Score E
Sequences producing significant alignments: (bits) Value
ref|NP_005488.1| gap junction protein, alpha 7, 45kD (conne... 802 0.0
ref|XP_008390.1| gap junction protein, alpha 7, 45kD (conne... 800 0.0
sp|P28228|CXA6_CANFA GAP JUNCTION ALPHA-6 PROTEIN (CONNEXIN... 788 0.0
ref|NP_032148.1| gap junction membrane channel protein alph... 784 0.0
sp|P18861|CXA6_CHICK GAP JUNCTION ALPHA-6 PROTEIN (CONNEXIN... 672 0.0
sp|Q92052|CXA6_BRARE GAP JUNCTION ALPHA-6 PROTEIN (CONNEXIN... 382 e-105
gb|AAB36619.1| (L46801) connexin [Danio rerio] 378 e-104
gb|AAD42022.1| (AF072451) connexin 44.2 [Danio rerio] 369 e-101
ref|XP_002109.1| connexin46.6 [Homo sapiens] 351 1e-95
ref|NP_065168.1| connexin46.6 [Homo sapiens] >gi|2738577|gb... 346 4e-94
ref|NP_034419.1| gap junction membrane channel protein alph... 252 7e-66
sp|P29415|CX56_CHICK GAP JUNCTION CX56 PROTEIN (CONNEXIN 56... 251 1e-65
gb|AAD56220.1| (AF177912) connexin 44 protein [Ovis aries] 247 1e-64
sp|P55917|CXA8_SHEEP GAP JUNCTION ALPHA-8 PROTEIN (CONNEXIN... 246 4e-64
gb|AAF01367.1|AF177913_1 (AF177913) connexin 49 protein [Ov... 245 9e-64
ref|NP_032149.1| gap junction membrane channel protein alph... 245 9e-64
emb|CAC16957.1| (AL138688) bA264J4.3 (novel connexin (gap j... 242 7e-63
sp|Q9Y6H8|CXA3_HUMAN GAP JUNCTION ALPHA-3 PROTEIN (CONNEXIN... 242 7e-63
ref|NP_058671.1| gap junction membrane channel protein alph... 238 6e-62
ref|NP_005258.1| gap junction protein, alpha 8, 50kD (conne... 238 6e-62
gb|AAF32309.1|AF217524_1 (AF217524) gap junction protein al... 237 1e-61
gb|AAG24880.1|AF304050_1 (AF304050) connexin 44.2 [Danio re... 236 2e-61
gb|AAG09541.1|AF288817_1 (AF288817) gap junction protein co... 236 2e-61
sp|P36381|CXA8_CHICK GAP JUNCTION ALPHA-8 PROTEIN (CONNEXIN... 236 2e-61
sp|P29414|CXA3_RAT GAP JUNCTION ALPHA-3 PROTEIN (CONNEXIN 4... 236 2e-61
gb|AAG24878.1| (AF304048) connexin 55.5 [Danio rerio] 227 2e-58
sp|P18860|CXA5_CHICK GAP JUNCTION ALPHA-5 PROTEIN (CONNEXIN... 227 2e-58
ref|NP_002051.1| connexin 37; gap junction protein, alpha 4... 226 4e-58
sp|Q92107|CXA9_RAJER GAP JUNCTION ALPHA-9 PROTEIN (CONNEXIN... 226 4e-58
ref|XP_001960.1| connexin 37 [Homo sapiens] 224 1e-57
gb|AAD31871.1|AF139102_1 (AF139102) connexin 37 [Homo sapie... 224 1e-57
sp|P35212|CXA4_HUMAN GAP JUNCTION ALPHA-4 PROTEIN (CONNEXIN... 224 1e-57
gb|AAD31873.1|AF139104_1 (AF139104) connexin 37 [Homo sapie... 224 1e-57
ref|NP_067686.1| gap junction membrane channel, protein alp... 222 4e-57
gb|AAG09406.1|AF179597_1 (AF179597) connexin 59 [Homo sapiens] 222 5e-57
ref|NP_032147.1| gap junction membrane channel protein alph... 222 5e-57
gb|AAD31872.1|AF139103_1 (AF139103) connexin 37 [Homo sapiens] 222 7e-57
sp|P16863|CXA1_XENLA GAP JUNCTION ALPHA-1 PROTEIN (CONNEXIN... 222 7e-57
gb|AAD56533.1|AF180815_1 (AF180815) truncated connexin 37 p... 221 9e-57
gb|AAD31870.1|AF139101_1 (AF139101) connexin 37 [Homo sapiens] 221 9e-57
gb|AAC31884.1| (AF059183) connexin 35 [Morone americana] 221 9e-57
sp|P18246|CXA1_BOVIN GAP JUNCTION ALPHA-1 PROTEIN (CONNEXIN... 216 3e-55
dbj|BAA05381.1| (D26333) similar to mouse lens connexin (Cx... 216 4e-55
ref|NP_000156.1| connexin 43; gap junction protein, alpha 1... 216 4e-55
gb|AAA53027.1| (M63801) connexin 43 [Mus musculus] 214 1e-54
ref|NP_036699.1| gap junction protein, alpha 1, 43 kD (conn... 214 1e-54
ref|NP_034418.1| gap junction membrane channel protein alph... 214 1e-54
sp|O57474|CXA1_BRARE GAP JUNCTION ALPHA-1 PROTEIN (CONNEXIN... 212 5e-54
sp|P14154|CXA1_CHICK GAP JUNCTION ALPHA-1 PROTEIN (CONNEXIN... 211 1e-53
prf||1714172A connexin 43 [Rattus norvegicus] 211 1e-53
>ref|NP_005488.1| gap junction protein, alpha 7, 45kD (connexin 45) [Homo sapiens]
sp|P36383|CXA6_HUMAN GAP JUNCTION ALPHA-6 PROTEIN (CONNEXIN 45) (CX45)
pir||I38430 connexin45 - human
gb|AAA60458.1| (U03493) connexin45 [Homo sapiens]
Length = 396
Score = 802 bits (2049), Expect = 0.0
Identities = 386/396 (97%), Positives = 386/396 (97%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC
Sbjct: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR
Sbjct: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
Query: 121 WKQHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
WKQHRAL PMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ
Sbjct: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
Query: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG
Sbjct: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
Query: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ
Sbjct: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
Query: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQN 360
YTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQN
Sbjct: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQN 360
Query: 361 NPHGPREKKAKVGSKAGSNKSTASSKSGDGKNSVWI 396
NPHGPREKKAKVGSKAGSNKSTASSKSGDGKNSVWI
Sbjct: 361 NPHGPREKKAKVGSKAGSNKSTASSKSGDGKNSVWI 396
>ref|XP_008390.1| gap junction protein, alpha 7, 45kD (connexin 45) [Homo sapiens]
Length = 396
Score = 800 bits (2043), Expect = 0.0
Identities = 385/396 (97%), Positives = 385/396 (97%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC
Sbjct: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR
Sbjct: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
Query: 121 WKQHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
WKQHRAL PMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ
Sbjct: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
Query: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG
Sbjct: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
Query: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ
Sbjct: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
Query: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQN 360
YTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQN
Sbjct: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQN 360
Query: 361 NPHGPREKKAKVGSKAGSNKSTASSKSGDGKNSVWI 396
NPHGPREKKAKVGSKAGSNKSTASSKSGDGK SVWI
Sbjct: 361 NPHGPREKKAKVGSKAGSNKSTASSKSGDGKTSVWI 396
>sp|P28228|CXA6_CANFA GAP JUNCTION ALPHA-6 PROTEIN (CONNEXIN 45) (CX45)
pir||B49024 connexin45 - dog
gb|AAA30839.1| (M81348) connexin 45 [Canis lupus]
Length = 396
Score = 788 bits (2012), Expect = 0.0
Identities = 376/396 (94%), Positives = 381/396 (95%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
MSWSFLTRLLEEIHNHSTFVGKIWLTVLI FRI LTAVGGESIYYDEQSKFVCNTEQPGC
Sbjct: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIAFRIALTAVGGESIYYDEQSKFVCNTEQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR
Sbjct: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
Query: 121 WKQHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
WKQHRAL PMMYPEMELES+KENKEQ+QPKPKHDGRRRIREDGLMKIYVLQ
Sbjct: 121 WKQHRALEETEEDHEEDPMMYPEMELESEKENKEQNQPKPKHDGRRRIREDGLMKIYVLQ 180
Query: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG
Sbjct: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
Query: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ
Sbjct: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
Query: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQN 360
YTELSNAKIAYKQNKAN AQEQQYGSHEENLPADLE LQREI+M QERLDLA+QAYSHQN
Sbjct: 301 YTELSNAKIAYKQNKANIAQEQQYGSHEENLPADLETLQREIKMVQERLDLAIQAYSHQN 360
Query: 361 NPHGPREKKAKVGSKAGSNKSTASSKSGDGKNSVWI 396
NPHGPREKKAKVGSKAGSNKS+ASSKSGDGKNSVWI
Sbjct: 361 NPHGPREKKAKVGSKAGSNKSSASSKSGDGKNSVWI 396
>ref|NP_032148.1| gap junction membrane channel protein alpha 7; connexin 45 [Mus
musculus]
sp|P28229|CXA6_MOUSE GAP JUNCTION ALPHA-6 PROTEIN (CONNEXIN 45) (CX45)
pir||S23589 connexin 45 - mouse
emb|CAA44814.1| (X63100) connexin 45 [Mus musculus]
Length = 396
Score = 784 bits (2003), Expect = 0.0
Identities = 375/396 (94%), Positives = 381/396 (95%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC
Sbjct: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR
Sbjct: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
Query: 121 WKQHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
WKQHRAL PMMYPEMELES+KENKEQSQPKPKHDGRRRIREDGLMKIYVLQ
Sbjct: 121 WKQHRALEETEEDHEEDPMMYPEMELESEKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
Query: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG
Sbjct: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
Query: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
LCLLLNIWEMLHLGFGTIRDSLNSKRREL+DPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ
Sbjct: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRRELDDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
Query: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQN 360
YTELSNAKIAYKQNKAN AQEQQYGSHEE+LPADLE LQREIRMAQERLDLA+QAY HQN
Sbjct: 301 YTELSNAKIAYKQNKANIAQEQQYGSHEEHLPADLETLQREIRMAQERLDLAIQAYHHQN 360
Query: 361 NPHGPREKKAKVGSKAGSNKSTASSKSGDGKNSVWI 396
NPHGPREKKAKVGSK+GSNKS+ SSKSGDGK SVWI
Sbjct: 361 NPHGPREKKAKVGSKSGSNKSSISSKSGDGKTSVWI 396
>sp|P18861|CXA6_CHICK GAP JUNCTION ALPHA-6 PROTEIN (CONNEXIN 45) (CX45)
pir||A37819 connexin-45 - chicken
gb|AAA48717.1| (M35044) connexin-45 [Gallus gallus]
Length = 394
Score = 672 bits (1715), Expect = 0.0
Identities = 327/399 (81%), Positives = 357/399 (88%), Gaps = 8/399 (2%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
MSWSFLTRLLEEIHNHSTFVGKIWL+VLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC
Sbjct: 1 MSWSFLTRLLEEIHNHSTFVGKIWLSVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKM-EHGEADKKAARSKPYAM 119
ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIA+M EH + D++ RSK ++
Sbjct: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIARMVEHSDVDRRF-RSKSFST 119
Query: 120 RWKQHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQP-KPKHDGRRRIREDGLMKIYV 178
RWKQHR L PMMYPE+ELES++ENKEQ P K KHDGRRRIREDGLM+IYV
Sbjct: 120 RWKQHRGLEEAEDDHEEDPMMYPEIELESERENKEQQPPAKAKHDGRRRIREDGLMRIYV 179
Query: 179 LQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGV 238
LQLL R FEVGFLIGQY LYGF+V P +VCSR PCPHKIDCFISRPTEKTIFLLIMYGV
Sbjct: 180 LQLLVRATFEVGFLIGQYLLYGFEVSPVFVCSRKPCPHKIDCFISRPTEKTIFLLIMYGV 239
Query: 239 TGLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQ 298
+ +CLLLN+WEMLHLGFGTIRD+LN+KR+ELED G YNYPFTWNTPSAPPGYNIAVKPDQ
Sbjct: 240 SCMCLLLNVWEMLHLGFGTIRDTLNNKRKELEDSGTYNYPFTWNTPSAPPGYNIAVKPDQ 299
Query: 299 IQYTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSH 358
+QYTELSNAK+AYKQNKAN AQEQQYGS+EEN+PADLE LQREI++AQERLD+A+QAY++
Sbjct: 300 MQYTELSNAKMAYKQNKANIAQEQQYGSNEENIPADLENLQREIKVAQERLDMAIQAYNN 359
Query: 359 QNNP-HGPREKKAKVGSKAGSNKSTASSKSGDGKNSVWI 396
QNNP REKK SKAGSNKS+ASSKSGDGKNSVWI
Sbjct: 360 QNNPGSSSREKK----SKAGSNKSSASSKSGDGKNSVWI 394
>sp|Q92052|CXA6_BRARE GAP JUNCTION ALPHA-6 PROTEIN (CONNEXIN 43.4) (CX43.4)
emb|CAA65473.1| (X96712) connexin 43.4 [Danio rerio]
Length = 380
Score = 382 bits (971), Expect = e-105
Identities = 194/356 (54%), Positives = 247/356 (68%), Gaps = 19/356 (5%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
MSWSFLTRLL+EI NHSTFVGKIWLT+ I+FRIVLT VGGESIYYDEQSKFVCNT+QPGC
Sbjct: 1 MSWSFLTRLLDEISNHSTFVGKIWLTLFIIFRIVLTVVGGESIYYDEQSKFVCNTQQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
ENVCYDAFAPLSHVRFWVFQIIL+ TP++MYLG+A+HKIA+ E + P R
Sbjct: 61 ENVCYDAFAPLSHVRFWVFQIILITTPTIMYLGFAMHKIARSNDVEYRPVNRKRMPMINR 120
Query: 121 WKQHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
+ +R PM+ E+ E +K ++ + KHDGRRRI+ DGLMK+Y+LQ
Sbjct: 121 GR-NRDYEEAEDNGEEDPMIMEEIVPEKEKAPEKSA---VKHDGRRRIKRDGLMKVYILQ 176
Query: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
LL+R +FEVGFL GQY LYGF+V P YVC+R PCPH +DCF+SRPTEKTIFLLIMY V+
Sbjct: 177 LLSRIIFEVGFLFGQYILYGFEVAPSYVCTRSPCPHTVDCFVSRPTEKTIFLLIMYAVSC 236
Query: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRR--ELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQ 298
LCL L + E+LHLG IRD+ + R ++ P A P P+APPGY+ A+K D+
Sbjct: 237 LCLSLTVLEILHLGLSGIRDAFRRRARHQSVQRPRA---PICRQVPTAPPGYHTALKKDK 293
Query: 299 IQYTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQ 354
+ + K + + +G +E+ D++ L+R +++AQ+ LDLA Q
Sbjct: 294 L--------SLGMKPEYNLDSGRESFG--DESSSRDIDRLRRHLKLAQQHLDLAYQ 339
>gb|AAB36619.1| (L46801) connexin [Danio rerio]
Length = 380
Score = 378 bits (961), Expect = e-104
Identities = 193/356 (54%), Positives = 245/356 (68%), Gaps = 19/356 (5%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
MSWSFLTRLL+EI NHSTFVGKIWLT+ I+FRIVLT VGGESIYYDEQSKFVCNT+QPGC
Sbjct: 1 MSWSFLTRLLDEISNHSTFVGKIWLTLFIIFRIVLTVVGGESIYYDEQSKFVCNTQQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
ENVCYDAFAPLSHVRFWVFQIIL+ TP++MYLG+A+HKIA+ E + P R
Sbjct: 61 ENVCYDAFAPLSHVRFWVFQIILITTPTIMYLGFAMHKIARSNDVEYRPVNRKRMPMINR 120
Query: 121 WKQHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
+R PM+ E+ E +K ++ + KHDGRRRI+ DGLMK+Y+LQ
Sbjct: 121 -GANRDYEEAEDNGEEDPMIMEEIVPEKEKAPEKSA---VKHDGRRRIKRDGLMKVYILQ 176
Query: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
LL+R +FEVGFL GQY LYGF+V P YVC+ PCPH +DCF+SRPTEKTIFLLIMY V+
Sbjct: 177 LLSRIIFEVGFLFGQYILYGFEVAPSYVCTPSPCPHTVDCFVSRPTEKTIFLLIMYAVSC 236
Query: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRR--ELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQ 298
LCL L + E+LHLG IRD+ + R ++ P A P P+APPGY+ A+K D+
Sbjct: 237 LCLSLTVLEILHLGLSGIRDAFRRRARHQSVQRPRA---PICRQVPTAPPGYHTALKKDK 293
Query: 299 IQYTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQ 354
+ + K + + +G +E+ D++ L+R +++AQ+ LDLA Q
Sbjct: 294 L--------SLGMKPEYNLDSGRESFG--DESSSRDIDRLRRHLKLAQQHLDLAYQ 339
>gb|AAD42022.1| (AF072451) connexin 44.2 [Danio rerio]
Length = 391
Score = 369 bits (938), Expect = e-101
Identities = 197/375 (52%), Positives = 246/375 (65%), Gaps = 26/375 (6%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
MSWSFLTRLL+EI NHSTFVGKIWLT+LI+FRIVLT VGGE+IY DEQSKFVC T+QPGC
Sbjct: 1 MSWSFLTRLLDEISNHSTFVGKIWLTLLIIFRIVLTVVGGETIYQDEQSKFVCKTQQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
ENVCYDAFAPLSHVRFWVFQII++ TPS+MYLG+A+HKIA+M E + + R
Sbjct: 61 ENVCYDAFAPLSHVRFWVFQIIVITTPSIMYLGFAMHKIARMADDEYRPRKRKMLSMVHR 120
Query: 121 WKQHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKP--------KHDGRRRIREDG 172
R PM+ E+E S+K NK + K KHDGRRRI+ DG
Sbjct: 121 -GMSRDYDMVDEMSEEVPMIPEEIE-PSEKNNKSAASTKTTAASDAAVKHDGRRRIKRDG 178
Query: 173 LMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFL 232
LMK+YVLQL++R FE+ FL GQY LYGF+V P Y+C+R PCPH +DCF+SRPTEKTIFL
Sbjct: 179 LMKVYVLQLISRVAFEIAFLFGQYILYGFEVSPSYICTRSPCPHTVDCFVSRPTEKTIFL 238
Query: 233 LIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSK-RRELEDPGAYNYPFTWNTPSAPPGYN 291
+IMY V+ LCL L + E+LHLG G +RDSL S+ R L PSAPPGY
Sbjct: 239 VIMYVVSVLCLALTVLEILHLGIGGLRDSLRSRTNRRLPVHRPSTSTICHRLPSAPPGYQ 298
Query: 292 IAVKPDQIQYTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDL 351
+K + S+ K+ + A++ +E G +N DL+ L+R +++AQ+ LD
Sbjct: 299 AVLK-------KYSSGKLK-AEFLADSGRESLGG---DNTTRDLDRLRRHLKIAQQHLDQ 347
Query: 352 AVQ----AYSHQNNP 362
A SH + P
Sbjct: 348 AYHTEEVGASHNSGP 362
>ref|XP_002109.1| connexin46.6 [Homo sapiens]
Length = 439
Score = 351 bits (890), Expect = 1e-95
Identities = 207/444 (46%), Positives = 259/444 (57%), Gaps = 56/444 (12%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
MSWSFLTRLLEEIHNHSTFVGK+WLTVL+VFRIVLTAVGGE+IY DEQ+KF CNT QPGC
Sbjct: 4 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 63
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
+NVCYDAFAPLSHVRFWVFQI++++TPSVMYLGYA+H++A+ E ++A R +P R
Sbjct: 64 DNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQER-RRALRRRPGPRR 122
Query: 121 WKQ------HRALXXXXXXXXXXPMMYPEMELESDK------------------------ 150
+ H PM+ E E ++
Sbjct: 123 APRAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTKAV 182
Query: 151 --ENKEQSQPKP--KHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPF 206
+ K P P +HDGRRRI+ +GLM++YV QL+AR FEV FL+GQY LYGF+V PF
Sbjct: 183 GADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPF 242
Query: 207 YVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKR 266
+ CSR PCPH +DCF+SRPTEKT+FLL+MY V+ LCLLLN+ EM HLG G+ +D++ +R
Sbjct: 243 FPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRR 302
Query: 267 RELEDPGAYNYPFTWNTPSAPP--GYNIAVKPDQIQYTELSNAKIAYKQNKANTA-QEQQ 323
P + P P A P +A PD + A+ QN AN A Q +
Sbjct: 303 ---GPPASAPAPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALR 359
Query: 324 YGSHEENLPAD------LEALQREIRMA---QERLDLAVQA--YSHQNNPHGPREKKAKV 372
G+ + D L A R A R A A Q P AK
Sbjct: 360 DGAAAGDRDRDSSPCVGLPAASRGPPRAGAPASRTGSATSAGTVGEQGRPGTHERPGAK- 418
Query: 373 GSKAGSNKSTASSKSGDGKNSVWI 396
+AGS K +ASS+ DGK +VWI
Sbjct: 419 -PRAGSEKGSASSR--DGKTTVWI 439
>ref|NP_065168.1| connexin46.6 [Homo sapiens]
gb|AAB94511.1| (AF014643) connexin46.6 [Homo sapiens]
Length = 436
Score = 346 bits (877), Expect = 4e-94
Identities = 205/444 (46%), Positives = 257/444 (57%), Gaps = 56/444 (12%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
MSWSFLTRLLEEIHNHSTFVGK+WLTVL+VFRIVLTAVGGE+IY DEQ+KF CNT QPGC
Sbjct: 1 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
+NVCYDAFAPLSHVRFWVF I++++TPSVMYLGYA+H++A+ E ++A R +P R
Sbjct: 61 DNVCYDAFAPLSHVRFWVFHIVVISTPSVMYLGYAVHRLARASEQER-RRALRRRPGPRR 119
Query: 121 WKQ------HRALXXXXXXXXXXPMMYPEMELESDK------------------------ 150
+ H PM+ E E ++
Sbjct: 120 APRAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTKAV 179
Query: 151 --ENKEQSQPKP--KHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPF 206
+ K P P +HDGRRRI+ +GLM++YV QL+AR FEV FL+GQY LYGF+V PF
Sbjct: 180 GADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPF 239
Query: 207 YVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKR 266
+ CSR PCP +DCF+SRPTEKT+FLL+MY V+ LCLLLN+ EM HLG G+ +D++ +R
Sbjct: 240 FPCSRQPCPQVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRR 299
Query: 267 RELEDPGAYNYPFTWNTPSAPP--GYNIAVKPDQIQYTELSNAKIAYKQNKANTA-QEQQ 323
P + P P A P +A PD + A+ QN AN A Q +
Sbjct: 300 ---GPPASAPAPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALR 356
Query: 324 YGSHEENLPAD------LEALQREIRMA---QERLDLAVQA--YSHQNNPHGPREKKAKV 372
G+ + D L A R A R A A Q P AK
Sbjct: 357 DGAAAGDRDRDSSPCVGLPAASRGPPRAGAPASRTGSATSAGTVGEQGRPGTHERPGAK- 415
Query: 373 GSKAGSNKSTASSKSGDGKNSVWI 396
+AGS K +ASS+ DGK +VWI
Sbjct: 416 -PRAGSEKGSASSR--DGKTTVWI 436
>ref|NP_034419.1| gap junction membrane channel protein alpha 10; connexin-57 [Mus
musculus]
emb|CAB40358.1| (AJ010741) connexin 57 [Mus musculus]
Length = 505
Score = 252 bits (636), Expect = 7e-66
Identities = 137/367 (37%), Positives = 204/367 (55%), Gaps = 36/367 (9%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
W+ L +LEE+H+HST VGKIWLT+L +FR+++ V E ++ DEQS F CNT+QPGC N
Sbjct: 4 WNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLGVAAEDVWDDEQSAFACNTQQPGCNN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
+CYD P+S +RFWV QII V++PS++Y+G+A++++ E K+ + K Y
Sbjct: 64 ICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRDFE-----KQRQKKKLY----- 113
Query: 123 QHRALXXXXXXXXXXPMMYPEMELES----DKENKEQSQPKPKHDGRRRIREDG-LMKIY 177
M PE++LE DKE + + K H ++ G L++ Y
Sbjct: 114 ------------LRAQMENPELDLEEQQRVDKELRRLEEQKKIH----KVPLKGCLLRTY 157
Query: 178 VLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYG 237
VL +L R+V EVGF+IGQY LYGFQ+HP Y C++ PCP+ +DCF+SRPTEKTIF+L M+
Sbjct: 158 VLHILTRSVLEVGFMIGQYILYGFQMHPIYKCTQAPCPNSVDCFVSRPTEKTIFMLFMHS 217
Query: 238 VTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPF-TWNTPSAPPGYNIAVKP 296
+ + LLLNI E+ HLG I +L+ K PF + N + P
Sbjct: 218 IAAISLLLNILEIFHLGIRKIMRALDGKSSSGNTENETGPPFHSTNYSGTQQCMVCSSLP 277
Query: 297 DQIQYTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAY 356
++I + +N + + N + Q H L D+ +R+ E+++ Q +
Sbjct: 278 ERISLLQANNKQQVIRVNIPRSKSMWQI-PHPRQLEVDVSCGKRD---WAEKIESCTQLH 333
Query: 357 SHQNNPH 363
H PH
Sbjct: 334 VHSPCPH 340
>sp|P29415|CX56_CHICK GAP JUNCTION CX56 PROTEIN (CONNEXIN 56)
pir||A45338 connexin-56 - chicken
gb|AAA48737.1| (L02838) connexin 56 [Gallus gallus]
Length = 510
Score = 251 bits (634), Expect = 1e-65
Identities = 120/264 (45%), Positives = 166/264 (62%), Gaps = 9/264 (3%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL RLLE HST +GK+WLTVL +FRI++ E ++ DEQS F CNT+QPGCEN
Sbjct: 4 WSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEEVWGDEQSDFTCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+RFWV QII V+TP+++YLG+ +H I +ME +K+ K +++
Sbjct: 64 VCYDKAFPISHIRFWVLQIIFVSTPTLIYLGHVLH-IVRMEEKRKEKEEELKKRGSVKDN 122
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDG-LMKIYVLQL 181
+ D K + P D R RIR G L++ Y+ +
Sbjct: 123 NYPGAATSGGGSGGGNNF-------KDPPIKMGKEKLPIRDERGRIRMGGALLRTYIFNI 175
Query: 182 LARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGL 241
+ +T+FEVGF++GQYFLYGF++ P Y CSR PCPH +DCFISRPTEKTIF++ M V +
Sbjct: 176 IFKTLFEVGFIVGQYFLYGFELKPVYQCSRPPCPHTVDCFISRPTEKTIFIIFMLVVASV 235
Query: 242 CLLLNIWEMLHLGFGTIRDSLNSK 265
LLLN+ E+ HLG+ ++ + S+
Sbjct: 236 SLLLNMLEIYHLGWKKLKQGMTSQ 259
>gb|AAD56220.1| (AF177912) connexin 44 protein [Ovis aries]
Length = 413
Score = 247 bits (625), Expect = 1e-64
Identities = 139/342 (40%), Positives = 183/342 (52%), Gaps = 56/342 (16%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL RLLE HST +GK+WLTVL +FRI++ E ++ DEQS F CNT+QPGCEN
Sbjct: 4 WSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEEVWGDEQSDFTCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SHVRFWV QII V+TP+++YLG+ +H + +ME E K+ P A
Sbjct: 64 VCYDRAFPISHVRFWVLQIIFVSTPTLIYLGHVLH-LVRME--EKRKEREEEPPKAA--- 117
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDG-LMKIYVLQL 181
+E P P D R ++R G L++ YV +
Sbjct: 118 ---------------------------GPAEEHQDPAPVRDDRGKVRIAGALLRTYVFNI 150
Query: 182 LARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGL 241
+ +T+FEVGF+ GQYFLYGFQ+ P Y C R PCP+ +DCFISRPTEKTIF+L M V +
Sbjct: 151 IFKTLFEVGFIAGQYFLYGFQLKPLYRCDRWPCPNTVDCFISRPTEKTIFILFMLAVACV 210
Query: 242 CLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAY--------NYPFTWNTPSAPPGYNIA 293
LLLN+ E+ HLG+ ++ + S R + PG+ P SAPP I
Sbjct: 211 SLLLNVLEIYHLGWKKLKQGMTSPFRP-DTPGSRAGSAKPMGGSPLLLPPNSAPPAVTIG 269
Query: 294 VKPDQIQYTELSNAKIAYKQNKANTAQEQQYGSHEENLPADL 335
P Y + ++ Q G E LPA L
Sbjct: 270 FPP-------------YYAPSASSLGQASAPGYPEPPLPAAL 298
>sp|P55917|CXA8_SHEEP GAP JUNCTION ALPHA-8 PROTEIN (CONNEXIN 49) (CX49) (LENS FIBER
PROTEIN MP70) (MP64) (MP38)
Length = 440
Score = 246 bits (621), Expect = 4e-64
Identities = 121/271 (44%), Positives = 173/271 (63%), Gaps = 25/271 (9%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL +LEE++ HST +G++WLTVL +FRI++ E ++ DEQS FVCNT+QPGCEN
Sbjct: 4 WSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R WV QII V+TPS++Y+G+A+H + +ME +++A +
Sbjct: 64 VCYDEAFPISHIRLWVLQIIFVSTPSLVYVGHAVHHV-RMEEKRKEREAEELSQQSPGNG 122
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDG-LMKIYVLQL 181
RA L +D+ + ++S K G ++ R +G L++ YV +
Sbjct: 123 GERA------------------PLAADQGSVKKSSSSSK--GTKKFRLEGTLLRTYVCHI 162
Query: 182 LARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGL 241
+ +T+FEVGF++G YFLYGF++ P Y CSR PCP+ +DCF+SRPTEKTIF+L M V +
Sbjct: 163 IFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASV 222
Query: 242 CLLLNIWEMLHLGFGTIRDSLNSKRRELEDP 272
L LNI EM HLG IR + +R +E P
Sbjct: 223 SLFLNILEMSHLGLKKIRSAF---KRPVEQP 250
>gb|AAF01367.1|AF177913_1 (AF177913) connexin 49 protein [Ovis aries]
Length = 440
Score = 245 bits (618), Expect = 9e-64
Identities = 120/271 (44%), Positives = 173/271 (63%), Gaps = 25/271 (9%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL +LEE++ HST +G++WLTVL +FRI++ + ++ DEQS FVCNT+QPGCEN
Sbjct: 4 WSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAADFVWGDEQSDFVCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R WV QII V+TPS++Y+G+A+H + +ME +++A +
Sbjct: 64 VCYDEAFPISHIRLWVLQIIFVSTPSLVYVGHAVHHV-RMEEKRKEREAEELSQQSPGNG 122
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDG-LMKIYVLQL 181
RA L +D+ + ++S K G ++ R +G L++ YV +
Sbjct: 123 GERA------------------PLAADQGSVKKSSSSSK--GTKKFRLEGTLLRTYVCHI 162
Query: 182 LARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGL 241
+ +T+FEVGF++G YFLYGF++ P Y CSR PCP+ +DCF+SRPTEKTIF+L M V +
Sbjct: 163 IFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASV 222
Query: 242 CLLLNIWEMLHLGFGTIRDSLNSKRRELEDP 272
L LNI EM HLG IR + +R +E P
Sbjct: 223 SLFLNILEMSHLGLKKIRSAF---KRPVEQP 250
>ref|NP_032149.1| gap junction membrane channel protein alpha 8; connexin 50; alpha 8
connexin [Mus musculus]
sp|P28236|CXA8_MOUSE GAP JUNCTION ALPHA-8 PROTEIN (CONNEXIN 50) (CX50) (LENS FIBER
PROTEIN MP70)
pir||I49624 gap junction protein - mouse
gb|AAA37497.1| (M91243) gap junction protein [Mus musculus]
Length = 440
Score = 245 bits (618), Expect = 9e-64
Identities = 122/271 (45%), Positives = 173/271 (63%), Gaps = 25/271 (9%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL +LEE++ HST +G++WLTVL +FRI++ E ++ DEQS FVCNT+QPGCEN
Sbjct: 4 WSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R WV QII V+TPS+MY+G+A+H + +ME D++A +
Sbjct: 64 VCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHHV-RMEEKRKDREAEEL------CQ 116
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDG-LMKIYVLQL 181
Q R+ + + D+ + +S K G ++ R +G L++ YV +
Sbjct: 117 QSRSNGGE------------RVPIAPDQASIRKSSSSSK--GTKKFRLEGTLLRTYVCHI 162
Query: 182 LARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGL 241
+ +T+FEVGF++G YFLYGF++ P Y CSR PCP+ +DCF+SRPTEKTIF+L M V +
Sbjct: 163 IFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVAFV 222
Query: 242 CLLLNIWEMLHLGFGTIRDSLNSKRRELEDP 272
L LNI EM HLG IR + +R +E P
Sbjct: 223 SLFLNIMEMSHLGMKGIRSAF---KRPVEQP 250
>emb|CAC16957.1| (AL138688) bA264J4.3 (novel connexin (gap junction protein)) [Homo
sapiens]
Length = 435
Score = 242 bits (610), Expect = 7e-63
Identities = 128/290 (44%), Positives = 173/290 (59%), Gaps = 40/290 (13%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL RLLE HST +GK+WLTVL +FRI++ E ++ DEQS F CNT+QPGCEN
Sbjct: 4 WSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+RFW QII V+TP+++YLG+ +H I +ME +KK R +
Sbjct: 64 VCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLH-IVRME----EKKKEREE------- 111
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKEN-KEQSQPKP-KHDGRRRIREDG-LMKIYVL 179
E +L+ + + KE Q P D R R+R G L++ YV
Sbjct: 112 --------------------EEQLKRESPSPKEPPQDNPSSRDDRGRVRMAGALLRTYVF 151
Query: 180 QLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
++ +T+FEVGF+ GQYFLYGF++ P Y C R PCP+ +DCFISRPTEKTIF++ M V
Sbjct: 152 NIIFKTLFEVGFIAGQYFLYGFELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVA 211
Query: 240 GLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPF-TWNTPSAPP 288
LLLN+ E+ HLG+ ++ + S+ P A P T + P PP
Sbjct: 212 CASLLLNMLEIYHLGWKKLKQGVTSRL----GPDASEAPLGTADPPPLPP 257
>sp|Q9Y6H8|CXA3_HUMAN GAP JUNCTION ALPHA-3 PROTEIN (CONNEXIN 46) (CX46)
gb|AAD42925.1| (AF075290) gap-junction protein alpha 3 [Homo sapiens]
Length = 435
Score = 242 bits (610), Expect = 7e-63
Identities = 128/290 (44%), Positives = 173/290 (59%), Gaps = 40/290 (13%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL RLLE HST +GK+WLTVL +FRI++ E ++ DEQS F CNT+QPGCEN
Sbjct: 4 WSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+RFW QII V+TP+++YLG+ +H I +ME +KK R +
Sbjct: 64 VCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLH-IVRME----EKKKEREE------- 111
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKEN-KEQSQPKP-KHDGRRRIREDG-LMKIYVL 179
E +L+ + + KE Q P D R R+R G L++ YV
Sbjct: 112 --------------------EEQLKRESPSPKEPPQDNPSSRDDRGRVRMAGALLRTYVF 151
Query: 180 QLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
++ +T+FEVGF+ GQYFLYGF++ P Y C R PCP+ +DCFISRPTEKTIF++ M V
Sbjct: 152 NIIFKTLFEVGFIAGQYFLYGFELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVA 211
Query: 240 GLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPF-TWNTPSAPP 288
LLLN+ E+ HLG+ ++ + S+ P A P T + P PP
Sbjct: 212 CASLLLNMLEIYHLGWKKLKQGVTSRL----GPDASEAPLGTADPPPLPP 257
>ref|NP_058671.1| gap junction membrane channel protein alpha 3; connexin 46; alpha 3
connexin [Mus musculus]
sp|Q64448|CXA3_MOUSE GAP JUNCTION ALPHA-3 PROTEIN (CONNEXIN 46) (CX46)
gb|AAB03211.1| (U44955) alpha3 connexin [Mus musculus]
Length = 417
Score = 238 bits (602), Expect = 6e-62
Identities = 125/304 (41%), Positives = 173/304 (56%), Gaps = 41/304 (13%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL RLLE HST +GK+WLTVL +FRI++ E ++ DEQS F CNT+QPGCEN
Sbjct: 4 WSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEEVWGDEQSDFTCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+RFW QII V+TP+++YLG+ +H I +ME +KK R + R
Sbjct: 64 VCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLH-IVRME----EKKKEREEELLRRDN 118
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDG-LMKIYVLQL 181
P+ + + P D R ++R G L++ YV +
Sbjct: 119 -------------------PQHGRGREPMRTGSPRDPPLRDDRGKVRIAGALLRTYVFNI 159
Query: 182 LARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGL 241
+ +T+FEVGF+ GQYFLYGFQ+ P Y C R PCP+ +DCFISRPTEKTIF++ M V
Sbjct: 160 IFKTLFEVGFIAGQYFLYGFQLQPLYRCDRWPCPNTVDCFISRPTEKTIFVIFMLAVACA 219
Query: 242 CLLLNIWEMLHLGFGTIR---------DSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNI 292
L+LN+ E+ HLG+ ++ D+ ++ + L+ P T S PP +I
Sbjct: 220 SLVLNMLEIYHLGWKKLKQGVTNHFNPDASEARHKPLD-------PLPAATSSGPPSVSI 272
Query: 293 AVKP 296
P
Sbjct: 273 GFPP 276
>ref|NP_005258.1| gap junction protein, alpha 8, 50kD (connexin 50); gap junction
membrane channel protein alpha-8; connexin 50; Gap
junction membrane channel protein alpha-8 (connexin 50)
[Homo sapiens]
sp|P48165|CXA8_HUMAN GAP JUNCTION ALPHA-8 PROTEIN (CONNEXIN 50) (CX50) (LENS FIBER
PROTEIN MP70)
pir||I39176 intrinsic membrane protein MP70 - human
gb|AAA77062.1| (U34802) intrinsic membrane protein MP70 [Homo sapiens]
Length = 432
Score = 238 bits (602), Expect = 6e-62
Identities = 117/271 (43%), Positives = 172/271 (63%), Gaps = 33/271 (12%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL +LEE++ HST +G++WLTVL +FRI++ E ++ DEQS FVCNT+QPGCEN
Sbjct: 4 WSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R WV QII V+TPS+MY+G+A+H + +ME +K+ +R + +
Sbjct: 64 VCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYV-RME----EKRKSRDEELGQQAG 118
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDG-LMKIYVLQL 181
+ D+ + ++S G ++ R +G L++ Y+ +
Sbjct: 119 TNGG---------------------PDQGSVKKSSGS---KGTKKFRLEGTLLRTYICHI 154
Query: 182 LARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGL 241
+ +T+FEVGF++G YFLYGF++ P Y CSR PCP+ +DCF+SRPTEKTIF+L M V +
Sbjct: 155 IFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASV 214
Query: 242 CLLLNIWEMLHLGFGTIRDSLNSKRRELEDP 272
L LN+ E+ HLG IR +L +R +E P
Sbjct: 215 SLFLNVMELSHLGLKGIRSAL---KRPVEQP 242
>gb|AAF32309.1|AF217524_1 (AF217524) gap junction protein alpha 8 [Homo sapiens]
Length = 433
Score = 237 bits (599), Expect = 1e-61
Identities = 117/273 (42%), Positives = 165/273 (59%), Gaps = 36/273 (13%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL +LEE++ HST +G++WLTVL +FRI++ E ++ DEQS FVCNT+QPGCEN
Sbjct: 4 WSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R WV QII V+TPS+MY+G+A+H + +ME ++A A
Sbjct: 64 VCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYV-RMEEKRKSREAEELGQQA---- 118
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPK--HDGRRRIREDG-LMKIYVL 179
+Q K G ++ R +G L++ Y+
Sbjct: 119 -------------------------GTNGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYIC 153
Query: 180 QLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
++ +T+FEVGF++G YFLYGF++ P Y CSR PCP+ +DCF+SRPTEKTIF+L M V
Sbjct: 154 HIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVA 213
Query: 240 GLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDP 272
+ L LN+ E+ HLG IR +L +R +E P
Sbjct: 214 SVSLFLNVMELGHLGLKGIRSAL---KRPVEQP 243
>gb|AAG24880.1|AF304050_1 (AF304050) connexin 44.2 [Danio rerio]
Length = 391
Score = 236 bits (597), Expect = 2e-61
Identities = 112/273 (41%), Positives = 167/273 (61%), Gaps = 22/273 (8%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL +LEE++ HST +G++WLTVL +FRI++ E ++ DEQS +VCNT+QPGCEN
Sbjct: 4 WSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDYVCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R WV QII V+TPS++Y+G+A+H + H E +K +
Sbjct: 64 VCYDEAFPISHIRLWVLQIIFVSTPSLVYVGHAVHHV----HMEEKRKE----------R 109
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
+ L P+ + + + KE + K + +G L++ Y+ ++
Sbjct: 110 EEAELNRQQENEERLPLAPDQGSVRTAKETSTKGSKKFRLEGT-------LLRTYICHII 162
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
+T+FE+GF++GQY+LYGF++ P Y CSR PCP+ +DCF+SRPTEKT+F++ M V +
Sbjct: 163 FKTLFEIGFVVGQYYLYGFRILPLYKCSRWPCPNTVDCFVSRPTEKTVFIIFMLAVACVS 222
Query: 243 LLLNIWEMLHLGFGTIRDSLNSK-RRELEDPGA 274
L LN E+ HLG I R ++E PGA
Sbjct: 223 LFLNFVEISHLGLKKIHFVFRKPVRPQVEGPGA 255
>gb|AAG09541.1|AF288817_1 (AF288817) gap junction protein connexin 44.1 [Danio rerio]
Length = 391
Score = 236 bits (597), Expect = 2e-61
Identities = 112/273 (41%), Positives = 167/273 (61%), Gaps = 22/273 (8%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL +LEE++ HST +G++WLTVL +FRI++ E ++ DEQS +VCNT+QPGCEN
Sbjct: 4 WSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDYVCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R WV QII V+TPS++Y+G+A+H + H E +K +
Sbjct: 64 VCYDEAFPISHIRLWVLQIIFVSTPSLVYVGHAVHHV----HMEEKRKE----------R 109
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
+ L P+ + + + KE + K + +G L++ Y+ ++
Sbjct: 110 EEAELNRQQENEERLPLAPDQGSVRTAKETSTKGSKKFRLEGT-------LLRTYICHII 162
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
+T+FE+GF++GQY+LYGF++ P Y CSR PCP+ +DCF+SRPTEKT+F++ M V +
Sbjct: 163 FKTLFEIGFVVGQYYLYGFRILPLYKCSRWPCPNTVDCFVSRPTEKTVFIIFMLAVACVS 222
Query: 243 LLLNIWEMLHLGFGTIRDSLNSK-RRELEDPGA 274
L LN E+ HLG I R ++E PGA
Sbjct: 223 LFLNFVEISHLGLKKIHFVFRKPVRPQVEGPGA 255
>sp|P36381|CXA8_CHICK GAP JUNCTION ALPHA-8 PROTEIN (CONNEXIN 45.6) (CX45.6)
pir||I50219 connexin 45.6 - chicken
gb|AAA57134.1| (L24799) connexin 45.6 [Gallus gallus]
Length = 400
Score = 236 bits (597), Expect = 2e-61
Identities = 114/268 (42%), Positives = 168/268 (62%), Gaps = 29/268 (10%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL +LE+++ ST +G++WLTVL +FRI++ E ++ DEQS FVCNT+QPGCEN
Sbjct: 4 WSFLGNILEQVNEQSTVIGRVWLTVLFIFRILILGTAAELVWGDEQSDFVCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R WV QII V+TPS++Y G+A+H + +ME +++ A + A
Sbjct: 64 VCYDEAFPISHIRLWVLQIIFVSTPSLVYFGHAVHHV-RMEEKRKEREEAERRQQA---- 118
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKH-DGRRRIREDG-LMKIYVLQ 180
E++ +K +Q K + DG ++ R +G L++ Y+L
Sbjct: 119 ----------------------EVDEEKLPLAPNQNKGNNPDGTKKFRLEGTLLRTYILH 156
Query: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
++ +T+FEVGF++GQYFLYGF++ P Y C R PCP+ +DCF+SRPTEKTIF++ M V
Sbjct: 157 IIFKTLFEVGFIVGQYFLYGFRILPLYRCGRWPCPNLVDCFVSRPTEKTIFIMFMLVVAA 216
Query: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRRE 268
+ L LN+ E+ HL IR +L E
Sbjct: 217 VSLFLNLVEISHLILKRIRRALRRPAEE 244
>sp|P29414|CXA3_RAT GAP JUNCTION ALPHA-3 PROTEIN (CONNEXIN 46) (CX46)
pir||S25764 connexin 46 - rat
emb|CAA41036.1| (X57970) connexin 46 [Rattus norvegicus]
Length = 416
Score = 236 bits (597), Expect = 2e-61
Identities = 124/304 (40%), Positives = 173/304 (56%), Gaps = 41/304 (13%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL RLLE HST +GK+WLTVL +FRI++ E ++ DEQS F CNT+QPGCEN
Sbjct: 4 WSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEEVWGDEQSDFTCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+RFW QII V+TP+++YLG+ +H I +ME +KK R + R
Sbjct: 64 VCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLH-IVRME----EKKKEREEELLRRDN 118
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDG-LMKIYVLQL 181
P+ + + P D R ++R G L++ YV +
Sbjct: 119 -------------------PQHGRGREPMRTGSPRDPPLRDDRGKVRIAGALLRTYVFNI 159
Query: 182 LARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGL 241
+ +T+FEVGF+ GQYFLYGFQ+ P Y C R PCP+ +DCFISRPTEKTIF++ M V
Sbjct: 160 IFKTLFEVGFIAGQYFLYGFQLQPLYRCDRWPCPNTVDCFISRPTEKTIFVIFMLAVACA 219
Query: 242 CLLLNIWEMLHLGFGTIR---------DSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNI 292
L+LN+ E+ HLG+ ++ D+ + + L+ P + S PP +I
Sbjct: 220 SLVLNMLEIYHLGWKKLKQGVTNHFNPDASEVRHKPLD-------PLSEAANSGPPSVSI 272
Query: 293 AVKP 296
+ P
Sbjct: 273 GLPP 276
>gb|AAG24878.1| (AF304048) connexin 55.5 [Danio rerio]
Length = 498
Score = 227 bits (573), Expect = 2e-58
Identities = 121/331 (36%), Positives = 182/331 (54%), Gaps = 43/331 (12%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
W+FL +LEE+H HST VGKIWLT+L +FR+++ V E ++ DEQ+ F+CNTEQPGC N
Sbjct: 4 WNFLGGILEEVHIHSTMVGKIWLTILFIFRMLVLGVAAEDVWNDEQADFICNTEQPGCRN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+S +R+WV Q+I V++PS++Y+G+A++++ +E KK A +
Sbjct: 64 VCYDKAFPISLIRYWVLQVIFVSSPSLVYMGHALYRLRALEKERQRKKMALRRELE---- 119
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
+ E+ + ++E ++ Q K R L++ YV ++
Sbjct: 120 -------------GVDVEMAEVRRKIERELRQIDQGKLNKAPLR----GSLLRTYVAHIV 162
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
R+ EV F+ GQY LYGFQ++ Y C R PCP+ +DCF+SRPTEK++F++ M + G+
Sbjct: 163 TRSAVEVFFMTGQYVLYGFQLNTLYKCEREPCPNAVDCFVSRPTEKSVFMVFMQCIAGIS 222
Query: 243 LLLNIWEMLHLGFGTIRD-SLNSKRRELEDPGAYNYP-------------------FTWN 282
L LNI E+LHLG+ ++ LN + +DP YP
Sbjct: 223 LFLNILEILHLGYKKLKKVILNYYAQLRDDPNDSYYPNKVKKDSVVHQTCIGTSTGRKAT 282
Query: 283 TPSAPPGYNIAV--KPDQIQYTELSNAKIAY 311
SAP GYN+ + PD Y L N A+
Sbjct: 283 IASAPSGYNLHLDRPPDGAAYPPLINPSSAF 313
>sp|P18860|CXA5_CHICK GAP JUNCTION ALPHA-5 PROTEIN (CONNEXIN 42) (CX42)
pir||B37819 connexin-42 - chicken
gb|AAA48716.1| (M35043) connexin-42 [Gallus gallus]
Length = 369
Score = 227 bits (573), Expect = 2e-58
Identities = 123/337 (36%), Positives = 185/337 (54%), Gaps = 37/337 (10%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL LEE+H HST VGK+WLTVL +FR+++ ++ DEQS F+C+T+QPGCEN
Sbjct: 4 WSFLGEFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAGPLWGDEQSDFMCDTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKI---AKMEHGEADKKAARSKPYAM 119
VCYD P+SHVRFWV QII V+TPS++Y+G+A+H + K + EA+++A K
Sbjct: 64 VCYDKAFPISHVRFWVLQIIFVSTPSLVYMGHAMHTVRMEEKRKMKEAEREAQEMKNSGD 123
Query: 120 RWKQHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVL 179
+ Q + + + EL E+ G + I L+ YV
Sbjct: 124 TYYQQKC------------PVAEKTELSCWDES-----------GGKIILRGSLLNTYVY 160
Query: 180 QLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
+L RT E+ F++GQY LYG + Y+C R PCPH ++C++SRPTEK +F++ M V
Sbjct: 161 SILIRTAMEIAFIVGQYILYGIFLETLYICQRAPCPHPVNCYVSRPTEKNVFIIFMLAVA 220
Query: 240 GLCLLLNIWEMLHLGFGTIRD--------SLNSKRRELEDPGAYNYPFTWNTPSAPPGYN 291
L L L++ E+ HLG+ ++ S ++ R LE + TP PP +N
Sbjct: 221 VLSLFLSLAELYHLGWKKAKERCSRAYKPSPSTAPRRLESAPQVERAQMY-TP--PPDFN 277
Query: 292 IAVKPDQIQYTELSNAKIAYKQNKANTAQEQQYGSHE 328
+ ++ + K+A +QN AN A E+ + +
Sbjct: 278 QCLASPNGKFISPFSNKMASQQNTANFATERVHSQED 314
>ref|NP_002051.1| connexin 37; gap junction protein, alpha 4, 37kD [Homo sapiens]
pir||I55593 connexin 37 - human
Length = 333
Score = 226 bits (570), Expect = 4e-58
Identities = 128/334 (38%), Positives = 188/334 (55%), Gaps = 29/334 (8%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
W FL +LL+++ HST VGKIWLTVL +FRI++ + GES++ DEQS F CNT QPGC N
Sbjct: 4 WGFLEKLLDQVREHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R+WV Q + V+TP+++YLG+ I+ +++ E A K+
Sbjct: 64 VCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIY-LSRREERLAQKEG----------- 111
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
+ RAL P P++E + ++ DGR RI LM YV +L
Sbjct: 112 ELRAL----------PAKDPQVERALAGIELQMAKISVAEDGRLRIPR-ALMGTYVASVL 160
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
++V E GFL GQ+ LYG+ + P +VC R PCP+ +DCF+SRPTEKTIF++ M V +
Sbjct: 161 CKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLIS 220
Query: 243 LLLNIWEMLHLGFGTIRDSLNSKRRELEDP--GAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
L+LN+ E++HL + + +++ + P G + P+T PP P
Sbjct: 221 LVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSSDPYTDQGLLLPPRGQGPSSPPCPT 280
Query: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPAD 334
Y LS++ +QN AN E++ S L D
Sbjct: 281 YNGLSSS----EQNWANLTTEERLASSRPPLFLD 310
>sp|Q92107|CXA9_RAJER GAP JUNCTION ALPHA-9 PROTEIN (CONNEXIN 35) (CX35)
gb|AAB09722.1| (U43290) connexin 35 [Raja sp.]
Length = 302
Score = 226 bits (570), Expect = 4e-58
Identities = 114/309 (36%), Positives = 179/309 (57%), Gaps = 32/309 (10%)
Query: 3 WSFLTRLLEE-IHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCE 61
W+ L RLLE + HST +G+I LTV+++FRI++ A+ GE++Y DEQ+ FVCNT QPGC
Sbjct: 4 WTILERLLEAAVQQHSTMIGRILLTVVVIFRILVVAIVGETVYDDEQTMFVCNTLQPGCN 63
Query: 62 NVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHG---------EADKKAA 112
CYD P+SH+R+WVFQII+V TPS+ ++ Y++H+ +K + DKK
Sbjct: 64 QACYDKAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSSKQRERQYSTVFITLDKDKK-- 121
Query: 113 RSKPYAMRWKQHRALXXXXXXXXXXPMMYPEMELESD-KENKEQSQPKPKHDGRRRI-RE 170
++ + + E++SD E KE ++ +I R+
Sbjct: 122 ---------REDNKIKNTTVNGVLQNSEFFTKEMQSDFLEVKEMQNSAARNSKMSKIRRQ 172
Query: 171 DGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTI 230
+G+ + Y++Q++ R E+GFL+GQYFLYGF+V Y C+R PC ++C++SRPTEKT+
Sbjct: 173 EGISRFYIIQVVFRNALEIGFLMGQYFLYGFKVPSMYECNRYPCVKMVECYVSRPTEKTV 232
Query: 231 FLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKR---------RELEDPGAYNYPFTW 281
FL+ M+ V+GLC++LN+ E+ HLG+ I+ ++ + R + P P
Sbjct: 233 FLVFMFAVSGLCVILNLAELNHLGWRKIKTAVRGAQERRKSIYEIRNKDSPHRIGVPNFG 292
Query: 282 NTPSAPPGY 290
T S+ Y
Sbjct: 293 RTQSSDSAY 301
>ref|XP_001960.1| connexin 37 [Homo sapiens]
Length = 454
Score = 224 bits (566), Expect = 1e-57
Identities = 126/334 (37%), Positives = 184/334 (54%), Gaps = 29/334 (8%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
W FL +LL+++ HST VGKIWLTVL +FRI++ + GES++ DEQS F CNT QPGC N
Sbjct: 125 WGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTN 184
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R+WV Q + V+TP+++YLG+ I+ + E R K +R
Sbjct: 185 VCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREER-------LRQKEGELR-- 235
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
P P++E ++ ++ DGR RIR LM YV +L
Sbjct: 236 -------------ALPAKDPQVERALAAVERQMAKISVAEDGRLRIR-GALMGTYVASVL 281
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
++V E GFL GQ+ LYG+ + P +VC R PCP+ +DCF+SRPTEKTIF++ M V +
Sbjct: 282 CKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLIS 341
Query: 243 LLLNIWEMLHLGFGTIRDSLNSKRRELEDP--GAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
L+LN+ E++HL + + +++ + P G + P+T P P
Sbjct: 342 LVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSSDPYTDQVFFYLPVGQGPSSPPCPT 401
Query: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPAD 334
Y LS++ +QN AN E++ S L D
Sbjct: 402 YNGLSSS----EQNWANLTTEERLASSRPPLFLD 431
>gb|AAD31871.1|AF139102_1 (AF139102) connexin 37 [Homo sapiens]
gb|AAD31874.1|AF139105_1 (AF139105) connexin 37 [Homo sapiens]
gb|AAD56940.1|AF181620_1 (AF181620) connexin 37 [Homo sapiens]
Length = 333
Score = 224 bits (566), Expect = 1e-57
Identities = 126/334 (37%), Positives = 184/334 (54%), Gaps = 29/334 (8%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
W FL +LL+++ HST VGKIWLTVL +FRI++ + GES++ DEQS F CNT QPGC N
Sbjct: 4 WGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R+WV Q + V+TP+++YLG+ I+ + E R K +R
Sbjct: 64 VCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREER-------LRQKEGELR-- 114
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
P P++E ++ ++ DGR RIR LM YV +L
Sbjct: 115 -------------ALPAKDPQVERALAAVERQMAKISVAEDGRLRIR-GALMGTYVASVL 160
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
++V E GFL GQ+ LYG+ + P +VC R PCP+ +DCF+SRPTEKTIF++ M V +
Sbjct: 161 CKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLIS 220
Query: 243 LLLNIWEMLHLGFGTIRDSLNSKRRELEDP--GAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
L+LN+ E++HL + + +++ + P G + P+T P P
Sbjct: 221 LVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSSDPYTDQVFFYLPVGQGPSSPPCPT 280
Query: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPAD 334
Y LS++ +QN AN E++ S L D
Sbjct: 281 YNGLSSS----EQNWANLTTEERLASSRPPLFLD 310
>sp|P35212|CXA4_HUMAN GAP JUNCTION ALPHA-4 PROTEIN (CONNEXIN 37) (CX37)
gb|AAD31869.1|AF139100_1 (AF139100) connexin 37 [Homo sapiens]
gb|AAA52558.2| (M96789) connexin 37 [Homo sapiens]
emb|CAB90268.1| (AL121988) dJ34M23.1 (gap junction protein, alpha 4, 37kD (connexin
37)) [Homo sapiens]
Length = 333
Score = 224 bits (566), Expect = 1e-57
Identities = 126/334 (37%), Positives = 184/334 (54%), Gaps = 29/334 (8%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
W FL +LL+++ HST VGKIWLTVL +FRI++ + GES++ DEQS F CNT QPGC N
Sbjct: 4 WGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R+WV Q + V+TP+++YLG+ I+ + E R K +R
Sbjct: 64 VCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREER-------LRQKEGELR-- 114
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
P P++E ++ ++ DGR RIR LM YV +L
Sbjct: 115 -------------ALPAKDPQVERALAAVERQMAKISVAEDGRLRIR-GALMGTYVASVL 160
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
++V E GFL GQ+ LYG+ + P +VC R PCP+ +DCF+SRPTEKTIF++ M V +
Sbjct: 161 CKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLIS 220
Query: 243 LLLNIWEMLHLGFGTIRDSLNSKRRELEDP--GAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
L+LN+ E++HL + + +++ + P G + P+T P P
Sbjct: 221 LVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSSDPYTDQVFFYLPVGQGPSSPPCPT 280
Query: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPAD 334
Y LS++ +QN AN E++ S L D
Sbjct: 281 YNGLSSS----EQNWANLTTEERLASSRPPLFLD 310
>gb|AAD31873.1|AF139104_1 (AF139104) connexin 37 [Homo sapiens]
gb|AAF62342.1|AF132674_1 (AF132674) connexin 37 [Homo sapiens]
Length = 333
Score = 224 bits (565), Expect = 1e-57
Identities = 126/334 (37%), Positives = 184/334 (54%), Gaps = 29/334 (8%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
W FL +LL+++ HST VGKIWLTVL +FRI++ + GES++ DEQS F CNT QPGC N
Sbjct: 4 WGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R+WV Q + V+TP+++YLG+ I+ + E R K +R
Sbjct: 64 VCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREER-------LRQKEGELR-- 114
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
P P++E ++ ++ DGR RIR LM YV +L
Sbjct: 115 -------------ALPAKDPQVERALAAIERQMAKISVAEDGRLRIR-GALMGTYVASVL 160
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
++V E GFL GQ+ LYG+ + P +VC R PCP+ +DCF+SRPTEKTIF++ M V +
Sbjct: 161 CKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLIS 220
Query: 243 LLLNIWEMLHLGFGTIRDSLNSKRRELEDP--GAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
L+LN+ E++HL + + +++ + P G + P+T P P
Sbjct: 221 LVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSSDPYTDQVFFYLPVGQGPSSPPCPT 280
Query: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPAD 334
Y LS++ +QN AN E++ S L D
Sbjct: 281 YNGLSSS----EQNWANLTTEERLASSRPPLFLD 310
>ref|NP_067686.1| gap junction membrane channel, protein alpha 4 (connexin 37)
[Rattus norvegicus]
sp|Q03190|CXA4_RAT GAP JUNCTION ALPHA-4 PROTEIN (CONNEXIN 37) (CX37)
pir||B42053 gap junction protein CX37 - rat
gb|AAA40999.1| (M76532) connexin [Rattus norvegicus]
Length = 333
Score = 222 bits (561), Expect = 4e-57
Identities = 124/326 (38%), Positives = 179/326 (54%), Gaps = 29/326 (8%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
W FL +LL+++ HST VGKIWLTVL +FRI++ + GES++ DEQS F CNT QPGC N
Sbjct: 4 WGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R+WV Q + V+TP+++YLG+ I+ + E R K +R
Sbjct: 64 VCYDQAFPISHIRYWVLQFLFVSTPTLIYLGHVIYLSRREER-------LRQKEGELR-- 114
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
P P +E + ++ DGR RIR LM YV+ +L
Sbjct: 115 -------------ALPSKDPHVERALAAIEHQMAKISVAEDGRLRIR-GALMGTYVISVL 160
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
++V E GFL GQ+ LYG+ + P +VC R PCPH +DC++SRPTEKTIF++ M V +
Sbjct: 161 CKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPHVVDCYVSRPTEKTIFIIFMLVVGVIS 220
Query: 243 LLLNIWEMLHLGFGTIRDSLNSKRRELEDP--GAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
L+LN+ E++HL + + ++R P G+ + P+ P P
Sbjct: 221 LVLNLLELVHLLCRCVSREIKARRDHDTRPAQGSASDPYPEQVFFYLPMGEGPSSPPCPT 280
Query: 301 YTELSNAKIAYKQNKANTAQEQQYGS 326
Y LS+ +QN AN E++ S
Sbjct: 281 YNGLSST----EQNWANLTTEERLTS 302
>gb|AAG09406.1|AF179597_1 (AF179597) connexin 59 [Homo sapiens]
Length = 515
Score = 222 bits (560), Expect = 5e-57
Identities = 111/265 (41%), Positives = 157/265 (58%), Gaps = 25/265 (9%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
W+ L LEE+H HST +GKIWLT+L +FR+++ V E ++ DEQS F+CNTEQPGC N
Sbjct: 4 WNLLGDTLEEVHIHSTMIGKIWLTILFIFRMLVLGVAAEDVWNDEQSGFICNTEQPGCRN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+S +R+WV Q+I V++PS++Y+G+A++++ +E KA
Sbjct: 64 VCYDQAFPISLIRYWVLQVIFVSSPSLVYMGHALYRLRVLEEERQRMKAQ---------- 113
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQS--QPKPKHDGRRRIREDGLMKIYVLQ 180
+ E E+ D+ EQ Q + + + +R L+ YV+
Sbjct: 114 ------------LRVELEEVEFEMPRDRRRLEQELCQLEKRKLNKAPLRGT-LLCTYVIH 160
Query: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
+ R+V EVGF+IGQY LYGF + P + C PCP+ IDCF+SRPTEKTIFLL M +
Sbjct: 161 IFTRSVVEVGFMIGQYLLYGFHLEPLFKCHGHPCPNIIDCFVSRPTEKTIFLLFMQSIAT 220
Query: 241 LCLLLNIWEMLHLGFGTIRDSLNSK 265
+ L LNI E+ HLGF I+ L K
Sbjct: 221 ISLFLNILEIFHLGFKKIKRGLWGK 245
>ref|NP_032147.1| gap junction membrane channel protein alpha 5; connexin 40 [Mus
musculus]
sp|Q01231|CXA5_MOUSE GAP JUNCTION ALPHA-5 PROTEIN (CONNEXIN 40) (CX40)
pir||S23111 connexin 40 - mouse
emb|CAA43850.1| (X61675) Cx40 [Mus musculus]
Length = 358
Score = 222 bits (560), Expect = 5e-57
Identities = 132/387 (34%), Positives = 198/387 (51%), Gaps = 46/387 (11%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL LEE+H HST +GK+WLTVL +FR+++ ES + DEQ+ F C+T QPGC+N
Sbjct: 4 WSFLGEFLEEVHKHSTVIGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPGCQN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIA-----KMEHGEADKKAARSKPY 117
VCYD P+SH+R+WV QII V+TPS++Y+G+A+H + K+ E K+A R+ Y
Sbjct: 64 VCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKQKLRDAEKAKEAHRTGAY 123
Query: 118 AMRWKQHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIY 177
YP E K + + DG+ + + L+ Y
Sbjct: 124 E----------------------YPVAE-------KAELSCWKEVDGKI-VLQGTLLNTY 153
Query: 178 VLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYG 237
V +L RT EV F++GQY LYG + +VC R PCPH ++C++SRPTEK +F++ M
Sbjct: 154 VCTILIRTTMEVAFIVGQYLLYGIFLDTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMMA 213
Query: 238 VTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELED---PGAYNYPFTWNTPSAPPGYNIAV 294
V GL L L++ E+ HLG+ IR R+ ++ PG TP PP +N +
Sbjct: 214 VAGLSLFLSLAELYHLGWKKIRQRFGKSRQGVDKHQLPGPPTSLVQSLTP--PPDFNQCL 271
Query: 295 KPDQIQ--YTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLA 352
K + +++ SN + K A E ++E +P + + E A
Sbjct: 272 KNSSGEKFFSDFSNNMGSRKNPDALATGEV---PNQEQIPGE-GFIHMHYSQKPEYASGA 327
Query: 353 VQAYSHQNNPHGPREKKAKVGSKAGSN 379
+ H + + +K SKA S+
Sbjct: 328 SAGHRLPQGYHSDKRRLSKASSKARSD 354
>gb|AAD31872.1|AF139103_1 (AF139103) connexin 37 [Homo sapiens]
Length = 333
Score = 222 bits (559), Expect = 7e-57
Identities = 125/334 (37%), Positives = 183/334 (54%), Gaps = 29/334 (8%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
W FL +LL+++ HST VGKIWLTVL +FRI++ + GES++ DEQS F CNT QPGC N
Sbjct: 4 WGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD +SH+R+WV Q + V+TP+++YLG+ I+ + E R K +R
Sbjct: 64 VCYDQAFSISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREER-------LRQKEGELR-- 114
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
P P++E ++ ++ DGR RIR LM YV +L
Sbjct: 115 -------------ALPAKDPQVERALTAVERQMAKISVAEDGRLRIR-GALMGTYVASVL 160
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
++V E GFL GQ+ LYG+ + P +VC R PCP+ +DCF+SRPTEKTIF++ M V +
Sbjct: 161 CKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLIS 220
Query: 243 LLLNIWEMLHLGFGTIRDSLNSKRRELEDP--GAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
L+LN+ E++HL + + +++ + P G + P+T P P
Sbjct: 221 LVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSSDPYTDQVFFYLPVGQGPSSPPCPT 280
Query: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPAD 334
Y LS++ +QN AN E++ S L D
Sbjct: 281 YNGLSSS----EQNWANLTTEERLASSRPPLFLD 310
>sp|P16863|CXA1_XENLA GAP JUNCTION ALPHA-1 PROTEIN (CONNEXIN 43) (CX43)
pir||A34575 gap junction protein Cx43 - African clawed frog
emb|CAA35108.1| (X17243) alpha-1 gap junction protein (AA 1-379) [Xenopus laevis]
Length = 379
Score = 222 bits (559), Expect = 7e-57
Identities = 127/338 (37%), Positives = 193/338 (56%), Gaps = 45/338 (13%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WS L RLL+++ +ST GK+WL+VL +FRI+L ES + DEQS FVCNT+QPGCEN
Sbjct: 4 WSALGRLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFVCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLG---YAIHKIAKMEHGEADKKAARSKPYAM 119
VCYD P+SHVRFWV QII V+TP+++YL Y + K K+ E + K +++
Sbjct: 64 VCYDKSFPISHVRFWVLQIIFVSTPTLLYLAHVFYLMRKEEKLNRKEEELKMVQNE---- 119
Query: 120 RWKQHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVL 179
M ++E++ K E+ G+ ++R GL++ Y++
Sbjct: 120 --------------GGNVDMHLKQIEIKKFKYGLEE-------HGKVKMR-GGLLRTYII 157
Query: 180 QLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
+L ++VFEVGF+I Q+++YGF + Y C R PCPH++DCF+SRPTEKTIF+ M V+
Sbjct: 158 SILFKSVFEVGFIIIQWYMYGFSLSAIYTCKRDPCPHQVDCFLSRPTEKTIFIWFMLIVS 217
Query: 240 GLCLLLNIWEMLHLGFGTIRDSLNSKR-------------RELEDP--GAYNYPFTWNTP 284
+ L LNI E+ ++ + +I+D + K+ +E P +N + P
Sbjct: 218 IVSLALNIIELFYVTYKSIKDGIKGKKDPFSATNDAVISGKECGSPKYAYFNGCSSPTAP 277
Query: 285 SAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQ 322
+PPGY + V ++ + + K A +QN AN + EQ
Sbjct: 278 MSPPGYKL-VTGERNPSSCRNYNKQASEQNWANYSAEQ 314
>gb|AAD56533.1|AF180815_1 (AF180815) truncated connexin 37 polymorph [Homo sapiens]
Length = 293
Score = 221 bits (558), Expect = 9e-57
Identities = 109/251 (43%), Positives = 154/251 (60%), Gaps = 23/251 (9%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
W FL +LL+++ HST VGKIWLTVL +FRI++ + GES++ DEQS F CNT QPGC N
Sbjct: 4 WGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R+WV Q + V+TP+++YLG+ I+ + E R K +R
Sbjct: 64 VCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREER-------LRQKEGELR-- 114
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
P P++E ++ ++ DGR RIR LM YV +L
Sbjct: 115 -------------ALPAKDPQVERALAAVERQMAKISVAEDGRLRIR-GALMGTYVASVL 160
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
++V E GFL GQ+ LYG+ + P +VC R PCP+ +DCF+SRPTEKTIF++ M V +
Sbjct: 161 CKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLIS 220
Query: 243 LLLNIWEMLHL 253
L+LN+ E++HL
Sbjct: 221 LVLNLLELVHL 231
>gb|AAD31870.1|AF139101_1 (AF139101) connexin 37 [Homo sapiens]
Length = 333
Score = 221 bits (558), Expect = 9e-57
Identities = 124/334 (37%), Positives = 183/334 (54%), Gaps = 29/334 (8%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
W FL +LL+++ HST VGKIWLTVL +FRI++ + GES++ DEQS F CNT QPGC N
Sbjct: 4 WGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R+WV Q + V+TP+++YLG+ I+ + E R K +R
Sbjct: 64 VCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREER-------LRQKEGELR-- 114
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
P P+++ ++ ++ DGR RIR LM Y +L
Sbjct: 115 -------------ALPAKDPQVKRAPAAVERQMAKISVAEDGRLRIR-GALMGTYDASVL 160
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
++V E GFL GQ+ LYG+ + P +VC R PCP+ +DCF+SRPTEKTIF++ M V +
Sbjct: 161 CKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLIS 220
Query: 243 LLLNIWEMLHLGFGTIRDSLNSKRRELEDP--GAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
L+LN+ E++HL + + +++ + P G + P+T P P
Sbjct: 221 LVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSSDPYTGQVFFYLPVGQGPSSPPCPT 280
Query: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPAD 334
Y LS++ +QN AN E++ S L D
Sbjct: 281 YNGLSSS----EQNWANLTTEERLASSRPPLFLD 310
>gb|AAC31884.1| (AF059183) connexin 35 [Morone americana]
Length = 304
Score = 221 bits (558), Expect = 9e-57
Identities = 109/270 (40%), Positives = 165/270 (60%), Gaps = 16/270 (5%)
Query: 3 WSFLTRLLEE-IHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCE 61
W+ L RLLE + HST +G+I LTV+++FRI++ A+ GE++Y DEQ+ FVCNT QPGC
Sbjct: 4 WTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCN 63
Query: 62 NVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRW 121
CYD P+SH+R+WVFQII+V TPS+ ++ Y++H+ AK K+ S Y
Sbjct: 64 QACYDKAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQ------KERRYSTVYLTLD 117
Query: 122 KQHRALXXXXXXXXXXPMMYPEM--------ELESD-KENKEQSQPKPKHDGRRRIREDG 172
K +L ++ + E E D E KE + + R++G
Sbjct: 118 KDQDSLKRDESKKIKNTIVNGVLQNTENSTKEAEPDCLEVKEIPNSAMRTTKSKMRRQEG 177
Query: 173 LMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFL 232
+ + Y++Q++ R E+GFL+GQYFLYGF V Y C R PC ++C++SRPTEKT+FL
Sbjct: 178 ISRFYIIQVVFRNALEIGFLVGQYFLYGFNVPSVYECDRYPCIKDVECYVSRPTEKTVFL 237
Query: 233 LIMYGVTGLCLLLNIWEMLHLGFGTIRDSL 262
+ M+ V+G C++LN+ E+ HLG+ I+ ++
Sbjct: 238 VFMFAVSGFCVVLNLAELNHLGWRKIKTAV 267
>sp|P18246|CXA1_BOVIN GAP JUNCTION ALPHA-1 PROTEIN (CONNEXIN 43) (CX43) (VASCULAR SMOOTH
MUSCLE CONNEXIN 43)
pir||A36623 gap junction protein Cx43 - bovine
gb|AAA30459.1| (J05535) vascular smooth muscle connexin43 [Bos taurus]
Length = 383
Score = 216 bits (545), Expect = 3e-55
Identities = 126/338 (37%), Positives = 190/338 (55%), Gaps = 41/338 (12%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WS L +LL+++ +ST GK+WL+VL +FRI+L ES + DEQS F CNT+QPGCEN
Sbjct: 4 WSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SHVRFWV QII V+ P+++YL + + + K E + +KK K A
Sbjct: 64 VCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEE--KLNKKEEELKVVAQ--- 118
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
M ++E++ K E+ G+ ++R GL++ Y++ +L
Sbjct: 119 ---------TDGANVDMHLKQIEIKKFKYGIEE-------HGKVKMR-GGLLRTYIISIL 161
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
++VFEV FL+ Q+++YGF + Y C R PCPH++DCF+SRPTEKTIF++ M V+ +
Sbjct: 162 FKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVS 221
Query: 243 LLLNIWEMLHLGFGTIRDSLNSKR----------RELEDPGAYNY--------PFTWNTP 284
L LNI E+ ++ F ++D + K +D G+ Y P +P
Sbjct: 222 LALNIIELFYVFFKGVKDRVKGKSDPYHTTTGPLSPSKDCGSPKYAYFNGCSSPTAPLSP 281
Query: 285 SAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQ 322
+PPGY + V D+ + + K A +QN AN + EQ
Sbjct: 282 MSPPGYKL-VTGDRNNSSCRNYNKQASEQNWANYSAEQ 318
>dbj|BAA05381.1| (D26333) similar to mouse lens connexin (Cx50) [Gallus gallus]
Length = 235
Score = 216 bits (544), Expect = 4e-55
Identities = 106/253 (41%), Positives = 157/253 (61%), Gaps = 30/253 (11%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL +LE+++ ST +G++WLTVL +FRI++ E ++ DEQS FVCNT+QPGCEN
Sbjct: 4 WSFLGNILEQVNEQSTVIGRVWLTVLFIFRILILGTAAELVWGDEQSDFVCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R WV QII V+TPS++Y G+A+ + +ME +++ A + A
Sbjct: 64 VCYDEAFPISHIRLWVLQIIFVSTPSLVYFGHAVXHV-RMEEKRKEREEAERRQQA---- 118
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKH-DGRRRIRED-GLMKIYVLQ 180
E++ +K +Q K + D ++ R D L + Y+L
Sbjct: 119 ----------------------EVDEEKLPLAPNQNKGNNPDXTKKFRLDLTLXRTYILH 156
Query: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
++ + +FEVGF++GQYFLYGF++ P Y C R CP+ +DCF+SRPTEKTIF++ M V
Sbjct: 157 IIFKXLFEVGFIVGQYFLYGFRILPLYRCGR-DCPNLVDCFVSRPTEKTIFIMFMLVVAA 215
Query: 241 LCLLLNIWEMLHL 253
+ L LN+ E+ HL
Sbjct: 216 VSLFLNLVEISHL 228
>ref|NP_000156.1| connexin 43; gap junction protein, alpha 1, 43kD [Homo sapiens]
ref|XP_004121.1| connexin 43 [Homo sapiens]
sp|P17302|CXA1_HUMAN GAP JUNCTION ALPHA-1 PROTEIN (CONNEXIN 43) (CX43) (GAP JUNCTION 43
KDA HEART PROTEIN)
pir||A35853 gap junction protein Cx43, cardiac - human
emb|CAA37122.1| (X52947) gap junction protein (AA 1-382) [Homo sapiens]
gb|AAA52131.1| (M65188) connexin 43 [Homo sapiens]
gb|AAD37802.2|AF151980_1 (AF151980) connexin 43 [Homo sapiens]
Length = 382
Score = 216 bits (544), Expect = 4e-55
Identities = 123/338 (36%), Positives = 187/338 (54%), Gaps = 42/338 (12%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WS L +LL+++ +ST GK+WL+VL +FRI+L ES + DEQS F CNT+QPGCEN
Sbjct: 4 WSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SHVRFWV QII V+ P+++YL + + + K E K
Sbjct: 64 VCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLN---------------K 108
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
+ L M ++E++ K E+ G+ ++R GL++ Y++ +L
Sbjct: 109 KEEELKVAQTDGVNVDMHLKQIEIKKFKYGIEE-------HGKVKMR-GGLLRTYIISIL 160
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
+++FEV FL+ Q+++YGF + Y C R PCPH++DCF+SRPTEKTIF++ M V+ +
Sbjct: 161 FKSIFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVS 220
Query: 243 LLLNIWEMLHLGFGTIRDSLNSKR----------RELEDPGAYNY--------PFTWNTP 284
L LNI E+ ++ F ++D + K +D G+ Y P +P
Sbjct: 221 LALNIIELFYVFFKGVKDRVKGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSP 280
Query: 285 SAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQ 322
+PPGY + V D+ + + K A +QN AN + EQ
Sbjct: 281 MSPPGYKL-VTGDRNNSSCRNYNKQASEQNWANYSAEQ 317
>gb|AAA53027.1| (M63801) connexin 43 [Mus musculus]
Length = 382
Score = 214 bits (540), Expect = 1e-54
Identities = 125/341 (36%), Positives = 190/341 (55%), Gaps = 48/341 (14%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WS L +LL+++ +ST GK+WL+VL +FRI+L ES + DEQS F CNT+QPGCEN
Sbjct: 4 WSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSXFRCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLG---YAIHKIAKMEHGEADKKAARSKPYAM 119
VCYD P+SHVRFWV QII V+ P+++YL Y + K K+ E + K A++ +
Sbjct: 64 VCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNV 123
Query: 120 RWKQHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVL 179
M ++E++ K E+ G+ ++R GL++ Y++
Sbjct: 124 E------------------MHLKQIEIKKFKYGIEE-------HGKVKMR-GGLLRTYII 157
Query: 180 QLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
+L ++VFEV FL+ Q+++YGF + Y C R PCPH++DCF+SRPTEKTIF++ M V+
Sbjct: 158 SILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVS 217
Query: 240 GLCLLLNIWEMLHLGFGTIRDSLNSKR----------RELEDPGAYNY--------PFTW 281
+ L LNI E+ ++ F ++D + + +D G+ Y P
Sbjct: 218 LVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAP 277
Query: 282 NTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQ 322
+P PPGY + V D+ + + K A +QN AN + EQ
Sbjct: 278 LSPXXPPGYKL-VTGDRNNSSCRNYNKQASEQNWANYSAEQ 317
>ref|NP_036699.1| gap junction protein, alpha 1, 43 kD (connexin 43) [Rattus
norvegicus]
sp|P08050|CXA1_RAT GAP JUNCTION ALPHA-1 PROTEIN (CONNEXIN 43) (CX43) (GAP JUNCTION 43
KDA HEART PROTEIN)
pir||S00532 gap junction protein Cx43 - rat
emb|CAA29855.1| (X06656) connexin43 (AA 1-382) [Rattus norvegicus]
prf||1404339A connexin 43 [Rattus norvegicus]
Length = 382
Score = 214 bits (540), Expect = 1e-54
Identities = 125/341 (36%), Positives = 191/341 (55%), Gaps = 48/341 (14%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WS L +LL+++ +ST GK+WL+VL +FRI+L ES + DEQS F CNT+QPGCEN
Sbjct: 4 WSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLG---YAIHKIAKMEHGEADKKAARSKPYAM 119
VCYD P+SHVRFWV QII V+ P+++YL Y + K K+ E + K A++ +
Sbjct: 64 VCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNV 123
Query: 120 RWKQHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVL 179
M ++E++ K E+ G+ ++R GL++ Y++
Sbjct: 124 E------------------MHLKQIEIKKFKYGIEE-------HGKVKMR-GGLLRTYII 157
Query: 180 QLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
+L ++VFEV FL+ Q+++YGF + Y C R PCPH++DCF+SRPTEKTIF++ M V+
Sbjct: 158 SILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVS 217
Query: 240 GLCLLLNIWEMLHLGFGTIRDSLNSKR----------RELEDPGAYNY--------PFTW 281
+ L LNI E+ ++ F ++D + + +D G+ Y P
Sbjct: 218 LVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAP 277
Query: 282 NTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQ 322
+P +PPGY + V D+ + + K A +QN AN + EQ
Sbjct: 278 LSPMSPPGYKL-VTGDRNNSSCRNYNKQASEQNWANYSAEQ 317
>ref|NP_034418.1| gap junction membrane channel protein alpha 1; connexin 43; alpha 1
connexin [Mus musculus]
sp|P23242|CXA1_MOUSE GAP JUNCTION ALPHA-1 PROTEIN (CONNEXIN 43) (CX43) (GAP JUNCTION 43
KDA HEART PROTEIN)
pir||A39802 gap junction protein Cx43 - mouse
emb|CAA43778.1| (X61576) connexin 43 [Mus musculus]
emb|CAA44640.1| (X62836) Connexin 43 [Mus musculus]
gb|AAA37444.1| (M61896) connexin 43 [Mus musculus]
Length = 382
Score = 214 bits (540), Expect = 1e-54
Identities = 125/341 (36%), Positives = 191/341 (55%), Gaps = 48/341 (14%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WS L +LL+++ +ST GK+WL+VL +FRI+L ES + DEQS F CNT+QPGCEN
Sbjct: 4 WSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLG---YAIHKIAKMEHGEADKKAARSKPYAM 119
VCYD P+SHVRFWV QII V+ P+++YL Y + K K+ E + K A++ +
Sbjct: 64 VCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNV 123
Query: 120 RWKQHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVL 179
M ++E++ K E+ G+ ++R GL++ Y++
Sbjct: 124 E------------------MHLKQIEIKKFKYGIEE-------HGKVKMR-GGLLRTYII 157
Query: 180 QLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
+L ++VFEV FL+ Q+++YGF + Y C R PCPH++DCF+SRPTEKTIF++ M V+
Sbjct: 158 SILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVS 217
Query: 240 GLCLLLNIWEMLHLGFGTIRDSLNSKR----------RELEDPGAYNY--------PFTW 281
+ L LNI E+ ++ F ++D + + +D G+ Y P
Sbjct: 218 LVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAP 277
Query: 282 NTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQ 322
+P +PPGY + V D+ + + K A +QN AN + EQ
Sbjct: 278 LSPMSPPGYKL-VTGDRNNSSCRNYNKQASEQNWANYSAEQ 317
>sp|O57474|CXA1_BRARE GAP JUNCTION ALPHA-1 PROTEIN (CONNEXIN 43) (CX43)
gb|AAC04759.1| (AF035481) connexin 43 [Danio rerio]
Length = 381
Score = 212 bits (535), Expect = 5e-54
Identities = 126/341 (36%), Positives = 183/341 (52%), Gaps = 49/341 (14%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WS L RLL+++ +ST GK+WL+VL +FRI++ ES + DEQS F CNT+QPGCEN
Sbjct: 4 WSALGRLLDKVQAYSTAGGKVWLSVLFIFRILVLGTAVESAWGDEQSAFKCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLG---YAIHKIAKMEHGEADKKAARSKPYAM 119
VCYD P+SHVRFWV QII V+TP+++YL Y + K K+ E + KA ++
Sbjct: 64 VCYDKSFPISHVRFWVLQIIFVSTPTLLYLAHVFYLMRKEEKLNRKEEELKAVQND---- 119
Query: 120 RWKQHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVL 179
+ ++EL+ K E+ K K G L++ Y+
Sbjct: 120 --------------GGDVELHLKKIELKKFKHGLEE-HGKVKMKG-------SLLRTYIF 157
Query: 180 QLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
++ +++ EV FL+ Q++LYGF + Y C R PCPH++DCF+SRPTEKTIF++ M V+
Sbjct: 158 SIIFKSICEVVFLVIQWYLYGFSLSAVYTCERTPCPHRVDCFLSRPTEKTIFIIFMLVVS 217
Query: 240 GLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGA------------YNY------PFTW 281
LLLNI E+ ++ F I+D + S++ G Y Y P
Sbjct: 218 LFSLLLNIIELFYVLFKRIKDRVKSRQNTQFPTGTLSPTPKELSTTKYAYYNGCSSPTAP 277
Query: 282 NTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQ 322
+P +PPGY +A + K A +QN AN + EQ
Sbjct: 278 LSPMSPPGYKLATGERTNSCRNYN--KQANEQNWANYSTEQ 316
>sp|P14154|CXA1_CHICK GAP JUNCTION ALPHA-1 PROTEIN (CONNEXIN 43) (CX43)
pir||A48171 gap junction protein Cx43 - chicken
gb|AAA48715.1| (M29003) connexin 43 [Gallus gallus]
Length = 381
Score = 211 bits (532), Expect = 1e-53
Identities = 122/337 (36%), Positives = 183/337 (54%), Gaps = 41/337 (12%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WS L +LL+++ +ST GK+WL+VL +FRI+L ES + DE F CNT+QPGCEN
Sbjct: 4 WSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEHVAFRCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SHVRFWV QII V+ P+++YL + + + K E K
Sbjct: 64 VCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLN---------------K 108
Query: 123 QHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
+ L M ++E++ K E+ G+ ++R GL++ Y++ +L
Sbjct: 109 REEELKVVQNDGVNVDMHLKQIEIKKFKYGIEE-------HGKVKMR-GGLLRTYIISIL 160
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
++VFEV FL+ Q+++YGF + Y C R PCPH++DCF+SRPTEKTIF++ M V+ +
Sbjct: 161 FKSVFEVAFLLIQWYIYGFSLSAIYTCERDPCPHRVDCFLSRPTEKTIFIVFMLVVSLVS 220
Query: 243 LLLNIWEMLHLGFGTIRDSLNSKRRELEDPGA-----------YNY------PFTWNTPS 285
L LNI E+ ++ F ++D + K G Y Y P +P
Sbjct: 221 LALNIIELFYVFFKGVKDRVKGKTDPYSHSGTMSPSKDCGSPKYAYYNGCSSPTAPLSPM 280
Query: 286 APPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQ 322
+PPGY + V D+ + + K A +QN AN + EQ
Sbjct: 281 SPPGYKL-VTGDRNNSSCRNYNKQASEQNWANYSAEQ 316
>prf||1714172A connexin 43 [Rattus norvegicus]
Length = 382
Score = 211 bits (531), Expect = 1e-53
Identities = 123/341 (36%), Positives = 189/341 (55%), Gaps = 48/341 (14%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WS L +LL+++ +ST GK+WL+VL +FRI+L ES + DEQS F C +QPGCEN
Sbjct: 4 WSALGKLLDKVQTYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCTNQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLG---YAIHKIAKMEHGEADKKAARSKPYAM 119
VCYD P+SHVRFWV QII V+ P+++YL Y + K K+ E + K A++ +
Sbjct: 64 VCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNV 123
Query: 120 RWKQHRALXXXXXXXXXXPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVL 179
M ++E++ K E+ G+ ++R GL++ Y++
Sbjct: 124 E------------------MHLKQIEIKKFKYGIEE-------HGKVKMR-GGLLRTYII 157
Query: 180 QLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
+L ++VFEV FL+ Q+++YGF + Y C R PCPH++DCF+SRPTEKTIF++ M V+
Sbjct: 158 SILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVS 217
Query: 240 GLCLLLNIWEMLHLGFGTIRDSLNSKR----------RELEDPGAYNY--------PFTW 281
+ L LNI E+ ++ F ++D + + +D G+ Y P
Sbjct: 218 LVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAP 277
Query: 282 NTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQ 322
+P +PPGY + V D+ + + K A +QN AN + EQ
Sbjct: 278 LSPMSPPGYKL-VTGDRNNSSCRNYNKQASEQNWANYSAEQ 317
Database: nr
Number of letters in database: 188,543,631
Number of sequences in database: 596,480
Lambda K H
0.320 0.136 0.416
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 153671674
Number of Sequences: 596480
Number of extensions: 6290171
Number of successful extensions: 18497
Number of sequences better than 10.0: 126
Number of HSP's better than 10.0 without gapping: 117
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 18240
Number of HSP's gapped (non-prelim): 201
length of query: 396
length of database: 188,543,631
effective HSP length: 54
effective length of query: 342
effective length of database: 156,333,711
effective search space: 53466129162
effective search space used: 53466129162
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.8 bits)
S2: 72 (32.5 bits)
