: 209 DNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELC 241
+ C+ G C Q G C P + C
Sbjct: 602 SGRGKCECGSCVCIQPGSYGDTCEKCPTCPDAC 634
>gb|AAD51955.1|AF170529_1 (AF170529) glycoprotein IIIa; GPIIIa [Oryctolagus cuniculus]
Length = 788
Score = 39.9 bits (91), Expect = 0.046
Identities = 28/93 (30%), Positives = 40/93 (42%), Gaps = 13/93 (13%)
Query: 158 YCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCV--W-GHCTKMATR-----GSNGTIC 208
YC+ F +C +G+ +C+ +C CGD LC W G+ TR SNG +C
Sbjct: 546 YCECDDF--SCVRYKGE--MCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLC 601
Query: 209 DNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELC 241
+ C+ G C Q G C P + C
Sbjct: 602 SGRGKCECGSCVCIQPGSYGDTCEKCPTCPDAC 634
>gb|AAD51953.1|AF170527_1 (AF170527) glycoprotein IIIa; GPIIIa [Sus scrofa]
Length = 784
Score = 39.9 bits (91), Expect = 0.046
Identities = 26/93 (27%), Positives = 40/93 (42%), Gaps = 13/93 (13%)
Query: 158 YCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLC------VWGHCTKMATR--GSNGTIC 208
YC+ F +C +G+ +C+ +C CGD LC + +CT SNG +C
Sbjct: 542 YCECDDF--SCVHYKGE--MCSGHGQCSCGDCLCDSDWTGFYCNCTTRTDTCLSSNGLLC 597
Query: 209 DNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELC 241
+ +C+ G C Q G C P + C
Sbjct: 598 SGRGNCECGSCVCIQPGSYGDTCEKCPTCPDAC 630
>gb|AAB71380.1| (U95204) platelet membrane glycoprotein IIIa beta subunit [Homo
sapiens]
Length = 784
Score = 39.9 bits (91), Expect = 0.046
Identities = 28/93 (30%), Positives = 40/93 (42%), Gaps = 13/93 (13%)
Query: 158 YCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCV--W-GHCTKMATR-----GSNGTIC 208
YC+ F +C +G+ +C+ +C CGD LC W G+ TR SNG +C
Sbjct: 546 YCECDDF--SCVRYKGE--MCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLC 601
Query: 209 DNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELC 241
+ C+ G C Q G C P + C
Sbjct: 602 SGRGKCECGSCVCIQPGSYGDTCEKCPTCPDAC 634
>gb|AAA67537.1| (M32686) glycoprotein IIIa [Homo sapiens]
Length = 762
Score = 39.9 bits (91), Expect = 0.046
Identities = 28/93 (30%), Positives = 40/93 (42%), Gaps = 13/93 (13%)
Query: 158 YCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCV--W-GHCTKMATR-----GSNGTIC 208
YC+ F +C +G+ +C+ +C CGD LC W G+ TR SNG +C
Sbjct: 520 YCECDDF--SCVRYKGE--MCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLC 575
Query: 209 DNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELC 241
+ C+ G C Q G C P + C
Sbjct: 576 SGRGKCECGSCVCIQPGSYGDTCEKCPTCPDAC 608
>pir||A60798 platelet glycoprotein IIIa beta chain (version 2) - human
(fragment)
Length = 778
Score = 39.9 bits (91), Expect = 0.046
Identities = 28/93 (30%), Positives = 40/93 (42%), Gaps = 13/93 (13%)
Query: 158 YCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCV--W-GHCTKMATR-----GSNGTIC 208
YC+ F +C +G+ +C+ +C CGD LC W G+ TR SNG +C
Sbjct: 536 YCECDDF--SCVRYKGE--MCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLC 591
Query: 209 DNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELC 241
+ C+ G C Q G C P + C
Sbjct: 592 SGRGKCECGSCVCIQPGSYGDTCEKCPTCPDAC 624
>pir||I77349 plate glycoprotein IIIa (GPIIIa) - human
gb|AAA35927.1| (M35999) plate glycoprotein IIIa (GPIIIa) [Homo sapiens]
Length = 788
Score = 39.9 bits (91), Expect = 0.046
Identities = 28/93 (30%), Positives = 40/93 (42%), Gaps = 13/93 (13%)
Query: 158 YCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCV--W-GHCTKMATR-----GSNGTIC 208
YC+ F +C +G+ +C+ +C CGD LC W G+ TR SNG +C
Sbjct: 546 YCECDDF--SCVRYKGE--MCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLC 601
Query: 209 DNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELC 241
+ C+ G C Q G C P + C
Sbjct: 602 SGRGKCECGSCVCIQPGSYGDTCEKCPTCPDAC 634
>pir||B36268 platelet glycoprotein IIIa-II - human (fragment)
Length = 753
Score = 39.9 bits (91), Expect = 0.046
Identities = 28/93 (30%), Positives = 40/93 (42%), Gaps = 13/93 (13%)
Query: 158 YCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCV--W-GHCTKMATR-----GSNGTIC 208
YC+ F +C +G+ +C+ +C CGD LC W G+ TR SNG +C
Sbjct: 519 YCECDDF--SCVRYKGE--MCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLC 574
Query: 209 DNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELC 241
+ C+ G C Q G C P + C
Sbjct: 575 SGRGKCECGSCVCIQPGSYGDTCEKCPTCPDAC 607
>ref|NP_000203.1| integrin beta chain, beta 3 precursor; platelet glycoprotein IIIa
precursor [Homo sapiens]
gb|AAA60122.1| (M20311) glycoprotein IIIa [Homo sapiens]
Length = 788
Score = 39.9 bits (91), Expect = 0.046
Identities = 28/93 (30%), Positives = 40/93 (42%), Gaps = 13/93 (13%)
Query: 158 YCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCV--W-GHCTKMATR-----GSNGTIC 208
YC+ F +C +G+ +C+ +C CGD LC W G+ TR SNG +C
Sbjct: 546 YCECDDF--SCVRYKGE--MCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLC 601
Query: 209 DNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELC 241
+ C+ G C Q G C P + C
Sbjct: 602 SGRGKCECGSCVCIQPGSYGDTCEKCPTCPDAC 634
>gb|AAA52600.1| (M57494) platelet glycoprotein IIIa [Homo sapiens]
Length = 761
Score = 39.9 bits (91), Expect = 0.046
Identities = 28/93 (30%), Positives = 40/93 (42%), Gaps = 13/93 (13%)
Query: 158 YCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCV--W-GHCTKMATR-----GSNGTIC 208
YC+ F +C +G+ +C+ +C CGD LC W G+ TR SNG +C
Sbjct: 519 YCECDDF--SCVRYKGE--MCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLC 574
Query: 209 DNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELC 241
+ C+ G C Q G C P + C
Sbjct: 575 SGRGKCECGSCVCIQPGSYGDTCEKCPTCPDAC 607
>sp|P05106|ITB3_HUMAN PLATELET MEMBRANE GLYCOPROTEIN IIIA PRECURSOR (GPIIIA) (INTEGRIN
BETA-3) (CD61)
pir||A26547 platelet glycoprotein IIIa beta chain precursor (version 1) - human
gb|AAA52589.1| (J02703) glycoprotein IIIa precursor [Homo sapiens]
Length = 788
Score = 39.9 bits (91), Expect = 0.046
Identities = 28/93 (30%), Positives = 40/93 (42%), Gaps = 13/93 (13%)
Query: 158 YCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCV--W-GHCTKMATR-----GSNGTIC 208
YC+ F +C +G+ +C+ +C CGD LC W G+ TR SNG +C
Sbjct: 546 YCECDDF--SCVRYKGE--MCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLC 601
Query: 209 DNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELC 241
+ C+ G C Q G C P + C
Sbjct: 602 SGRGKCECGSCVCIQPGSYGDTCEKCPTCPDAC 634
>gb|AAD49737.1|AF170525_1 (AF170525) glycoprotein GPIIIa [Canis familiaris]
Length = 784
Score = 39.5 bits (90), Expect = 0.060
Identities = 28/93 (30%), Positives = 40/93 (42%), Gaps = 13/93 (13%)
Query: 158 YCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCV--W-GHCTKMATR-----GSNGTIC 208
YC+ F +C +G+ +C+ +C CGD LC W G+ TR SNG +C
Sbjct: 542 YCECDDF--SCVRYKGE--MCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLC 597
Query: 209 DNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELC 241
+ C+ G C Q G C P + C
Sbjct: 598 GGRGKCECGSCVCIQPGSYGDTCEKCPTCPDAC 630
>pdb|1IMT| Mamba Intestinal Toxin 1, Nmr, 39 Structures
Length = 80
Score = 39.5 bits (90), Expect = 0.060
Identities = 23/67 (34%), Positives = 28/67 (41%), Gaps = 7/67 (10%)
Query: 208 CDNQRDCQPGLCCAFQRGLL-FPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCP 266
C+ C G CCA + VCTP+ GE CH PAS + + CP
Sbjct: 7 CERDLQCGKGTCCAVSLWIKSVRVCTPVGTSGEDCH-PASHKIPFSGQRMH-----HTCP 60
Query: 267 CASGLLC 273
CA L C
Sbjct: 61 CAPNLAC 67
>emb|CAB40149.1| (AL031316) dJ28O10.1(LAMB3 (laminin, beta 3 (nicein
(125KD),kalinin(140KD), BM600 (125KD)))) [Homo sapiens]
Length = 786
Score = 39.5 bits (90), Expect = 0.060
Identities = 36/121 (29%), Positives = 48/121 (38%), Gaps = 19/121 (15%)
Query: 174 QRMLCTRDSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTP 233
QR C SE C V+ A++G+ G +CDN RD G C + F P
Sbjct: 314 QRCDCNGHSETCHFDPAVFA-----ASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRP 368
Query: 234 LPVEGELCHDPASRLLDLITWELEPDGALDRCPC---ASGLLCQPH-SHSLVYVCKPTFV 289
E C I+ E +PDGA+ PC +C+ H +CKP F
Sbjct: 369 GASIQETC----------ISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFT 418
Query: 290 G 290
G
Sbjct: 419 G 419
>gb|AAD13680.1| (AF116270) platelet glycoprotein IIIa [Canis familiaris]
Length = 784
Score = 39.5 bits (90), Expect = 0.060
Identities = 28/93 (30%), Positives = 40/93 (42%), Gaps = 13/93 (13%)
Query: 158 YCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCV--W-GHCTKMATR-----GSNGTIC 208
YC+ F +C +G+ +C+ +C CGD LC W G+ TR SNG +C
Sbjct: 542 YCECDDF--SCVRYKGE--MCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLC 597
Query: 209 DNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELC 241
+ C+ G C Q G C P + C
Sbjct: 598 GGRGKCECGSCVCIQPGSYGDTCEKCPTCPDAC 630
>ref|NP_000219.1| laminin subunit beta 3 precursor [Homo sapiens]
dbj|BAA22263.1| (D37766) Laminin-5 beta3 chain [Homo sapiens]
Length = 1172
Score = 39.5 bits (90), Expect = 0.060
Identities = 36/121 (29%), Positives = 48/121 (38%), Gaps = 19/121 (15%)
Query: 174 QRMLCTRDSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTP 233
QR C SE C V+ A++G+ G +CDN RD G C + F P
Sbjct: 314 QRCDCNGHSETCHFDPAVFA-----ASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRP 368
Query: 234 LPVEGELCHDPASRLLDLITWELEPDGALDRCPC---ASGLLCQPH-SHSLVYVCKPTFV 289
E C I+ E +PDGA+ PC +C+ H +CKP F
Sbjct: 369 GASIQETC----------ISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFT 418
Query: 290 G 290
G
Sbjct: 419 G 419
>sp|Q13751|LMB3_HUMAN LAMININ BETA-3 CHAIN PRECURSOR (LAMININ B1K CHAIN) (KALININ B1
CHAIN)
gb|AAC51352.1| (U17760) laminin S B3 chain [Homo sapiens]
Length = 1172
Score = 39.5 bits (90), Expect = 0.060
Identities = 36/121 (29%), Positives = 48/121 (38%), Gaps = 19/121 (15%)
Query: 174 QRMLCTRDSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTP 233
QR C SE C V+ A++G+ G +CDN RD G C + F P
Sbjct: 314 QRCDCNGHSETCHFDPAVFA-----ASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRP 368
Query: 234 LPVEGELCHDPASRLLDLITWELEPDGALDRCPC---ASGLLCQPH-SHSLVYVCKPTFV 289
E C I+ E +PDGA+ PC +C+ H +CKP F
Sbjct: 369 GASIQETC----------ISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFT 418
Query: 290 G 290
G
Sbjct: 419 G 419
>ref|NP_002204.1| integrin, beta 5 [Homo sapiens]
gb|AAA52707.1| (M35011) integrin beta-5 subunit [Homo sapiens]
Length = 796
Score = 39.5 bits (90), Expect = 0.060
Identities = 37/130 (28%), Positives = 52/130 (39%), Gaps = 21/130 (16%)
Query: 154 GPSMYCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCVWGHC-------TKMAT-RGSN 204
GP C ++C R + +LC+ EC CG+ C G+ T ++T RG +
Sbjct: 545 GPFCECD----NFSC--ARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDISTCRGRD 598
Query: 205 GTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDR 264
G IC + C G C + G +C P C D S D + L G D
Sbjct: 599 GQICSERGHCLCGQCQCTEPGAFGEMCEKCPT----CPDACSTKRDCVECLLLHSGKPDN 654
Query: 265 CPCASGLLCQ 274
C S LC+
Sbjct: 655 QTCHS--LCR 662
>sp|P18084|ITB5_HUMAN INTEGRIN BETA-5 PRECURSOR
emb|CAA37188.1| (X53002) precusor polypeptide (AA -23 to 776) [Homo sapiens]
Length = 799
Score = 39.5 bits (90), Expect = 0.060
Identities = 37/130 (28%), Positives = 52/130 (39%), Gaps = 21/130 (16%)
Query: 154 GPSMYCQFASFQYTCQPCRGQRMLCTRDSEC-CGDQLCVWGHC-------TKMAT-RGSN 204
GP C ++C R + +LC+ EC CG+ C G+ T ++T RG +
Sbjct: 545 GPFCECD----NFSC--ARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDISTCRGRD 598
Query: 205 GTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDR 264
G IC + C G C + G +C P C D S D + L G D
Sbjct: 599 GQICSERGHCLCGQCQCTEPGAFGEMCEKCPT----CPDACSTKRDCVECLLLHSGKPDN 654
Query: 265 CPCASGLLCQ 274
C S LC+
Sbjct: 655 QTCHS--LCR 662
Database: nr
Number of letters in database: 182,691,300
Number of sequences in database: 580,189
Lambda K H
0.320 0.137 0.439
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 113970005
Number of Sequences: 580189
Number of extensions: 4808187
Number of successful extensions: 15034
Number of sequences better than 10.0: 134
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 118
Number of HSP's that attempted gapping in prelim test: 14699
Number of HSP's gapped (non-prelim): 395
length of query: 350
length of database: 182,691,300
effective HSP length: 51
effective length of query: 299
effective length of database: 153,101,661
effective search space: 45777396639
effective search space used: 45777396639
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.8 bits)
S2: 72 (32.5 bits)
