Score E
Sequences producing significant alignments: (bits) Value
ref|NP_002499.1| nidogen (enactin); Nidogen; nidogen (entac... 2554 0.0
pir||MMHUND nidogen precursor - human 2548 0.0
emb|CAA57709.1| (X82245) nidogen [Homo sapiens] 2536 0.0
ref|NP_035047.1| nidogen [Mus musculus] >gi|128200|sp|P1049... 2197 0.0
emb|CAA32642.1| (X14480) prenidogen (AA -28 to 1217) [Mus m... 2194 0.0
gb|AAA57261.1| (M27445) nidogen [Homo sapiens] 1273 0.0
sp|Q14112|NID2_HUMAN NIDOGEN-2 PRECURSOR (NID-2) (OSTEONIDO... 822 0.0
ref|NP_031387.1| nidogen 2; nidogen 2 (osteonidogen) [Homo ... 822 0.0
gb|AAF44680.1|AF239837_1 (AF239837) nidogen 1; entactin [Ga... 804 0.0
ref|NP_032721.1| nidogen 2 [Mus musculus] >gi|8928260|sp|O8... 779 0.0
sp|P08460|NIDO_RAT NIDOGEN (ENTACTIN) >gi|92554|pir||S14828... 483 e-135
gb|AAA77652.1| (L17324) entactin [Mus musculus] 370 e-101
gb|AAA41120.1| (M15797) entactin [Rattus norvegicus] 331 3e-89
pir||T22674 hypothetical protein F54F3.1 - Caenorhabditis e... 265 2e-69
pir||S31213 nidogen precursor - sea squirt (Halocynthia ror... 261 3e-68
gb|AAF58809.1| (AE003830) CG12908 gene product [Drosophila ... 260 8e-68
dbj|BAA32468.1| (AB011540) MEGF7 [Homo sapiens] 202 2e-50
dbj|BAA88688.1| (AB011533) MEGF7 [Rattus norvegicus] 201 4e-50
pir||JE0329 low density lipoprotein receptor - human >gi|38... 192 1e-47
ref|NP_002326.1| low density lipoprotein receptor-related p... 192 1e-47
pir||JE0372 low density lipoprotein receptor related protei... 192 1e-47
gb|AAC70183.1| (AF077847) LDL receptor member LR3 [Mus musc... 191 3e-47
ref|NP_032539.1| low density lipoprotein-related protein 5 ... 191 3e-47
ref|NP_002327.1| low density lipoprotein receptor-related p... 189 2e-46
ref|NP_032540.1| low density lipoprotein-related protein 6 ... 186 1e-45
ref|NP_061027.1| low density lipoprotein receptor related p... 185 3e-45
gb|AAF58373.1| (AE003818) LRP6 gene product [Drosophila mel... 181 4e-44
gb|AAF28358.1|AF223365_1 (AF223365) LDL-related protein LRP... 181 4e-44
gb|AAF81758.1|AF270884_1 (AF270884) low density lipoprotein... 178 3e-43
ref|NP_002323.1| low density lipoprotein-related protein 1 ... 178 4e-43
gb|AAF59114.2| (AE003838) CG8706 gene product [Drosophila m... 176 1e-42
ref|NP_032538.1| low density lipoprotein receptor related p... 176 1e-42
emb|CAA03855.1| (AJ000010) lipophorin receptor [Locusta mig... 174 6e-42
emb|CAA11963.1| (AJ224450) entactin [Rattus norvegicus] 167 8e-40
gb|AAF48538.1| (AE003500) CG8909 gene product [Drosophila m... 166 2e-39
gb|AAC34396.1| (AF056116) LRP1 [Takifugu rubripes] 165 2e-39
sp|P98157|LRP1_CHICK LOW-DENSITY LIPOPROTEIN RECEPTOR-RELAT... 165 3e-39
emb|CAA57882.1| (X82509) low-density lipoprotein receptor-r... 159 2e-37
sp|Q99088|LDL2_XENLA LOW-DENSITY LIPOPROTEIN RECEPTOR 2 PRE... 157 5e-37
pir||QRXLL2 LDL receptor 2 precursor - African clawed frog 157 9e-37
gb|AAC14024.1| (AF053364) epidermal growth factor precursor... 153 1e-35
ref|NP_004516.1| low density lipoprotein-related protein 2;... 152 2e-35
emb|CAA65729.1| (X97001) LR8B [Gallus gallus] 152 2e-35
ref|NP_059992.1| apolipoprotein E receptor 2 [Homo sapiens]... 148 3e-34
pir||QRXLL1 LDL receptor 1 precursor - African clawed frog 148 3e-34
dbj|BAA21825.1| (D86407) ApoER2delta4-7 [Homo sapiens] 148 5e-34
ref|NP_004622.1| low density lipoprotein receptor-related p... 148 5e-34
sp|Q99087|LDL1_XENLA LOW-DENSITY LIPOPROTEIN RECEPTOR 1 PRE... 147 8e-34
ref|NP_034830.1| low density lipoprotein receptor [Mus musc... 145 2e-33
pir||I48623 low density lipoprotein receptor - mouse >gi|74... 145 2e-33
>ref|NP_002499.1| nidogen (enactin); Nidogen; nidogen (entactin) [Homo sapiens]
sp|P14543|NIDO_HUMAN NIDOGEN PRECURSOR (ENTACTIN)
gb|AAA59932.1| (M30269) nidogen [Homo sapiens]
Length = 1247
Score = 2554 bits (6547), Expect = 0.0
Identities = 1211/1247 (97%), Positives = 1211/1247 (97%)
Query: 1 MLASSSRIRAAWTRAXXXXXXXAGPVGCLSRQELFPFGPGQXXXXXXXXXXFVSPALELS 60
MLASSSRIRAAWTRA AGPVGCLSRQELFPFGPGQ FVSPALELS
Sbjct: 1 MLASSSRIRAAWTRALLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELS 60
Query: 61 GALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKV 120
GALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKV
Sbjct: 61 GALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKV 120
Query: 121 YYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ 180
YYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ
Sbjct: 121 YYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ 180
Query: 181 AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFA 240
AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFA
Sbjct: 181 AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFA 240
Query: 241 NDRESIENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILXXXXXXXXXXXXXXXXXXX 300
NDRESIENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVIL
Sbjct: 241 NDRESIENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILGTEDGAEYDDEDEDYDLAT 300
Query: 301 TRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF 360
TRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF
Sbjct: 301 TRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF 360
Query: 361 HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTG 420
HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTG
Sbjct: 361 HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTG 420
Query: 421 NGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETV 480
NGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETV
Sbjct: 421 NGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETV 480
Query: 481 GYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI 540
GYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI
Sbjct: 481 GYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI 540
Query: 541 DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGAS 600
DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGAS
Sbjct: 541 DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGAS 600
Query: 601 PSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYAFSNSIGPV 660
PSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYAFSNSIGPV
Sbjct: 601 PSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYAFSNSIGPV 660
Query: 661 REGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
REGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV
Sbjct: 661 REGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
Query: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT 780
CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT
Sbjct: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT 780
Query: 781 GGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV 840
GGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV
Sbjct: 781 GGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV 840
Query: 841 PGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVD 900
PGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVD
Sbjct: 841 PGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVD 900
Query: 901 RDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLE 960
RDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLE
Sbjct: 901 RDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLE 960
Query: 961 GNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDL 1020
GNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDL
Sbjct: 961 GNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDL 1020
Query: 1021 GSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYW 1080
GSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYW
Sbjct: 1021 GSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYW 1080
Query: 1081 TDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQ 1140
TDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQ
Sbjct: 1081 TDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQ 1140
Query: 1141 PSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT 1200
PSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT
Sbjct: 1141 PSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT 1200
Query: 1201 ALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIERK 1247
ALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIERK
Sbjct: 1201 ALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIERK 1247
>pir||MMHUND nidogen precursor - human
Length = 1247
Score = 2548 bits (6531), Expect = 0.0
Identities = 1209/1247 (96%), Positives = 1209/1247 (96%)
Query: 1 MLASSSRIRAAWTRAXXXXXXXAGPVGCLSRQELFPFGPGQXXXXXXXXXXFVSPALELS 60
MLASSSRIRAAWTRA AGPVGCLSRQELFPFGPGQ FVSPALELS
Sbjct: 1 MLASSSRIRAAWTRALLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELS 60
Query: 61 GALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKV 120
GALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKV
Sbjct: 61 GALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKV 120
Query: 121 YYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ 180
YYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ
Sbjct: 121 YYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ 180
Query: 181 AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFA 240
AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFA
Sbjct: 181 AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFA 240
Query: 241 NDRESIENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILXXXXXXXXXXXXXXXXXXX 300
NDRESIENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVIL
Sbjct: 241 NDRESIENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILGTEDGAEYDDEDEDYDLAT 300
Query: 301 TRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF 360
TRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF
Sbjct: 301 TRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF 360
Query: 361 HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTG 420
HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTG
Sbjct: 361 HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTG 420
Query: 421 NGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETV 480
NGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETV
Sbjct: 421 NGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETV 480
Query: 481 GYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI 540
GYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI
Sbjct: 481 GYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI 540
Query: 541 DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGAS 600
DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGAS
Sbjct: 541 DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGAS 600
Query: 601 PSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYAFSNSIGPV 660
PSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYA SNSIGPV
Sbjct: 601 PSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPV 660
Query: 661 REGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
REGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV
Sbjct: 661 REGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
Query: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT 780
CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT
Sbjct: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT 780
Query: 781 GGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV 840
GGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV
Sbjct: 781 GGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV 840
Query: 841 PGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVD 900
PGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVD
Sbjct: 841 PGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVD 900
Query: 901 RDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLE 960
RDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLE
Sbjct: 901 RDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLE 960
Query: 961 GNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDL 1020
GNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDL
Sbjct: 961 GNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDL 1020
Query: 1021 GSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYW 1080
GSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYW
Sbjct: 1021 GSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYW 1080
Query: 1081 TDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQ 1140
TDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGL FDAFSSQLCWVDAGTNRAECLNPSQ
Sbjct: 1081 TDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQ 1140
Query: 1141 PSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT 1200
PSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT
Sbjct: 1141 PSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT 1200
Query: 1201 ALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIERK 1247
ALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIERK
Sbjct: 1201 ALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIERK 1247
>emb|CAA57709.1| (X82245) nidogen [Homo sapiens]
Length = 1246
Score = 2536 bits (6500), Expect = 0.0
Identities = 1205/1247 (96%), Positives = 1206/1247 (96%), Gaps = 1/1247 (0%)
Query: 1 MLASSSRIRAAWTRAXXXXXXXAGPVGCLSRQELFPFGPGQXXXXXXXXXXFVSPALELS 60
MLASSSRIRAAWTRA AGPVGCLSRQ FP P + FVSPALELS
Sbjct: 1 MLASSSRIRAAWTRALLLPLLLAGPVGCLSRQSSFPSAPDRDLELEDGDD-FVSPALELS 59
Query: 61 GALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKV 120
GALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKV
Sbjct: 60 GALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKV 119
Query: 121 YYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ 180
YYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ
Sbjct: 120 YYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ 179
Query: 181 AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFA 240
AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFA
Sbjct: 180 AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFA 239
Query: 241 NDRESIENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILXXXXXXXXXXXXXXXXXXX 300
NDRESIENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVIL
Sbjct: 240 NDRESIENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILGTEDGAEYDDEDEDYDLAT 299
Query: 301 TRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF 360
TRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF
Sbjct: 300 TRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF 359
Query: 361 HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTG 420
HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTG
Sbjct: 360 HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTG 419
Query: 421 NGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETV 480
NGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETV
Sbjct: 420 NGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETV 479
Query: 481 GYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI 540
GYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI
Sbjct: 480 GYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI 539
Query: 541 DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGAS 600
DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGAS
Sbjct: 540 DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGAS 599
Query: 601 PSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYAFSNSIGPV 660
PSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYAFSNSIGPV
Sbjct: 600 PSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYAFSNSIGPV 659
Query: 661 REGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
REGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV
Sbjct: 660 REGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 719
Query: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT 780
CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT
Sbjct: 720 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT 779
Query: 781 GGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV 840
GGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV
Sbjct: 780 GGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV 839
Query: 841 PGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVD 900
PGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVD
Sbjct: 840 PGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVD 899
Query: 901 RDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLE 960
RDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLE
Sbjct: 900 RDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLE 959
Query: 961 GNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDL 1020
GNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDL
Sbjct: 960 GNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDL 1019
Query: 1021 GSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYW 1080
GSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYW
Sbjct: 1020 GSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYW 1079
Query: 1081 TDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQ 1140
TDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQ
Sbjct: 1080 TDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQ 1139
Query: 1141 PSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT 1200
PSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT
Sbjct: 1140 PSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT 1199
Query: 1201 ALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIERK 1247
ALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIERK
Sbjct: 1200 ALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIERK 1246
>ref|NP_035047.1| nidogen [Mus musculus]
sp|P10493|NIDO_MOUSE NIDOGEN PRECURSOR (ENTACTIN)
pir||MMMSND nidogen precursor - mouse
emb|CAA32408.1| (X14194) enactin precursor (AA -28 to 1217) [Mus musculus]
prf||1504282A entactin [Mus musculus]
Length = 1245
Score = 2197 bits (5630), Expect = 0.0
Identities = 1036/1247 (83%), Positives = 1100/1247 (88%), Gaps = 2/1247 (0%)
Query: 1 MLASSSRIRAAWTRAXXXXXXXAGPVGCLSRQELFPFGPGQXXXXXXXXXXFVSPALELS 60
ML +S A WT A GP GCL+RQELFPFGPGQ VSP+LEL
Sbjct: 1 MLDASGCSWAMWTWALLQLLLLVGPGGCLNRQELFPFGPGQGDLELEAGDDVVSPSLELI 60
Query: 61 GALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKV 120
G L FYDR+DI +VYVTTNGIIA SEPPA E HPG FPP+FG+VAPFLADLDTTDGLG V
Sbjct: 61 GELSFYDRTDITSVYVTTNGIIAMSEPPATEYHPGTFPPSFGSVAPFLADLDTTDGLGNV 120
Query: 121 YYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ 180
YYREDLSP I Q AAE V RGFPE+SFQP+S VVVTWESVAPY GPS P ++GKRNTFQ
Sbjct: 121 YYREDLSPFIIQMAAEYVQRGFPEVSFQPTSVVVVTWESVAPYGGPSSSPAEEGKRNTFQ 180
Query: 181 AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFA 240
AVLASS+SSSYAIFLYPEDGLQF TTFSKK+ +QVPAVV FS+G VGFLWKSNGAYNIFA
Sbjct: 181 AVLASSNSSSYAIFLYPEDGLQFFTTFSKKDESQVPAVVGFSKGLVGFLWKSNGAYNIFA 240
Query: 241 NDRESIENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILXXXXXXXXXXXXXXXXXXX 300
NDRESIENLAKSSN+G QGVWVFEIGSPAT GVV ADV L
Sbjct: 241 NDRESIENLAKSSNAGHQGVWVFEIGSPATAKGVVSADVNLDLDDDGADYEDEDYDLVT- 299
Query: 301 TRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF 360
+ LGLEDV T S+ RRG D ++VP +LSP ATERP G PTERTRSFQL E F
Sbjct: 300 SHLGLEDVATPSPSHSP-RRGYPDPHNVPRILSPGYEATERPRGVPTERTRSFQLPAERF 358
Query: 361 HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTG 420
Q HPQVIDVDEVEETGVVFSYNT S+QTCANNRHQCSVHAECRDYATGFCC CVA YTG
Sbjct: 359 PQHHPQVIDVDEVEETGVVFSYNTGSQQTCANNRHQCSVHAECRDYATGFCCRCVANYTG 418
Query: 421 NGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETV 480
NGRQCVAEGSPQRVNGKVKGRIFVGSSQVP+VFENTDLHSYVVMNHGRSYTAISTIPETV
Sbjct: 419 NGRQCVAEGSPQRVNGKVKGRIFVGSSQVPVVFENTDLHSYVVMNHGRSYTAISTIPETV 478
Query: 481 GYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI 540
GYSLLPLAP+GGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTF+GHPG LV+KQ+FSGI
Sbjct: 479 GYSLLPLAPIGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFLGHPGKLVLKQQFSGI 538
Query: 541 DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGAS 600
DEHGHLTI TELEGRVPQIP+G+SVHIEPYTELYHYS+SVITSSSTREYTV EP++DGA+
Sbjct: 539 DEHGHLTISTELEGRVPQIPYGASVHIEPYTELYHYSSSVITSSSTREYTVMEPDQDGAA 598
Query: 601 PSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYAFSNSIGPV 660
PS + YQWRQTITFQEC HDD+RPALPSTQQLSVDSVFVLYN+EE+ILRYA SNSIGPV
Sbjct: 599 PSHTHIYQWRQTITFQECAHDDARPALPSTQQLSVDSVFVLYNKEERILRYALSNSIGPV 658
Query: 661 REGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
R+GSPDALQNPCYIGTHGCD+NAACRPGP TQFTCECSIGFRGDG+TCYDIDECSEQPS
Sbjct: 659 RDGSPDALQNPCYIGTHGCDSNAACRPGPGTQFTCECSIGFRGDGQTCYDIDECSEQPSR 718
Query: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT 780
CG+H +CNN PGTFRCECVEGY FSD GTCVA DQRPINYCETGLHNCDIPQRAQCIY
Sbjct: 719 CGNHAVCNNLPGTFRCECVEGYHFSDRGTCVAAEDQRPINYCETGLHNCDIPQRAQCIYM 778
Query: 781 GGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV 840
GGSSYTCSCLPGFSGDG+AC+DVDECQ SRCHPDAFCYNTPGSFTCQCKPGYQGDGFRC+
Sbjct: 779 GGSSYTCSCLPGFSGDGRACRDVDECQHSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCM 838
Query: 841 PGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVD 900
PGEV KTRCQ EREHILGAAG D QRP G+FVP+CD +GHY PTQCH STGYCWCVD
Sbjct: 839 PGEVSKTRCQLEREHILGAAGGADAQRPTLQGMFVPQCDEYGHYVPTQCHHSTGYCWCVD 898
Query: 901 RDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLE 960
RDGRE+EG+RT PGM PPCLSTVAPPIHQGP VPTAVIPLPPGTHLLFAQTGKIERLPLE
Sbjct: 899 RDGRELEGSRTPPGMRPPCLSTVAPPIHQGPVVPTAVIPLPPGTHLLFAQTGKIERLPLE 958
Query: 961 GNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDL 1020
NTM+KTE KAFLH+PAKVIIGLAFDCVDK+VYWTDI+EPSIGRASLHGGEPTTIIRQDL
Sbjct: 959 RNTMKKTERKAFLHIPAKVIIGLAFDCVDKVVYWTDISEPSIGRASLHGGEPTTIIRQDL 1018
Query: 1021 GSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYW 1080
GSPEGIA+DHLGR IFWTDS LDRIEVAK+DGTQRRVLF+T LVNPRGIVTD VRGNLYW
Sbjct: 1019 GSPEGIALDHLGRTIFWTDSQLDRIEVAKMDGTQRRVLFDTGLVNPRGIVTDPVRGNLYW 1078
Query: 1081 TDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQ 1140
TDWNRDNPKIETS+MDGTNRRIL QD+LGLPNGL FDAFSSQLCWVDAGT+RAECLNP+Q
Sbjct: 1079 TDWNRDNPKIETSHMDGTNRRILAQDNLGLPNGLTFDAFSSQLCWVDAGTHRAECLNPAQ 1138
Query: 1141 PSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT 1200
P RRK LEGLQYPFAVTSYGKNLY+TDWK NSV+A+DLAISKE D F PHKQTRLYGIT
Sbjct: 1139 PGRRKVLEGLQYPFAVTSYGKNLYYTDWKTNSVIAMDLAISKEMDTFHPHKQTRLYGITI 1198
Query: 1201 ALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIERK 1247
ALSQCPQGHNYCSVNNGGCTHLCL TPGSRTCRCPDNTLGVDCIERK
Sbjct: 1199 ALSQCPQGHNYCSVNNGGCTHLCLPTPGSRTCRCPDNTLGVDCIERK 1245
>emb|CAA32642.1| (X14480) prenidogen (AA -28 to 1217) [Mus musculus]
Length = 1245
Score = 2194 bits (5622), Expect = 0.0
Identities = 1035/1247 (82%), Positives = 1100/1247 (87%), Gaps = 2/1247 (0%)
Query: 1 MLASSSRIRAAWTRAXXXXXXXAGPVGCLSRQELFPFGPGQXXXXXXXXXXFVSPALELS 60
ML +S A WT A GP GCL+RQELFPFGPGQ VSP+LEL
Sbjct: 1 MLDASGCSWAMWTWALLQLLLLVGPGGCLNRQELFPFGPGQGDLELEAGDDVVSPSLELI 60
Query: 61 GALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKV 120
G L FYDR+DI +VYVTTNGIIA SEPPA E HPG FPP+FG+VAPFLADLDTTDGLG V
Sbjct: 61 GELSFYDRTDITSVYVTTNGIIAMSEPPATEYHPGTFPPSFGSVAPFLADLDTTDGLGNV 120
Query: 121 YYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ 180
YYREDLSP I Q AAE V RGFPE+SFQP+S VVVTWESVAPY GPS ++GKRNTFQ
Sbjct: 121 YYREDLSPFIIQMAAEYVQRGFPEVSFQPTSVVVVTWESVAPYGGPSSSLAEEGKRNTFQ 180
Query: 181 AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFA 240
AVLASS+SSSYAIFLYPEDGLQF TTFSKK+ +QVPAVV FS+G VGFLWKSNGAYNIFA
Sbjct: 181 AVLASSNSSSYAIFLYPEDGLQFFTTFSKKDESQVPAVVGFSKGLVGFLWKSNGAYNIFA 240
Query: 241 NDRESIENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILXXXXXXXXXXXXXXXXXXX 300
NDRESIENLAKSSN+G QGVWVFEIGSPAT GVV ADV L
Sbjct: 241 NDRESIENLAKSSNAGHQGVWVFEIGSPATAKGVVSADVNLDLDDDGADYEDEDYDLVT- 299
Query: 301 TRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF 360
+ LGLEDV T S+ RRG D ++VP +LSP ATERP G PTERTRSFQL E F
Sbjct: 300 SHLGLEDVATPSPSHSP-RRGYPDPHNVPRILSPGYEATERPRGVPTERTRSFQLPAERF 358
Query: 361 HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTG 420
Q HPQVIDVDEVEETGVVFSYNT S+QTCANNRHQCSVHAECRDYATGFCC CVA YTG
Sbjct: 359 PQHHPQVIDVDEVEETGVVFSYNTGSQQTCANNRHQCSVHAECRDYATGFCCRCVANYTG 418
Query: 421 NGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETV 480
NGRQCVAEGSPQRVNGKVKGRIFVGSSQVP+VFENTDLHSYVVMNHGRSYTAISTIPETV
Sbjct: 419 NGRQCVAEGSPQRVNGKVKGRIFVGSSQVPVVFENTDLHSYVVMNHGRSYTAISTIPETV 478
Query: 481 GYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI 540
GYSLLPLAP+GGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTF+GHPG LV+KQ+FSGI
Sbjct: 479 GYSLLPLAPIGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFLGHPGKLVLKQQFSGI 538
Query: 541 DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGAS 600
DEHGHLTI TELEGRVPQIP+G+SVHIEPYTELYHYS+SVITSSSTREYTV EP++DGA+
Sbjct: 539 DEHGHLTISTELEGRVPQIPYGASVHIEPYTELYHYSSSVITSSSTREYTVMEPDQDGAA 598
Query: 601 PSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYAFSNSIGPV 660
PS + YQWRQTITFQEC HDD+RPALPSTQQLSVDSVFVLYN+EE+ILRYA SNSIGPV
Sbjct: 599 PSHTHIYQWRQTITFQECAHDDARPALPSTQQLSVDSVFVLYNKEERILRYALSNSIGPV 658
Query: 661 REGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
++GSPDALQNPCYIGTHGCD+NAACRPGP TQFTCECSIGFRGDG+TCYDIDECSEQPS
Sbjct: 659 KDGSPDALQNPCYIGTHGCDSNAACRPGPGTQFTCECSIGFRGDGQTCYDIDECSEQPSR 718
Query: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT 780
CG+H +CNN PGTFRCECVEGY FSD GTCVA DQRPINYCETGLHNCDIPQRAQCIY
Sbjct: 719 CGNHAVCNNLPGTFRCECVEGYHFSDRGTCVAAEDQRPINYCETGLHNCDIPQRAQCIYM 778
Query: 781 GGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV 840
GGSSYTCSCLPGFSGDG+AC+DVDECQ SRCHPDAFCYNTPGSFTCQCKPGYQGDGFRC+
Sbjct: 779 GGSSYTCSCLPGFSGDGRACRDVDECQHSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCM 838
Query: 841 PGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVD 900
PGEV KTRCQ EREHILGAAG D QRP G+FVP+CD +GHY PTQCH STGYCWCVD
Sbjct: 839 PGEVSKTRCQLEREHILGAAGGADAQRPTLQGMFVPQCDEYGHYVPTQCHHSTGYCWCVD 898
Query: 901 RDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLE 960
RDGRE+EG+RT PGM PPCLSTVAPPIHQGP VPTAVIPLPPGTHLLFAQTGKIERLPLE
Sbjct: 899 RDGRELEGSRTPPGMRPPCLSTVAPPIHQGPVVPTAVIPLPPGTHLLFAQTGKIERLPLE 958
Query: 961 GNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDL 1020
NTM+KTEAKAFLH+PAKVIIGLAFDCVDK+VYWTDI+EPSIGRASLHGGEPTTIIRQDL
Sbjct: 959 RNTMKKTEAKAFLHIPAKVIIGLAFDCVDKVVYWTDISEPSIGRASLHGGEPTTIIRQDL 1018
Query: 1021 GSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYW 1080
GSPEGIA+DHLGR IFWTDS LDRIEVAK+DGTQRRVLF+T LVNPRGIVTD VRGNLYW
Sbjct: 1019 GSPEGIALDHLGRTIFWTDSQLDRIEVAKMDGTQRRVLFDTGLVNPRGIVTDPVRGNLYW 1078
Query: 1081 TDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQ 1140
TDWNRDNPKIETS+MDGTNRRIL QD+LGLPNGL FDAFSSQLCWVDAGT+RAECLNP+Q
Sbjct: 1079 TDWNRDNPKIETSHMDGTNRRILAQDNLGLPNGLTFDAFSSQLCWVDAGTHRAECLNPAQ 1138
Query: 1141 PSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT 1200
P RRK LEGLQYPFAVTSYGKNLY+TDWK NSV+A+DLAISKE D F PHKQTRLYGIT
Sbjct: 1139 PGRRKVLEGLQYPFAVTSYGKNLYYTDWKTNSVIAMDLAISKEMDTFHPHKQTRLYGITI 1198
Query: 1201 ALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIERK 1247
ALSQCPQGHNYCSVNNGGCTHLCL TPGSRTCRCPDNTLGVDCIERK
Sbjct: 1199 ALSQCPQGHNYCSVNNGGCTHLCLPTPGSRTCRCPDNTLGVDCIERK 1245
>gb|AAA57261.1| (M27445) nidogen [Homo sapiens]
Length = 581
Score = 1273 bits (3258), Expect = 0.0
Identities = 580/581 (99%), Positives = 580/581 (99%)
Query: 667 ALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTI 726
ALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTI
Sbjct: 1 ALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTI 60
Query: 727 CNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYT 786
CNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYT
Sbjct: 61 CNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYT 120
Query: 787 CSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEK 846
CSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEK
Sbjct: 121 CSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEK 180
Query: 847 TRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREV 906
TRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREV
Sbjct: 181 TRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREV 240
Query: 907 EGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRK 966
EGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRK
Sbjct: 241 EGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRK 300
Query: 967 TEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGI 1026
TEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGI
Sbjct: 301 TEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGI 360
Query: 1027 AVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRD 1086
AVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRD
Sbjct: 361 AVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRD 420
Query: 1087 NPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKA 1146
NPKIETSYMDGTNRRILVQDDLGLPNGL FDAFSSQLCWVDAGTNRAECLNPSQPSRRKA
Sbjct: 421 NPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKA 480
Query: 1147 LEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCP 1206
LEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCP
Sbjct: 481 LEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCP 540
Query: 1207 QGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIERK 1247
QGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIERK
Sbjct: 541 QGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIERK 581
>sp|Q14112|NID2_HUMAN NIDOGEN-2 PRECURSOR (NID-2) (OSTEONIDOGEN)
emb|CAA11418.1| (AJ223500) nidogen-2 [Homo sapiens]
Length = 1375
Score = 822 bits (2099), Expect = 0.0
Identities = 403/922 (43%), Positives = 552/922 (59%), Gaps = 101/922 (10%)
Query: 371 DEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGS 430
D + VF+YN +++TC +N QCS HA C DYATGFCC C + + GNG+ C+ EG+
Sbjct: 469 DNIGSNTEVFTYNAANKETCEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHCLPEGA 528
Query: 431 PQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPV 490
P RVNGKV G + VG + P+ F + DLH+Y+V N GR+YTAIS IP+ +LLPL P+
Sbjct: 529 PHRVNGKVSGHLHVGHT--PVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPI 586
Query: 491 GGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDT 550
GG+ GW+FA+E+ G +NGFS+ G FT EVTF + I Q G+D +L+I T
Sbjct: 587 GGLFGWLFALEKPGSENGFSLAGAAFTHDMEVTFYPGEETVRITQTAEGLDPENYLSIKT 646
Query: 551 ELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSRIYTYQWR 610
++G+VP +P + HI PY ELYHYS S +TS+S+R+Y++T + ++ ++Y+
Sbjct: 647 NIQGQVPYVPANFTAHISPYKELYHYSDSTVTSTSSRDYSLTF-----GAINQTWSYRIH 701
Query: 611 QTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYAFSNSIGPVREGSPDALQN 670
Q IT+Q C H P+ P+TQQL+VD VF LYN EE++LR+A +N IGPV+E S N
Sbjct: 702 QNITYQVCRHAPRHPSFPTTQQLNVDRVFALYNDEERVLRFAVTNQIGPVKEDSDPTPVN 761
Query: 671 PCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNH 730
PCY G+H CDT A C PG +TCEC+ G++GDGR C D +EC+ CG +++C N
Sbjct: 762 PCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINL 821
Query: 731 PGTFRCECVEGYQFSDEG-TCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSC 789
PG++RCEC GY+F+D+ TC+ + P N CE G H C +A+C++ GGS+++C+C
Sbjct: 822 PGSYRCECRSGYEFADDRHTCILITP--PANPCEDGSHTCAPAGQARCVHHGGSTFSCAC 879
Query: 790 LPGFSGDGQACQDVDE----------------------CQPS------RCHPDAF----- 816
LPG++GDG C DVDE CQP +C PD+
Sbjct: 880 LPGYAGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTP 939
Query: 817 ----------------------------------CYNTPGSFTCQCKPGYQGDGFRCVPG 842
C+ + G C G++ G + PG
Sbjct: 940 CEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPG 999
Query: 843 EVEK-------------TRCQHEREHILGAAGAT--DPQRPIPPGLFVPECDAHGHYAPT 887
T C+ RE++L G T D Q +VP+CD GH+ P
Sbjct: 1000 STPPHCGPSPEPTQRPPTICERWRENLLEHYGGTPRDDQ-------YVPQCDDLGHFIPL 1052
Query: 888 QCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLL 947
QCHG + +CWCVD+DGREV+GTR++PG TP C+ TVAPP+ + P V P GT LL
Sbjct: 1053 QCHGKSDFCWCVDKDGREVQGTRSQPGTTPACIPTVAPPMVR-PTPRPDVTPPSVGTFLL 1111
Query: 948 FAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASL 1007
+ Q +I LPL G ++K AK L + +I+G+ +DC ++MVYWTD+ +I RA L
Sbjct: 1112 YTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGL 1171
Query: 1008 H-GGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNP 1066
G EP TI+ L SPEG+A+DH+ R ++WTDS LD+IE A LDG++R+VLF TDLVNP
Sbjct: 1172 ELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNP 1231
Query: 1067 RGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWV 1126
R I D +RGNLYWTDWNR+ PKIETS +DG NRRIL+ D+GLPNGL FD FS LCW
Sbjct: 1232 RAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWA 1291
Query: 1127 DAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDA 1186
DAGT + EC P RR L+YPF++ SY + Y TDW+ + VV+++ + TD
Sbjct: 1292 DAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDE 1351
Query: 1187 FQPHKQTRLYGITTALSQCPQG 1208
+ P +++ LYGIT CP G
Sbjct: 1352 YLPEQRSHLYGITAVYPYCPTG 1373
Score = 177 bits (444), Expect = 7e-43
Identities = 109/256 (42%), Positives = 142/256 (54%), Gaps = 7/256 (2%)
Query: 29 LSRQELFPFGPGQXXXXXXXXXXFVSPALELSGALRFYDRSDIDAVYVTTNGIIATSEPP 88
L ELFP G S ++L+ L FY+ + +YV TNGII+T + P
Sbjct: 31 LHPDELFPHGESWGDQLLQEGDDESSAVVKLANPLHFYE-ARFSNLYVGTNGIISTQDFP 89
Query: 89 AKESHPGL-FPPTFGAVAPFLADLDTTDGLGKVYYREDLSPSITQRAAECVHRGFPEIS- 146
+ + FP F A+APFLAD+DT+ G G+V YRED SP++ AA V GFP +
Sbjct: 90 RETQYVDYDFPTDFPAIAPFLADIDTSHGRGRVLYREDTSPAVLGLAARYVRAGFPRSAR 149
Query: 147 FQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQAVLASSDSSSYAIFLYPEDGLQFHTT 206
F P+ A + TWE V Y+ R G+ NTFQAVLAS S SYA+FLYP +GLQF T
Sbjct: 150 FTPTHAFLATWEQVGAYEEVKRGALPSGELNTFQAVLASDGSDSYALFLYPANGLQFLGT 209
Query: 207 FSKKENN---QVPAVVAFSQGSVGFLWKSNGAYNIFANDRESIENLAKSSNSGQQGVWVF 263
K+ N Q+PA V F +G L KS G Y + +S++NL + SN G GVW F
Sbjct: 210 RPKESYNVQLQLPARVGFCRGEADDL-KSEGPYFSLTSTEQSVKNLYQLSNLGIPGVWAF 268
Query: 264 EIGSPATTNGVVPADV 279
IGS + + V PA V
Sbjct: 269 HIGSTSPLDNVRPAAV 284
>ref|NP_031387.1| nidogen 2; nidogen 2 (osteonidogen) [Homo sapiens]
pir||G00043 osteonidogen - human
dbj|BAA13087.1| (D86425) osteonidogen [Homo sapiens]
dbj|BAA24112.1| (AB009799) osteonidogen [Homo sapiens]
Length = 1376
Score = 822 bits (2099), Expect = 0.0
Identities = 403/922 (43%), Positives = 552/922 (59%), Gaps = 101/922 (10%)
Query: 371 DEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGS 430
D + VF+YN +++TC +N QCS HA C DYATGFCC C + + GNG+ C+ EG+
Sbjct: 470 DNIGSNTEVFTYNAANKETCEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHCLPEGA 529
Query: 431 PQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPV 490
P RVNGKV G + VG + P+ F + DLH+Y+V N GR+YTAIS IP+ +LLPL P+
Sbjct: 530 PHRVNGKVSGHLHVGHT--PVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPI 587
Query: 491 GGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDT 550
GG+ GW+FA+E+ G +NGFS+ G FT EVTF + I Q G+D +L+I T
Sbjct: 588 GGLFGWLFALEKPGSENGFSLAGAAFTHDMEVTFYPGEETVRITQTAEGLDPENYLSIKT 647
Query: 551 ELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSRIYTYQWR 610
++G+VP +P + HI PY ELYHYS S +TS+S+R+Y++T + ++ ++Y+
Sbjct: 648 NIQGQVPYVPANFTAHISPYKELYHYSDSTVTSTSSRDYSLTF-----GAINQTWSYRIH 702
Query: 611 QTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYAFSNSIGPVREGSPDALQN 670
Q IT+Q C H P+ P+TQQL+VD VF LYN EE++LR+A +N IGPV+E S N
Sbjct: 703 QNITYQVCRHAPRHPSFPTTQQLNVDRVFALYNDEERVLRFAVTNQIGPVKEDSDPTPVN 762
Query: 671 PCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNH 730
PCY G+H CDT A C PG +TCEC+ G++GDGR C D +EC+ CG +++C N
Sbjct: 763 PCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINL 822
Query: 731 PGTFRCECVEGYQFSDEG-TCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSC 789
PG++RCEC GY+F+D+ TC+ + P N CE G H C +A+C++ GGS+++C+C
Sbjct: 823 PGSYRCECRSGYEFADDRHTCILITP--PANPCEDGSHTCAPAGQARCVHHGGSTFSCAC 880
Query: 790 LPGFSGDGQACQDVDE----------------------CQPS------RCHPDAF----- 816
LPG++GDG C DVDE CQP +C PD+
Sbjct: 881 LPGYAGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTP 940
Query: 817 ----------------------------------CYNTPGSFTCQCKPGYQGDGFRCVPG 842
C+ + G C G++ G + PG
Sbjct: 941 CEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPG 1000
Query: 843 EVEK-------------TRCQHEREHILGAAGAT--DPQRPIPPGLFVPECDAHGHYAPT 887
T C+ RE++L G T D Q +VP+CD GH+ P
Sbjct: 1001 STPPHCGPSPEPTQRPPTICERWRENLLEHYGGTPRDDQ-------YVPQCDDLGHFIPL 1053
Query: 888 QCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLL 947
QCHG + +CWCVD+DGREV+GTR++PG TP C+ TVAPP+ + P V P GT LL
Sbjct: 1054 QCHGKSDFCWCVDKDGREVQGTRSQPGTTPACIPTVAPPMVR-PTPRPDVTPPSVGTFLL 1112
Query: 948 FAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASL 1007
+ Q +I LPL G ++K AK L + +I+G+ +DC ++MVYWTD+ +I RA L
Sbjct: 1113 YTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGL 1172
Query: 1008 H-GGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNP 1066
G EP TI+ L SPEG+A+DH+ R ++WTDS LD+IE A LDG++R+VLF TDLVNP
Sbjct: 1173 ELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNP 1232
Query: 1067 RGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWV 1126
R I D +RGNLYWTDWNR+ PKIETS +DG NRRIL+ D+GLPNGL FD FS LCW
Sbjct: 1233 RAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWA 1292
Query: 1127 DAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDA 1186
DAGT + EC P RR L+YPF++ SY + Y TDW+ + VV+++ + TD
Sbjct: 1293 DAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDE 1352
Query: 1187 FQPHKQTRLYGITTALSQCPQG 1208
+ P +++ LYGIT CP G
Sbjct: 1353 YLPEQRSHLYGITAVYPYCPTG 1374
Score = 89.7 bits (219), Expect = 2e-16
Identities = 53/109 (48%), Positives = 66/109 (59%), Gaps = 4/109 (3%)
Query: 174 GKRNTFQAVLASSDSSSYAIFLYPEDGLQFHTTFSKKENN---QVPAVVAFSQGSVGFLW 230
G+ NTFQAVLAS S SYA+FLYP +GLQF T K+ N Q+PA V F +G L
Sbjct: 178 GELNTFQAVLASDGSDSYALFLYPANGLQFLGTRPKESYNVQLQLPARVGFCRGEADDL- 236
Query: 231 KSNGAYNIFANDRESIENLAKSSNSGQQGVWVFEIGSPATTNGVVPADV 279
KS G Y + +S++NL + SN G GVW F IGS + + V PA V
Sbjct: 237 KSEGPYFSLTSTEQSVKNLYQLSNLGIPGVWAFHIGSTSPLDNVRPAAV 285
>gb|AAF44680.1|AF239837_1 (AF239837) nidogen 1; entactin [Gallus gallus]
Length = 474
Score = 804 bits (2055), Expect = 0.0
Identities = 358/474 (75%), Positives = 409/474 (85%), Gaps = 1/474 (0%)
Query: 773 QRAQCIYTGGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGY 832
QRAQC+YTGGS+Y C+CLPGFSGDG+AC+D+DECQ CHPDAFCYNTPGSF+CQCK GY
Sbjct: 1 QRAQCVYTGGSAYICTCLPGFSGDGRACEDIDECQQGHCHPDAFCYNTPGSFSCQCKAGY 60
Query: 833 QGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGS 892
+GDGF+CV G V KT+CQHE+E LG+ G T QR I G F+P+CD HG+Y PTQCHGS
Sbjct: 61 RGDGFQCVLGGVIKTKCQHEKEVALGSGG-TFFQREIRVGQFIPQCDEHGNYVPTQCHGS 119
Query: 893 TGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTG 952
TGYCWCVDRDG E++GTR+ PG+ PPCLST APP+ GP+V IPLPPGTHLLFAQ+G
Sbjct: 120 TGYCWCVDRDGNEIDGTRSGPGVRPPCLSTAAPPVGIGPSVRPDTIPLPPGTHLLFAQSG 179
Query: 953 KIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEP 1012
KIE +PLEGN M+K AKA LH+P KVIIG+A+DC+DKMVYWTDI+ PSI RASLHGGEP
Sbjct: 180 KIEHVPLEGNNMKKNGAKALLHIPDKVIIGVAYDCMDKMVYWTDISGPSISRASLHGGEP 239
Query: 1013 TTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTD 1072
TTIIR DLGSPEGIA+DHLGRNIFWTDS LDRIEVA+LDG QRR+LF+T LVNPR IV D
Sbjct: 240 TTIIRTDLGSPEGIALDHLGRNIFWTDSQLDRIEVARLDGRQRRILFDTGLVNPRAIVVD 299
Query: 1073 SVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNR 1132
VRGNLYWTDWNR+ PKIETSYMDGTNRRILV+DDLGLPNGL FD +SS LCWVDAGT R
Sbjct: 300 PVRGNLYWTDWNREAPKIETSYMDGTNRRILVKDDLGLPNGLTFDPYSSMLCWVDAGTKR 359
Query: 1133 AECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQ 1192
EC+NP+Q RRK +EG+QYPF VTSYGKNLY+TDW+ ++VVA+D IS E D FQPHK+
Sbjct: 360 LECMNPNQLGRRKIVEGIQYPFGVTSYGKNLYYTDWRRDAVVAVDRMISVENDNFQPHKR 419
Query: 1193 TRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIER 1246
+RLYGITTA +QCP GHNYC+VNNGGCTHLCLATP R+CRCPDNT+GVDCIER
Sbjct: 420 SRLYGITTAFAQCPGGHNYCTVNNGGCTHLCLATPEGRSCRCPDNTVGVDCIER 473
Score = 34.4 bits (77), Expect = 7.9
Identities = 15/33 (45%), Positives = 17/33 (51%)
Query: 397 CSVHAECRDYATGFCCSCVAGYTGNGRQCVAEG 429
C A C + F C C AGY G+G QCV G
Sbjct: 39 CHPDAFCYNTPGSFSCQCKAGYRGDGFQCVLGG 71
>ref|NP_032721.1| nidogen 2 [Mus musculus]
sp|O88322|NID2_MOUSE NIDOGEN-2 PRECURSOR (NID-2) (ENTACTIN-2)
dbj|BAA32609.1| (AB017202) entactin-2 [Mus musculus]
Length = 1403
Score = 779 bits (1989), Expect = 0.0
Identities = 391/929 (42%), Positives = 539/929 (57%), Gaps = 110/929 (11%)
Query: 371 DEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGS 430
D V VF+YN + +TC ++ +CS HA C DY TGFCC C + + GNG+ C+ EG+
Sbjct: 492 DHVGFNDQVFTYNGANLETCEHSHGRCSQHAFCTDYTTGFCCHCQSRFYGNGKHCLPEGA 551
Query: 431 PQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPV 490
P RVNGKV GR+ VG +P+ F + DLH+Y+V N GR+YTAIS +P+ +LLP+ P+
Sbjct: 552 PHRVNGKVSGRLRVG--HIPVHFTDVDLHAYIVGNDGRAYTAISHVPQPAAQALLPVLPI 609
Query: 491 GGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGN--LVIKQRFSGIDEHGHLTI 548
GG+ GW+FA+E+ G +NGFS+TG F EVTF HPG + I Q G+D +L+I
Sbjct: 610 GGLFGWLFALEKPGSENGFSLTGATFVHDVEVTF--HPGEERVCITQTAEGLDPENYLSI 667
Query: 549 DTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSRIYTYQ 608
T +EG+VP IP + HI PY E YHY SV+TSSS+R +++T S ++ ++Y
Sbjct: 668 KTNIEGQVPFIPANFTAHITPYKEFYHYRDSVVTSSSSRSFSLTS-----GSINQTWSYH 722
Query: 609 WRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYAFSNSIGPVREGSPDAL 668
Q IT+Q C H A+P+TQQL+VD F LY+++E +LR+A +N IGPV S
Sbjct: 723 IDQNITYQACRHAPRHLAIPATQQLTVDRAFALYSEDEGVLRFAVTNQIGPVEVDSAPVG 782
Query: 669 QNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICN 728
NPCY G+H CDT A C PG +TCEC+ GF+GDGR+C D++EC+ CG +++C
Sbjct: 783 VNPCYDGSHTCDTTARCHPGTGVDYTCECTPGFQGDGRSCVDVNECATGFHRCGPNSVCV 842
Query: 729 NHPGTFRCECVEGYQFSDEG-TCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTC 787
N G++RCEC GY+F+D+ TC+ + P N C G H C +A+CI+ GGSS++C
Sbjct: 843 NLVGSYRCECRSGYEFADDQHTCILIAP--PPNPCFDGSHTCAPEGQARCIHHGGSSFSC 900
Query: 788 SCL---------------------------------------PGFSGDGQACQD------ 802
+CL PG+ GDG C
Sbjct: 901 ACLPGFIGTGHQCSDVDECAENRCHEAAICYNTPGSFSCRCQPGYRGDGFHCTSDTVPED 960
Query: 803 ---------------------------VDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGD 835
+ +C C+ + G C + G++
Sbjct: 961 SISGLKPCEYQQRYAQTQHAYPGSRIHIPQCDDQGNFVPLQCHGSTGFCWCVDRNGHEVP 1020
Query: 836 GFRCVPGEVE-------------KTRCQHEREHILGAAGAT--DPQRPIPPGLFVPECDA 880
G + PG +T C+ RE +L G T D Q +VP+CD
Sbjct: 1021 GTQTPPGSTPPHCGPPPEPTQRPRTVCERWRESLLEHYGGTPRDDQ-------YVPQCDD 1073
Query: 881 HGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPL 940
GH+ P QCHG + +CWCVD+DGRE++GTR++PG P C+ TVAPP+ + P V P
Sbjct: 1074 LGHFIPLQCHGKSDFCWCVDKDGRELQGTRSQPGTRPACIPTVAPPVVR-PTPRPDVTPP 1132
Query: 941 PPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEP 1000
GT LL+AQ +I LP G+ ++K A+ L + +++G+ +DC ++MVYWTD+
Sbjct: 1133 SVGTFLLYAQGQQIGHLPFNGSRLQKDAARTLLSLHGSIVVGIDYDCRERMVYWTDVAGR 1192
Query: 1001 SIGRASLHGG-EPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLF 1059
+I RASL G EP TII L SPEG+A+DH R ++WTDS LD+IE A+LDG++R+VLF
Sbjct: 1193 TISRASLEAGAEPETIITSGLISPEGLAIDHFRRTMYWTDSGLDKIERAELDGSERKVLF 1252
Query: 1060 ETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAF 1119
TDLVNPR I D +RGNLYWTDWNR+ PKIETS +DG NRRIL+ D+GLPNGL FD F
Sbjct: 1253 HTDLVNPRAITVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINKDIGLPNGLTFDPF 1312
Query: 1120 SSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLA 1179
S LCW DAGT + EC P RR L YPF++ SY + Y TDW+ + V++++
Sbjct: 1313 SKLLCWADAGTKKLECTLPDGTGRRVIQNHLNYPFSIVSYADHFYHTDWRRDGVISVNKD 1372
Query: 1180 ISKETDAFQPHKQTRLYGITTALSQCPQG 1208
+ TD F P +++ LYGIT CP G
Sbjct: 1373 SGQFTDEFLPEQRSHLYGITAVYPYCPTG 1401
Score = 178 bits (446), Expect = 4e-43
Identities = 110/260 (42%), Positives = 143/260 (54%), Gaps = 8/260 (3%)
Query: 26 VGCLSRQELFPFGPGQXXXXXXXXXXFVSPALELSGALRFYDRSDIDAVYVTTNGIIATS 85
VG L ELFP+G S A++L+ LRFYD + ++YV TNGII+T
Sbjct: 28 VGALRPDELFPYGESWGDQLLPEGDDESSAAVKLAIPLRFYD-AQFSSLYVGTNGIISTQ 86
Query: 86 EPPAKESH-PGLFPPTFGAVAPFLADLDTTDGLGKVYYREDLSPSITQRAAECVHRGFP- 143
+ P + + FP F A+APFLAD+DT+ G++ YRED S ++ AA V GFP
Sbjct: 87 DFPRETQYVDDDFPTDFPAIAPFLADIDTSHSRGRILYREDTSGAVLSLAARYVRTGFPL 146
Query: 144 -EISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQAVLASSDSSSYAIFLYPEDGLQ 202
SF P+ A + TWE V Y+ SR G+ NTFQAVLAS +S +YA FLYP +GLQ
Sbjct: 147 SGSSFTPTHAFLATWEHVGAYEEVSRGAAPSGELNTFQAVLASDESDTYAFFLYPANGLQ 206
Query: 203 FHTTFSKKENN---QVPAVVAFSQGSVGFLWKSNGAYNIFANDRESIENLAKSSNSGQQG 259
F T K+ N Q+PA V F +G L K Y N + ++NL + SN G G
Sbjct: 207 FFGTRPKESYNVQLQLPARVGFCRGEADDL-KREALYFSLTNTEQFVKNLYQLSNLGIPG 265
Query: 260 VWVFEIGSPATTNGVVPADV 279
VW F IGS + V PA V
Sbjct: 266 VWAFHIGSRFALDNVRPATV 285
>sp|P08460|NIDO_RAT NIDOGEN (ENTACTIN)
pir||S14828 nidogen - rat (fragment)
Length = 324
Score = 483 bits (1231), Expect = e-135
Identities = 241/325 (74%), Positives = 261/325 (80%), Gaps = 1/325 (0%)
Query: 91 ESHPGLFPPTFGAVAPFLADLDTTDGLGKVYYREDLSPSITQRAAECVHRGFPEISFQPS 150
E HPG FPP+FG+VAPFLADLDTTDGLG VYYREDLSP I Q AAE V RGFPE+SFQP+
Sbjct: 1 EFHPGTFPPSFGSVAPFLADLDTTDGLGNVYYREDLSPFIIQMAAEYVQRGFPEVSFQPT 60
Query: 151 SAVVVTWESVAPYQGPSRDPDQKGKRNTFQAVLASSDSSSYAIFLYPEDGLQFHTTFSKK 210
S VVVTWES+APY GPS ++GKRNTFQAVLASS+SSSYAIFLYP+DGLQF TTFSKK
Sbjct: 61 SVVVVTWESMAPYGGPSGSLVEEGKRNTFQAVLASSNSSSYAIFLYPDDGLQFFTTFSKK 120
Query: 211 ENNQVPAVVAFSQGSVGFLWKSNGAYNIFANDRESIENLAKSSNSGQQGVWVFEIGSPAT 270
+ NQVPAVV FS+G GFLWKSNGAYNIFANDRESIENLAKSSN+G QGVWVFEIGSPAT
Sbjct: 121 DENQVPAVVGFSKGLEGFLWKSNGAYNIFANDRESIENLAKSSNAGHQGVWVFEIGSPAT 180
Query: 271 TNGVVPADVILXXXXXXXXXXXXXXXXXXXTRLGLEDVGTTPFSYKALRRGGADTYSVPS 330
GVVPADV L + LGLEDV T PF + RRG D ++VP
Sbjct: 181 AKGVVPADVNL-DVDDDGADYEDEDYDLQTSHLGLEDVATQPFPSHSPRRGYPDPHNVPR 239
Query: 331 VLSPRRAATERPLGPPTERTRSFQLAVETFHQQHPQVIDVDEVEETGVVFSYNTDSRQTC 390
L+P ATERP G PTERT+SFQL VE F Q+HPQVIDVDEVEETGVVFSYNT S+QTC
Sbjct: 240 TLAPSYEATERPHGIPTERTKSFQLPVERFPQKHPQVIDVDEVEETGVVFSYNTGSQQTC 299
Query: 391 ANNRHQCSVHAECRDYATGFCCSCV 415
ANNRHQCSVHAECRDYATGFCC CV
Sbjct: 300 ANNRHQCSVHAECRDYATGFCCRCV 324
>gb|AAA77652.1| (L17324) entactin [Mus musculus]
Length = 250
Score = 370 bits (939), Expect = e-101
Identities = 185/250 (74%), Positives = 200/250 (80%)
Query: 1 MLASSSRIRAAWTRAXXXXXXXAGPVGCLSRQELFPFGPGQXXXXXXXXXXFVSPALELS 60
ML +S A WT A GP GCL+RQELFPFGPGQ VSP+LEL
Sbjct: 1 MLDASGCSWAMWTWALLQLLLLVGPGGCLNRQELFPFGPGQGDLELEAGDDVVSPSLELI 60
Query: 61 GALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKV 120
G L FYDR+DI +VYVTTNGIIA SEPPA E HPG FPP+FG+VAPFLADLDTTDGLG V
Sbjct: 61 GELSFYDRTDITSVYVTTNGIIAMSEPPATEYHPGTFPPSFGSVAPFLADLDTTDGLGNV 120
Query: 121 YYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ 180
YYREDLSP I Q AAE V RGFPE+SFQP+S VVVTWESVAPY GPS P ++GKRNTFQ
Sbjct: 121 YYREDLSPFIIQMAAEYVQRGFPEVSFQPTSVVVVTWESVAPYGGPSSSPAEEGKRNTFQ 180
Query: 181 AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFA 240
AVLASS+SSSYAIFLYPEDGLQF TTFSKK+ +QVPAVV FS+G VGFLWKSNGAYNIFA
Sbjct: 181 AVLASSNSSSYAIFLYPEDGLQFFTTFSKKDESQVPAVVGFSKGLVGFLWKSNGAYNIFA 240
Query: 241 NDRESIENLA 250
NDRESIENLA
Sbjct: 241 NDRESIENLA 250
>gb|AAA41120.1| (M15797) entactin [Rattus norvegicus]
Length = 243
Score = 331 bits (840), Expect = 3e-89
Identities = 169/242 (69%), Positives = 187/242 (76%), Gaps = 1/242 (0%)
Query: 91 ESHPGLFPPTFGAVAPFLADLDTTDGLGKVYYREDLSPSITQRAAECVHRGFPEISFQPS 150
E HPG FPP+FG+VAPFLADLDTTDGLG VYYREDLSP I Q AAE V RGFPE+SFQP+
Sbjct: 1 EFHPGTFPPSFGSVAPFLADLDTTDGLGNVYYREDLSPFIIQMAAEYVQRGFPEVSFQPT 60
Query: 151 SAVVVTWESVAPYQGPSRDPDQKGKRNTFQAVLASSDSSSYAIFLYPEDGLQFHTTFSKK 210
S VVVTWES+AP GPS ++GKRNTFQAVLASS+SSSYAIFLYP+DGLQF TTFSKK
Sbjct: 61 SVVVVTWESMAPCGGPSGSLVEEGKRNTFQAVLASSNSSSYAIFLYPDDGLQFFTTFSKK 120
Query: 211 ENNQVPAVVAFSQGSVGFLWKSNGAYNIFANDRESIENLAKSSNSGQQGVWVFEIGSPAT 270
+ NQVPAVV FS+G GFLWKSNGAYNIFANDRES+E+LAKSSN+G QGVWVFEIGSPAT
Sbjct: 121 DENQVPAVVGFSKGLEGFLWKSNGAYNIFANDRESMEDLAKSSNAGHQGVWVFEIGSPAT 180
Query: 271 TNGVVPADVILXXXXXXXXXXXXXXXXXXXTRLGLEDVGTTPFSYKALRRGGADTYSVPS 330
GVVPADV L + LGLEDV T PF + RRG D ++VP
Sbjct: 181 AKGVVPADVNL-DVDDDGADYEDEDYDLQTSHLGLEDVATQPFPSHSPRRGYPDPHNVPR 239
Query: 331 VL 332
L
Sbjct: 240 TL 241
>pir||T22674 hypothetical protein F54F3.1 - Caenorhabditis elegans
emb|CAB01972.1| (Z79696) Similarity to Mouse nidogen (SW:NIDO_MOUSE)~cDNA EST yk7a9.5
comes from this gene~cDNA EST yk7a9.3 comes from this
gene~cDNA EST yk38f9.3 comes from this gene~cDNA EST
yk38f9.5 comes from this gene~cDNA EST yk33c12.5 comes
from this gene~cDNA >
Length = 1584
Score = 265 bits (670), Expect = 2e-69
Identities = 205/712 (28%), Positives = 310/712 (42%), Gaps = 82/712 (11%)
Query: 574 YHYSTSVITSSSTREYTVTEPE----RDGASPSRIYTYQWRQTITFQECVHDDSRPALPS 629
YH+S + T Y E AS + R F +CV++ R + +
Sbjct: 913 YHHSLGYYQCACTEPYVGNGVECTLPGSSASAPELGCDVTRDCSEFADCVYE--RSSTGA 970
Query: 630 TQQLSVDSVFV---LYNQEEKILRYAFSNSIGPVREGSPDALQNPCYIGTHGCDTNAACR 686
T + S + Y + ++ A S S+ P P + T C+ N C
Sbjct: 971 TFRCVCQSGYTGDGKYCMQSQLAISAISPSV-------PQLPSEPAVLSTASCNPN--CG 1021
Query: 687 PGPRT-------QFTCECSIGFRGDGRTCYDIDECS---EQPSVC--------GSHTICN 728
P + Q+ CEC F GDG C + + + QP C H + N
Sbjct: 1022 PDAQCVYDDHNRQYRCECYAAFMGDGYNCVPLAKPNMVPAQPKTCVESSDCHINGHCVIN 1081
Query: 729 NH-PGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGG-SSYT 786
H G + C+C+ G FS +G ++ R + C + Q A C+Y +++
Sbjct: 1082 EHGAGEYICQCLPG--FSGDG----FINCRGADQCNPSNPSACY-QNAHCVYDAILNAHA 1134
Query: 787 CSCLPGFSGDGQAC---QDVDEC--QPSRCHPDAFC--YNTPGSFTCQCKPGYQGDGF-R 838
C C+ GF GDG +C C +P CH +A C ++ ++ C CKPG GDG+ +
Sbjct: 1135 CKCVDGFKGDGTSCVPYAPATNCNLEPRICHANAQCVMHHDTNAYECICKPGSSGDGYTK 1194
Query: 839 CVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDA----HGHYAPTQCHGSTG 894
C +E RC + H A T G + +C+A +GH +
Sbjct: 1195 C--DVIETPRCTNCSIHAYCAQNPTS-------GAYQCKCNAGYNGNGHLCVSMSS---- 1241
Query: 895 YCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKI 954
C+D E PG + H G + LL A+ I
Sbjct: 1242 ---CLDDRSLCDENADCVPGEAGHYVCNCHYGYH-GDGRSCSPESSTRSDKLLVARGMAI 1297
Query: 955 ERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTT 1014
E +T K + +P + +G+ FDC ++ + W+D++ SI +SL+G E +
Sbjct: 1298 ----FERSTNPDEYGKQLIVIPHHIPVGIDFDCKEEKIVWSDMSGHSIRTSSLNGTEHKS 1353
Query: 1015 IIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSV 1074
++L SPEGIAVD RN+++ DS D I VA L+G ++ L LVNPR +V D
Sbjct: 1354 YFNKELSSPEGIAVDWSSRNVYYADSMNDEIGVASLNGKFKKSLVTEGLVNPRSVVLDLY 1413
Query: 1075 RGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAE 1134
+LY++DW+R+NP I MDG N R+ + +D+ LPNGL +LCWVDAG +R
Sbjct: 1414 GRHLYYSDWHRENPYIGRVDMDGKNNRVFLNEDVHLPNGLTILPNRRELCWVDAGNHRLS 1473
Query: 1135 CLNPSQPSRRKALEGLQYPFAVT-SYGKNLYFTDWKMNSVVALDLAISKETDAFQPH--K 1191
C+ + RR LQYPF +T + Y+TDWK N + ++ + + +FQ
Sbjct: 1474 CIQYNGAGRRTVFSSLQYPFGLTHDEEQKFYWTDWKDNRIHSVGV-YGEGYRSFQISLGG 1532
Query: 1192 QTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDC 1243
+++GI C CS +NGGC HLCL C CPDN C
Sbjct: 1533 SGKVFGILAVPKSCVGPSTPCSEDNGGCQHLCLPGQNGAVCECPDNVKVKGC 1584
Score = 214 bits (539), Expect = 5e-54
Identities = 173/626 (27%), Positives = 264/626 (41%), Gaps = 115/626 (18%)
Query: 356 AVETFHQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQ-CSVHAECRDYATGFCCSC 414
A E HQQH Q D+ ++ + + +C+ + C ++ C+D+ GFCC+C
Sbjct: 329 AQEQHHQQHHQP---DQPQQQPQRSQEGSLPKMSCSQRDDKSCHANSVCQDFEGGFCCNC 385
Query: 415 VAGYTGNGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAIS 474
G+ GNG++C+ +G PQR++G +G I +++PI + T+LH++ G +TA+S
Sbjct: 386 DTGFYGNGKECLPKGEPQRISGSFEGVI----NRIPI--DKTELHTFATSTDGNVHTAVS 439
Query: 475 TIPETVGYSLLPLAPVGGIIGWMFA-VEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVI 533
IP +G+ L L +GG++GW+FA V+ NGF +TGG F R + + + I
Sbjct: 440 KIPSDLGHPLRFLYSIGGVMGWLFADVQSPNVYNGFQLTGGLFNRTVAL-HIEQNYYVTI 498
Query: 534 KQRFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELY-HYSTSVITSSSTREYTVT 592
KQ FSG + H + + G +P I GS V Y E Y +TS + + V
Sbjct: 499 KQEFSGRNIHDYFKSHLFVSGTLPDIAPGSEVIFPDYEEEYVRERRGYLTSKAAFDVIV- 557
Query: 593 EPERDGASPSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYA 652
RDG + + Y Q ITF+EC + + + +L V + V+YN +E ++RY
Sbjct: 558 ---RDGGN-VQTYRMSVDQQITFEECPNKEF--DRDHSMKLHVKRINVVYNDDEGVVRYG 611
Query: 653 FSN----SIGPVREG-------------SPDALQNPCYI--GTHGCDTNAACRPGPR--- 690
N S+GP S A + P I + T++ C PG
Sbjct: 612 AKNFATRSVGPAVSAPSGGHFDRRQHGQSNMASERPIEIPSQSESISTDSVCAPGRHQCT 671
Query: 691 ----------TQFTCECSIGFRGD-------GRTCYDIDECSEQPSVCGSHTICNNHPGT 733
+ CEC G++ G C D+DEC C H C N PG+
Sbjct: 672 LPNMKCRVVDPSYRCECEPGYQAAHDASSHIGWICQDLDECQRGDHNCDQHAKCTNRPGS 731
Query: 734 FRCECVEGYQFSDEGTCV------------------AVVDQRPINYCETGLHNCDIPQRA 775
F C+C++GYQ D +C+ A V +C T + C Q
Sbjct: 732 FSCQCLQGYQ-GDGRSCIREHQASHHEHNQQTPQEMAGVGATTEGFC-TAHNQCH--QWG 787
Query: 776 QCIYTG-GSSYTCSCLPGFSGDG-QACQDVDECQPSR----------------CHPDAFC 817
+C++T + C C + GDG C +E P C +A C
Sbjct: 788 ECVFTSEHPTGRCKCRGWYVGDGVNHCGPPEENMPKHNANIPQRGGQACGSYVCDVNAEC 847
Query: 818 YNTP-GSFTCQCKPGYQGDGFRCV----PGEVEKTRCQHEREHILGAAGATDPQRPIPPG 872
P G C CK G+ G+G C + +HE++ G+ G
Sbjct: 848 MPEPSGGSECVCKAGFSGNGVTCESLLDDRHAHSSHNRHEQQQQTGSLGKVCRSH----- 902
Query: 873 LFVPECDAHGHYAPTQCHGSTGYCWC 898
EC HG A H S GY C
Sbjct: 903 ---DECSEHGSCA---YHHSLGYYQC 922
Score = 57.8 bits (137), Expect = 7e-07
Identities = 53/226 (23%), Positives = 79/226 (34%), Gaps = 34/226 (15%)
Query: 655 NSIGPVREGSPDALQN-------PCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRT 707
N GP E P N C G++ CD NA C P P C C GF G+G T
Sbjct: 812 NHCGPPEENMPKHNANIPQRGGQAC--GSYVCDVNAECMPEPSGGSECVCKAGFSGNGVT 869
Query: 708 CYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLH 767
C + + S H G+ C + S+ G+C + Y +
Sbjct: 870 CESLLDDRHAHSSHNRHEQ-QQQTGSLGKVCRSHDECSEHGSCAY---HHSLGYYQCACT 925
Query: 768 NCDIPQRAQCIYTGGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQ 827
+ +C G S+ + D C + +C R +T +F C
Sbjct: 926 EPYVGNGVECTLPGSSASAPELGCDVTRD---CSEFADCVYERS-------STGATFRCV 975
Query: 828 CKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGL 873
C+ GY GDG C+ ++ + A + PQ P P +
Sbjct: 976 CQSGYTGDGKYCMQSQL-----------AISAISPSVPQLPSEPAV 1010
Score = 39.5 bits (90), Expect = 0.24
Identities = 33/133 (24%), Positives = 55/133 (40%), Gaps = 15/133 (11%)
Query: 66 YDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKVYYRED 125
Y +D ++++ NGI+ +P E GL + A+A F + T G+ D
Sbjct: 54 YMEQSVDELFLSHNGIVGLGKP-TPEKIGGLMTISTPAIAVFYVPV--TSGVIDYRVSSD 110
Query: 126 LSPSITQRAAECVHRGFPEISFQPSSAVVVTWESV--APYQGPSRDPDQKGKRNTFQAVL 183
+T+ + + F AV++TW + A GP+ +FQ +
Sbjct: 111 DQGLLTKLTQDVKQVFADAVEFHGLQAVIITWTQIENAEKDGPA----------SFQLAI 160
Query: 184 ASSDSSSYAIFLY 196
S S+YAIF Y
Sbjct: 161 VSDGISTYAIFRY 173
Score = 38.3 bits (87), Expect = 0.53
Identities = 17/36 (47%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 397 CSVHAECRDYATG--FCCSCVAGYTGNGRQCVAEGS 430
CS+HA C T + C C AGY GNG CV+ S
Sbjct: 1206 CSIHAYCAQNPTSGAYQCKCNAGYNGNGHLCVSMSS 1241
Score = 37.5 bits (85), Expect = 0.91
Identities = 17/46 (36%), Positives = 25/46 (53%), Gaps = 1/46 (2%)
Query: 386 SRQTCANNRHQCSVHAECRDYATG-FCCSCVAGYTGNGRQCVAEGS 430
S +C ++R C +A+C G + C+C GY G+GR C E S
Sbjct: 1238 SMSSCLDDRSLCDENADCVPGEAGHYVCNCHYGYHGDGRSCSPESS 1283
>pir||S31213 nidogen precursor - sea squirt (Halocynthia roretzi)
dbj|BAA03127.1| (D14038) entactin/nidogen [Halocynthia roretzi]
Length = 1161
Score = 261 bits (661), Expect = 3e-68
Identities = 146/395 (36%), Positives = 206/395 (51%), Gaps = 34/395 (8%)
Query: 873 LFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPA 932
LFV +C G Y P QC S YC+CVDR+G E+ +R + + ++ P
Sbjct: 770 LFVVQCKPDGEYLPRQCVAS--YCFCVDRNGLEISNSRVETRIAGIGVDLDCQDFNE-PI 826
Query: 933 VPTAVIP------------------LPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLH 974
+P V+P +P L+FAQ+ I L R+T A+
Sbjct: 827 IPDIVVPEVVVTQVPDREPEVPRQRIPESGKLIFAQSMGINIADLP--ITRETAAQRLYG 884
Query: 975 VPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHG-GEPTTIIRQDLGSPEGIAVDHLGR 1033
+ IGL +DC +KM YW+ + + +I A L G G + I+ L SPEGIAVD +
Sbjct: 885 RYDQTPIGLTYDCTNKMYYWSSVVKRAIYSAELEGDGSHSVIVNSKLRSPEGIAVDFISG 944
Query: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
N++W DS DRIEV+ DG+ R L + L+NPRGI D G LYWTDW R +PKI +
Sbjct: 945 NLYWADSEYDRIEVSNTDGSNRMTLIDEGLMNPRGIAVDPFHGRLYWTDWYRKSPKIMMA 1004
Query: 1094 YMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL----EG 1149
MDG+N + + + L LPN + D ++ ++C++DAGT R EC+N RR
Sbjct: 1005 DMDGSNVQTIASEGLELPNDITIDFYNEKVCFIDAGTKRVECMNLDGSGRRTIYVLPSPP 1064
Query: 1150 LQYPFAVTSYGKNLYFTDWK-MNSVVALDLAISKETDAFQP---HKQTRLYGITTALSQC 1205
Q+PF + G L+++ W+ V A++ P H QT YGI SQC
Sbjct: 1065 KQHPFGLAIDGDVLFYSTWRGSKEVHAVNWRTGDNVAISGPRGTHGQT--YGIAVVHSQC 1122
Query: 1206 PQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLG 1240
P+G+NYC +NGGC+HLCL TP R C+CP + G
Sbjct: 1123 PRGYNYCGQDNGGCSHLCLPTPYGRVCKCPPDAFG 1157
Score = 110 bits (273), Expect = 8e-23
Identities = 80/294 (27%), Positives = 128/294 (43%), Gaps = 24/294 (8%)
Query: 372 EVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGSP 431
+V E +N D C CS CR+ GFCC C GY GNG+ C+ +
Sbjct: 256 QVSEVNFNEDFNIDLEAECGT---PCSDFGTCREVGNGFCCVCDEGYFGNGQVCIEKDIA 312
Query: 432 QRVNGKVKGRIFVGSSQVPIVFENT---DLHSYVVMNHGRSYTAIS-TIPETVGYSLLPL 487
R NG+V G V + E DLH YVV + GR++T ++ + + SL P+
Sbjct: 313 VRYNGQVSGYSIVLNHDNSWSNETAGAIDLHGYVVTSEGRAFTVLNGNLSPALARSLQPM 372
Query: 488 APVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI--DEHG- 544
G +GW+F+ NG +GG+ + + + I Q++ + DE G
Sbjct: 373 TIFGTTLGWLFSKTTQPAINGVQYSGGKVSSHTYIRYTTGAYEFRIDQKYDRVVSDESGV 432
Query: 545 --HLTIDTELEGRVPQIPFGSSVHIEPYTELY-HYSTSVITSSSTREYTVTEPERDGASP 601
L GR+P + +V I+ Y+++Y +I + TR YTV
Sbjct: 433 GKVLNGKMTFRGRLPAVGEKDTVTIDDYSQVYTKTGPGIIRTHDTRSYTVR--------- 483
Query: 602 SRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYAFSN 655
+ ++Y QTI F+ C ++ +P + V ++ Y E LR+A +N
Sbjct: 484 NVTHSYTVDQTIKFEGC--EERFAEVPDENIVKVSHIYAEYVTSEANLRFAMNN 535
Score = 89.3 bits (218), Expect = 2e-16
Identities = 71/215 (33%), Positives = 102/215 (47%), Gaps = 29/215 (13%)
Query: 54 SPALELSGALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDT 113
SP +LS + FYD+ D+V V T+G I A L +APF++DLDT
Sbjct: 42 SPQQKLSMPIVFYDQK-YDSVTVHTDGFITLENVGADTDGEVL-------LAPFMSDLDT 93
Query: 114 TDGLGKVYYREDLSPSITQRAAECVHRGFPEIS--FQPSSAVVVTWESVAPYQGPSRDPD 171
+ G +++RE + RA V F E + F S VVTW+ V Q SR+
Sbjct: 94 -ELSGDIFFREHKDNATIARANTDVREAFIETAGDFNAGSVFVVTWDKV---QSASRED- 148
Query: 172 QKGKRNTFQAVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWK 231
G TFQ ++A+ ++++AIFLYP+DGL K N+V A F+ G L
Sbjct: 149 --GVTFTFQCIVATDGAATFAIFLYPQDGLAVGENAVKGVRNEVTARAGFNDGGREQL-- 204
Query: 232 SNGAYNIFANDRESIENLAKSSNSGQQGVWVFEIG 266
+ S + L N+G QG W+F+IG
Sbjct: 205 ----------EILSADELLGGDNAGSQGQWIFQIG 229
Score = 52.7 bits (124), Expect = 2e-05
Identities = 36/104 (34%), Positives = 46/104 (43%), Gaps = 15/104 (14%)
Query: 840 VPGEVEKTR---------CQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCH 890
VP E E T+ C+ E + A D + I +F P C G +AP QC
Sbjct: 585 VPEEFEPTKPTFTEPMTVCERELQE---AERMRDLGKEIADEIFFPTCTNLGTFAPRQCT 641
Query: 891 GSTGYCWCVDRD-GREVEGTRTRP--GMTPPCLSTVAPPIHQGP 931
CWCVD+D G E++GTR+ P G C PP Q P
Sbjct: 642 TYDSVCWCVDQDSGVEIDGTRSLPREGYGLDCSDVRPPPPSQTP 685
>gb|AAF58809.1| (AE003830) CG12908 gene product [Drosophila melanogaster]
Length = 1352
Score = 260 bits (657), Expect = 8e-68
Identities = 191/630 (30%), Positives = 274/630 (43%), Gaps = 118/630 (18%)
Query: 662 EGSPDALQNPCYIGTHGCDTNAACR-PGPRTQFTCECSIGFRGDGRTCYDI--DECSEQP 718
+G +A PC + + C NA C G + C C GFRGDG C I D C+ +P
Sbjct: 782 DGERNADLIPCDVDEN-CHINATCNWYGQELRHICTCQPGFRGDGYNCDPISDDSCAIRP 840
Query: 719 SVCGSHTIC--NNHPGTFRCECVEGYQFSDEGTCVAVVDQRPIN-----YCETGLHNC-- 769
+C H C H G C+C GY + +A Q + +C+ G+ C
Sbjct: 841 DICDVHADCVYEEHLGKSECQCQAGYTGNGFNCQLAAECQSAEHCGENAFCDDGVCRCQA 900
Query: 770 ----DIPQRA----QC--IYTGGSSYT----------CSCLPGFSGDG-QACQDVDECQP 808
D+ R +C ++ G ++ C CL G+ GD C +P
Sbjct: 901 DFERDVSDRCVPAGRCGSVFCGSNAICKWDSAEGVQYCDCLDGYQGDALTGCTS----KP 956
Query: 809 SRCHP------DAFCYNT--PGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAA 860
CH A C T P ++ CQC G++GDG+ C+ E+ C +
Sbjct: 957 LSCHVLNNCGIHATCEPTEDPANYECQCIAGFKGDGYVCI----EEQNCLNN-------- 1004
Query: 861 GATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCL 920
P L CD + QC + CV G G+ +
Sbjct: 1005 ----------PTL----CDMNA-----QCRSTNSGLVCVCNQGFFGNGSLCQERQ----- 1040
Query: 921 STVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVI 980
HQ L+ +Q I R+PL G +R A++
Sbjct: 1041 -------HQD------------SDFLIVSQGVMIARVPLNGRNVRPISV-------AQMA 1074
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGE--PTTIIRQDLGSPEGIAVDHLGRNIFWT 1038
IGL DCV+ VYW DI+ I G + P +++ SPEGIA+D + R ++W
Sbjct: 1075 IGLDKDCVEGRVYWGDISTKKIVSTKYDGTDLRPFITTGRNIESPEGIAIDVISRRLYWA 1134
Query: 1039 DSNLDRIEVAKLDGTQ-RRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 1097
DS D IEVA LD R V+ LVNPRGI D R L+W+DW+R++PKIE S +DG
Sbjct: 1135 DSAKDTIEVASLDDPSLRAVIINKQLVNPRGIAVDPYREKLFWSDWDRESPKIEMSNLDG 1194
Query: 1098 TNRRILV-QDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAV 1156
T R +L+ +DD+ LPN L S ++C+ DAGT + EC+ P R L YPF +
Sbjct: 1195 TGRELLLGKDDVTLPNSLVVLENSGEVCYADAGTKKVECIEPQNRQIRTISNELSYPFGI 1254
Query: 1157 TSYGKNLYFTDWKMNSVVALDLAISKETDAFQP-HKQTRLYGITTALSQCPQGHNYCSVN 1215
T Y+TDW V +D +++T P ++YG+T CPQ + C ++
Sbjct: 1255 TFTHDQFYWTDWTTKKVEIVDSLGARQTPIQPPFFGSHKMYGMTVVEQHCPQYQSPCQIS 1314
Query: 1216 NGGCT--HLCLA---TPGSRTCRCPDNTLG 1240
NGGCT LCL P ++C+C + G
Sbjct: 1315 NGGCTDSRLCLVNRQAPSGKSCKCTSASTG 1344
Score = 195 bits (491), Expect = 2e-48
Identities = 143/492 (29%), Positives = 213/492 (43%), Gaps = 64/492 (13%)
Query: 389 TCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGSPQRVNGKVKGRIFVGSSQ 448
+C + HQC AEC D A G+CC C +G+ GNG+ C+A P RV G + G + ++
Sbjct: 284 SCQAHAHQCHEKAECHDKAEGYCCVCGSGFYGNGKSCLANDQPIRVTGTLTGEL----NK 339
Query: 449 VPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNG 508
P V E L SYVV + GR+YT I+ + +G L + P+ + W+FA G NG
Sbjct: 340 QP-VSEEAKLQSYVVTSEGRTYTTINPLTPELGAQLRLVLPLLTTVPWLFAKSVGGVANG 398
Query: 509 FSITGGEFTRQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIE 568
+ +TGG +T + + F NL + Q F G++ L++ E+ G VP + + + +
Sbjct: 399 YQLTGGVYTHVSRLQF-DSGENLHVNQTFEGLNYWDQLSVKIEIYGEVPAVAADAVLILP 457
Query: 569 PYTELYHYS-TSVITSSSTREYTVTEPERDGASPSRIYTYQWRQTITFQECVHDDSRPAL 627
Y E Y + + S +TE + R+ Q Q I ++ C+ DD
Sbjct: 458 DYVEEYTFERPGELKSVQVLNINITEEQ-------RVLGLQVEQRILYRSCLRDDEADPS 510
Query: 628 PSTQQLSVDSVFVLYNQEEKILRYAFSNSIGPVREGSPDALQNPCYIGTHGCDTNAACRP 687
+ + V + Y + ++ LR + +G E N C GT C N+ C P
Sbjct: 511 ATKVLQKISKVALDYVERDQALRIGAMSKVGVTPE------SNACNDGTADCVENSVCVP 564
Query: 688 GPRTQFTCECSIGFRG--DGR---TCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGY 742
T + C+C GF D R C DIDEC+ VC + +C+N G F C C EG+
Sbjct: 565 YEDT-YRCDCYHGFAAQLDERGVEVCLDIDECATGSHVCDENAVCDNTEGGFNCYCTEGF 623
Query: 743 QFSDEGTCVAVVDQRPINY-----------CETGLHNCDIP--------QRAQCIYTGGS 783
+ + C++ I Y E + P +R Y +
Sbjct: 624 E-GNGYRCLSNSTADNIEYPPAVEGQAEPTSEPSPNPSPYPDQGQDQEREREDDQYPQPN 682
Query: 784 SYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV--- 840
Y + Q Q DEC RC DA CY C C G+ GDG+ C
Sbjct: 683 PYPYP-------EEQIPQHPDECY--RCSKDADCYQG----RCTCHEGFDGDGYTCTNIC 729
Query: 841 -PGEV-EKTRCQ 850
GEV E RC+
Sbjct: 730 GHGEVWENGRCE 741
Score = 79.2 bits (192), Expect = 3e-13
Identities = 60/214 (28%), Positives = 101/214 (47%), Gaps = 21/214 (9%)
Query: 57 LELSGALRFYDRSDIDAVYVTTNGIIA-TSEPPAKESHPGLFPPTFGAVAPFLADLDTT- 114
L+L + FY + +Y+ TNGI+ SE P + P FP + ++A F +++DT+
Sbjct: 60 LQLEQPIHFYGEQ-YEQLYINTNGILTFNSEFPEYLNQP--FPLEYASIAAFYSNVDTSF 116
Query: 115 -DGLGKVYYREDLSPSITQRAAECVHRGFPEIS-FQPSSAVVVTWESVAPYQGPSRDPDQ 172
D + E SI RA+ V F S F+ +V TW +V + D
Sbjct: 117 SDEGTSISLFESKEQSILDRASSLVRYAFSSQSEFEARQVIVATWRNVGYF-------DS 169
Query: 173 KGKR-NTFQAVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWK 231
K R NTFQ L +++ S++ F+YP+ GL + + + + GF+ +
Sbjct: 170 KTDRLNTFQVALIANEQSTFVQFIYPDGGLNW------LQGETAGLGLPDIRAQAGFVAE 223
Query: 232 SNGAYNIFANDRESIENLAKSSNSGQQGVWVFEI 265
Y + + E+ L++S+N G GVW+FE+
Sbjct: 224 DGRFYTLNGSGSENARFLSESTNLGVPGVWLFEV 257
Score = 53.5 bits (126), Expect = 1e-05
Identities = 50/169 (29%), Positives = 67/169 (39%), Gaps = 45/169 (26%)
Query: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCEC 738
C +A C G C C GF GDG TC +I CG + N RCE
Sbjct: 701 CSKDADCYQG-----RCTCHEGFDGDGYTCTNI---------CGHGEVWENG----RCEP 742
Query: 739 VEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGDGQ 798
+ + + C A+ + R C G + QR C+ + F G+
Sbjct: 743 LLLERHDVDPLCDALGECR----CPYGYELSEDSQR------------CTYVQEFDGERN 786
Query: 799 A----CQDVDECQPSRCHPDAFC--YNTPGSFTCQCKPGYQGDGFRCVP 841
A C DVDE CH +A C Y C C+PG++GDG+ C P
Sbjct: 787 ADLIPC-DVDE----NCHINATCNWYGQELRHICTCQPGFRGDGYNCDP 830
Score = 43.4 bits (100), Expect = 0.016
Identities = 19/63 (30%), Positives = 31/63 (49%), Gaps = 3/63 (4%)
Query: 372 EVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGSP 431
+++E GV + D CA H C +A C + GF C C G+ GNG +C++ +
Sbjct: 580 QLDERGVEVCLDIDE---CATGSHVCDENAVCDNTEGGFNCYCTEGFEGNGYRCLSNSTA 636
Query: 432 QRV 434
+
Sbjct: 637 DNI 639
Score = 41.4 bits (95), Expect = 0.061
Identities = 16/38 (42%), Positives = 21/38 (55%)
Query: 388 QTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQC 425
Q C NN C ++A+CR +G C C G+ GNG C
Sbjct: 999 QNCLNNPTLCDMNAQCRSTNSGLVCVCNQGFFGNGSLC 1036
Score = 39.5 bits (90), Expect = 0.24
Identities = 21/48 (43%), Positives = 25/48 (51%), Gaps = 4/48 (8%)
Query: 382 YNTD--SRQTCANNRHQCSVHAEC--RDYATGFCCSCVAGYTGNGRQC 425
YN D S +CA C VHA+C ++ C C AGYTGNG C
Sbjct: 826 YNCDPISDDSCAIRPDICDVHADCVYEEHLGKSECQCQAGYTGNGFNC 873
>dbj|BAA32468.1| (AB011540) MEGF7 [Homo sapiens]
Length = 1576
Score = 202 bits (509), Expect = 2e-50
Identities = 111/305 (36%), Positives = 164/305 (53%), Gaps = 11/305 (3%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKV---IIGLAFDCVDKMVYWTDIT 998
P T+LLF+ G I R+ L+ T +HVP +I L +D VD VY+TD+
Sbjct: 1023 PETYLLFSSRGSIRRISLD------TSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVF 1076
Query: 999 EPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVL 1058
I RA L+G T+I + L + +G+AVD + RN++WTD+ + IE ++LDG+ R+VL
Sbjct: 1077 LDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVL 1136
Query: 1059 FETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDA 1118
L PR I +G L+WTDW KIE + +DG+ R++L+ DLG PNGL D
Sbjct: 1137 INNSLDEPRAIAVFPRKGYLFWTDWGH-IAKIERANLDGSERKVLINTDLGWPNGLTLDY 1195
Query: 1119 FSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDL 1178
+ ++ WVDA +R E + + R+ + + +PFA+T + +Y+TDW+ S+ +D
Sbjct: 1196 DTRRIYWVDAHLDRIESADLNGKLRQVLVGHVSHPFALTQQDRWIYWTDWQTKSIQRVDK 1255
Query: 1179 AISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNT 1238
+ + + + L I Q G N C VNNGGCTHLC A C CPD
Sbjct: 1256 YSGRNKETVLANVE-GLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFVCACPDEP 1314
Query: 1239 LGVDC 1243
C
Sbjct: 1315 DSQPC 1319
Score = 191 bits (481), Expect = 3e-47
Identities = 103/266 (38%), Positives = 152/266 (56%), Gaps = 8/266 (3%)
Query: 973 LHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLG 1032
+++ K I + D + VYW+D T I RA+L G + II L + +G+AVD +G
Sbjct: 747 INITMKNTIAVGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIG 806
Query: 1033 RNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIET 1092
R ++WTD+ +RIEV LDG+ R+VL +L +PR IV G +YWTDW +N K+E
Sbjct: 807 RKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWG-ENAKLER 865
Query: 1093 SYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQY 1152
S MDG++R +L+ ++LG PNGL D SSQL W DA T R E + + +R + +Q+
Sbjct: 866 SGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQH 925
Query: 1153 PFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGI--TTALSQC-PQGH 1209
P+ +T +Y+TDW+ S+ D K T + ++ L G+ A+ + P G
Sbjct: 926 PYGLTLLDSYIYWTDWQTRSIHRAD----KGTGSNVILVRSNLPGLMDMQAVDRAQPLGF 981
Query: 1210 NYCSVNNGGCTHLCLATPGSRTCRCP 1235
N C NGGC+HLCL P +C CP
Sbjct: 982 NKCGSRNGGCSHLCLPRPSGFSCACP 1007
Score = 186 bits (467), Expect = 1e-45
Identities = 102/257 (39%), Positives = 142/257 (54%), Gaps = 4/257 (1%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
I L F ++V+W+D+T I RA+L+G ++ L SP G+AVD + ++WTDS
Sbjct: 142 IALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDS 201
Query: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
RIEVA LDG R+VL +L PR I + G +YWTDW + P+IE S MDG+ R
Sbjct: 202 GTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWG-NTPRIEASSMDGSGR 260
Query: 1101 RILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL--EGLQYPFAVTS 1158
RI+ L PNGL D ++ WVDA + E N S RKA+ +GL +PFA+T
Sbjct: 261 RIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERAN-LDGSHRKAVISQGLPHPFAITV 319
Query: 1159 YGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGG 1218
+ +LY+TDW S+ + + K + + + T + P G N C NNGG
Sbjct: 320 FEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGG 379
Query: 1219 CTHLCLATPGSRTCRCP 1235
CTHLCL + + TC CP
Sbjct: 380 CTHLCLPSGQNYTCACP 396
Score = 183 bits (460), Expect = 1e-44
Identities = 103/294 (35%), Positives = 154/294 (52%), Gaps = 10/294 (3%)
Query: 946 LLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRA 1005
LLFA+ I R+ + + + + L +D D VYWTD++ +I RA
Sbjct: 415 LLFARRMDIRRISFDTEDLSDDVIPL---ADVRSAVALDWDSRDDHVYWTDVSTDTISRA 471
Query: 1006 SLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVN 1065
G ++ L SP G+A+D + ++WTD+ DRIEVA DG+ R VL +L
Sbjct: 472 KWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDR 531
Query: 1066 PRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCW 1125
PR IV + + G +YWTDW +PKIE + MD + R++++ +L PNGL D S +L W
Sbjct: 532 PRDIVVEPMGGYMYWTDWGA-SPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYW 590
Query: 1126 VDAGTNRAECLNPSQPSRRKALEG--LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKE 1183
DAG E S+RK L G L +PF +T YG+ +Y+TDW+ S+ + D +
Sbjct: 591 ADAGMKTIEFAG-LDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLD 649
Query: 1184 TDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSR--TCRCP 1235
+ Q + + L I + P C++ NGGC+HLCL +P +C CP
Sbjct: 650 RETLQENLE-NLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCP 702
Score = 48.8 bits (114), Expect = 4e-04
Identities = 30/98 (30%), Positives = 42/98 (42%), Gaps = 9/98 (9%)
Query: 659 PVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFR--GDGRTCYDIDECSE 716
P + P + C + GC G C C G+R DG TC D++EC+E
Sbjct: 16 PQQNCRPRTGEENCNVNNGGCAQKCQMVRGA---VQCTCHTGYRLTEDGHTCQDVNECAE 72
Query: 717 QPSVCGSHTICNNHPGTFRCECVEGYQF-SDEGTCVAV 753
+ C C N G F+C C GY+ D +C A+
Sbjct: 73 E-GYCSQG--CTNSEGAFQCWCETGYELRPDRRSCKAL 107
Score = 46.9 bits (109), Expect = 0.001
Identities = 29/86 (33%), Positives = 42/86 (48%), Gaps = 9/86 (10%)
Query: 755 DQRPINYCE--TGLHNCDIPQR--AQCIYTGGSSYTCSCLPGF--SGDGQACQDVDEC-Q 807
D+ P C TG NC++ AQ + C+C G+ + DG CQDV+EC +
Sbjct: 13 DESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAE 72
Query: 808 PSRCHPDAFCYNTPGSFTCQCKPGYQ 833
C C N+ G+F C C+ GY+
Sbjct: 73 EGYCSQG--CTNSEGAFQCWCETGYE 96
>dbj|BAA88688.1| (AB011533) MEGF7 [Rattus norvegicus]
Length = 1298
Score = 201 bits (506), Expect = 4e-50
Identities = 109/298 (36%), Positives = 163/298 (54%), Gaps = 11/298 (3%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPA---KVIIGLAFDCVDKMVYWTDIT 998
P T+LLF+ G I R+ L+ T+ +HVP +I L +D VD VY+TD+
Sbjct: 745 PETYLLFSSRGSIRRISLD------TDDHTDVHVPVPGLNNVISLDYDSVDGKVYYTDVF 798
Query: 999 EPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVL 1058
I RA L+G T+I L + +G+AVD + RN++WTD+ + IE ++LDG+ R+VL
Sbjct: 799 LDVIRRADLNGSNMETVIGHGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVL 858
Query: 1059 FETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDA 1118
L PR I +G L+WTDW KIE + +DG+ R++L+ DLG PNGL D
Sbjct: 859 INNSLDEPRAIAVFPRKGYLFWTDWGH-IAKIERANLDGSERKVLINADLGWPNGLTLDY 917
Query: 1119 FSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDL 1178
+ ++ WVDA +R E + + R+ + + +PFA+T + +Y+TDW+ S+ +D
Sbjct: 918 DTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDK 977
Query: 1179 AISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPD 1236
+ + + + L I Q G N C VNNGGC+HLC A C CPD
Sbjct: 978 YSGRNKETVLANVE-GLMDIIVVSPQRQTGTNACGVNNGGCSHLCFARASDFVCACPD 1034
Score = 194 bits (488), Expect = 5e-48
Identities = 101/263 (38%), Positives = 147/263 (55%), Gaps = 2/263 (0%)
Query: 973 LHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLG 1032
+++ K I + D ++ VYW+D T I RASL G + II L + +G+AVD +G
Sbjct: 469 INMTMKNTIAIGVDPLEGKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTDGLAVDAIG 528
Query: 1033 RNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIET 1092
R ++WTD+ +RIEV LDG+ R+VL +L +PR IV G +YWTDW +N K+E
Sbjct: 529 RKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWG-ENAKLER 587
Query: 1093 SYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQY 1152
S MDG++R +L+ ++LG PNGL D SSQL W DA T R E + + +R + +Q+
Sbjct: 588 SGMDGSDRTVLINNNLGWPNGLTVDKTSSQLLWADAHTERIEVADLNGANRHTLVSPVQH 647
Query: 1153 PFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC 1212
P+ +T +Y+TDW+ S+ D + + + L I P G N C
Sbjct: 648 PYGLTLLDSYIYWTDWQTRSIHRADKSTGSNVILVRSN-LPGLMDIQAVDRAQPLGFNKC 706
Query: 1213 SVNNGGCTHLCLATPGSRTCRCP 1235
NGGC+HLCL P +C CP
Sbjct: 707 GSRNGGCSHLCLPRPSGFSCACP 729
Score = 188 bits (472), Expect = 4e-46
Identities = 106/294 (36%), Positives = 155/294 (52%), Gaps = 10/294 (3%)
Query: 946 LLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRA 1005
LLFA+ I R+ + + + + L +D D VYWTD++ +I RA
Sbjct: 137 LLFARRMDIRRISFDTEDLSDDVIPL---ADVRSAVALDWDSRDDHVYWTDVSTDTISRA 193
Query: 1006 SLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVN 1065
G ++ L SP G+A+D + ++WTD+ DRIEVA DG+ R VL +L
Sbjct: 194 KWDGTGQKVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDR 253
Query: 1066 PRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCW 1125
PR IV + + G +YWTDW +PKIE + MD +NR++++ +L PNGL D S +L W
Sbjct: 254 PRDIVVEPMGGYMYWTDWGA-SPKIERAGMDASNRQVIISSNLTWPNGLAIDYGSQRLYW 312
Query: 1126 VDAGTNRAECLNPSQPSRRKALEG--LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKE 1183
DAG E S+RK L G L +PF +T YG+ +Y+TDW+ S+ + D +
Sbjct: 313 ADAGMKTIEFAG-LDGSKRKVLIGSQLPHPFGLTLYGQRIYWTDWQTKSIQSADRLTGLD 371
Query: 1184 TDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSR--TCRCP 1235
+ Q + + L I Q P C+V NGGC+HLCL +P +C CP
Sbjct: 372 RETLQENLE-NLMDIHVFHRQRPPVTTPCAVENGGCSHLCLRSPSPSGFSCTCP 424
Score = 74.1 bits (179), Expect = 9e-12
Identities = 42/116 (36%), Positives = 61/116 (52%), Gaps = 3/116 (2%)
Query: 1122 QLCWVDAGTNRAECLNPSQPSRRKAL--EGLQYPFAVTSYGKNLYFTDWKMNSVVALDLA 1179
++ WVDA + E N S RKA+ +GL +PFA+T + +LY+TDW S+ + +
Sbjct: 4 RMYWVDAKHHVIERAN-LDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKF 62
Query: 1180 ISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCP 1235
K + + + T + P G N C NNGGCTHLCL + + TC CP
Sbjct: 63 TGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCACP 118
Score = 46.5 bits (108), Expect = 0.002
Identities = 26/84 (30%), Positives = 42/84 (49%), Gaps = 4/84 (4%)
Query: 1032 GRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIE 1091
GR ++W D+ IE A LDG+ R+ + L +P I +LYWTDW+ +
Sbjct: 2 GRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITV--FEDSLYWTDWHTKSINSA 59
Query: 1092 TSYMDGTNRRILVQDDLGLPNGLH 1115
+ G N+ I +++ L P +H
Sbjct: 60 NKF-TGKNQEI-IRNKLHFPMDIH 81
>pir||JE0329 low density lipoprotein receptor - human
gb|AAC72791.1| (AF077820) LDL receptor member LR3 [Homo sapiens]
Length = 1615
Score = 192 bits (484), Expect = 1e-47
Identities = 104/263 (39%), Positives = 143/263 (53%), Gaps = 18/263 (6%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
I + +D ++ VYWTD +I RA L G T++ ++ P+GIAVD + RN++WTD+
Sbjct: 376 IAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDT 435
Query: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
DRIEV +L+GT R++L DL PR I V G +YWTDW +NPKIE + +DG R
Sbjct: 436 GTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWG-ENPKIECANLDGQER 494
Query: 1101 RILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSY 1159
R+LV LG PNGL D +L W DA T++ E +N RR LE L + F T
Sbjct: 495 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLL 554
Query: 1160 GKNLYFTDWKMNSV-------VALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC 1212
G +Y+TDW+ S+ + D+ I + D L G+ G N C
Sbjct: 555 GDFIYWTDWQRRSIERVHKVKASRDVIIDQLPD---------LMGLKAVNVAKVVGTNPC 605
Query: 1213 SVNNGGCTHLCLATPGSRTCRCP 1235
+ NGGC+HLC TP + C CP
Sbjct: 606 ADRNGGCSHLCFFTPHATRCGCP 628
Score = 187 bits (470), Expect = 7e-46
Identities = 106/293 (36%), Positives = 145/293 (49%), Gaps = 7/293 (2%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
P L+F I R+ LE N A K L FD + +YWTD++ +
Sbjct: 643 PEAFLVFTSRAAIHRISLETNN----NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKT 698
Query: 1002 IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
I RA ++G ++ L PEG+AVD +G+N++W D+ +RIEVA+LDG R+VL
Sbjct: 699 ISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWR 758
Query: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSS 1121
DL NPR + D +G +YWT+W P+I ++MDGTN LV D +G N L D
Sbjct: 759 DLDNPRSLALDPTKGYIYWTEWG-GKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDYADQ 816
Query: 1122 QLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS 1181
+L W D TN E N R + L +PF +T Y +Y+TDW ++S+ D
Sbjct: 817 RLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSG 876
Query: 1182 KETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRC 1234
+ Q H + I S G N C NNG C LCLA PG C C
Sbjct: 877 RNRTLIQGHLDF-VMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGC 928
Score = 187 bits (469), Expect = 9e-46
Identities = 119/315 (37%), Positives = 162/315 (50%), Gaps = 23/315 (7%)
Query: 930 GPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVD 989
G P A PL LLFA + + G + T + L A V F
Sbjct: 24 GCPAPAAASPL-----LLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAV----DFQFSK 74
Query: 990 KMVYWTDITEPSIGRASLH--GGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEV 1047
VYWTD++E +I + L+ G ++ L SP+G+A D +G+ ++WTDS +RIEV
Sbjct: 75 GAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEV 134
Query: 1048 AKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDD 1107
A L+GT R+VLF DL PR I D G +YWTDW + P+IE + MDG+ R+I+V D
Sbjct: 135 ANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWG-ETPRIERAGMDGSTRKIIVDSD 193
Query: 1108 LGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNLYFT 1166
+ PNGL D +L W DA + N R+K +EG L +PFA+T G LY+T
Sbjct: 194 IYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWT 253
Query: 1167 DWKMNSVVALDLAISKETDAFQPHKQTRLYG--ITTALSQ--CPQGHNYCSVNNGGCTHL 1222
DW+ S+ A +K T + + LY LSQ P H C +NGGC+HL
Sbjct: 254 DWQTRSI----HACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHL 309
Query: 1223 CLATPGS--RTCRCP 1235
CL +P TC CP
Sbjct: 310 CLLSPSEPFYTCACP 324
Score = 117 bits (291), Expect = 6e-25
Identities = 95/317 (29%), Positives = 141/317 (43%), Gaps = 40/317 (12%)
Query: 941 PPGTHLLFAQTGKIER------------LPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCV 988
PP T LLF+Q I R LPL G +R +A + +D +
Sbjct: 943 PPTTFLLFSQKSAISRMIPDDQHSPDLILPLHG--LRNVKA-------------IDYDPL 987
Query: 989 DKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGS-----PEGIAVDHLGRNIFWTDSNLD 1043
DK +YW D + +I RA G +P + G P +++D R +FWT +
Sbjct: 988 DKFIYWVDGRQ-NIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATN 1046
Query: 1044 RIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRIL 1103
I V +L G V+ D PR IV ++ RG LY+T+ KIE + +DGT R +L
Sbjct: 1047 TINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVL 1106
Query: 1104 VQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALE--GLQYPFAVTSYGK 1161
L P L D +L WVDA R E + S + R LE + P +T GK
Sbjct: 1107 FTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLS-GANRLTLEDANIVQPLGLTILGK 1165
Query: 1162 NLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGI--TTALSQCPQGHNYCSVNNGGC 1219
+LY+ D + + ++ + Q + L GI +S + C+ +NGGC
Sbjct: 1166 HLYWIDRQQQMIERVEKTTGDKRTRIQ-GRVAHLTGIHAVEEVSLEEFSAHPCARDNGGC 1224
Query: 1220 THLCLAT-PGSRTCRCP 1235
+H+C+A G+ C CP
Sbjct: 1225 SHICIAKGDGTPRCSCP 1241
>ref|NP_002326.1| low density lipoprotein receptor-related protein 7; low density
lipoprotein-related protein 5 [Homo sapiens]
gb|AAC36467.1| (AF064548) low-density lipoprotein receptor-related protein 5 [Homo
sapiens]
Length = 1615
Score = 192 bits (484), Expect = 1e-47
Identities = 104/263 (39%), Positives = 143/263 (53%), Gaps = 18/263 (6%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
I + +D ++ VYWTD +I RA L G T++ ++ P+GIAVD + RN++WTD+
Sbjct: 376 IAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDT 435
Query: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
DRIEV +L+GT R++L DL PR I V G +YWTDW +NPKIE + +DG R
Sbjct: 436 GTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWG-ENPKIECANLDGQER 494
Query: 1101 RILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSY 1159
R+LV LG PNGL D +L W DA T++ E +N RR LE L + F T
Sbjct: 495 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLL 554
Query: 1160 GKNLYFTDWKMNSV-------VALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC 1212
G +Y+TDW+ S+ + D+ I + D L G+ G N C
Sbjct: 555 GDFIYWTDWQRRSIERVHKVKASRDVIIDQLPD---------LMGLKAVNVAKVVGTNPC 605
Query: 1213 SVNNGGCTHLCLATPGSRTCRCP 1235
+ NGGC+HLC TP + C CP
Sbjct: 606 ADRNGGCSHLCFFTPHATRCGCP 628
Score = 187 bits (470), Expect = 7e-46
Identities = 106/293 (36%), Positives = 145/293 (49%), Gaps = 7/293 (2%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
P L+F I R+ LE N A K L FD + +YWTD++ +
Sbjct: 643 PEAFLVFTSRAAIHRISLETNN----NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKT 698
Query: 1002 IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
I RA ++G ++ L PEG+AVD +G+N++W D+ +RIEVA+LDG R+VL
Sbjct: 699 ISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWR 758
Query: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSS 1121
DL NPR + D +G +YWT+W P+I ++MDGTN LV D +G N L D
Sbjct: 759 DLDNPRSLALDPTKGYIYWTEWG-GKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDYADQ 816
Query: 1122 QLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS 1181
+L W D TN E N R + L +PF +T Y +Y+TDW ++S+ D
Sbjct: 817 RLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSG 876
Query: 1182 KETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRC 1234
+ Q H + I S G N C NNG C LCLA PG C C
Sbjct: 877 RNRTLIQGHLDF-VMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGC 928
Score = 187 bits (469), Expect = 9e-46
Identities = 119/315 (37%), Positives = 162/315 (50%), Gaps = 23/315 (7%)
Query: 930 GPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVD 989
G P A PL LLFA + + G + T + L A V F
Sbjct: 24 GCPAPAAASPL-----LLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAV----DFQFSK 74
Query: 990 KMVYWTDITEPSIGRASLH--GGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEV 1047
VYWTD++E +I + L+ G ++ L SP+G+A D +G+ ++WTDS +RIEV
Sbjct: 75 GAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEV 134
Query: 1048 AKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDD 1107
A L+GT R+VLF DL PR I D G +YWTDW + P+IE + MDG+ R+I+V D
Sbjct: 135 ANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWG-ETPRIERAGMDGSTRKIIVDSD 193
Query: 1108 LGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNLYFT 1166
+ PNGL D +L W DA + N R+K +EG L +PFA+T G LY+T
Sbjct: 194 IYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWT 253
Query: 1167 DWKMNSVVALDLAISKETDAFQPHKQTRLYG--ITTALSQ--CPQGHNYCSVNNGGCTHL 1222
DW+ S+ A +K T + + LY LSQ P H C +NGGC+HL
Sbjct: 254 DWQTRSI----HACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHL 309
Query: 1223 CLATPGS--RTCRCP 1235
CL +P TC CP
Sbjct: 310 CLLSPSEPFYTCACP 324
Score = 117 bits (291), Expect = 6e-25
Identities = 95/317 (29%), Positives = 141/317 (43%), Gaps = 40/317 (12%)
Query: 941 PPGTHLLFAQTGKIER------------LPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCV 988
PP T LLF+Q I R LPL G +R +A + +D +
Sbjct: 943 PPTTFLLFSQKSAISRMIPDDQHSPDLILPLHG--LRNVKA-------------IDYDPL 987
Query: 989 DKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGS-----PEGIAVDHLGRNIFWTDSNLD 1043
DK +YW D + +I RA G +P + G P +++D R +FWT +
Sbjct: 988 DKFIYWVDGRQ-NIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATN 1046
Query: 1044 RIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRIL 1103
I V +L G V+ D PR IV ++ RG LY+T+ KIE + +DGT R +L
Sbjct: 1047 TINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVL 1106
Query: 1104 VQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALE--GLQYPFAVTSYGK 1161
L P L D +L WVDA R E + S + R LE + P +T GK
Sbjct: 1107 FTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLS-GANRLTLEDANIVQPLGLTILGK 1165
Query: 1162 NLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGI--TTALSQCPQGHNYCSVNNGGC 1219
+LY+ D + + ++ + Q + L GI +S + C+ +NGGC
Sbjct: 1166 HLYWIDRQQQMIERVEKTTGDKRTRIQ-GRVAHLTGIHAVEEVSLEEFSAHPCARDNGGC 1224
Query: 1220 THLCLAT-PGSRTCRCP 1235
+H+C+A G+ C CP
Sbjct: 1225 SHICIAKGDGTPRCSCP 1241
>pir||JE0372 low density lipoprotein receptor related protein - human
dbj|BAA33051.1| (AB017498) Lipoprotein Receptor Related Protein 5 [Homo sapiens]
Length = 1615
Score = 192 bits (484), Expect = 1e-47
Identities = 104/263 (39%), Positives = 143/263 (53%), Gaps = 18/263 (6%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
I + +D ++ VYWTD +I RA L G T++ ++ P+GIAVD + RN++WTD+
Sbjct: 376 IAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDT 435
Query: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
DRIEV +L+GT R++L DL PR I V G +YWTDW +NPKIE + +DG R
Sbjct: 436 GTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWG-ENPKIECANLDGQER 494
Query: 1101 RILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSY 1159
R+LV LG PNGL D +L W DA T++ E +N RR LE L + F T
Sbjct: 495 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLL 554
Query: 1160 GKNLYFTDWKMNSV-------VALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC 1212
G +Y+TDW+ S+ + D+ I + D L G+ G N C
Sbjct: 555 GDFIYWTDWQRRSIERVHKVKASRDVIIDQLPD---------LMGLKAVNVAKVVGTNPC 605
Query: 1213 SVNNGGCTHLCLATPGSRTCRCP 1235
+ NGGC+HLC TP + C CP
Sbjct: 606 ADRNGGCSHLCFFTPHATRCGCP 628
Score = 187 bits (470), Expect = 7e-46
Identities = 106/293 (36%), Positives = 145/293 (49%), Gaps = 7/293 (2%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
P L+F I R+ LE N A K L FD + +YWTD++ +
Sbjct: 643 PEAFLVFTSRAAIHRISLETNN----NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKT 698
Query: 1002 IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
I RA ++G ++ L PEG+AVD +G+N++W D+ +RIEVA+LDG R+VL
Sbjct: 699 ISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWR 758
Query: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSS 1121
DL NPR + D +G +YWT+W P+I ++MDGTN LV D +G N L D
Sbjct: 759 DLDNPRSLALDPTKGYIYWTEWG-GKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDYADQ 816
Query: 1122 QLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS 1181
+L W D TN E N R + L +PF +T Y +Y+TDW ++S+ D
Sbjct: 817 RLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSG 876
Query: 1182 KETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRC 1234
+ Q H + I S G N C NNG C LCLA PG C C
Sbjct: 877 RNRTLIQGHLDF-VMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGC 928
Score = 187 bits (469), Expect = 9e-46
Identities = 119/315 (37%), Positives = 162/315 (50%), Gaps = 23/315 (7%)
Query: 930 GPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVD 989
G P A PL LLFA + + G + T + L A V F
Sbjct: 24 GCPAPAAASPL-----LLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAV----DFQFSK 74
Query: 990 KMVYWTDITEPSIGRASLH--GGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEV 1047
VYWTD++E +I + L+ G ++ L SP+G+A D +G+ ++WTDS +RIEV
Sbjct: 75 GAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEV 134
Query: 1048 AKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDD 1107
A L+GT R+VLF DL PR I D G +YWTDW + P+IE + MDG+ R+I+V D
Sbjct: 135 ANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWG-ETPRIERAGMDGSTRKIIVDSD 193
Query: 1108 LGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNLYFT 1166
+ PNGL D +L W DA + N R+K +EG L +PFA+T G LY+T
Sbjct: 194 IYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWT 253
Query: 1167 DWKMNSVVALDLAISKETDAFQPHKQTRLYG--ITTALSQ--CPQGHNYCSVNNGGCTHL 1222
DW+ S+ A +K T + + LY LSQ P H C +NGGC+HL
Sbjct: 254 DWQTRSI----HACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHL 309
Query: 1223 CLATPGS--RTCRCP 1235
CL +P TC CP
Sbjct: 310 CLLSPSEPFYTCACP 324
Score = 117 bits (291), Expect = 6e-25
Identities = 95/317 (29%), Positives = 141/317 (43%), Gaps = 40/317 (12%)
Query: 941 PPGTHLLFAQTGKIER------------LPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCV 988
PP T LLF+Q I R LPL G +R +A + +D +
Sbjct: 943 PPTTFLLFSQKSAISRMIPDDQHSPDLILPLHG--LRNVKA-------------IDYDPL 987
Query: 989 DKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGS-----PEGIAVDHLGRNIFWTDSNLD 1043
DK +YW D + +I RA G +P + G P +++D R +FWT +
Sbjct: 988 DKFIYWVDGRQ-NIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATN 1046
Query: 1044 RIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRIL 1103
I V +L G V+ D PR IV ++ RG LY+T+ KIE + +DGT R +L
Sbjct: 1047 TINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVL 1106
Query: 1104 VQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALE--GLQYPFAVTSYGK 1161
L P L D +L WVDA R E + S + R LE + P +T GK
Sbjct: 1107 FTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLS-GANRLTLEDANIVQPLGLTILGK 1165
Query: 1162 NLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGI--TTALSQCPQGHNYCSVNNGGC 1219
+LY+ D + + ++ + Q + L GI +S + C+ +NGGC
Sbjct: 1166 HLYWIDRQQQMIERVEKTTGDKRTRIQ-GRVAHLTGIHAVEEVSLEEFSAHPCARDNGGC 1224
Query: 1220 THLCLAT-PGSRTCRCP 1235
+H+C+A G+ C CP
Sbjct: 1225 SHICIAKGDGTPRCSCP 1241
>gb|AAC70183.1| (AF077847) LDL receptor member LR3 [Mus musculus]
Length = 1614
Score = 191 bits (481), Expect = 3e-47
Identities = 103/263 (39%), Positives = 144/263 (54%), Gaps = 18/263 (6%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
I + +D ++ VYWTD +I RA L G T++ ++ P+GIAVD + RN++WTD+
Sbjct: 375 IAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDT 434
Query: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
DRIEV +L+GT R++L DL PR IV V G +YWTDW +NPKIE + +DG +R
Sbjct: 435 GTDRIEVTRLNGTSRKILVSEDLDEPRAIVLHPVMGLMYWTDWG-ENPKIECANLDGRDR 493
Query: 1101 RILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSY 1159
+LV LG PNGL D +L W DA T++ E +N R+ LE L + F T
Sbjct: 494 HVLVNTSLGWPNGLALDLQEGKLYWGDAKTDKIEVINIDGTKRKTLLEDKLPHIFGFTLL 553
Query: 1160 GKNLYFTDWKMNSV-------VALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC 1212
G +Y+TDW+ S+ + D+ I + D L G+ G N C
Sbjct: 554 GDFIYWTDWQRRSIERVHKVKASRDVIIDQLPD---------LMGLKAVNVAKVVGTNPC 604
Query: 1213 SVNNGGCTHLCLATPGSRTCRCP 1235
+ NGGC+HLC TP + C CP
Sbjct: 605 ADGNGGCSHLCFFTPRATKCGCP 627
Score = 188 bits (472), Expect = 4e-46
Identities = 107/293 (36%), Positives = 145/293 (48%), Gaps = 7/293 (2%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
P L+F I R+ LE N A K L FD + +YWTD++ +
Sbjct: 642 PEAFLVFTSRATIHRISLETNN----NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKT 697
Query: 1002 IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
I RA ++G +I L PEG+AVD +G+N++W D+ +RIEVA+LDG R+VL
Sbjct: 698 ISRAFMNGSSVEHVIEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWR 757
Query: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSS 1121
DL NPR + D +G +YWT+W P+I ++MDGTN LV D +G N L D
Sbjct: 758 DLDNPRSLALDPTKGYIYWTEWG-GKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDYADQ 815
Query: 1122 QLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS 1181
+L W D TN E N R + L YPF +T Y +Y+TDW ++S+ D
Sbjct: 816 RLYWTDLDTNMIESSNMLGQERMVIADDLPYPFGLTQYSDYIYWTDWNLHSIERADKTSG 875
Query: 1182 KETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRC 1234
+ Q H + I S G N C +NG C LCLA PG C C
Sbjct: 876 RNRTLIQGHLDF-VMDILVFHSSRQDGLNDCVHSNGQCGQLCLAIPGGHRCGC 927
Score = 188 bits (472), Expect = 4e-46
Identities = 120/336 (35%), Positives = 167/336 (48%), Gaps = 19/336 (5%)
Query: 905 EVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTM 964
E TR P PP L V VP A PL LLFA + + G +
Sbjct: 2 ETAPTRAPPPPPPPLLLLVL----YCSLVPAAASPL-----LLFANRRDVRLVDAGGVKL 52
Query: 965 RKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLH--GGEPTTIIRQDLGS 1022
T + L A V F VYWTD++E +I + L+ G I+ L S
Sbjct: 53 ESTIVASGLEDAAAV----DFQFSKGAVYWTDVSEEAIKQTYLNQTGAAAQNIVISGLVS 108
Query: 1023 PEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTD 1082
P+G+A D +G+ ++WTDS +RIEVA L+GT R+VLF DL PR I D G +YWTD
Sbjct: 109 PDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTD 168
Query: 1083 WNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPS 1142
W + P+IE + MDG+ R+I+V D+ PNGL D +L W DA + N
Sbjct: 169 WG-EAPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHHANLDGSF 227
Query: 1143 RRKALEG-LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTA 1201
R+K +EG L +PFA+T G LY+TDW+ S+ A + ++ + + +
Sbjct: 228 RQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKWTGEQRKEILSALYSPMDIQVLS 287
Query: 1202 LSQCPQGHNYCSVNNGGCTHLCLATPGS--RTCRCP 1235
+ P H C +NGGC+HLCL +P +C CP
Sbjct: 288 QERQPPFHTPCEEDNGGCSHLCLLSPREPFYSCACP 323
Score = 116 bits (289), Expect = 1e-24
Identities = 95/317 (29%), Positives = 144/317 (44%), Gaps = 40/317 (12%)
Query: 941 PPGTHLLFAQTGKIER------------LPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCV 988
PP T LLF+Q I R LPL G +R +A + +D +
Sbjct: 942 PPSTFLLFSQKFAISRMIPDDQLSPDLVLPLHG--LRNVKA-------------INYDPL 986
Query: 989 DKMVYWTDITEPSIGRASLHGGEPTTIIR--QDLG---SPEGIAVDHLGRNIFWTDSNLD 1043
DK +YW D + +I RA G +P+ + Q L P +++D R +FWT +
Sbjct: 987 DKFIYWVDGRQ-NIKRAKDDGTQPSMLTSPSQSLSPDRQPHDLSIDIYSRTLFWTCEATN 1045
Query: 1044 RIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRIL 1103
I V +LDG V+ D PR I ++ RG +Y+T+ KIE + +DGT R +L
Sbjct: 1046 TINVHRLDGDAMGVVLRGDRDKPRAIAVNAERGYMYFTNMQDHAAKIERASLDGTEREVL 1105
Query: 1104 VQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALE--GLQYPFAVTSYGK 1161
L P L D +L WVDA R E + S + R LE + P +T G+
Sbjct: 1106 FTTGLIRPVALVVDNALGKLFWVDADLKRIESCDLS-GANRLTLEDANIVQPVGLTVLGR 1164
Query: 1162 NLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGI--TTALSQCPQGHNYCSVNNGGC 1219
+LY+ D + + ++ + Q + T L GI +S + C+ +NGGC
Sbjct: 1165 HLYWIDRQQQMIERVEKTTGDKRTRVQ-GRVTHLTGIHAVEEVSLEEFSAHPCARDNGGC 1223
Query: 1220 THLCLAT-PGSRTCRCP 1235
+H+C+A G+ C CP
Sbjct: 1224 SHICIAKGDGTPRCSCP 1240
>ref|NP_032539.1| low density lipoprotein-related protein 5 [Mus musculus]
gb|AAC36468.1| (AF064984) low-density lipoprotein receptor-related protein 5 [Mus
musculus]
Length = 1614
Score = 191 bits (481), Expect = 3e-47
Identities = 103/263 (39%), Positives = 144/263 (54%), Gaps = 18/263 (6%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
I + +D ++ VYWTD +I RA L G T++ ++ P+GIAVD + RN++WTD+
Sbjct: 375 IAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDT 434
Query: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
DRIEV +L+GT R++L DL PR IV V G +YWTDW +NPKIE + +DG +R
Sbjct: 435 GTDRIEVTRLNGTSRKILVSEDLDEPRAIVLHPVMGLMYWTDWG-ENPKIECANLDGRDR 493
Query: 1101 RILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSY 1159
+LV LG PNGL D +L W DA T++ E +N R+ LE L + F T
Sbjct: 494 HVLVNTSLGWPNGLALDLQEGKLYWGDAKTDKIEVINIDGTKRKTLLEDKLPHIFGFTLL 553
Query: 1160 GKNLYFTDWKMNSV-------VALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC 1212
G +Y+TDW+ S+ + D+ I + D L G+ G N C
Sbjct: 554 GDFIYWTDWQRRSIERVHKVKASRDVIIDQLPD---------LMGLKAVNVAKVVGTNPC 604
Query: 1213 SVNNGGCTHLCLATPGSRTCRCP 1235
+ NGGC+HLC TP + C CP
Sbjct: 605 ADGNGGCSHLCFFTPRATKCGCP 627
Score = 188 bits (472), Expect = 4e-46
Identities = 107/293 (36%), Positives = 145/293 (48%), Gaps = 7/293 (2%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
P L+F I R+ LE N A K L FD + +YWTD++ +
Sbjct: 642 PEAFLVFTSRATIHRISLETNN----NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKT 697
Query: 1002 IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
I RA ++G +I L PEG+AVD +G+N++W D+ +RIEVA+LDG R+VL
Sbjct: 698 ISRAFMNGSSVEHVIEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWR 757
Query: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSS 1121
DL NPR + D +G +YWT+W P+I ++MDGTN LV D +G N L D
Sbjct: 758 DLDNPRSLALDPTKGYIYWTEWG-GKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDYADQ 815
Query: 1122 QLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS 1181
+L W D TN E N R + L YPF +T Y +Y+TDW ++S+ D
Sbjct: 816 RLYWTDLDTNMIESSNMLGQERMVIADDLPYPFGLTQYSDYIYWTDWNLHSIERADKTSG 875
Query: 1182 KETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRC 1234
+ Q H + I S G N C +NG C LCLA PG C C
Sbjct: 876 RNRTLIQGHLDF-VMDILVFHSSRQDGLNDCVHSNGQCGQLCLAIPGGHRCGC 927
Score = 188 bits (472), Expect = 4e-46
Identities = 120/336 (35%), Positives = 167/336 (48%), Gaps = 19/336 (5%)
Query: 905 EVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTM 964
E TR P PP L V VP A PL LLFA + + G +
Sbjct: 2 ETAPTRAPPPPPPPLLLLVL----YCSLVPAAASPL-----LLFANRRDVRLVDAGGVKL 52
Query: 965 RKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLH--GGEPTTIIRQDLGS 1022
T + L A V F VYWTD++E +I + L+ G I+ L S
Sbjct: 53 ESTIVASGLEDAAAV----DFQFSKGAVYWTDVSEEAIKQTYLNQTGAAAQNIVISGLVS 108
Query: 1023 PEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTD 1082
P+G+A D +G+ ++WTDS +RIEVA L+GT R+VLF DL PR I D G +YWTD
Sbjct: 109 PDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTD 168
Query: 1083 WNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPS 1142
W + P+IE + MDG+ R+I+V D+ PNGL D +L W DA + N
Sbjct: 169 WG-EAPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSF 227
Query: 1143 RRKALEG-LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTA 1201
R+K +EG L +PFA+T G LY+TDW+ S+ A + ++ + + +
Sbjct: 228 RQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKWTGEQRKEILSALYSPMDIQVLS 287
Query: 1202 LSQCPQGHNYCSVNNGGCTHLCLATPGS--RTCRCP 1235
+ P H C +NGGC+HLCL +P +C CP
Sbjct: 288 QERQPPFHTPCEEDNGGCSHLCLLSPREPFYSCACP 323
Score = 116 bits (289), Expect = 1e-24
Identities = 95/317 (29%), Positives = 144/317 (44%), Gaps = 40/317 (12%)
Query: 941 PPGTHLLFAQTGKIER------------LPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCV 988
PP T LLF+Q I R LPL G +R +A + +D +
Sbjct: 942 PPSTFLLFSQKFAISRMIPDDQLSPDLVLPLHG--LRNVKA-------------INYDPL 986
Query: 989 DKMVYWTDITEPSIGRASLHGGEPTTIIR--QDLG---SPEGIAVDHLGRNIFWTDSNLD 1043
DK +YW D + +I RA G +P+ + Q L P +++D R +FWT +
Sbjct: 987 DKFIYWVDGRQ-NIKRAKDDGTQPSMLTSPSQSLSPDRQPHDLSIDIYSRTLFWTCEATN 1045
Query: 1044 RIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRIL 1103
I V +LDG V+ D PR I ++ RG +Y+T+ KIE + +DGT R +L
Sbjct: 1046 TINVHRLDGDAMGVVLRGDRDKPRAIAVNAERGYMYFTNMQDHAAKIERASLDGTEREVL 1105
Query: 1104 VQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALE--GLQYPFAVTSYGK 1161
L P L D +L WVDA R E + S + R LE + P +T G+
Sbjct: 1106 FTTGLIRPVALVVDNALGKLFWVDADLKRIESCDLS-GANRLTLEDANIVQPVGLTVLGR 1164
Query: 1162 NLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGI--TTALSQCPQGHNYCSVNNGGC 1219
+LY+ D + + ++ + Q + T L GI +S + C+ +NGGC
Sbjct: 1165 HLYWIDRQQQMIERVEKTTGDKRTRVQ-GRVTHLTGIHAVEEVSLEEFSAHPCARDNGGC 1223
Query: 1220 THLCLAT-PGSRTCRCP 1235
+H+C+A G+ C CP
Sbjct: 1224 SHICIAKGDGTPRCSCP 1240
>ref|NP_002327.1| low density lipoprotein receptor-related protein 6; low density
lipoprotein-related protein 6 [Homo sapiens]
pir||JE0272 low density lipoprotein receptor-related protein 6 - human
gb|AAC33006.1| (AF074264) LDL receptor-related protein 6 [Homo sapiens]
Length = 1613
Score = 189 bits (474), Expect = 2e-46
Identities = 109/295 (36%), Positives = 150/295 (49%), Gaps = 8/295 (2%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
P LLF++ I R+ LE N A K L FD D +YWTDI+ +
Sbjct: 630 PEAFLLFSRRADIRRISLETNNNNV----AIPLTGVKEASALDFDVTDNRIYWTDISLKT 685
Query: 1002 IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
I RA ++G ++ L PEG+AVD LG+N++W D+ +RIEV+KLDG R+VL
Sbjct: 686 ISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWK 745
Query: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSS 1121
DL +PR + D G +YWT+W PKI+ + MDG+ R LV ++G NGL D
Sbjct: 746 DLDSPRALALDPAEGFMYWTEWG-GKPKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKR 803
Query: 1122 QLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS 1181
+L W D TN E N +R + L +PF +T Y +Y+TDW S+ +
Sbjct: 804 RLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSG 863
Query: 1182 KETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATP-GSRTCRCP 1235
+ Q H + I S G N C+ +NG C+HLCLA P G C CP
Sbjct: 864 QNRTIIQGHLD-YVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCP 917
Score = 183 bits (460), Expect = 1e-44
Identities = 113/331 (34%), Positives = 168/331 (50%), Gaps = 16/331 (4%)
Query: 914 GMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTH--------LLFAQTGKIERLPLEGNTMR 965
G + CL + P +Q A PT V L G LL A+ + R+ L+ T
Sbjct: 292 GCSHLCLMSPVKPFYQC-ACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLD--TPD 348
Query: 966 KTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEG 1025
T+ L + I + +D V+ +YWTD +I R+ + G ++ + P+G
Sbjct: 349 FTDIVLQLE-DIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDG 407
Query: 1026 IAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNR 1085
IAVD + RN++WTD+ DRIEV +L+GT R++L DL PR IV D + G +YWTDW
Sbjct: 408 IAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWG- 466
Query: 1086 DNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRK 1145
+ PKIE + +DG++R +LV LG PNGL D ++ W DA T++ E +N RR
Sbjct: 467 EIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRV 526
Query: 1146 ALEG-LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQ 1204
+E + + F T G +Y+TDW+ S+ + ++ + L G+
Sbjct: 527 LVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIID--QLPDLMGLKATNVH 584
Query: 1205 CPQGHNYCSVNNGGCTHLCLATPGSRTCRCP 1235
G N C+ NGGC+HLCL P C CP
Sbjct: 585 RVIGSNPCAEENGGCSHLCLYRPQGLRCACP 615
Score = 169 bits (425), Expect = 1e-40
Identities = 96/256 (37%), Positives = 142/256 (54%), Gaps = 19/256 (7%)
Query: 991 MVYWTDITEPSIGRASLHGGEPT-TIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAK 1049
++YW+D++E +I R + E ++ L SP+G+A D LG ++WTDS +RIEV+
Sbjct: 64 LIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSN 123
Query: 1050 LDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLG 1109
LDG+ R+VLF +L PR I D G +YWTDW + PKIE + MDG++R I++ ++
Sbjct: 124 LDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWG-EVPKIERAGMDGSSRFIIINSEIY 182
Query: 1110 LPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNLYFTDW 1168
PNGL D +L W DA N N +R+ ++G L +PFA+T + LY+TDW
Sbjct: 183 WPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDW 242
Query: 1169 KMNSVVALDLAISK-----ETDAFQPHKQTRLYGITTALSQ--CPQGHNYCSVNNGGCTH 1221
+S++A + + +D F P A SQ P N C ++NGGC+H
Sbjct: 243 STHSILACNKYTGEGLREIHSDIFSPMD-------IHAFSQQRQPNATNPCGIDNGGCSH 295
Query: 1222 LCLATPGS--RTCRCP 1235
LCL +P C CP
Sbjct: 296 LCLMSPVKPFYQCACP 311
Score = 114 bits (283), Expect = 6e-24
Identities = 82/305 (26%), Positives = 144/305 (46%), Gaps = 16/305 (5%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
P T LLF+Q I R+ ++ + + +H + + + +D +DK +YW D +
Sbjct: 932 PTTFLLFSQKSAINRMVID--EQQSPDIILPIH-SLRNVRAIDYDPLDKQLYWIDSRQNM 988
Query: 1002 IGRASLHGGEPTTIIRQDLGS------PEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQR 1055
I +A G + T++ + S P +++D R I+WT + I V +LDG
Sbjct: 989 IRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSV 1048
Query: 1056 RVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLH 1115
V+ + + PR IV + +G +Y+T+ +PKIE + +DGT R +L L P L
Sbjct: 1049 GVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALA 1108
Query: 1116 FDAFSSQLCWVDAGTNRAECLNPSQPSRRKALE--GLQYPFAVTSYGKNLYFTDWKMNSV 1173
D+ +L W D+ R E + S + R LE + P +T + LY+ D + +
Sbjct: 1109 LDSRLGKLFWADSDLRRIESSDLS-GANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMI 1167
Query: 1174 VALDLAISKETDAFQPH--KQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLAT-PGSR 1230
+D+ + Q + + ++ + Q + H C+ +NGGC+H+CL G+
Sbjct: 1168 EKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHP-CAQDNGGCSHICLVKGDGTT 1226
Query: 1231 TCRCP 1235
C CP
Sbjct: 1227 RCSCP 1231
>ref|NP_032540.1| low density lipoprotein-related protein 6 [Mus musculus]
pir||JE0273 low density lipoprotein receptor-related protein 6 - mouse
gb|AAC33007.1| (AF074265) LDL receptor-related protein 6 [Mus musculus]
Length = 1613
Score = 186 bits (468), Expect = 1e-45
Identities = 108/295 (36%), Positives = 150/295 (50%), Gaps = 8/295 (2%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
P LLF++ I R+ LE N A K L FD D +YWTDI+ +
Sbjct: 630 PEAFLLFSRRADIRRISLETNNNNV----AIPLTGVKEASALDFDVTDNRIYWTDISLKT 685
Query: 1002 IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
I RA ++G ++ L PEG+AVD LG+N++W D+ +RIEV+KLDG R+VL
Sbjct: 686 ISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWK 745
Query: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSS 1121
DL +PR + D G +YWT+W PKI+ + MDG+ R LV ++G NGL D
Sbjct: 746 DLDSPRALALDPAEGFMYWTEWG-GKPKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKR 803
Query: 1122 QLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS 1181
+L W D TN E + +R + L +PF +T Y +Y+TDW S+ +
Sbjct: 804 RLYWTDLDTNLIESSDMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSG 863
Query: 1182 KETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATP-GSRTCRCP 1235
+ Q H + I S G N C+ +NG C+HLCLA P G C CP
Sbjct: 864 QNRTIIQGHLD-YVMDILVFHSSRQAGWNECASSNGHCSHLCLAVPVGGFVCGCP 917
Score = 182 bits (458), Expect = 2e-44
Identities = 112/331 (33%), Positives = 168/331 (49%), Gaps = 16/331 (4%)
Query: 914 GMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTH--------LLFAQTGKIERLPLEGNTMR 965
G + CL + P +Q A PT V + G LL A+ + R+ L+ T
Sbjct: 292 GCSHLCLMSPVKPFYQC-ACPTGVKLMENGKTCKDGATELLLLARRTDLRRISLD--TPD 348
Query: 966 KTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEG 1025
T+ L + I + +D V+ +YWTD +I R+ + G ++ + P+G
Sbjct: 349 FTDIVLQLE-DIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDG 407
Query: 1026 IAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNR 1085
IAVD + RN++WTD+ DRIEV +L+GT R++L DL PR IV D + G +YWTDW
Sbjct: 408 IAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWG- 466
Query: 1086 DNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRK 1145
+ PKIE + +DG++R +LV LG PNGL D + W DA T++ E +N RR
Sbjct: 467 EIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGRRV 526
Query: 1146 ALEG-LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQ 1204
+E + + F T G +Y+TDW+ S+ + ++ + L G+
Sbjct: 527 LVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIID--QLPDLMGLKATSVH 584
Query: 1205 CPQGHNYCSVNNGGCTHLCLATPGSRTCRCP 1235
G N C+ +NGGC+HLCL P C CP
Sbjct: 585 RVIGSNPCAEDNGGCSHLCLYRPQGLRCACP 615
Score = 169 bits (425), Expect = 1e-40
Identities = 89/249 (35%), Positives = 140/249 (55%), Gaps = 5/249 (2%)
Query: 991 MVYWTDITEPSIGRASLHGGEPT-TIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAK 1049
++YW+D++E +I R + E ++ L SP+G+A D LG ++WTDS +RIEV+
Sbjct: 64 LIYWSDVSEEAIKRTEFNKSESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSN 123
Query: 1050 LDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLG 1109
LDG+ R+VLF +L PR I D G +YWTDW + PKIE + MDG++R +++ ++
Sbjct: 124 LDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWG-EVPKIERAGMDGSSRFVIINTEIY 182
Query: 1110 LPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNLYFTDW 1168
PNGL D +L W DA N N +R+ ++G L +PFA+T + LY+TDW
Sbjct: 183 WPNGLTLDYQERKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDTLYWTDW 242
Query: 1169 KMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPG 1228
+S++A + + + + + + + P N C ++NGGC+HLCL +P
Sbjct: 243 NTHSILACNKYTGEGLREIHSNIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPV 302
Query: 1229 S--RTCRCP 1235
C CP
Sbjct: 303 KPFYQCACP 311
Score = 118 bits (293), Expect = 4e-25
Identities = 82/305 (26%), Positives = 146/305 (46%), Gaps = 16/305 (5%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
P T LLF+Q I R+ ++ + + +H + + + +D +DK +YW D + S
Sbjct: 932 PSTFLLFSQKSAINRMVID--EQQSPDIILPIH-SLRNVRAIDYDPLDKQLYWIDSRQNS 988
Query: 1002 IGRASLHGGEPTTIIRQDLGS------PEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQR 1055
I +A GG+ ++ + + P +++D R I+WT + I+V +LDG
Sbjct: 989 IRKAHEDGGQGFNVVANSVANQNLEIQPYDLSIDIYSRYIYWTCEATNVIDVTRLDGRSV 1048
Query: 1056 RVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLH 1115
V+ + + PR IV + +G +Y+T+ +PKIE + +DGT R +L L P L
Sbjct: 1049 GVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALA 1108
Query: 1116 FDAFSSQLCWVDAGTNRAECLNPSQPSRRKALE--GLQYPFAVTSYGKNLYFTDWKMNSV 1173
D+ +L W D+ R E + S + R LE + P +T + LY+ D + +
Sbjct: 1109 LDSKLGKLFWADSDLRRIESSDLS-GANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMI 1167
Query: 1174 VALDLAISKETDAFQPH--KQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLAT-PGSR 1230
+D+ + Q + + ++ + Q + H C+ +NGGC+H+CL G+
Sbjct: 1168 EKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHP-CAQDNGGCSHICLVKGDGTT 1226
Query: 1231 TCRCP 1235
C CP
Sbjct: 1227 RCSCP 1231
>ref|NP_061027.1| low density lipoprotein receptor related protein-deleted in tumor
[Homo sapiens]
gb|AAF70379.1|AF176832_1 (AF176832) low density lipoprotein receptor related protein-deleted
in tumor [Homo sapiens]
Length = 4599
Score = 185 bits (464), Expect = 3e-45
Identities = 104/267 (38%), Positives = 148/267 (54%), Gaps = 12/267 (4%)
Query: 983 LAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWT-DSN 1041
L F +Y+ D T IGR + G E TI++ DL + EGIAVD +G N++WT D +
Sbjct: 561 LDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGH 620
Query: 1042 LDRIEVAKLD--GTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDN-----PKIETSY 1094
I VA+L+ R+ L E ++ +PRGIV D V G +YWTDW D +IE ++
Sbjct: 621 RKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAW 680
Query: 1095 MDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG--LQY 1152
MDG NR+I V + PNGL D ++ L W DA + E + + R+ G L +
Sbjct: 681 MDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNH 740
Query: 1153 PFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC 1212
PF ++ +G +++TD+ S+ LDL S+ T H++ L+G+ + QG N C
Sbjct: 741 PFGLSHHGNYVFWTDYMNGSIFQLDLITSEVT--LLRHERPPLFGLQIYDPRKQQGDNMC 798
Query: 1213 SVNNGGCTHLCLATPGSRTCRCPDNTL 1239
VNNGGC+ LCLA PG R C C DN L
Sbjct: 799 RVNNGGCSTLCLAIPGGRVCACADNQL 825
Score = 159 bits (399), Expect = 1e-37
Identities = 96/275 (34%), Positives = 137/275 (48%), Gaps = 28/275 (10%)
Query: 981 IGLAFDCVDKMVYWTDITEPSI--GRASLHGGEPT--TIIRQDLGSPEGIAVDHLGRNIF 1036
I L F ++YWTD+ E I G+ S GG ++ L +PEG+ VD + NI+
Sbjct: 1291 IALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIY 1350
Query: 1037 WTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMD 1096
W DSNLD+IEVAKLDG+ R L + +PR I D G L+WTDW+ + P+IE++ M
Sbjct: 1351 WIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMS 1410
Query: 1097 GTNRRILVQD--DLGLPNGLHFDAFSSQLCWVDA-----------GTNRAECLNPSQPSR 1143
G R+ + +D PNGL D F ++ W DA GTN E +
Sbjct: 1411 GAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEII------- 1463
Query: 1144 RKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALS 1203
+ E L +PFAV+ YG +Y+TDW+ N++ + + Q S
Sbjct: 1464 -RGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPS 1522
Query: 1204 QCPQGHNYCSVNN--GGCTHLCLATPG-SRTCRCP 1235
+ PQ N C+ N+ G C+H+CL S C CP
Sbjct: 1523 RQPQAPNPCAANDGKGPCSHMCLINHNRSAACACP 1557
Score = 144 bits (359), Expect = 7e-33
Identities = 153/615 (24%), Positives = 241/615 (38%), Gaps = 132/615 (21%)
Query: 662 EGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDEC---SEQP 718
+G D + T GC N C F C + C D+C S++
Sbjct: 2782 DGERDCPDGSDELSTAGCAPNNTC---DENAFMCHNKVCIPKQF-VCDHDDDCGDGSDES 2837
Query: 719 SVCGSHTICNNHPGTFRCECVEG-------YQFSDEGTCVAVVDQRPIN-YCETGLHNCD 770
CG GT C +G +Q + C D+ P+N C++ +C+
Sbjct: 2838 PQCGYRQC-----GTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCN 2892
Query: 771 ----IPQRAQCIYTGG---SSYTCSCLPGFSGDGQACQDVDEC---QPSRCHPDAFCYNT 820
+ + +CI +GG + C G D + C ++EC + S C D C +
Sbjct: 2893 SSFFMCKNGRCIPSGGLCDNKDDC----GDGSDERNCH-INECLSKKVSGCSQD--CQDL 2945
Query: 821 PGSFTCQCKPGYQ--GDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPEC 878
P S+ C+C PG+Q DG CV + EC
Sbjct: 2946 PVSYKCKCWPGFQLKDDGKTCVD---------------------------------IDEC 2972
Query: 879 DAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPC--LSTVAPPIHQGPAVPTA 936
+ G QC + G C+ DG E++ P C LS P
Sbjct: 2973 SS-GFPCSQQCINTYGTYKCLCTDGYEIQ-----PDNPNGCKSLSDEEP----------- 3015
Query: 937 VIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTD 996
L+ A +I ++ +G+ L +I + FD ++ +YW D
Sbjct: 3016 --------FLILADHHEIRKISTDGSNY------TLLKQGLNNVIAIDFDYREEFIYWID 3061
Query: 997 ITEPS---IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGT 1053
+ P+ I R L+G + + + P +AVD +G+N++W+D+ IEV+KL+G
Sbjct: 3062 SSRPNGSRINRMCLNGSDIKVV--HNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGL 3119
Query: 1054 QRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNG 1113
+L L PR + D G LYW D + P I MDGTN+ ++++ + P
Sbjct: 3120 YPTILVSKRLKFPRDLSLDPQAGYLYWIDC-CEYPHIGRVGMDGTNQSVVIETKISRPMA 3178
Query: 1114 LHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKA-LEGLQYPFAVTSYGKNLYFTDWKMNS 1172
L D + +L W D N E N R K + + A+T + +Y+TD K S
Sbjct: 3179 LTIDYVNRRLYWAD--ENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKS 3236
Query: 1173 VVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNY---------CSVNNGGCTHLC 1223
+S+ + + +Y A++ H+Y C +NNGGC+HLC
Sbjct: 3237 -------LSRAHKTSGADRLSLIYS-WHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLC 3288
Query: 1224 LATPG-SRTCRCPDN 1237
L PG + TC CP N
Sbjct: 3289 LLAPGKTHTCACPTN 3303
Score = 131 bits (327), Expect = 4e-29
Identities = 89/275 (32%), Positives = 133/275 (48%), Gaps = 9/275 (3%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
+G+ F + +YWTD+ I RA II LG EGIAVD + NI+WTD
Sbjct: 1913 VGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDH 1972
Query: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
+ IEVA+L+G+ R V+ L PR I +G L+WT+W + P I + +DG+ +
Sbjct: 1973 GFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQ-MPCIGKARLDGSEK 2031
Query: 1101 RILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLN-PSQPSRRKALEGLQYP-FAVTS 1158
+LV + PNG+ D ++L W DA T++ E ++ + +R L G F+V
Sbjct: 2032 VVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAV 2091
Query: 1159 YGKNLYFTD--WKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNN 1216
+G +Y++D SV + ET + L + +G N C+ +N
Sbjct: 2092 FGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDN 2151
Query: 1217 GGCTHLCLATPGS-RTCRCPDNTL---GVDCIERK 1247
GGC LCL S RTC C L GV C+ +
Sbjct: 2152 GGCKQLCLYRGNSRRTCACAHGYLAEDGVTCLRHE 2186
Score = 126 bits (314), Expect = 1e-27
Identities = 85/260 (32%), Positives = 128/260 (48%), Gaps = 21/260 (8%)
Query: 985 FDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLD- 1043
FD ++ +YWTDI +I RA ++G T+I +D+ S G+AVD + RN++W S D
Sbjct: 1613 FDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDE 1672
Query: 1044 -RIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRI 1102
+I VA+LDG+ + + + P+ + VRG LYWTD N I + MDG+N +I
Sbjct: 1673 TQINVARLDGSLKTSIIH-GIDKPQCLAAHPVRGKLYWTDGN----TINMANMDGSNSKI 1727
Query: 1103 LVQDDLGLPNGLHFDAFSSQLCWVDAGT---NRAECLNPSQPSRRKALEGLQYPFAVTSY 1159
L Q+ P GL D ++L W+ +G NR + E L A+T
Sbjct: 1728 LFQNQKE-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIM 1786
Query: 1160 GKNLYFTDWKMNSVVALDLAISKETDAFQP----HKQTRLYGITTALSQCPQGHNYCSVN 1215
K L++ D + L + D P +K + + + + QG N C +N
Sbjct: 1787 DKKLWWADQNL-----AQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLN 1841
Query: 1216 NGGCTHLCLAT-PGSRTCRC 1234
NGGC+ LCL T +RTC C
Sbjct: 1842 NGGCSQLCLPTSETTRTCMC 1861
Score = 92.1 bits (225), Expect = 3e-17
Identities = 65/273 (23%), Positives = 122/273 (43%), Gaps = 19/273 (6%)
Query: 978 KVIIGLAFDCVDKM-----VYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLG 1032
K +I LAFD + ++++D +I + E +I +++GS EG+A
Sbjct: 2222 KNVIALAFDYNQRRKGTNRIFYSDAHFGNI-QLIKDNWEDRQVIVENVGSVEGLAYHRAW 2280
Query: 1033 RNIFWTDSNLDRIEVAKLDGTQ------RRVLFETDLVNPRGIVTDSVRGNLYWTDWNRD 1086
++WT S I +D T+ V+ ++ +P + D + ++WT+WN
Sbjct: 2281 DTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQ 2340
Query: 1087 NPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKA 1146
+P I S + G N +++V D+ PNGL D + +L + D + E R
Sbjct: 2341 HPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVI 2400
Query: 1147 LEGLQYPF-AVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQ---PHKQTRLYGITTAL 1202
++ F ++ Y ++++DW +++ + +T + PH+ + +
Sbjct: 2401 VKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDT 2460
Query: 1203 SQCPQGHNYCSVNNGGCTHLCLATPGSR-TCRC 1234
+ C + C++ NGGC LCL TP R C C
Sbjct: 2461 NSCEL--SPCALLNGGCHDLCLLTPNGRVNCSC 2491
Score = 88.9 bits (217), Expect = 3e-16
Identities = 114/468 (24%), Positives = 180/468 (38%), Gaps = 89/468 (19%)
Query: 789 CLPGFSGDGQACQDV-DECQPSRCHPDAFCYNTPGSFTCQCKPGYQ--GDGFRCVPGEVE 845
C G+ +G CQ++ CQ C C S C C+ G++ DG C +
Sbjct: 103 CPDGYD-EGVHCQELLSNCQQLNCQYK--CTMVRNSTRCYCEDGFEITEDGRSCKDQD-- 157
Query: 846 KTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPT--QCHGSTGYCWCVDRDG 903
EC +G + T HGS C CV+
Sbjct: 158 -------------------------------ECAVYGTCSQTCRNTHGSYT-CSCVEGYL 185
Query: 904 REVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNT 963
+ + + + P T PPI LL A IE L G+
Sbjct: 186 MQPDNRSCKAKIEP----TDRPPI------------------LLIANFETIEVFYLNGSK 223
Query: 964 MRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS-------IGRASLHGGEPTTII 1016
M + V I L F + M+ W + E S I +A E T I
Sbjct: 224 MATLSS-----VNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINI 278
Query: 1017 RQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRG 1076
Q + + +A+D L RN+++ D DRI V +G+ L + +L NP+ I D + G
Sbjct: 279 LQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAG 338
Query: 1077 NLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECL 1136
L++TD+ + K+E MDG NR ++ P L D + + WVD + +
Sbjct: 339 KLFFTDYG-NVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVV 397
Query: 1137 NPSQPSRRKALEGLQ--YPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTR 1194
+ +R ++G Q + + +T + LY T+ ++V ++ TD K
Sbjct: 398 DYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINR--FNGTDIHSLIKIEN 455
Query: 1195 LYGIT--TALSQCPQGHNYCSVN----NGGCTHLCLATPG--SRTCRC 1234
+GI +Q + C V+ GGC+H+CL + +RTCRC
Sbjct: 456 AWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRC 503
Score = 76.9 bits (186), Expect = 1e-12
Identities = 79/288 (27%), Positives = 109/288 (37%), Gaps = 62/288 (21%)
Query: 989 DKMVYWTDITEPSIGRASLHGGEP----TTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDR 1044
D +++ T I +HG E + +I + P IAVD + NI+WTD +
Sbjct: 3933 DMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMH 3992
Query: 1045 ---------------IEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPK 1089
I V +L+G L P I + RG +YWT D+
Sbjct: 3993 WFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVG-DHSH 4051
Query: 1090 IETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVD-----------AGTNRAECLNP 1138
IE + MDGT RRILVQ +L P GL D FS ++ W D G+N ++
Sbjct: 4052 IEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSS 4111
Query: 1139 SQPSRRKALEGLQYPFAVTSYGKNLYFTDWK----------MNSVVALDLAISKETDAFQ 1188
Q GL +P + + +Y K SV L L I K
Sbjct: 4112 KQ--------GLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEYLALNIDKTKGVLI 4163
Query: 1189 PHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPD 1236
H+ +L P N C + C LCL P TC CP+
Sbjct: 4164 SHRYKQL--------DLP---NPCL--DLACEFLCLLNPSGATCVCPE 4198
Score = 50.0 bits (117), Expect = 2e-04
Identities = 48/150 (32%), Positives = 64/150 (42%), Gaps = 43/150 (28%)
Query: 711 IDECSEQPSV-CG-SHTICNNHPGTFRC-----------ECVEGYQFSDEGTCVAVVDQR 757
+D C E+ + C +H C GT +C +C +GY DEG
Sbjct: 66 LDTCPEEVEIKCPLNHIACL---GTNKCVHLSQLCNGVLDCPDGY---DEGV-------- 111
Query: 758 PINYCETGLHNCDIPQRAQCIYTGG---SSYTCSCLPGF--SGDGQACQDVDECQP-SRC 811
+C+ L NC Q+ C Y +S C C GF + DG++C+D DEC C
Sbjct: 112 ---HCQELLSNC---QQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTC 165
Query: 812 HPDAFCYNTPGSFTCQCKPGY--QGDGFRC 839
C NT GS+TC C GY Q D C
Sbjct: 166 SQT--CRNTHGSYTCSCVEGYLMQPDNRSC 193
Score = 47.6 bits (111), Expect = 8e-04
Identities = 26/95 (27%), Positives = 41/95 (42%), Gaps = 4/95 (4%)
Query: 662 EGSPDA-LQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
+GS + L + C + GC + + PG +C + D +TC +D CS
Sbjct: 1165 DGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLK- 1223
Query: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVD 755
C +C H T +C C EG++ +G VD
Sbjct: 1224 CSQ--VCEQHKHTVKCSCYEGWKLDVDGESCTSVD 1256
Score = 45.7 bits (106), Expect = 0.003
Identities = 26/69 (37%), Positives = 33/69 (47%), Gaps = 6/69 (8%)
Query: 690 RTQFTCECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFS-D 746
R C C GF DGR+C D DEC+ C C N G++ C CVEGY D
Sbjct: 133 RNSTRCYCEDGFEITEDGRSCKDQDECAVY-GTCSQ--TCRNTHGSYTCSCVEGYLMQPD 189
Query: 747 EGTCVAVVD 755
+C A ++
Sbjct: 190 NRSCKAKIE 198
Score = 41.4 bits (95), Expect = 0.061
Identities = 46/179 (25%), Positives = 65/179 (35%), Gaps = 33/179 (18%)
Query: 677 HGCDTNAACRPGPRTQFTC----ECSIGFRGD---GRTCYDIDECSEQPSVCGSHTICNN 729
H C N C +++ C EC D G+ Y C + C +
Sbjct: 3721 HRCRNNRICL---QSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCI-- 3775
Query: 730 HPGTFRCE----CVEGYQFSDEGTCVAVVDQRPINY-CETGLHNCDIPQRAQCIYTGGSS 784
P +C+ C +G SDE C P Y CE ++ C I T S
Sbjct: 3776 -PMDLQCDRLDDCGDG---SDEQGCRIA----PTEYTCEDNVNPCGDDAYCNQIKT---S 3824
Query: 785 YTCSCLPGFSGD--GQACQDVDECQP-SRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV 840
C C PGF + + C+D++EC C C N GS+ C C +Q C+
Sbjct: 3825 VFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQ--CINVEGSYKCVCDQNFQERNNTCI 3881
Score = 41.0 bits (94), Expect = 0.080
Identities = 47/184 (25%), Positives = 62/184 (33%), Gaps = 59/184 (32%)
Query: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCEC 738
C C P + TC C++GF G CG T+C + C
Sbjct: 4257 CQNGGTCVPSVLGRPTCSCALGFTGPN---------------CGK-TVCEDF-------C 4293
Query: 739 VEGYQFSDEGTCVAVVDQRPINYCE---TG--------LHNCDIPQRAQCIYTGGSSYTC 787
G GTC+ +P +C+ TG H C C S C
Sbjct: 4294 QNG------GTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYC--VNSESCTIGDDGSXEC 4345
Query: 788 SCLPGFSGDGQACQDVDECQPSRCH----------PDAFCYNTPGSF--TCQCKPGYQGD 835
C + +G C +VD+C RCH D FC T G +CQ GY +
Sbjct: 4346 VCPTRY--EGPKC-EVDKC--VRCHGGHCIINKDSEDIFCNCTNGKIASSCQLCDGYCYN 4400
Query: 836 GFRC 839
G C
Sbjct: 4401 GGTC 4404
Score = 39.9 bits (91), Expect = 0.18
Identities = 52/219 (23%), Positives = 77/219 (34%), Gaps = 62/219 (28%)
Query: 726 ICNNHPGTFRCECVEGYQFSDEGTCV--AVVDQRPINYCETGLHNCDIPQRAQCIYTGGS 783
+C +P C C EG ++ GTC +++D CE G +CI
Sbjct: 4184 LCLLNPSGATCVCPEG-KYLINGTCNDDSLLDDSCKLTCENG---------GRCILNEKG 4233
Query: 784 SYTCSCLPGFSGD-------GQACQDVDECQPS-------------------------RC 811
C C P +SG+ CQ+ C PS C
Sbjct: 4234 DLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFC 4293
Query: 812 HPDAFCYNTPGSFT-CQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATD---PQR 867
C T G+ C C+P Y GD RC V C + +G G+ + P R
Sbjct: 4294 QNGGTCIVTAGNQPYCHCQPEYTGD--RC-QYYVCHHYCVNSESCTIGDDGSXECVCPTR 4350
Query: 868 PIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREV 906
P V +C +CHG G+C +++D ++
Sbjct: 4351 YEGPKCEVDKC--------VRCHG--GHC-IINKDSEDI 4378
Score = 38.7 bits (88), Expect = 0.41
Identities = 21/79 (26%), Positives = 37/79 (46%), Gaps = 1/79 (1%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
+GL+ D V+ +YW +I R +L GG I + A+ + + ++W D
Sbjct: 1736 VGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQ 1795
Query: 1041 NLDRI-EVAKLDGTQRRVL 1058
NL ++ +K DG +L
Sbjct: 1796 NLAQLGTCSKRDGRNPTIL 1814
Score = 35.6 bits (80), Expect = 3.5
Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 7/39 (17%)
Query: 1205 CPQGHNY------CSVNNGGCTHLCLATPG-SRTCRCPD 1236
CP G + CS+NNGGC++ C PG C CP+
Sbjct: 1163 CPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPE 1201
>gb|AAF58373.1| (AE003818) LRP6 gene product [Drosophila melanogaster]
Length = 1612
Score = 181 bits (455), Expect = 4e-44
Identities = 91/258 (35%), Positives = 141/258 (54%), Gaps = 2/258 (0%)
Query: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 1037
K I + +D V++ +YW+D+ +I RA G T + ++ P+G+A+D L RN++W
Sbjct: 368 KYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDFVTSEVRHPDGLALDWLARNLYW 427
Query: 1038 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 1097
TD+ DRIEV +LDGT R+VL L PR I G ++W+DWN PK+E + +DG
Sbjct: 428 TDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDG 487
Query: 1098 TNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL-EGLQYPFAV 1156
+ R +LV ++LG PNG+ D + + W D T++ E N RR + + L++ F +
Sbjct: 488 SERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKHLFGL 547
Query: 1157 TSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNN 1216
+ LY+TDW+ S+ I+ + L G+ + +G N C+V N
Sbjct: 548 SILDDYLYWTDWQRRSIDRAH-KITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAVRN 606
Query: 1217 GGCTHLCLATPGSRTCRC 1234
GGC+HLCL P CRC
Sbjct: 607 GGCSHLCLNRPRDYVCRC 624
Score = 151 bits (378), Expect = 4e-35
Identities = 94/267 (35%), Positives = 130/267 (48%), Gaps = 14/267 (5%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGE--------PTTIIRQDLGSPEGIAVDHLG 1032
+ + F +V WTD I A + T+I L PEG+A+D
Sbjct: 56 MAIDFYYAKNLVCWTDSGREIIECAQTNSSALQPLLRAPKQTVISTGLDKPEGLAMDWYT 115
Query: 1033 RNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIET 1092
I+WTD +RIEVA LDG ++VLF TDL PR + R L WTDW + PKIE
Sbjct: 116 DKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAVAVVPARKLLIWTDWG-EYPKIER 174
Query: 1093 SYMDG--TNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGL 1150
+ MDG +R LV++ + PNGL D + + W D + + + SRR + L
Sbjct: 175 ASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHHFIDVMRLDGSSRRTIVNNL 234
Query: 1151 QYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHN 1210
+YPF++T Y LY+TDW+ S+ ALDL + + K Q P N
Sbjct: 235 KYPFSLTFYDDRLYWTDWQRGSLNALDLQTRELKELIDTPKAPNSVRAWDPSLQ-PYEDN 293
Query: 1211 YCSVNNGGCTHLCLATPGSR--TCRCP 1235
C+ NNG C+HLCL S+ +C CP
Sbjct: 294 PCAHNNGNCSHLCLLATNSQGFSCACP 320
Score = 148 bits (369), Expect = 5e-34
Identities = 105/317 (33%), Positives = 154/317 (48%), Gaps = 25/317 (7%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVII---GLAFDCVDKMVYWTDIT 998
P LLF++ I R+ +E N + + +P K + L ++ +YWTD
Sbjct: 640 PAAFLLFSRQEHIGRISIEYNEGNHNDER----IPFKDVRDAHALDVSVAERRIYWTDQK 695
Query: 999 EPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVL 1058
I RA L+G I+ L P+GIAVD L NI+W+D+ RIEVA+LDG+ RRVL
Sbjct: 696 SKCIFRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVL 755
Query: 1059 FETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDA 1118
+ PR +V + RG +YWT+ D+ I + MDG++ + +V GL FD
Sbjct: 756 LWKGVEEPRSLVLEPRRGYMYWTESPTDS--IRRAAMDGSDLQTIVA-GANHAAGLTFDQ 812
Query: 1119 FSSQLCWVDAGTNRAECLNPSQPSRRKALEG--LQYPFAVTSYGKNLYFTDWKMNSVVAL 1176
+ +L W +R+ L G + P+AV+ Y +Y++DW +
Sbjct: 813 ETRRLYWATQSRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSDWNTGDIE-- 870
Query: 1177 DLAISKETDAFQPHKQTRLYGITTAL---SQCPQGHNYCSVNNGGCTHLCLATPGSR--T 1231
+ K T + + + IT+ L + G N C VNNGGC+HLCLA PG R T
Sbjct: 871 --RVHKTTGQNRSLVHSGMTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMT 928
Query: 1232 CRCPDNTL----GVDCI 1244
C CP + GV CI
Sbjct: 929 CACPTHYQLAKDGVSCI 945
Score = 64.0 bits (153), Expect = 1e-08
Identities = 77/337 (22%), Positives = 143/337 (41%), Gaps = 30/337 (8%)
Query: 912 RPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKA 971
R GMT C P H A V +PP +++F+Q RL T+
Sbjct: 924 RRGMTCAC------PTHYQLA-KDGVSCIPPRNYIIFSQRNCFGRL-----LPNTTDCPN 971
Query: 972 F-LHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDH 1030
L V K I + +D + +YW + SI R+ +G + + + G P +A+D
Sbjct: 972 IPLPVSGKNIRAVDYDPITHHIYWIEGRSHSIKRSLANGTKVSLLANS--GQPFDLAIDI 1029
Query: 1031 LGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKI 1090
+GR +FWT S + I V G V+ D PR I +++ L+WTD + I
Sbjct: 1030 IGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVG-SHQAI 1088
Query: 1091 ETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALE-G 1149
+ +DG N R+ + L L D S + + A R + ++ + +++ +
Sbjct: 1089 IRARVDG-NERVELAYKLEGVTALALDQQSDMIYY--AHGKRIDAIDINGKNKKTLVSMH 1145
Query: 1150 LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQ-- 1207
+ + + G +Y+ D K + ++ E + + + ++ I + P+
Sbjct: 1146 ISQVINIAALGGFVYWLDDKTG---VERITVNGERRSAELQRLPQITDIRAVWTPDPKVL 1202
Query: 1208 GHNYCSVNNGGCTHLCLATPG--SRT---CRCPDNTL 1239
++ C + C+H+C+A+ +RT C CP + +
Sbjct: 1203 RNHTCMHSRTKCSHICIASGEGIARTRDVCSCPKHLM 1239
>gb|AAF28358.1|AF223365_1 (AF223365) LDL-related protein LRP6 [Drosophila melanogaster]
Length = 1678
Score = 181 bits (455), Expect = 4e-44
Identities = 91/258 (35%), Positives = 141/258 (54%), Gaps = 2/258 (0%)
Query: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFW 1037
K I + +D V++ +YW+D+ +I RA G T + ++ P+G+A+D L RN++W
Sbjct: 434 KYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDFVTSEVRHPDGLALDWLARNLYW 493
Query: 1038 TDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDG 1097
TD+ DRIEV +LDGT R+VL L PR I G ++W+DWN PK+E + +DG
Sbjct: 494 TDTVXDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDG 553
Query: 1098 TNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL-EGLQYPFAV 1156
+ R +LV ++LG PNG+ D + + W D T++ E N RR + + L++ F +
Sbjct: 554 SERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKHLFGL 613
Query: 1157 TSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNN 1216
+ LY+TDW+ S+ I+ + L G+ + +G N C+V N
Sbjct: 614 SILDDYLYWTDWQRRSIDRAH-KITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAVRN 672
Query: 1217 GGCTHLCLATPGSRTCRC 1234
GGC+HLCL P CRC
Sbjct: 673 GGCSHLCLNRPRDYVCRC 690
Score = 151 bits (378), Expect = 4e-35
Identities = 94/267 (35%), Positives = 130/267 (48%), Gaps = 14/267 (5%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGE--------PTTIIRQDLGSPEGIAVDHLG 1032
+ + F +V WTD I A + T+I L PEG+A+D
Sbjct: 122 MAIDFYYAKNLVCWTDSGREIIECAQTNSSALQPLLRAPKQTVISTGLDKPEGLAMDWYT 181
Query: 1033 RNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIET 1092
I+WTD +RIEVA LDG ++VLF TDL PR + R L WTDW + PKIE
Sbjct: 182 DKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAVAVVPARKLLIWTDWG-EYPKIER 240
Query: 1093 SYMDG--TNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGL 1150
+ MDG +R LV++ + PNGL D + + W D + + + SRR + L
Sbjct: 241 ASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHHFIDVMRLDGSSRRTIVNNL 300
Query: 1151 QYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHN 1210
+YPF++T Y LY+TDW+ S+ ALDL + + K Q P N
Sbjct: 301 KYPFSLTFYDDRLYWTDWQRGSLNALDLQTRELKELIDTPKAPNSVRAWDPSLQ-PYEDN 359
Query: 1211 YCSVNNGGCTHLCLATPGSR--TCRCP 1235
C+ NNG C+HLCL S+ +C CP
Sbjct: 360 PCAHNNGNCSHLCLLATNSQGFSCACP 386
Score = 148 bits (369), Expect = 5e-34
Identities = 105/317 (33%), Positives = 154/317 (48%), Gaps = 25/317 (7%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVII---GLAFDCVDKMVYWTDIT 998
P LLF++ I R+ +E N + + +P K + L ++ +YWTD
Sbjct: 706 PAAFLLFSRQEHIGRISIEYNEGNHNDER----IPFKDVRDAHALDVSVAERRIYWTDQK 761
Query: 999 EPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVL 1058
I RA L+G I+ L P+GIAVD L NI+W+D+ RIEVA+LDG+ RRVL
Sbjct: 762 SKCIFRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVL 821
Query: 1059 FETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDA 1118
+ PR +V + RG +YWT+ D+ I + MDG++ + +V GL FD
Sbjct: 822 LWKGVEEPRSLVLEPRRGYMYWTESPTDS--IRRAAMDGSDLQTIVA-GANHAAGLTFDQ 878
Query: 1119 FSSQLCWVDAGTNRAECLNPSQPSRRKALEG--LQYPFAVTSYGKNLYFTDWKMNSVVAL 1176
+ +L W +R+ L G + P+AV+ Y +Y++DW +
Sbjct: 879 ETRRLYWATQSRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSDWNTGDIE-- 936
Query: 1177 DLAISKETDAFQPHKQTRLYGITTAL---SQCPQGHNYCSVNNGGCTHLCLATPGSR--T 1231
+ K T + + + IT+ L + G N C VNNGGC+HLCLA PG R T
Sbjct: 937 --RVHKTTGQNRSLVHSGMTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMT 994
Query: 1232 CRCPDNTL----GVDCI 1244
C CP + GV CI
Sbjct: 995 CACPTHYQLAKDGVSCI 1011
Score = 64.0 bits (153), Expect = 1e-08
Identities = 77/337 (22%), Positives = 143/337 (41%), Gaps = 30/337 (8%)
Query: 912 RPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKA 971
R GMT C P H A V +PP +++F+Q RL T+
Sbjct: 990 RRGMTCAC------PTHYQLA-KDGVSCIPPRNYIIFSQRNCFGRL-----LPNTTDCPN 1037
Query: 972 F-LHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDH 1030
L V K I + +D + +YW + SI R+ +G + + + G P +A+D
Sbjct: 1038 IPLPVSGKNIRAVDYDPITHHIYWIEGRSHSIKRSLANGTKVSLLANS--GQPFDLAIDI 1095
Query: 1031 LGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKI 1090
+GR +FWT S + I V G V+ D PR I +++ L+WTD + I
Sbjct: 1096 IGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVG-SHQAI 1154
Query: 1091 ETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALE-G 1149
+ +DG N R+ + L L D S + + A R + ++ + +++ +
Sbjct: 1155 IRARVDG-NERVELAYKLEGVTALALDQQSDMIYY--AHGKRIDAIDINGKNKKTLVSMH 1211
Query: 1150 LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQ-- 1207
+ + + G +Y+ D K + ++ E + + + ++ I + P+
Sbjct: 1212 ISQVINIAALGGFVYWLDDKTG---VERITVNGERRSAELQRLPQITDIRAVWTPDPKVL 1268
Query: 1208 GHNYCSVNNGGCTHLCLATPG--SRT---CRCPDNTL 1239
++ C + C+H+C+A+ +RT C CP + +
Sbjct: 1269 RNHTCMHSRTKCSHICIASGEGIARTRDVCSCPKHLM 1305
>gb|AAF81758.1|AF270884_1 (AF270884) low density lipoprotein receptor related protein
LRP1B/LRP-DIT [Mus musculus]
Length = 4599
Score = 178 bits (447), Expect = 3e-43
Identities = 100/267 (37%), Positives = 144/267 (53%), Gaps = 12/267 (4%)
Query: 983 LAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWT-DSN 1041
L F +Y+ D T IGR + G E TI++ DL + EGIAVD +G N++WT D +
Sbjct: 561 LDFHAEANYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGH 620
Query: 1042 LDRIEVAKLD--GTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDN-----PKIETSY 1094
I VA+L+ R+ L E + +PR IV D V G +YWTDW D +IE ++
Sbjct: 621 RKTINVARLEKASQSRKTLLEGGMSHPRAIVVDPVNGWMYWTDWKEDKIDDSVGRIEKAW 680
Query: 1095 MDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG--LQY 1152
MDG NR++ V + PNGL D +S L W DA + E + + R+ G L +
Sbjct: 681 MDGVNRQVFVTSKMLWPNGLTLDFHTSTLYWCDAYYDHIEKVFLNGTHRKVVYSGKELNH 740
Query: 1153 PFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC 1212
PF ++ +G +++TD+ S+ LDL ++ T H++ L+G+ + QG N C
Sbjct: 741 PFGLSHHGNYVFWTDYMNGSIFQLDLMTNEVT--LLRHERAPLFGLQIYDPRKQQGDNMC 798
Query: 1213 SVNNGGCTHLCLATPGSRTCRCPDNTL 1239
+NNGGC LCLA P R C C DN L
Sbjct: 799 RINNGGCGTLCLAIPAGRVCACADNQL 825
Score = 159 bits (398), Expect = 2e-37
Identities = 96/275 (34%), Positives = 136/275 (48%), Gaps = 28/275 (10%)
Query: 981 IGLAFDCVDKMVYWTDITEPSI--GRASLHGGEPT--TIIRQDLGSPEGIAVDHLGRNIF 1036
I L F ++YWTD+ E I G+ S GG ++ L +PEG+ VD + NI+
Sbjct: 1291 IALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIY 1350
Query: 1037 WTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMD 1096
W DSNLD+IEV+KLDG+ R L + +PR I D G L+WTDW+ + P+IE++ M
Sbjct: 1351 WIDSNLDQIEVSKLDGSLRATLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMS 1410
Query: 1097 GTNRRILVQD--DLGLPNGLHFDAFSSQLCWVDA-----------GTNRAECLNPSQPSR 1143
G R+ + +D PNGL D F ++ W DA GTN E +
Sbjct: 1411 GAGRKTIYKDMKTGAWPNGLTVDHFERRIVWTDARSDAIYSAFYDGTNMIEII------- 1463
Query: 1144 RKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALS 1203
+ E L +PFAV+ YG +Y+TDW+ N++ + + Q S
Sbjct: 1464 -RGHEYLSHPFAVSLYGSEVYWTDWRTNTLAKANKWTGQNVSVIQKTSAQPFDLQIYHPS 1522
Query: 1204 QCPQGHNYCSVN--NGGCTHLCLATPG-SRTCRCP 1235
+ PQ N C+ N G C+HLCL S C CP
Sbjct: 1523 RQPQAPNPCAANEGRGPCSHLCLINHNRSAACACP 1557
Score = 145 bits (363), Expect = 2e-33
Identities = 160/609 (26%), Positives = 241/609 (39%), Gaps = 120/609 (19%)
Query: 662 EGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDEC---SEQP 718
+G D + + GC N C F C + C D+C S++
Sbjct: 2782 DGERDCPDGSDELSSAGCAPNNTC---DENAFMCHNKVCIPKQF-VCDHDDDCGDGSDEF 2837
Query: 719 SVCGSHTICNNHPGTFRC---ECVEG--YQFSDEGTCVAVVDQRPIN-YCETGLHNCD-- 770
CG + C P FRC C+ +Q + C D+ PIN C + H+C+
Sbjct: 2838 LQCG-YRQCG--PEEFRCADGRCLVNTLWQCDGDFDCPDSSDEAPINPRCRSAEHSCNSS 2894
Query: 771 --IPQRAQCIYTGG-SSYTCSCLPGFSGDGQACQDVDEC---QPSRCHPDAFCYNTPGSF 824
+ + +CI + G C G D C ++EC + S C D C + P S+
Sbjct: 2895 FFMCKNGRCIPSDGLCDIRDDC--GDGSDETNCH-INECLSKKISGCSQD--CQDLPVSY 2949
Query: 825 TCQCKPGYQ--GDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHG 882
C+C PG+Q DG CV + EC + G
Sbjct: 2950 KCKCWPGFQLKDDGKTCVD---------------------------------IDECSS-G 2975
Query: 883 HYAPTQCHGSTGY--CWCVDRDGREVEGTRTRPGMTPPC--LSTVAPPIHQGPAVPTAVI 938
QC + G C C EG T+P C LS P
Sbjct: 2976 FPCSQQCINTYGTYKCHCA-------EGYETQPDNPNGCRSLSDEEP------------- 3015
Query: 939 PLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDIT 998
L+ A +I ++ +G+ L +I L FD ++ +YW D +
Sbjct: 3016 ------FLILADQHEIRKISTDGSNY------TLLKQGLNNVIALDFDYREEFIYWIDSS 3063
Query: 999 EPS---IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQR 1055
P+ I R L+G + + + P +AVD +G+N++W+D+ IEV+KL+G
Sbjct: 3064 RPNGSRINRMCLNGSDIKVV--HNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYP 3121
Query: 1056 RVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLH 1115
VL L PR + D GNLYW D + P I MDGTN+ ++++ + P L
Sbjct: 3122 TVLVSKRLKFPRDLSLDPRAGNLYWIDC-CEYPHIGRVGMDGTNQSVVIETKISRPMALT 3180
Query: 1116 FDAFSSQLCWVDAGTNRAECLNPSQPSRRKA-LEGLQYPFAVTSYGKNLYFTDWKMNSVV 1174
D + +L W D N E N R K + + A+T + +Y+TD K S+
Sbjct: 3181 IDYVNHRLYWAD--ENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSL- 3237
Query: 1175 ALDLAISKETDAFQPHKQTRLYGITT-----ALSQCPQGHNYCSVNNGGCTHLCLATPG- 1228
+ K + A + + IT + Q + C+VNNGGC+HLCL PG
Sbjct: 3238 ---SRVHKTSGADRLSLINSWHAITDIQVYHSYRQPDVSKHLCTVNNGGCSHLCLLGPGK 3294
Query: 1229 SRTCRCPDN 1237
+ TC CP N
Sbjct: 3295 THTCACPTN 3303
Score = 128 bits (318), Expect = 4e-28
Identities = 92/299 (30%), Positives = 143/299 (47%), Gaps = 23/299 (7%)
Query: 946 LLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRA 1005
LL+A+ +I + ++ + A + +I FD ++ +YWTDI +I RA
Sbjct: 1576 LLYARRSEIRGVDIDNPYVNFITAFTVPDIDDVAVID--FDASEERLYWTDIKTQTITRA 1633
Query: 1006 SLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLD--RIEVAKLDGTQRRVLFETDL 1063
++G T+I +D+ S G+AVD + RN++W S D +I VA+LDG+ + + +
Sbjct: 1634 FINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIH-GI 1692
Query: 1064 VNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQL 1123
P+ + VRG LYWTD N I + MDG+N +IL Q+ P GL D ++L
Sbjct: 1693 DKPQCLAAHPVRGKLYWTDGN----TINMANMDGSNSKILFQNQKE-PVGLSIDYVENKL 1747
Query: 1124 CWVDAGT---NRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAI 1180
W+ +G NR + E L A+T K L++ D + L
Sbjct: 1748 YWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNL-----AQLGT 1802
Query: 1181 SKETDAFQP----HKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLAT-PGSRTCRC 1234
+ D P +K + + + + QG N C VNNGGC+ LCL T +RTC C
Sbjct: 1803 CNKRDGRNPSILRNKTSGVVHMKVYDKEAQQGSNSCQVNNGGCSQLCLPTSETTRTCMC 1861
Score = 127 bits (316), Expect = 7e-28
Identities = 87/279 (31%), Positives = 133/279 (47%), Gaps = 9/279 (3%)
Query: 977 AKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIF 1036
A +G+ F + +YWTD+ I RA ++ LG EGIAVD + NI+
Sbjct: 1909 AAFAVGIDFHAENDTIYWTDMGLNKISRAKRDQTWKEDVVTNGLGRVEGIAVDWIAGNIY 1968
Query: 1037 WTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMD 1096
WTD + IEVA+L+G+ R V+ L PR I +G L+WT+W + P I + +D
Sbjct: 1969 WTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGFLFWTEWGQ-VPCIGKARLD 2027
Query: 1097 GTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKA-LEGLQYP-F 1154
G+ + ++V + PNG+ D ++L W DA +++ E ++ + R+ L G F
Sbjct: 2028 GSEKVMIVSVGITWPNGISIDYEENKLYWCDARSDKIERIDLDTGANREVLLSGSNVDLF 2087
Query: 1155 AVTSYGKNLYFTD--WKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC 1212
+V +G +Y++D SV + ET + L I +G N C
Sbjct: 2088 SVAVFGAYIYWSDRAHANGSVRRGHKNDATETVTMRTGLGVNLKEIKIFNRVREKGTNVC 2147
Query: 1213 SVNNGGCTHLCLATPGS-RTCRCPDNTL---GVDCIERK 1247
+ NGGC LCL S RTC C L GV C+ +
Sbjct: 2148 AKENGGCQQLCLYRGNSRRTCACAHGYLAGDGVTCLRHE 2186
Score = 92.1 bits (225), Expect = 3e-17
Identities = 66/273 (24%), Positives = 122/273 (44%), Gaps = 19/273 (6%)
Query: 978 KVIIGLAFDCVDKM-----VYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLG 1032
K II LAFD + ++++D +I + E +I +++GS EG+A
Sbjct: 2222 KNIIALAFDYNQRREGTNRIFYSDAHFGNI-QLIKDNWEDRQVIVENVGSVEGLAYHRAW 2280
Query: 1033 RNIFWTDSNLDRIEVAKLDGTQ------RRVLFETDLVNPRGIVTDSVRGNLYWTDWNRD 1086
++WT S+ I +D T+ V+ ++ +P + D + ++WT+WN
Sbjct: 2281 DTLYWTSSSTSSITRHTVDQTRPGAIDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQ 2340
Query: 1087 NPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKA 1146
+P I + + G N ++V D+ PNGL D + +L + D + E R
Sbjct: 2341 HPSIMRATLTGKNAHVVVSTDILTPNGLTIDHRAEKLYFSDGSLGKIERCEYDGSQRHVI 2400
Query: 1147 LEGLQYPF-AVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQ---PHKQTRLYGITTAL 1202
++ F ++ Y ++++DW +++ + ET + PH+ + +
Sbjct: 2401 VKSGPGTFLSLAVYDSYIFWSDWGRRAILRSNKYTGGETKILRSDIPHQPMGIIAVANDT 2460
Query: 1203 SQCPQGHNYCSVNNGGCTHLCLATPGSR-TCRC 1234
+ C + C++ NGGC LCL TP R C C
Sbjct: 2461 NSCEL--SPCALLNGGCHDLCLLTPDGRVNCSC 2491
Score = 89.7 bits (219), Expect = 2e-16
Identities = 67/227 (29%), Positives = 108/227 (47%), Gaps = 13/227 (5%)
Query: 1018 QDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGN 1077
Q + E +A D L RNI++ D DRI V +G+ L E++L NP+ I D + G
Sbjct: 280 QSFQNVEQMAFDWLTRNIYFVDHVSDRIFVCNFNGSVCVTLIESELHNPKAIAADPIAGK 339
Query: 1078 LYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLN 1137
L++TD+ + PKIE +DG NR +V P+ L D + + WVD + ++
Sbjct: 340 LFFTDYG-NVPKIERCDLDGMNRTRIVYSKAEQPSALALDLVNRLVYWVDLYLDYVGVVD 398
Query: 1138 PSQPSRRKALEGLQ--YPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRL 1195
+R ++G Q + + +T + LY T +++ ++ TD K
Sbjct: 399 YQGKNRHTIVQGRQVKHLYGITVFEDYLYATSSDNFNIIRINR--FNGTDIHSIIKMESA 456
Query: 1196 YGITT--ALSQCPQGHNYCSVN----NGGCTHLCLATPG--SRTCRC 1234
GI T +Q + C V+ GGC+H+CL + +RTCRC
Sbjct: 457 RGIRTYQKRTQPTVRSHACEVDAYGMPGGCSHICLLSSSYKTRTCRC 503
Score = 73.4 bits (177), Expect = 1e-11
Identities = 67/252 (26%), Positives = 95/252 (37%), Gaps = 46/252 (18%)
Query: 1015 IIRQDLGSPEGIAVDHLGRNIFWTDSNLDR---------------IEVAKLDGTQRRVLF 1059
+I + P IAVD + N++WTD + I V +L+G L
Sbjct: 3963 LICPEFKRPRDIAVDWVAGNVYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLL 4022
Query: 1060 ETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAF 1119
P I + RG +YWT D+ IE + MDGT RR+LVQ +L P GL D F
Sbjct: 4023 TNMAGEPYAIAVNPKRGMMYWTVIG-DHSHIEEAAMDGTLRRVLVQKNLQRPTGLTVDHF 4081
Query: 1120 SSQLCWVD-----AGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWK----- 1169
++ W D G+ + +P K +GL +P + + +Y K
Sbjct: 4082 GERIYWADFELSIIGSVLYDGSSPVVSVSSK--QGLLHPHRIDVFEDYIYGAGPKNGIFR 4139
Query: 1170 -----MNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCL 1224
SV L L + K H+ +L L C LCL
Sbjct: 4140 VQKFGHGSVEVLALGVDKTKSILVSHRYKQLNLPNPCLDL-------------SCDFLCL 4186
Query: 1225 ATPGSRTCRCPD 1236
P TC CP+
Sbjct: 4187 LNPSGATCICPE 4198
Score = 46.1 bits (107), Expect = 0.002
Identities = 27/64 (42%), Positives = 32/64 (49%), Gaps = 6/64 (9%)
Query: 690 RTQFTCECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGY-QFSD 746
R C C GF DGR+C D DECS +C C N G++ C CVEGY SD
Sbjct: 133 RNATRCYCEDGFEVAEDGRSCKDQDECSIY-GICSQ--TCKNTYGSYACSCVEGYIMQSD 189
Query: 747 EGTC 750
+C
Sbjct: 190 NRSC 193
Score = 45.7 bits (106), Expect = 0.003
Identities = 23/64 (35%), Positives = 35/64 (53%), Gaps = 1/64 (1%)
Query: 991 MVYWTDITEPS-IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAK 1049
M+YWT I + S I A++ G +++++L P G+ VDH G I+W D L I
Sbjct: 4040 MMYWTVIGDHSHIEEAAMDGTLRRVLVQKNLQRPTGLTVDHFGERIYWADFELSIIGSVL 4099
Query: 1050 LDGT 1053
DG+
Sbjct: 4100 YDGS 4103
Score = 43.0 bits (99), Expect = 0.021
Identities = 49/199 (24%), Positives = 75/199 (37%), Gaps = 45/199 (22%)
Query: 675 GTHGCDTNAACRPGPRTQFTCECSIGFR-GDGRTCYDIDECSEQPSVCGSHT-------- 725
G C N+ P +F C + +R + R C +++ + CG ++
Sbjct: 3695 GEDDCGDNSDEAPDMCVKFLCPPTRPYRCRNDRICLQLEKICNGINDCGDNSDEEHCSGK 3754
Query: 726 -------------ICNNH---PGTFRCE----CVEGYQFSDEGTCVAVVDQRPINY-CET 764
C+N P +C+ C +G SDE C+ + PI + CE
Sbjct: 3755 LSLKSKPCKKDEFTCSNRNCIPMELQCDSLDDCGDG---SDEQGCL----KTPIEHTCEN 3807
Query: 765 GLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGD--GQACQDVDECQP-SRCHPDAFCYNTP 821
+ C I T S C C PGF + G+ C D++EC C C NT
Sbjct: 3808 NGNPCGDDAYCNQIKT---SVFCRCKPGFQRNMKGRECADLNECLLFGIC--SHHCLNTR 3862
Query: 822 GSFTCQCKPGYQGDGFRCV 840
GS+ C C +Q C+
Sbjct: 3863 GSYKCVCDQNFQEKNNSCI 3881
Score = 41.4 bits (95), Expect = 0.061
Identities = 33/110 (30%), Positives = 48/110 (43%), Gaps = 25/110 (22%)
Query: 737 ECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGG---SSYTCSCLPGF 793
+C +G+ DEG +C+ L +C Q+ C + ++ C C GF
Sbjct: 102 DCPDGF---DEG-----------GHCQELLPSC---QQLNCQFKCAMVRNATRCYCEDGF 144
Query: 794 --SGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGY--QGDGFRC 839
+ DG++C+D DEC C NT GS+ C C GY Q D C
Sbjct: 145 EVAEDGRSCKDQDECSIYGICSQT-CKNTYGSYACSCVEGYIMQSDNRSC 193
Score = 41.0 bits (94), Expect = 0.080
Identities = 24/95 (25%), Positives = 38/95 (39%), Gaps = 4/95 (4%)
Query: 662 EGSPDA-LQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
+GS + L + C + GC + + PG +C + D RTC +D C+ S
Sbjct: 1165 DGSDEGDLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGHQLKKDNRTCEIVDYCA---SH 1221
Query: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVD 755
+C +C C EG+ +G VD
Sbjct: 1222 LRCSQVCEQQKHMVKCSCYEGWALGTDGESCTSVD 1256
Score = 40.2 bits (92), Expect = 0.14
Identities = 22/79 (27%), Positives = 36/79 (44%), Gaps = 1/79 (1%)
Query: 983 LAFDCVDKMVYWTDITE-PSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSN 1041
+A D + +++TD P I R L G T I+ P +A+D + R ++W D
Sbjct: 331 IAADPIAGKLFFTDYGNVPKIERCDLDGMNRTRIVYSKAEQPSALALDLVNRLVYWVDLY 390
Query: 1042 LDRIEVAKLDGTQRRVLFE 1060
LD + V G R + +
Sbjct: 391 LDYVGVVDYQGKNRHTIVQ 409
Score = 39.1 bits (89), Expect = 0.31
Identities = 51/219 (23%), Positives = 76/219 (34%), Gaps = 62/219 (28%)
Query: 726 ICNNHPGTFRCECVEGYQFSDEGTCV--AVVDQRPINYCETGLHNCDIPQRAQCIYTGGS 783
+C +P C C EG ++ GTC +++D CE G +CI
Sbjct: 4184 LCLLNPSGATCICPEG-KYMMNGTCHDDSLLDDSCKLTCENG---------GRCILNEKG 4233
Query: 784 SYTCSCLPGFSGD-------GQACQDVDECQPS-------------------------RC 811
C C P +SG CQ+ C PS C
Sbjct: 4234 DLRCHCWPSYSGGRCEVNHCSNYCQNGGTCIPSTLGRPTCICALGFTGPNCGKAVCEDSC 4293
Query: 812 HPDAFCYNTPGSFT-CQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATD---PQR 867
H C T G+ C C+ Y GD RC V C + +G G+ + P R
Sbjct: 4294 HNGGSCVVTAGNQPYCHCQADYTGD--RC-QYYVCHHYCVNSESCTIGNDGSVECVCPTR 4350
Query: 868 PIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREV 906
P + +C +CHG G+C +++D ++
Sbjct: 4351 YEGPKCEIDKC--------VRCHG--GHC-IINKDNEDI 4378
Score = 37.5 bits (85), Expect = 0.91
Identities = 43/184 (23%), Positives = 59/184 (31%), Gaps = 59/184 (32%)
Query: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCEC 738
C C P + TC C++GF G CG +C + C
Sbjct: 4257 CQNGGTCIPSTLGRPTCICALGFTGPN---------------CGK-AVCED-------SC 4293
Query: 739 VEGYQFSDEGTCVAVVDQRPINYCETGL-----------HNCDIPQRAQCIYTGGSSYTC 787
G G+CV +P +C+ H C C S C
Sbjct: 4294 HNG------GSCVVTAGNQPYCHCQADYTGDRCQYYVCHHYC--VNSESCTIGNDGSVEC 4345
Query: 788 SCLPGFSGDGQACQDVDECQPSRCH----------PDAFCYNTPGSF--TCQCKPGYQGD 835
C + +G C ++D+C RCH D FC T G +CQ GY +
Sbjct: 4346 VCPTRY--EGPKC-EIDKC--VRCHGGHCIINKDNEDIFCNCTNGKIASSCQLCDGYCYN 4400
Query: 836 GFRC 839
G C
Sbjct: 4401 GGTC 4404
Score = 35.6 bits (80), Expect = 3.5
Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 7/39 (17%)
Query: 1205 CPQGHNY------CSVNNGGCTHLCLATPG-SRTCRCPD 1236
CP G + CS+NNGGC++ C PG C CP+
Sbjct: 1163 CPDGSDEGDLCDECSLNNGGCSNHCSVVPGRGIVCSCPE 1201
>ref|NP_002323.1| low density lipoprotein-related protein 1 (alpha-2-macroglobulin
receptor) [Homo sapiens]
sp|Q07954|LRP1_HUMAN LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1 PRECURSOR (LRP)
(ALPHA-2-MACROGLOBULIN RECEPTOR) (A2MR) (APOLIPOPROTEIN E
RECEPTOR) (APOER) (CD91)
pir||S02392 alpha-2-macroglobulin receptor precursor - human
emb|CAA32112.1| (X13916) LDL-receptor related precursor (AA -19 to 4525) [Homo
sapiens]
gb|AAC64265.1| (AF058427) lipoprotein receptor-related protein [Homo sapiens]
Length = 4544
Score = 178 bits (446), Expect = 4e-43
Identities = 161/599 (26%), Positives = 240/599 (39%), Gaps = 112/599 (18%)
Query: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNH-------- 730
CD + C G C TC D + + H +C++
Sbjct: 2794 CDGDKDCADGADESIAAGCLYN-----STCDDREFMCQNRQCIPKHFVCDHDRDCADGSD 2848
Query: 731 -----------PGTFRC---ECVEGYQFSDEGT--CVAVVDQRPIN-YCETGLHNCDIPQ 773
P FRC C+ Q+ +G C D+ P N +C + H C+
Sbjct: 2849 ESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSPEHKCNASS 2908
Query: 774 RAQCIYTGGSSYTCSCLP----GFSGDGQACQDVDEC---QPSRCHPDAFCYNTPGSFTC 826
+ C + C G S D + C ++EC + S C D C + F C
Sbjct: 2909 QFLCSSGRCVAEALLCNGQDDCGDSSDERGCH-INECLSRKLSGCSQD--CEDLKIGFKC 2965
Query: 827 QCKPGYQ--GDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHY 884
+C+PG++ DG C + T + I + HG Y
Sbjct: 2966 RCRPGFRLKDDGRTCADVDECSTTFPCSQRCI----------------------NTHGSY 3003
Query: 885 APTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGT 944
C CV EG R G C AV P
Sbjct: 3004 K----------CLCV-------EGYAPRGGDPHSC---------------KAVTDEEP-- 3029
Query: 945 HLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS--I 1002
L+FA + +L L+G+ L + L FD ++M+YWTD+T I
Sbjct: 3030 FLIFANRYYLRKLNLDGSNY------TLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMI 3083
Query: 1003 GRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETD 1062
R L+G + R L +P+G+AVD +G N++W D D IEV+KL+G R VL +
Sbjct: 3084 RRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSG 3143
Query: 1063 LVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQ 1122
L PR +V D G LYWTDW D+ I MDG++R ++V + PNGL D + +
Sbjct: 3144 LREPRALVVDVQNGYLYWTDWG-DHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTER 3202
Query: 1123 LCWVDAGTNRAECLNPSQPSRRKAL-EGLQYPFAVTSYGKNLYFTDWKMNSV--VALDLA 1179
+ W DA + E + +R L + + + FA+T + +Y+TDW+ S+
Sbjct: 3203 IYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTG 3262
Query: 1180 ISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATP-GSRTCRCPDN 1237
+K H+ L+ + AL Q ++ C VNNGGC++LCL +P G C CP N
Sbjct: 3263 TNKTLLISTLHRPMDLH-VFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTN 3320
Score = 162 bits (405), Expect = 3e-38
Identities = 99/280 (35%), Positives = 151/280 (53%), Gaps = 18/280 (6%)
Query: 983 LAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNL 1042
L F +Y+ D T IGR + G E TI++ + + EG+AVD +G N++WTD
Sbjct: 564 LDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGP 623
Query: 1043 DR-IEVAKLD--GTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRD-----NPKIETSY 1094
+ I VA+L+ R+ L E + +PR IV D + G +YWTDW D ++E ++
Sbjct: 624 KKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAW 683
Query: 1095 MDGTNRRILVQDDLGL-PNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG--LQ 1151
MDG++R I V L PNGL D + +L WVDA +R E + + R+ EG L
Sbjct: 684 MDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELN 743
Query: 1152 YPFAVTSYGKNLYFTDWKMNSVVALDLAI--SKETDAFQPHKQTRLYGITTALSQCPQ-G 1208
+ F + +G L++T+++ SV L+ + + T ++ ++ I +Q Q G
Sbjct: 744 HAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVG 803
Query: 1209 HNYCSVNNGGCTHLCLATPGSRTCRCPDNTL----GVDCI 1244
N C VNNGGC+ LCLATPGSR C C ++ + GV C+
Sbjct: 804 TNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCL 843
Score = 161 bits (403), Expect = 5e-38
Identities = 96/268 (35%), Positives = 135/268 (49%), Gaps = 14/268 (5%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTT----IIRQDLGSPEGIAVDHLGRNIF 1036
I L F +YWTD+ E I R L T +I+ L +PEG+AVD + NI+
Sbjct: 1300 IALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIY 1359
Query: 1037 WTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMD 1096
W +SNLD+IEVAKLDGT R L D+ +PR I D G L+WTDW+ P+IE + M
Sbjct: 1360 WVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMS 1419
Query: 1097 GTNRRILVQD--DLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---LQ 1151
G RR + ++ G PNGL D ++ W+DA ++ + L G L
Sbjct: 1420 GAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLS 1479
Query: 1152 YPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT-ALSQCPQGHN 1210
+PFAVT YG +Y+TDW+ N++ + Q T+ + + S+ P N
Sbjct: 1480 HPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQ-RTNTQPFDLQVYHPSRQPMAPN 1538
Query: 1211 YCSVN--NGGCTHLCLATPG-SRTCRCP 1235
C N G C+HLCL + +C CP
Sbjct: 1539 PCEANGGQGPCSHLCLINYNRTVSCACP 1566
Score = 138 bits (345), Expect = 3e-31
Identities = 98/333 (29%), Positives = 153/333 (45%), Gaps = 16/333 (4%)
Query: 916 TPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHV 975
T C+ T + G V G+ LL++ I +PL+ N ++ A + V
Sbjct: 1868 TRSCMCTAGYSLRSGQQACEGV-----GSFLLYSVHEGIRGIPLDPND----KSDALVPV 1918
Query: 976 PA-KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRN 1034
+ +G+ F + +YW D+ +I RA ++ +G EGIAVD + N
Sbjct: 1919 SGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGN 1978
Query: 1035 IFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSY 1094
I+WTD D IEVA+L+G+ R V+ L PR I +G L+WT+W + P+IE S
Sbjct: 1979 IYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQ-YPRIERSR 2037
Query: 1095 MDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL--EGLQY 1152
+DGT R +LV + PNG+ D +L W DA T++ E ++ R+ +
Sbjct: 2038 LDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMD 2097
Query: 1153 PFAVTSYGKNLYFTDWKMNSVVALDLAISKETDA--FQPHKQTRLYGITTALSQCPQGHN 1210
F+V+ + +Y++D + + TD+ + +L I +G N
Sbjct: 2098 MFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTN 2157
Query: 1211 YCSVNNGGCTHLCL-ATPGSRTCRCPDNTLGVD 1242
C+V NGGC LCL G R C C L D
Sbjct: 2158 VCAVANGGCQQLCLYRGRGQRACACAHGMLAED 2190
Score = 126 bits (313), Expect = 2e-27
Identities = 89/278 (32%), Positives = 126/278 (45%), Gaps = 51/278 (18%)
Query: 992 VYWTDITEPSIGRASLHGGEPTTIIRQD---------------LGSPEGIAVDHLGRNIF 1036
VYWT+ +I SL P T + L P GIA+D + N++
Sbjct: 3914 VYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVY 3973
Query: 1037 WTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMD 1096
WTDS D IEVA++ G R+ L + P IV D +RG +YW+DW ++PKIET+ MD
Sbjct: 3974 WTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWG-NHPKIETAAMD 4032
Query: 1097 GTNRRILVQDDLGLPNGLHFDAFSSQLCWVDA-----GTNRAECLNPSQPSRRKALEGLQ 1151
GT R LVQD++ P GL D + +L W DA G+ R +P + K GL
Sbjct: 4033 GTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSK--RGLS 4090
Query: 1152 YPFAVTSYGKNLYFTDWKMNSV-----------VALDLAISKETDA--FQPHKQTRLYGI 1198
+PF++ + +Y + N V V L +S +D + HKQ
Sbjct: 4091 HPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQ------ 4144
Query: 1199 TTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPD 1236
P+ N C + C LCL +P C CP+
Sbjct: 4145 -------PEVTNPC--DRKKCEWLCLLSPSGPVCTCPN 4173
Score = 121 bits (301), Expect = 4e-26
Identities = 85/265 (32%), Positives = 134/265 (50%), Gaps = 24/265 (9%)
Query: 983 LAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWT--DS 1040
L +D ++ VYW+D+ +I RA ++G T++ DL + G+AVD + RN+FWT D+
Sbjct: 1620 LDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDT 1679
Query: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
N +I VA+LDG+ + + + L P G+V +RG LYWT D I + MDG+NR
Sbjct: 1680 NKKQINVARLDGSFKNAVVQ-GLEQPHGLVVHPLRGKLYWT----DGDNISMANMDGSNR 1734
Query: 1101 RILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPF----AV 1156
+L G P GL D S+L W+ +G + N S + ++ ++ A+
Sbjct: 1735 TLLFSGQKG-PVGLAIDFPESKLYWISSGNHTINRCN-LDGSGLEVIDAMRSQLGKATAL 1792
Query: 1157 TSYGKNLYFTDW---KMNSVVALD---LAISKETDAFQPHKQTRLYGITTALSQCPQGHN 1210
G L++ D KM + D + + + H ++Y + L +G N
Sbjct: 1793 AIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMH--MKVYDESIQLDH--KGTN 1848
Query: 1211 YCSVNNGGCTHLCLAT-PGSRTCRC 1234
CSVNNG C+ LCL T +R+C C
Sbjct: 1849 PCSVNNGDCSQLCLPTSETTRSCMC 1873
Score = 104 bits (256), Expect = 8e-21
Identities = 74/276 (26%), Positives = 125/276 (44%), Gaps = 23/276 (8%)
Query: 978 KVIIGLAFDC-------VDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDH 1030
K +I LAFD ++++DI +I + + G TI+ +++GS EG+A
Sbjct: 2234 KNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIV-ENVGSVEGLAYHR 2292
Query: 1031 LGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLV-------NPRGIVTDSVRGNLYWTDW 1083
++WT I +D T R FE + V +PR V D + ++WT+W
Sbjct: 2293 GWDTLYWTSYTTSTITRHTVDQT-RPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNW 2351
Query: 1084 NRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSR 1143
N +P I + + G N L++ D+ PNGL D + +L + DA ++ E R
Sbjct: 2352 NEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHR 2411
Query: 1144 RKALEGLQ-YPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQ---PHKQTRLYGIT 1199
L+ +PF + YG+++++TDW +V + + + P + + +
Sbjct: 2412 YVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVA 2471
Query: 1200 TALSQCPQGHNYCSVNNGGCTHLCLAT-PGSRTCRC 1234
+ C + C +NNGGC LCL T G C C
Sbjct: 2472 NDTNSCEL--SPCRINNGGCQDLCLLTHQGHVNCSC 2505
Score = 87.0 bits (212), Expect = 1e-15
Identities = 113/480 (23%), Positives = 184/480 (37%), Gaps = 52/480 (10%)
Query: 795 GDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHERE 854
G +A + + + RC P+ +N G+ C C+ G E C+
Sbjct: 56 GSDEAPEICPQSKAQRCQPNE--HNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRE--- 110
Query: 855 HILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGT----- 909
+ G Q P L P C + + Q G T C D D V GT
Sbjct: 111 -LQGNCSRLGCQHHCVPTLDGPTCYCNSSFQ-LQADGKT----CKDFDECSVYGTCSQLC 164
Query: 910 -RTRPGMTPPCLST-VAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKT 967
T C+ + P ++ + PP LL A + I L G
Sbjct: 165 TNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPV--LLIANSQNILATYLSG-----A 217
Query: 968 EAKAFLHVPAKVIIGLAFDCVDKMVYWTDI----TEPSIGRASLHG-----GEPTTIIRQ 1018
+ + + F ++ V W + + + A + G E T I
Sbjct: 218 QVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISL 277
Query: 1019 DLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNL 1078
L E +A+D L N ++ D DRI V +G L + +L NP+GI D G +
Sbjct: 278 SLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKV 337
Query: 1079 YWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNP 1138
++TD+ + PK+E MDG NR LV + P+G+ D S + W DA + E ++
Sbjct: 338 FFTDYGQ-IPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDY 396
Query: 1139 SQPSRRKALEG--LQYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPH 1190
R+ ++G +++ + +T + LY T+ + SV+ ++ S E
Sbjct: 397 EGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRV 456
Query: 1191 KQTRLYGITTALSQCPQGHNYCSVNN-----GGCTHLCLATPG--SRTCRCPDN-TLGVD 1242
+ I Q P+ ++ N+ GGC+ +CL +RTCRC +LG D
Sbjct: 457 DKGGALHIYHQRRQ-PRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSD 515
Score = 50.4 bits (118), Expect = 1e-04
Identities = 30/72 (41%), Positives = 38/72 (52%), Gaps = 9/72 (12%)
Query: 694 TCECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFS-DEGTC 750
TC C+ F+ DG+TC D DECS C +C N G+F C CVEGY D +C
Sbjct: 132 TCYCNSSFQLQADGKTCKDFDECSVY-GTCSQ--LCTNTDGSFICGCVEGYLLQPDNRSC 188
Query: 751 VA---VVDQRPI 759
A VD+ P+
Sbjct: 189 KAKNEPVDRPPV 200
Score = 50.4 bits (118), Expect = 1e-04
Identities = 55/175 (31%), Positives = 68/175 (38%), Gaps = 23/175 (13%)
Query: 680 DTNAACRPGP---RTQFTCECSIGFRGDG-RTCYDIDECSEQPSVCGSHTICNNHPGTFR 735
D C P R Q TC S G+R DG R C D + E P +C P
Sbjct: 22 DAPKTCSPKQFACRDQITC-ISKGWRCDGERDCPDGSD--EAPEICPQSKAQRCQPNEHN 78
Query: 736 CE----CVEGYQFSDE-GTCVAVVDQRPINYCETGLHNCD-IPQRAQCIYTGGSSYTCSC 789
C CV + + C+ D+ P +C NC + + C+ T TC C
Sbjct: 79 CLGTELCVPMSRLCNGVQDCMDGSDEGP--HCRELQGNCSRLGCQHHCVPTLDGP-TCYC 135
Query: 790 LPGFS--GDGQACQDVDECQP-SRCHPDAFCYNTPGSFTCQCKPGY--QGDGFRC 839
F DG+ C+D DEC C C NT GSF C C GY Q D C
Sbjct: 136 NSSFQLQADGKTCKDFDECSVYGTC--SQLCTNTDGSFICGCVEGYLLQPDNRSC 188
Score = 47.3 bits (110), Expect = 0.001
Identities = 50/180 (27%), Positives = 65/180 (35%), Gaps = 45/180 (25%)
Query: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHP-GTFRCE 737
C +C R Q C C + GD C ++D+C E C + C P G C
Sbjct: 4204 CFNGGSCFLNARRQPKCRCQPRYTGD--KC-ELDQCWEH---CRNGGTCAASPSGMPTCR 4257
Query: 738 CVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGDG 797
C G+ T Q YC + C G+ C CLPGF G
Sbjct: 4258 CPTGF------TGPKCTQQVCAGYCANN---------STCTVNQGNQPQCRCLPGFLG-- 4300
Query: 798 QACQDVDECQPSRCHPDAFCYN-------TPGSFTCQCKPGYQGDGFRCVPGEVEK-TRC 849
D CQ +C +C N GS C+C ++G RC EV K +RC
Sbjct: 4301 ------DRCQYRQC--SGYCENFGTCQMAADGSRQCRCTAYFEGS--RC---EVNKCSRC 4347
Score = 44.1 bits (102), Expect = 0.009
Identities = 49/206 (23%), Positives = 68/206 (32%), Gaps = 53/206 (25%)
Query: 665 PDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSH 724
PD +PC + GC PG + C + DGRTC + C+ VC +
Sbjct: 3287 PDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTC--VSNCTASQFVCKND 3344
Query: 725 TICNNHPGTFRCECVEGY-QFSDEGTCVAVVDQRPINY-CETGL---------------- 766
P ++C+ + SDE RP + C TG+
Sbjct: 3345 KCI---PFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQD 3401
Query: 767 ----HNCDI----PQRAQCIYTGGSSYTCSCLPGFSGDGQACQDVDEC---QPSRCHPDA 815
NCDI P + +C T C+PG C D C + R P+
Sbjct: 3402 NSDEANCDIHVCLPSQFKCTNTN------RCIPGIF----RCNGQDNCGDGEDERDCPEV 3451
Query: 816 FCYNTPGSFTCQCKPGYQGDGFRCVP 841
C P F C RC+P
Sbjct: 3452 TC--APNQFQCSITK-------RCIP 3468
Score = 37.1 bits (84), Expect = 1.2
Identities = 36/151 (23%), Positives = 63/151 (40%), Gaps = 12/151 (7%)
Query: 929 QGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCV 988
QG P ++ P L + I ++G+ + L K +GLA D
Sbjct: 1699 QGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSN------RTLLFSGQKGPVGLAIDFP 1752
Query: 989 DKMVYWTDITEPSIGRASLHGG--EPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRI- 1045
+ +YW +I R +L G E +R LG +A+ +G ++W D +++
Sbjct: 1753 ESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAI--MGDKLWWADQVSEKMG 1810
Query: 1046 EVAKLDGTQRRVL-FETDLVNPRGIVTDSVR 1075
+K DG+ VL T LV + +S++
Sbjct: 1811 TCSKADGSGSVVLRNSTTLVMHMKVYDESIQ 1841
Score = 36.7 bits (83), Expect = 1.6
Identities = 14/25 (56%), Positives = 16/25 (64%), Gaps = 1/25 (4%)
Query: 1212 CSVNNGGCTHLCLATPGSR-TCRCP 1235
CS+NNGGC+H C PG C CP
Sbjct: 1185 CSLNNGGCSHNCSVAPGEGIVCSCP 1209
Score = 36.4 bits (82), Expect = 2.0
Identities = 22/95 (23%), Positives = 38/95 (39%), Gaps = 4/95 (4%)
Query: 662 EGSPDA-LQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
+GS + L + C + GC N + PG +C + D TC C++
Sbjct: 1174 DGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLK- 1232
Query: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVD 755
C C+ + + +C C EG+ +G +D
Sbjct: 1233 CSQK--CDQNKFSVKCSCYEGWVLEPDGESCRSLD 1265
Score = 35.2 bits (79), Expect = 4.6
Identities = 23/109 (21%), Positives = 43/109 (39%), Gaps = 16/109 (14%)
Query: 1076 GNLYWTDWN------RDNPKIETSYMDGTNRRILVQ-------DDLGLPNGLHFDAFSSQ 1122
G +YWT+W+ R P +RR + + L +P G+ D +
Sbjct: 3912 GRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGN 3971
Query: 1123 LCWVDAGTNRAECLNPSQPSRRKALEGL---QYPFAVTSYGKNLYFTDW 1168
+ W D+G + E +R+ + G+ + V +Y++DW
Sbjct: 3972 VYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDW 4020
>gb|AAF59114.2| (AE003838) CG8706 gene product [Drosophila melanogaster]
Length = 4601
Score = 176 bits (443), Expect = 1e-42
Identities = 159/574 (27%), Positives = 240/574 (41%), Gaps = 74/574 (12%)
Query: 714 CSEQPSVCGSHTICNNHPGTFRCE--CVEGYQFSDEGTCVAVVDQRPINYCETGLHNC-D 770
C + VC C N+ CE C G ++ C + ++ C+ G+H+C D
Sbjct: 966 CRQFADVCDGIDNCGNNADEMECEQECEHGEKY-----CRPIGCYGEMHMCD-GIHDCLD 1019
Query: 771 IPQRAQCIYTGGSSYTCS-------CLPGFSGDGQACQDVDECQPS--RCHPDAFCYNTP 821
A C T ++ + C P AC EC P RC + C++
Sbjct: 1020 FSDEANCNQTKSDNHPVTEWKELGECAPLEF----ACMFPFECIPDFLRCDGISHCFDKT 1075
Query: 822 GSFTCQCKPGYQGDGFRCVPGEVEKTRCQHEREHILG---AAGATDPQRPIPPGLFVPE- 877
F C + D V E C ++ + G D + G +
Sbjct: 1076 DEFNCTHINTTRFDMNETVICEHPDRLCGFSKQCVTVDQLCDGKNDCEDTTDEGFLCADK 1135
Query: 878 -CDAHGHYAPTQCHGST-GY-CWCVDRDGREVEGTR-------------------TRPGM 915
CD GH +CH + GY C C D + G R + G
Sbjct: 1136 LCD-RGHECSHRCHNTPEGYICSCPDHLYLQPNGKRCSMQHACDHWDTCSQVCESSGKGY 1194
Query: 916 TPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHV 975
CL + TA P +++F I+ + L KT +
Sbjct: 1195 DCRCLDGFDLGFDRFTCKSTA----PDEPYVIFTNRQDIKGINL------KTLNVGNFYS 1244
Query: 976 PAKVIIGLAFDCVDKM---VYWTDITEPSIGRASLHGGE---PTTIIRQDLGSPEGIAVD 1029
+ II L F ++ +YWTD+ + I R L G +I L + EG+AVD
Sbjct: 1245 SLRNIIALDFLYNNESNVEIYWTDVIDDKIYRGHLVGESLRNVEAVIHSGLSTTEGLAVD 1304
Query: 1030 HLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPK 1089
+G+N++W DSNLD+IEVAKL+G+ RR L ++ +PR I D G L+WTDW+ ++P+
Sbjct: 1305 WVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPRAIALDPREGLLFWTDWDDNSPR 1364
Query: 1090 IETSYMDGTNRRILV---QDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKA 1146
IE + M G RR++ Q G PNGL D ++ WVDA ++
Sbjct: 1365 IERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHVV 1424
Query: 1147 L---EGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTA-L 1202
L E L +PFA++ + +Y+TDW+ SV+ + + Q Q++ +GI
Sbjct: 1425 LRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQ-RTQSQPFGIQVLHS 1483
Query: 1203 SQCPQGHNYCSVNNGGCTHLCLAT-PGSRTCRCP 1235
S+ P N C NNGGC+HLCL + G+ C CP
Sbjct: 1484 SRQPWDRNPCGENNGGCSHLCLLSGRGTFKCECP 1517
Score = 127 bits (316), Expect = 7e-28
Identities = 84/286 (29%), Positives = 136/286 (47%), Gaps = 38/286 (13%)
Query: 981 IGLAFDCVDKMVYWTDITEP--SIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWT 1038
+ L +D + +YW+D+T +I R + T+ + L +P+G+AVD + +N++W
Sbjct: 3027 VALDYDWDSQCLYWSDVTSTVGTIKRYCPKENKTQTLHQAMLKNPDGLAVDWVAKNLYWC 3086
Query: 1039 DSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGT 1098
D LD IEV++LDG R+VL L PRGI + +++W+DW D+P I + MDG+
Sbjct: 3087 DKGLDTIEVSQLDGKYRKVLINEYLREPRGIALHPYQQHIFWSDWG-DSPHIGKAGMDGS 3145
Query: 1099 NRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRR-------KALEGLQ 1151
N +++++D LG PN L + QL W DA + + R L L
Sbjct: 3146 NPKMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLH 3205
Query: 1152 YPFAVTSYGKNLYFTDWKMNSV-----------VALDLAISKETD--AFQPHKQTRLYGI 1198
+ FA+ + ++Y++DW+ S+ L I + D F P++Q
Sbjct: 3206 HIFAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQ------ 3259
Query: 1199 TTALSQCPQGHNYCSVNNGGCTHLCLATPGS--RTCRCPDNTLGVD 1242
Q P N C N C+ LC+ +P C CP N + D
Sbjct: 3260 -----QQPMSGNPCLAAN--CSTLCVLSPEEPYYKCMCPTNFILAD 3298
Score = 120 bits (298), Expect = 1e-25
Identities = 82/316 (25%), Positives = 143/316 (44%), Gaps = 16/316 (5%)
Query: 941 PPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPA-KVIIGLAFDCVDKMVYWTDITE 999
P LLF+ IE + + + + + + + +I + ++ +++VY++D+
Sbjct: 2154 PYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQL 2213
Query: 1000 PSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKL-------DG 1052
+I + +G ++ Q EG+A D + +FWT +N I +L D
Sbjct: 2214 STINQVHFNGTGHRVLLEQQQ-RVEGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQ 2272
Query: 1053 TQ---RRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLG 1109
Q ++VL + PRGI + G +YWT+WN +P I+ SY+ G ++++ D+
Sbjct: 2273 NQVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIK 2332
Query: 1110 LPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGL-QYPFAVTSYGKNLYFTDW 1168
+PN L D +L W DA ++ E N +R ++ FA+ YG L++TDW
Sbjct: 2333 MPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDW 2392
Query: 1169 KMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQ-GHNYCSVNNGGCTHLC-LAT 1226
+++VV + + + H TR GI + N C + NG C +C L
Sbjct: 2393 VLHAVVRANKYTGTDVLFLREH-VTRPMGIVAVQNTSINCDANQCKILNGQCEDVCILNK 2451
Query: 1227 PGSRTCRCPDNTLGVD 1242
G TC C L D
Sbjct: 2452 SGQATCHCTQGVLAPD 2467
Score = 83.9 bits (204), Expect = 1e-14
Identities = 104/426 (24%), Positives = 161/426 (37%), Gaps = 60/426 (14%)
Query: 706 RTCYDIDEC---SEQPSVCGSHTICNNHPGTFRCE---CVEGYQFSDE-GTCVAVVDQRP 758
+TC +C S++ S +HT N FRC+ C+ D C D+
Sbjct: 2850 QTCDGKPDCGDGSDETSSLCAHTRGCNGTDDFRCKNGACIHADLLCDRRNDCADFSDEEL 2909
Query: 759 INYCETGLHNCDIPQ--RAQCIYTGGSSYTCSCLPGFS---GDGQACQDVDECQPSRCHP 813
N ++ C IP +C Y C C PG+ C D+DEC +
Sbjct: 2910 CN-----VNECLIPDICEHEC-EDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCS 2963
Query: 814 DAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGL 873
C NT GS+ C C GY H H A +
Sbjct: 2964 QT-CINTYGSYKCLCAKGY--------------ALVDH---HTCKATSNVSMELIFSNRY 3005
Query: 874 FVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAV 933
++ + D G+ + S D D + + + T + P ++ +
Sbjct: 3006 YIRQVDMTGNGSILINELSNAVALDYDWDSQCLYWSDVT--STVGTIKRYCPKENKTQTL 3063
Query: 934 PTAVIPLPPG-------THLLFAQTG--KIERLPLEGNTMRKTEAKAFLHVPAKVIIGLA 984
A++ P G +L + G IE L+G RK +L P G+A
Sbjct: 3064 HQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGK-YRKVLINEYLREPR----GIA 3118
Query: 985 FDCVDKMVYWTDITE-PSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLD 1043
+ ++W+D + P IG+A + G P IIR LG P + + + +FW D+ D
Sbjct: 3119 LHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTISFETQQLFWGDARED 3178
Query: 1044 RIEVAKLDGTQRRVLFE---TDLVNPRGIVTDSV-RGNLYWTDWNRDNPKIE-TSYMDGT 1098
I V+ LDG R+L L+N I +V G++YW+DW + IE S +G
Sbjct: 3179 TISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDW--ETKSIEYCSIFNGQ 3236
Query: 1099 NRRILV 1104
N L+
Sbjct: 3237 NCTTLI 3242
Score = 80.4 bits (195), Expect = 1e-13
Identities = 71/266 (26%), Positives = 116/266 (42%), Gaps = 23/266 (8%)
Query: 992 VYWTDITEPSIGRASLHGGEPTTII---------RQD-LGSPEGIAVDHLGRNIFWTDSN 1041
+YW D SI R G + TI+ +QD LG GIA+D + NI+W+D+
Sbjct: 1891 LYWGDNELGSISRVKRDGTQRETILEALNLVGYKQQDWLG---GIAIDWVAGNIYWSDTK 1947
Query: 1042 LDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRR 1101
+ IEVA+LDG+ R V+ ++L P + D ++G L++ I +DG+
Sbjct: 1948 RNIIEVARLDGSHRYVVV-SNLEKPTALAVDPLQGLLFYV----TQQHIGRVGLDGSQPF 2002
Query: 1102 ILVQDDLG--LPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL-EGLQYPFAVTS 1158
+LV L D ++++ W + + ++ R + L E L P A+
Sbjct: 2003 VLVNQTRANWAVGSLVLDIEATKVYWCERYPDALMKVDYDGNLREQLLNESLNNPVALAK 2062
Query: 1159 YGKNLYFTDWKMNS--VVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNN 1216
G LY+ + K N + LA ++ +Q + + +G N C+ +N
Sbjct: 2063 MGDYLYWAENKYNEGIIRVAPLANLSQSKVVLQTEQDAIRDLKIYSKHLQRGSNPCAHSN 2122
Query: 1217 GGCTHLCLATPGSRTCRCPDNTLGVD 1242
G C LCL S C C + L D
Sbjct: 2123 GACEQLCLFNGTSAVCACAHSRLASD 2148
Score = 78.8 bits (191), Expect = 3e-13
Identities = 66/267 (24%), Positives = 115/267 (42%), Gaps = 28/267 (10%)
Query: 999 EPSIG-RASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRV 1057
EPS R+ G + ++ Q L +A D + +++WT +++VA L + +
Sbjct: 558 EPSCSIRSQSLNGSVSRLLAQGLKRVHAVAFDWINDHLYWTSHK--KMQVAPLRNLSKVL 615
Query: 1058 LFETDLVNPRGIVTDSVRGNLYWTDWNRDNPK--IETSYMDGTNRRILVQDDLGLP---- 1111
F TD + + D G LYW+ W + + I +S+MDGT++ +L + +P
Sbjct: 616 TFNTDC-DAMSLELDPTTGLLYWSQWESQSCEAGIYSSWMDGTHKELLAKGTSSMPMQWP 674
Query: 1112 NGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQY-PFAVTSYGKNLYFTDWKM 1170
L D + +L W D + E + R + Q+ P+++ +Y+ D K
Sbjct: 675 RSLDVDRRTKELYWCDIRLSTIELMRLDGTGREVLFKSDQFHPYSIVQNNGLIYWADNKN 734
Query: 1171 NSVVALDLAISKETDAFQP--HKQT-------RLYGITTALSQCPQGHNYCSVNNGGCTH 1221
++++ + + F H Q R++ I A PQ + C+ + C
Sbjct: 735 STILRFHAHQANLSSTFSSTVHLQRTGRAADLRIFDI--ASQPLPQTPSACAQSK--CPG 790
Query: 1222 LCLATPGSRTCRCPD----NTLGVDCI 1244
+CL TP CRCPD N G CI
Sbjct: 791 MCLNTPKGAICRCPDGFTLNGTGSHCI 817
Score = 74.9 bits (181), Expect = 5e-12
Identities = 69/275 (25%), Positives = 118/275 (42%), Gaps = 25/275 (9%)
Query: 989 DKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLD-RIEV 1047
+ ++W+DI + I A + G II ++ P G AVD + RN++++ + I
Sbjct: 1574 ESRIFWSDIQQNEISSAGISNGLIEPIINTNIEKPYGFAVDWIARNMYFSSGQIKCNILA 1633
Query: 1048 AKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDN--PKIETSYMDGTNRRILVQ 1105
+ L G ++ E DL IV D G +YW D ++E S +DG++R ++ Q
Sbjct: 1634 SNLKGEFASIIHE-DLNMVDSIVLDPANGKMYWIHSASDGSMSQLEQSNLDGSSRSLIYQ 1692
Query: 1106 DDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNLY 1164
+ L L D S +L + + A P +R+ + + ++T Y LY
Sbjct: 1693 HENNL-QSLTMDFDSQRLYYAYDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLY 1751
Query: 1165 FTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTA---LSQCPQGHNYCS--VNNGGC 1219
F + ++ ++ + KE + + + I + + G N C+ GGC
Sbjct: 1752 FPE----NIQSVIMQCEKEACSNMSYLRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGC 1807
Query: 1220 THLCLATPG-SRTCRC-------PDNTLGVDCIER 1246
LCLAT CRC P+N G C+ R
Sbjct: 1808 QQLCLATSSIDHVCRCALGYDVEPNNPTG--CVPR 1840
Score = 62.1 bits (148), Expect = 4e-08
Identities = 43/171 (25%), Positives = 79/171 (46%), Gaps = 12/171 (7%)
Query: 1072 DSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDA--- 1128
D +G +++TDW P + S +DG+NR +LV D + P+ + D + + W+D
Sbjct: 299 DPTKGFMFYTDWT---PSLSRSLLDGSNRTVLVTDQVYHPSSVTLDLANELVYWIDIYKD 355
Query: 1129 GTNRAECLNPSQPSRRKALEG---LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETD 1185
NR + ++ + ++ L+ L+ AV + ++Y W ++VALD S +T
Sbjct: 356 EVNRVDYEGRNRWTLKRPLDSPVPLKTIHAVEVFENSIYLAAWMDTAIVALD-KFSLKTH 414
Query: 1186 AFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLA--TPGSRTCRC 1234
Q + + P+ + C NN GC +C+ T G + +C
Sbjct: 415 ILQSNVSRGANLRIFHRQKQPEVAHPCRDNNAGCNQICVPQWTKGFASAKC 465
Score = 51.5 bits (121), Expect = 5e-05
Identities = 114/514 (22%), Positives = 174/514 (33%), Gaps = 93/514 (18%)
Query: 672 CYIGTHGCD------TNAACRPGP-RTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSH 724
C+ CD N+ C PG R + +C G D C + CSE CG+
Sbjct: 3505 CFSSKATCDPTYFKCNNSKCIPGRWRCDYENDCGDG--SDELNC-QMRNCSESEFRCGTG 3561
Query: 725 TICNNHPGTFRCEC-VEGYQFSDEGTCVAVVDQRPI-----NYCETGLHNCDIPQRAQCI 778
C H +RC+ + SDE C + N C + CD
Sbjct: 3562 K-CIKH--NYRCDGEIHCDDNSDEINCNITCKENQFKCAAFNTCINKQYKCDGDDDCP-- 3616
Query: 779 YTGGSSYTCSCLPG-FS-GDGQA------------CQD-----VDECQPSRCHPDAF-CY 818
G C+C FS G+G+ C D ++ C + CH +AF C
Sbjct: 3617 -DGSDEVNCTCHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDESLETCAKTHCHANAFKCR 3675
Query: 819 N---TPGSFTCQ----CKPGYQGDGFRCVPGEVEKTR---CQHEREHILGAAGATDPQRP 868
N S C C G D V + K R Q E + + A D Q
Sbjct: 3676 NQLCVRNSALCDGINDC--GENEDESDAVCAALPKCRHDQFQCENDDCISKAFRCDGQYN 3733
Query: 869 IPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIH 928
G C P C + C+++ A H
Sbjct: 3734 CVDGSDEMNCQ------PPVCGFGSCSQICIEKKAGHYN-------------CKCADGYH 3774
Query: 929 QGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKV-IIGLAFDC 987
+GP + P LL A + R L T F K+ + +
Sbjct: 3775 KGPEKNATCLASGPDQILLLASEQEF-RFILPAKQEGTTVVGFFQTDSLKIDVFDILIRP 3833
Query: 988 VDKMVYWTD----------ITEPSIG----RASLHGGEPTTIIRQDLGSPEGIAVDHLGR 1033
D +++W D I P + R E T +L P+ +AVD + +
Sbjct: 3834 KDTLLFWIDSHHGKVHTMKIATPHVEGTGVRVRRDLKELTAFNIPELDDPKSLAVDWISQ 3893
Query: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
++ DS ++I ++G + L T + NP IV + + W+ I +
Sbjct: 3894 RVYIIDSRHNQILATDIEGKKYISLVSTGM-NPTDIVLEPESRIMIWSTLENG---ILVA 3949
Query: 1094 YMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVD 1127
+DG+N++ LV+ D+G P L D + +L W D
Sbjct: 3950 SLDGSNKKSLVERDVGWPISLSMDYPTGRLYWAD 3983
Score = 46.1 bits (107), Expect = 0.002
Identities = 23/75 (30%), Positives = 32/75 (42%), Gaps = 3/75 (4%)
Query: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCEC 738
C N P + + + + C D DECSE P C +C N PG++ C C
Sbjct: 69 CSFNCKLTPQGARCYCPKDQVPESSNSTRCVDYDECSE-PGTCDQ--VCRNTPGSYECSC 125
Query: 739 VEGYQFSDEGTCVAV 753
V GY + C A+
Sbjct: 126 VSGYAKTKGNRCRAI 140
Score = 45.7 bits (106), Expect = 0.003
Identities = 48/159 (30%), Positives = 60/159 (37%), Gaps = 37/159 (23%)
Query: 684 ACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQ 743
A RPGP T +C F G R +C E C C+N +C+
Sbjct: 13 ASRPGPNGD-TPKCR-AFEGQCRN----GDCLELSRFCDGRWDCDNDE--LQCD------ 58
Query: 744 FSDEGTCVAVVDQRPINYCETGLHNCDI-PQRAQCIYTGGSSYTCSCLPGFSGDGQACQD 802
C A+ C NC + PQ A+C Y S + C D
Sbjct: 59 -KQNAACAAL-------NCS---FNCKLTPQGARC-------YCPKDQVPESSNSTRCVD 100
Query: 803 VDEC-QPSRCHPDAFCYNTPGSFTCQCKPGY-QGDGFRC 839
DEC +P C D C NTPGS+ C C GY + G RC
Sbjct: 101 YDECSEPGTC--DQVCRNTPGSYECSCVSGYAKTKGNRC 137
Score = 45.3 bits (105), Expect = 0.004
Identities = 63/274 (22%), Positives = 88/274 (31%), Gaps = 58/274 (21%)
Query: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCEC 738
C+ CR CEC GF G + C +IDEC++ GS I G +C+C
Sbjct: 4235 CENGGICRETLTGTPQCECPDGFTG--KRC-EIDECADFCKNGGSCVISTK--GQRQCKC 4289
Query: 739 VEGY--QFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGD 796
GY + + +C ++C G C GG +C+C P + G+
Sbjct: 4290 PSGYFGEHCESNSCR--------DFCRNG---------GTCSERGGR-LSCTCPPRYIGE 4331
Query: 797 G------------QACQDV-----DECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRC 839
C + D C C C+ G C C + GD C
Sbjct: 4332 SCESDLCKTSSPPHFCDNTKVPTRDPCTLMICQNAGTCHIIKGVALCNCTDQWNGD--LC 4389
Query: 840 VPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQC----HGSTGY 895
+ C R G D R +P C G + C H G
Sbjct: 4390 TLPVTDDNPC--ARYCANGGVCHLDEYR-------LPHCSCIGEWQGNACEMPPHCVGGE 4440
Query: 896 CWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQ 929
C V R G + PCLS A + +
Sbjct: 4441 C-NVCRPGSSINECLCENNRVVPCLSDSADALKE 4473
Score = 43.8 bits (101), Expect = 0.012
Identities = 22/63 (34%), Positives = 30/63 (46%), Gaps = 6/63 (9%)
Query: 693 FTCECSIGFR---GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGT 749
+ C C G++ C DIDEC EQ + C N G+++C C +GY D T
Sbjct: 2932 YQCHCRPGYKVLPKSPHLCTDIDECDEQQPCSQT---CINTYGSYKCLCAKGYALVDHHT 2988
Query: 750 CVA 752
C A
Sbjct: 2989 CKA 2991
Score = 42.2 bits (97), Expect = 0.036
Identities = 35/160 (21%), Positives = 52/160 (31%), Gaps = 37/160 (23%)
Query: 712 DECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDI 771
D C ++C + + + C+C EGY +D+G C A D + L C I
Sbjct: 4072 DPCKSSRALC---ILSSESSVGYSCKCAEGYVMTDDGVCKAHADIPDYCPLQCNLGTCKI 4128
Query: 772 PQRAQCIYTGGSSYTCSCLPGFSGD-------GQACQDVDECQPSRCHPDAFCYNTPGSF 824
C C P F G+ CQ+ C + P + P
Sbjct: 4129 VDHVP---------KCICQPQFEGELCEHYRCSGYCQNYGVCSVAPALPGS---QEPPPL 4176
Query: 825 TCQCKPGYQG---------------DGFRCVPGEVEKTRC 849
C C G+ G +G C+ E E +C
Sbjct: 4177 KCTCTAGWSGARCETSMPACQSRCHNGGSCLISETEGMKC 4216
Score = 41.0 bits (94), Expect = 0.080
Identities = 34/98 (34%), Positives = 45/98 (45%), Gaps = 17/98 (17%)
Query: 670 NPCYIGTHGCDTNAACRPGPRT---QFTCE----CSIGFRGDGR-TCYD-IDECSEQPSV 720
N C G + +++A C P+ QF CE S FR DG+ C D DE + QP V
Sbjct: 3690 NDC--GENEDESDAVCAALPKCRHDQFQCENDDCISKAFRCDGQYNCVDGSDEMNCQPPV 3747
Query: 721 CG----SHTICNNHPGTFRCECVEGYQFSDE--GTCVA 752
CG S G + C+C +GY E TC+A
Sbjct: 3748 CGFGSCSQICIEKKAGHYNCKCADGYHKGPEKNATCLA 3785
Score = 40.6 bits (93), Expect = 0.11
Identities = 43/199 (21%), Positives = 63/199 (31%), Gaps = 48/199 (24%)
Query: 656 SIGPVREGS--PDALQNPCYIGTHG-------------CDTNAACRPGPRTQFTCECSIG 700
S+ P GS P L+ C G G C +C C C
Sbjct: 4162 SVAPALPGSQEPPPLKCTCTAGWSGARCETSMPACQSRCHNGGSCLISETEGMKCSCPKM 4221
Query: 701 FRGDGRTCYDIDECSEQPSVCGSHTICNNH-PGTFRCECVEGYQFSDEGTCVAVVDQRPI 759
F G+ + C C + IC GT +CEC +G+ T
Sbjct: 4222 FTGE-----QCEHCRNL--TCENGGICRETLTGTPQCECPDGF------TGKRCEIDECA 4268
Query: 760 NYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGD---GQACQDVDECQPSRCHPDAF 816
++C+ G C+ + C C G+ G+ +C+D C
Sbjct: 4269 DFCKNG---------GSCVISTKGQRQCKCPSGYFGEHCESNSCRDF-------CRNGGT 4312
Query: 817 CYNTPGSFTCQCKPGYQGD 835
C G +C C P Y G+
Sbjct: 4313 CSERGGRLSCTCPPRYIGE 4331
Score = 40.2 bits (92), Expect = 0.14
Identities = 19/69 (27%), Positives = 38/69 (54%), Gaps = 1/69 (1%)
Query: 990 KMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAK 1049
+++ W+ + E I ASL G +++ +D+G P +++D+ ++W D IE +
Sbjct: 3935 RIMIWSTL-ENGILVASLDGSNKKSLVERDVGWPISLSMDYPTGRLYWADYRKGTIETCR 3993
Query: 1050 LDGTQRRVL 1058
L+G R V+
Sbjct: 3994 LNGKDRNVV 4002
Score = 38.7 bits (88), Expect = 0.41
Identities = 50/198 (25%), Positives = 72/198 (36%), Gaps = 42/198 (21%)
Query: 665 PDALQNPCYIGTHGCDT-----NAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPS 719
PD C +GT C C+P QF E +R G C + CS P+
Sbjct: 4114 PDYCPLQCNLGT--CKIVDHVPKCICQP----QFEGELCEHYRCSGY-CQNYGVCSVAPA 4166
Query: 720 VCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPIN-----YCETGLHNCDIPQR 774
+ GS P +C C G+ + T + R N ET C P+
Sbjct: 4167 LPGSQ-----EPPPLKCTCTAGWSGARCETSMPACQSRCHNGGSCLISETEGMKCSCPKM 4221
Query: 775 ---AQCIY-------TGG-------SSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFC 817
QC + GG + C C GF+G + C+ +DEC + +
Sbjct: 4222 FTGEQCEHCRNLTCENGGICRETLTGTPQCECPDGFTG--KRCE-IDECADFCKNGGSCV 4278
Query: 818 YNTPGSFTCQCKPGYQGD 835
+T G C+C GY G+
Sbjct: 4279 ISTKGQRQCKCPSGYFGE 4296
Score = 36.4 bits (82), Expect = 2.0
Identities = 19/76 (25%), Positives = 33/76 (43%), Gaps = 1/76 (1%)
Query: 983 LAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNL 1042
L D +++TD T PS+ R+ L G T ++ + P + +D ++W D
Sbjct: 296 LDLDPTKGFMFYTDWT-PSLSRSLLDGSNRTVLVTDQVYHPSSVTLDLANELVYWIDIYK 354
Query: 1043 DRIEVAKLDGTQRRVL 1058
D + +G R L
Sbjct: 355 DEVNRVDYEGRNRWTL 370
>ref|NP_032538.1| low density lipoprotein receptor related protein [Mus musculus]
emb|CAA47817.1| (X67469) AM2 receptor [Mus musculus]
Length = 4545
Score = 176 bits (442), Expect = 1e-42
Identities = 164/599 (27%), Positives = 239/599 (39%), Gaps = 112/599 (18%)
Query: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNH-------- 730
CD + C G T C TC D + + H +C++
Sbjct: 2795 CDGDKDCTDGADESVTAGCLYN-----STCDDREFMCQNRLCIPKHFVCDHDRDCADGSD 2849
Query: 731 -----------PGTFRC---ECVEGYQFSDEGT--CVAVVDQRPIN-YCETGLHNCDIPQ 773
P FRC C+ Q+ +G C D+ P N +C + H C+
Sbjct: 2850 ESPECEYPTCGPNEFRCANGRCLSSRQWECDGENDCHDHSDEAPKNPHCTSPEHKCNASS 2909
Query: 774 RAQCIYTGGSSYTCSCLP----GFSGDGQACQDVDEC---QPSRCHPDAFCYNTPGSFTC 826
+ C + C G D + C V+EC + S C D C + F C
Sbjct: 2910 QFLCSSGRCVAEALLCNGQDDCGDGSDERGCH-VNECLSRKLSGCSQD--CEDLKIGFKC 2966
Query: 827 QCKPGYQ--GDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHY 884
+C+PG++ DG C L T P + + HG Y
Sbjct: 2967 RCRPGFRLKDDGRTCAD---------------LDECSTTFPCSQLC-------INTHGSY 3004
Query: 885 APTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGT 944
C CV EG R G C AV P
Sbjct: 3005 K----------CLCV-------EGYAPRGGDPHSC---------------KAVTDEEP-- 3030
Query: 945 HLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS--I 1002
L+FA + +L L+G+ L + LAFD ++M+YWT +T I
Sbjct: 3031 FLIFANRYYLRKLNLDGSNY------TLLKQGLNNAVALAFDYREQMIYWTGVTTQGSMI 3084
Query: 1003 GRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETD 1062
R L+G + R L +P+G+AVD +G N++W D D IEV+KL+G R VL +
Sbjct: 3085 RRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSG 3144
Query: 1063 LVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQ 1122
L PR +V D G LYWTDW D+ I MDG+ R I+V + PNGL D + +
Sbjct: 3145 LREPRALVVDVQNGYLYWTDWG-DHSLIGRIGMDGSGRSIIVDTKITWPNGLTVDYVTER 3203
Query: 1123 LCWVDAGTNRAECLNPSQPSRRKAL-EGLQYPFAVTSYGKNLYFTDWKMNSV--VALDLA 1179
+ W DA + E + +R L + + + FA+T + +Y+TDW+ S+
Sbjct: 3204 IYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTG 3263
Query: 1180 ISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATP-GSRTCRCPDN 1237
+K H+ L+ + AL Q ++ C VNNGGC++LCL +P G C CP N
Sbjct: 3264 ANKTLLISTLHRPMDLH-VFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTN 3321
Score = 160 bits (400), Expect = 1e-37
Identities = 99/284 (34%), Positives = 148/284 (51%), Gaps = 26/284 (9%)
Query: 983 LAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNL 1042
L F +Y+ D T IGR + G E TI++ + + EG+AVD +G N++WTD
Sbjct: 565 LDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGP 624
Query: 1043 DR-IEVAKLD--GTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRD-----NPKIETSY 1094
+ I VA+L+ R+ L E + +PR IV D + G +YWTDW D ++E ++
Sbjct: 625 KKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAW 684
Query: 1095 MDGTNRRILVQDDLGL-PNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG--LQ 1151
MDG++R I V L PNGL D + +L WVDA +R E + + R+ EG L
Sbjct: 685 MDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELN 744
Query: 1152 YPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQ-------PHKQTRLYGITTALSQ 1204
+ F + +G L++T+++ SV L+ ++ P + R+Y +
Sbjct: 745 HAFGLCHHGNYLFWTEYRSGSVYRLERGVAGAPPTVTLLRSERPPIFEIRMYDA----HE 800
Query: 1205 CPQGHNYCSVNNGGCTHLCLATPGSRTCRCPD----NTLGVDCI 1244
G N C VNNGGC+ LCLATPGSR C C + +T GV C+
Sbjct: 801 QQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDTDGVTCL 844
Score = 154 bits (386), Expect = 5e-36
Identities = 92/256 (35%), Positives = 128/256 (49%), Gaps = 13/256 (5%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTT----IIRQDLGSPEGIAVDHLGRNIF 1036
I L F +YWTD E I R L T +I+ L +PEG+AVD + NI+
Sbjct: 1301 IALDFHLSQSALYWTDAVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIY 1360
Query: 1037 WTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMD 1096
W +SNLD+IEVAKLDGT R L D+ +PR I D G L+WTDW+ P+IE + M
Sbjct: 1361 WVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMS 1420
Query: 1097 GTNRRILVQD--DLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---LQ 1151
G RR + ++ G NGL D ++ W+DA ++ + L G L
Sbjct: 1421 GAGRRTIHRETGSGGCANGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLS 1480
Query: 1152 YPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT-ALSQCPQGHN 1210
+PFAVT YG +Y+TDW+ N++ + Q T+ + + S+ P N
Sbjct: 1481 HPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQ-RTNTQPFDLQVYHPSRQPMAPN 1539
Query: 1211 YCSVN--NGGCTHLCL 1224
C N G C+HLCL
Sbjct: 1540 PCEANGGRGPCSHLCL 1555
Score = 135 bits (337), Expect = 3e-30
Identities = 97/333 (29%), Positives = 150/333 (44%), Gaps = 16/333 (4%)
Query: 916 TPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHV 975
T C+ T + G V G+ LL++ I +PL+ N ++ A + V
Sbjct: 1869 TRSCMCTAGYSLRSGQQACEGV-----GSFLLYSVHEGIRGIPLDPND----KSDALVPV 1919
Query: 976 PA-KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRN 1034
+ +G+ F + +YW D+ +I RA ++ +G EGIAVD + N
Sbjct: 1920 SGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGN 1979
Query: 1035 IFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSY 1094
I+WTD D IEVA+L+G+ R V+ L PR I +G L+WT+W P+IE S
Sbjct: 1980 IYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGH-YPRIERSR 2038
Query: 1095 MDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL--EGLQY 1152
+DGT R +LV + PNG+ D +L W DA ++ E ++ R+ +
Sbjct: 2039 LDGTERVVLVNVSISWPNGISVDYQGGKLYWCDARMDKIERIDLETGENREVVLSSNNMD 2098
Query: 1153 PFAVTSYGKNLYFTDWKMNSVVALDLAISKETDA--FQPHKQTRLYGITTALSQCPQGHN 1210
F+V+ + +Y++D + TD+ + +L I +G N
Sbjct: 2099 MFSVSVFEDFIYWSDRTHANGSIKRGCKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTN 2158
Query: 1211 YCSVNNGGCTHLCL-ATPGSRTCRCPDNTLGVD 1242
C+V NGGC LCL G R C C L D
Sbjct: 2159 VCAVANGGCQQLCLYRGGGQRACACAHGMLAED 2191
Score = 129 bits (321), Expect = 2e-28
Identities = 90/278 (32%), Positives = 127/278 (45%), Gaps = 51/278 (18%)
Query: 992 VYWTDITEPSIGRASLHGGEPTTIIRQD---------------LGSPEGIAVDHLGRNIF 1036
VYWT+ +I SL P T + L P GIA+D + N++
Sbjct: 3915 VYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVY 3974
Query: 1037 WTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMD 1096
WTDS D IEVA++ G R+ L + P IV D +RG +YW+DW ++PKIET+ MD
Sbjct: 3975 WTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWG-NHPKIETAAMD 4033
Query: 1097 GTNRRILVQDDLGLPNGLHFDAFSSQLCWVDA-----GTNRAECLNPSQPSRRKALEGLQ 1151
GT R LVQD++ P GL D + +L W DA G+ R +P + K GL
Sbjct: 4034 GTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSK--RGLS 4091
Query: 1152 YPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHK--QTRLYGITTALSQC---- 1205
+PF++ + +Y + N V F+ HK + LY +T LS
Sbjct: 4092 HPFSIDVFEDYIYGVTYINNRV-------------FKIHKFGHSPLYNLTGGLSHASDVV 4138
Query: 1206 -------PQGHNYCSVNNGGCTHLCLATPGSRTCRCPD 1236
P+ N C + C LCL +P C CP+
Sbjct: 4139 LYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPVCTCPN 4174
Score = 119 bits (296), Expect = 2e-25
Identities = 84/265 (31%), Positives = 133/265 (49%), Gaps = 24/265 (9%)
Query: 983 LAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWT--DS 1040
L +D ++ VYW+D+ +I RA ++G T++ DL + G+AVD + RN+FWT D+
Sbjct: 1621 LDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDT 1680
Query: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
N +I VA+LDG+ + + + L P G+V +RG LYWT D I + MDG+N
Sbjct: 1681 NKKQINVARLDGSFKNAVVQ-GLEQPHGLVVHPLRGKLYWT----DGDNISMANMDGSNH 1735
Query: 1101 RILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPF----AV 1156
+L G P GL D S+L W+ +G + N S + ++ ++ A+
Sbjct: 1736 TLLFSGQKG-PVGLAIDFPESKLYWISSGNHTINRCN-LDGSELEVIDTMRSQLGKATAL 1793
Query: 1157 TSYGKNLYFTDW---KMNSVVALD---LAISKETDAFQPHKQTRLYGITTALSQCPQGHN 1210
G L++ D KM + D + + + H ++Y + L +G N
Sbjct: 1794 AIMGDKLWWADQVSEKMGTCNKADGSGSVVLRNSTTLVMH--MKVYDESIQLEH--EGTN 1849
Query: 1211 YCSVNNGGCTHLCLAT-PGSRTCRC 1234
CSVNNG C+ LCL T +R+C C
Sbjct: 1850 PCSVNNGDCSQLCLPTSETTRSCMC 1874
Score = 105 bits (259), Expect = 4e-21
Identities = 79/279 (28%), Positives = 127/279 (45%), Gaps = 29/279 (10%)
Query: 978 KVIIGLAFDC-------VDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDH 1030
K +I LAFD ++++DI +I + + G TTI+ +++GS EG+A
Sbjct: 2235 KNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSGRTTIV-ENVGSVEGLAYHR 2293
Query: 1031 LGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLV-------NPRGIVTDSVRGNLYWTDW 1083
++WT I +D T R FE + V +PR V D + ++WT+W
Sbjct: 2294 GWDTLYWTSYTTSTITRHTVDQT-RPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNW 2352
Query: 1084 NRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSR 1143
N +P I + + G N L++ D+ PNGL D + +L + DA ++ E R
Sbjct: 2353 NELHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHR 2412
Query: 1144 RKALEGLQ-YPFAVTSYGKNLYFTDW------KMNSVVALDLAISKETDAFQPHKQTRLY 1196
L+ +PF + YG+++++TDW + N V D+ + + QP +
Sbjct: 2413 YVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKYVGSDMKLLRVDIPQQPMGIIAVA 2472
Query: 1197 GITTALSQCPQGHNYCSVNNGGCTHLCLAT-PGSRTCRC 1234
T + P C +NNGGC LCL T G C C
Sbjct: 2473 NDTNSCELSP-----CRINNGGCQDLCLLTHQGHVNCSC 2506
Score = 87.0 bits (212), Expect = 1e-15
Identities = 118/485 (24%), Positives = 188/485 (38%), Gaps = 62/485 (12%)
Query: 795 GDGQACQDVDECQPSRCHPDAF-CYNT----PGSFTCQCKPGYQGDGFRCVPGEVEKTRC 849
G +A + + + RC P+ C T P S C G Q C+ G E C
Sbjct: 57 GSDEAPEICPQSKAQRCPPNEHSCLGTELCVPMSRLCN---GIQD----CMDGSDEGAHC 109
Query: 850 QHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGT 909
+ R + G P P G P C + + + G T C D D V GT
Sbjct: 110 RELRANC-SRMGCQHHCVPTPSG---PTCYCNSSFQ-LEADGKT----CKDFDECSVYGT 160
Query: 910 ------RTRPGMTPPCLST-VAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGN 962
T T C+ + P ++ + PP LL A + I L G
Sbjct: 161 CSQLCTNTDGSFTCGCVEGYLLQPDNRSCKAKNEPVDRPPV--LLIANSQNILATYLSG- 217
Query: 963 TMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDI----TEPSIGRASLHG-----GEPT 1013
+ + + F ++ V W + + + A + G E T
Sbjct: 218 ----AQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHT 273
Query: 1014 TIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDS 1073
I L E +A+D L N ++ D DRI V +G L + +L NP+GI D
Sbjct: 274 INISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDP 333
Query: 1074 VRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRA 1133
G +++TD+ + PK+E MDG NR LV + P+G+ D S + W DA +
Sbjct: 334 AMGKVFFTDYGQ-IPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYI 392
Query: 1134 ECLNPSQPSRRKALEG--LQYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETD 1185
E ++ R+ ++G +++ + +T + LY T+ + SV+ ++ S E
Sbjct: 393 EVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANTQQKTSVIRVNRFNSTEYQ 452
Query: 1186 AFQPHKQTRLYGITTALSQCPQGHNYCSVNN-----GGCTHLCLATPG--SRTCRCPDN- 1237
+ I Q P+ ++ N+ GGC+ +CL +RTCRC
Sbjct: 453 VVTRVDKGGALHIYHQRRQ-PRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGF 511
Query: 1238 TLGVD 1242
+LG D
Sbjct: 512 SLGSD 516
Score = 53.5 bits (126), Expect = 1e-05
Identities = 58/187 (31%), Positives = 70/187 (37%), Gaps = 47/187 (25%)
Query: 680 DTNAACRPGP---RTQFTCECSIGFRGDG-RTCYDIDECSEQPSVCGSHTICNNHPGTFR 735
D C P R Q TC S G+R DG R C D + E P +C P
Sbjct: 23 DAPKTCSPKQFACRDQITC-ISKGWRCDGERDCPDGSD--EAPEICPQSKAQRCPPNEHS 79
Query: 736 C-----------------ECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCD-IPQRAQC 777
C +C++G SDEG +C NC + + C
Sbjct: 80 CLGTELCVPMSRLCNGIQDCMDG---SDEGA-----------HCRELRANCSRMGCQHHC 125
Query: 778 IYTGGSSYTCSCLPGFS--GDGQACQDVDECQP-SRCHPDAFCYNTPGSFTCQCKPGY-- 832
+ T S TC C F DG+ C+D DEC C C NT GSFTC C GY
Sbjct: 126 VPTP-SGPTCYCNSSFQLEADGKTCKDFDECSVYGTC--SQLCTNTDGSFTCGCVEGYLL 182
Query: 833 QGDGFRC 839
Q D C
Sbjct: 183 QPDNRSC 189
Score = 52.3 bits (123), Expect = 3e-05
Identities = 35/89 (39%), Positives = 44/89 (49%), Gaps = 14/89 (15%)
Query: 678 GCDTNAACRP-GPRTQFTCECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNNHPGTF 734
GC + P GP TC C+ F+ DG+TC D DECS C +C N G+F
Sbjct: 120 GCQHHCVPTPSGP----TCYCNSSFQLEADGKTCKDFDECSVY-GTCSQ--LCTNTDGSF 172
Query: 735 RCECVEGYQFS-DEGTCVA---VVDQRPI 759
C CVEGY D +C A VD+ P+
Sbjct: 173 TCGCVEGYLLQPDNRSCKAKNEPVDRPPV 201
Score = 47.3 bits (110), Expect = 0.001
Identities = 55/221 (24%), Positives = 75/221 (33%), Gaps = 54/221 (24%)
Query: 665 PDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSH 724
PD +PC + GC PG + C + GDGRTC + C+ VC +
Sbjct: 3288 PDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGGDGRTC--VSNCTASQFVCKND 3345
Query: 725 TICNNHPGTFRCECVEGY-QFSDEGTCVAVVDQRPINY-CETGL---------------- 766
P ++C+ + SDE RP + C TG+
Sbjct: 3346 KCI---PFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQD 3402
Query: 767 ----HNCDI----PQRAQCIYTGGSSYTCSCLPGF--------SGDGQACQDVDECQPSR 810
NCDI P + +C T C+PG GDG +D +C
Sbjct: 3403 NSDEANCDIHVCLPSQFKCTNTN------RCIPGIFRCNGQDNCGDG---EDERDCPEVT 3453
Query: 811 CHPDAFCYNTPGSFTCQCKPGYQ--GDGFRCVPGEVEKTRC 849
C P+ F S T +C P CV G E C
Sbjct: 3454 CAPNQF----QCSITKRCIPRVWVCDRDNHCVDGSDEPANC 3490
Score = 46.9 bits (109), Expect = 0.001
Identities = 52/180 (28%), Positives = 66/180 (35%), Gaps = 45/180 (25%)
Query: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHP-GTFRCE 737
C +C R Q C C + GD C ++D+C E C + C P G C
Sbjct: 4205 CFNGGSCFLNARRQPKCRCQPRYTGD--KC-ELDQCWEY---CHNGGTCAASPSGMPTCR 4258
Query: 738 CVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGDG 797
C G+ C A V YC + C G+ C CLPGF G
Sbjct: 4259 CPTGFTGPK---CTAQVCA---GYCSNN---------STCTVNQGNQPQCRCLPGFLG-- 4301
Query: 798 QACQDVDECQPSRCHPDAFCYN-------TPGSFTCQCKPGYQGDGFRCVPGEVEK-TRC 849
D CQ +C FC N GS C+C ++G RC EV K +RC
Sbjct: 4302 ------DRCQYRQC--SGFCENFGTCQMAADGSRQCRCTVYFEGP--RC---EVNKCSRC 4348
Score = 37.9 bits (86), Expect = 0.70
Identities = 28/99 (28%), Positives = 47/99 (47%), Gaps = 6/99 (6%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTI--IRQDLGSPEGIAVDHLGRNIFWT 1038
+GLA D + +YW +I R +L G E I +R LG +A+ +G ++W
Sbjct: 1746 VGLAIDFPESKLYWISSGNHTINRCNLDGSELEVIDTMRSQLGKATALAI--MGDKLWWA 1803
Query: 1039 DSNLDRIEVA-KLDGTQRRVL-FETDLVNPRGIVTDSVR 1075
D +++ K DG+ VL T LV + +S++
Sbjct: 1804 DQVSEKMGTCNKADGSGSVVLRNSTTLVMHMKVYDESIQ 1842
Score = 37.5 bits (85), Expect = 0.91
Identities = 23/91 (25%), Positives = 38/91 (41%), Gaps = 5/91 (5%)
Query: 662 EGSPDA-LQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
+GS + L + C + GC N + PG +C + D TC C++
Sbjct: 1175 DGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGSDNHTCQIQSYCAKHLK- 1233
Query: 721 CGSHTICNNHPGTFRCECVEGYQFSDEG-TC 750
C C+ + + +C C EG+ +G TC
Sbjct: 1234 CSQK--CDQNKFSVKCSCYEGWVLEPDGETC 1262
Score = 36.7 bits (83), Expect = 1.6
Identities = 14/25 (56%), Positives = 16/25 (64%), Gaps = 1/25 (4%)
Query: 1212 CSVNNGGCTHLCLATPGSR-TCRCP 1235
CS+NNGGC+H C PG C CP
Sbjct: 1186 CSLNNGGCSHNCSVAPGEGIVCSCP 1210
Score = 35.2 bits (79), Expect = 4.6
Identities = 23/109 (21%), Positives = 43/109 (39%), Gaps = 16/109 (14%)
Query: 1076 GNLYWTDWN------RDNPKIETSYMDGTNRRILVQ-------DDLGLPNGLHFDAFSSQ 1122
G +YWT+W+ R P +RR + + L +P G+ D +
Sbjct: 3913 GRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGN 3972
Query: 1123 LCWVDAGTNRAECLNPSQPSRRKALEGL---QYPFAVTSYGKNLYFTDW 1168
+ W D+G + E +R+ + G+ + V +Y++DW
Sbjct: 3973 VYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDW 4021
>emb|CAA03855.1| (AJ000010) lipophorin receptor [Locusta migratoria]
Length = 883
Score = 174 bits (436), Expect = 6e-42
Identities = 174/633 (27%), Positives = 254/633 (39%), Gaps = 100/633 (15%)
Query: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCE- 737
CD N C G + C+ R D TC + +C +Q VC C + C
Sbjct: 152 CDDNPDCSDGSDEK---ACNETCRSDEFTCAN-SKCIQQRWVCDRDDDCGDGSDEKDCPK 207
Query: 738 --CVEGYQF--SDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLP-- 791
C +F SD C+ Q C+ L D C TG S+ CLP
Sbjct: 208 TTCAPETEFNCSDNNMCITARWQ-----CDGDLDCQDGSDEQGCTSTGPISH---CLPRE 259
Query: 792 ------------GFSGDGQ------ACQDVDECQPSRCHPDAF-CYNT---PGSFTCQ-- 827
+ DG + +DV C C PD F C N PG C
Sbjct: 260 FECLDRMTCIHQSWVCDGDRDCPDGSDEDVSRCHNMTCRPDQFQCRNRICIPGHLHCSGH 319
Query: 828 --CKPGYQGDGFRC---VPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVP------ 876
C G D C VP KT + + + D + P P
Sbjct: 320 ADCSDG--SDEENCTSPVPKCDPKTEFECGGGMCIPLSSVCDKKPDCPNWEDEPQEKCGK 377
Query: 877 -ECDAHGHYAPTQCHGSTG--YCWC------VDRDGREVEGTRTRPGM-TPPCLS---TV 923
EC + +C + YC C VD + PG + C++ T
Sbjct: 378 NECAVNNGGCSQKCVDTPAGYYCDCLPGYKLVDNHTCDDVNECEIPGACSQECINEKGTF 437
Query: 924 APPIHQG----PAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKV 979
+G P PT + LLFA+ I ++ L+ + M + K
Sbjct: 438 KCQCVEGYLRDPRDPTRCKAMEGHASLLFARRHDIRKISLDHHEMTA------IVNDTKS 491
Query: 980 IIGLAFDCVDKMVYWTDITEPSIGRASL-HGGEPTTIIRQDLGSPEGIAVDHLGRNIFWT 1038
L F M++W+D+++ I +A + G E T +I+ L + +G+AVD + +I+WT
Sbjct: 492 ATALDFVFRTGMIFWSDVSDQKIYKAPIDEGSERTVVIKDQLTTSDGLAVDWIYNHIYWT 551
Query: 1039 DSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGT 1098
D+ + IE+A +G R++L + +L PR I + + G +YWTDW NPKIE + MDG
Sbjct: 552 DTGKNTIELANFEGNMRKILIKDELEEPRAIAVNPLDGWMYWTDWG-TNPKIERAGMDGA 610
Query: 1099 NRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL---EGLQYPFA 1155
+R+ +V ++ PNGL D ++ WVDA N N RR L E LQ+PF+
Sbjct: 611 HRQTIVSYEVKWPNGLTLDLVKRRVYWVDAKLNVISSCNYDGSGRRVILYSPEHLQHPFS 670
Query: 1156 VTSYGKNLYFTDW------KMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGH 1209
VT++ +Y+TDW K N D++ T Q +Y + P G
Sbjct: 671 VTTFEDWVYWTDWDKQAVYKANKFNGKDVSAITATHMLQNPMVIHVY----HPYRQPDGE 726
Query: 1210 NYCSVNNGGCTHLCL------ATPGSRTCRCPD 1236
N+C NG C+HLCL A +C CPD
Sbjct: 727 NHCQAVNGHCSHLCLPAAQINAHSPKISCACPD 759
Score = 56.2 bits (133), Expect = 2e-06
Identities = 28/75 (37%), Positives = 38/75 (50%), Gaps = 7/75 (9%)
Query: 669 QNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFR-GDGRTCYDIDECSEQPSVCGSHTIC 727
+N C + GC P + C+C G++ D TC D++EC E P C C
Sbjct: 377 KNECAVNNGGCSQKCVDTPAG---YYCDCLPGYKLVDNHTCDDVNEC-EIPGACSQE--C 430
Query: 728 NNHPGTFRCECVEGY 742
N GTF+C+CVEGY
Sbjct: 431 INEKGTFKCQCVEGY 445
>emb|CAA11963.1| (AJ224450) entactin [Rattus norvegicus]
Length = 109
Score = 167 bits (418), Expect = 8e-40
Identities = 81/108 (75%), Positives = 88/108 (81%)
Query: 303 LGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETFHQ 362
LGLEDV T PF + RRG D ++VP L+P ATERP G PTERT+SFQL VE F Q
Sbjct: 2 LGLEDVATQPFPSHSPRRGYPDPHNVPRTLAPSYEATERPHGIPTERTKSFQLPVERFPQ 61
Query: 363 QHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGF 410
+HPQVIDVDEVEETGVVFSYNT S+QTCANNRHQCSVHAECRDYATGF
Sbjct: 62 KHPQVIDVDEVEETGVVFSYNTGSQQTCANNRHQCSVHAECRDYATGF 109
>gb|AAF48538.1| (AE003500) CG8909 gene product [Drosophila melanogaster]
Length = 2009
Score = 166 bits (415), Expect = 2e-39
Identities = 151/538 (28%), Positives = 218/538 (40%), Gaps = 90/538 (16%)
Query: 715 SEQPSVCGSHTI-CNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINY-CETGLHNCDIP 772
SE P CGS CNN + +GY C A D+ + C+ G C
Sbjct: 436 SEHPLTCGSDEFTCNNGRCILKTWLCDGYP-----DCAAGEDEVECHLQCDLGQFLCPTK 490
Query: 773 QRAQ----CIYTGGSSYTCS----CLPGFSGDGQACQDVDEC-QPSRCHPDAFCYNTP-G 822
Q C++ + C C G D C +C +PS C + C T G
Sbjct: 491 QNLTNLKICVH---QKHICDGHNECPAG--EDEADCPKERKCSEPSPC--EQLCIETTAG 543
Query: 823 SFTCQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHG 882
S C C+ GY D + ++++ CQ+ L P C
Sbjct: 544 SNECACRLGYVMDKNKVNCTDIDE--CQY---------------------LTSPVCSQ-- 578
Query: 883 HYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPP 942
+CH + G C G + P + A+ A+
Sbjct: 579 -----KCHNTMGSFKCSCETGY-----------------ILRPDLRSCKALGGAMT---- 612
Query: 943 GTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSI 1002
LL A I R+ L N R + LH I L F +++W+D++ I
Sbjct: 613 ---LLVANRWDIRRVTLSNN--RYSAIVKGLHNA----IALDFHHRKGLMFWSDVSTDVI 663
Query: 1003 GRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETD 1062
++G +I+ L SP GIAVD + +FWTDS R+EV+ G R V+ D
Sbjct: 664 KMVYMNGTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYD 723
Query: 1063 LVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQ 1122
L PR IV +W+DW NPKIE +YMDGT R++++ + PNGL D +S+
Sbjct: 724 LDKPRAIVVHPGEALAFWSDWG-PNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSK 782
Query: 1123 LCWVDAGTNRAECLNPSQPSRRKALE-GLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS 1181
+ W DA + EC N R K L L +PFA+T + +Y+TDW +V A D
Sbjct: 783 IYWADAKQHAIECSNLDGSDRNKILSTHLPHPFALTLFEDTMYWTDWNTKTVSAADKITG 842
Query: 1182 KETDAFQPHKQTRLYGITTALSQCPQGHNYCSVN----NGGCTHLCLATPGSRTCRCP 1235
KE A + + ++ P+ + C + GGC+HLCL SR C CP
Sbjct: 843 KEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCLPNKTSRRCGCP 900
Score = 163 bits (408), Expect = 1e-38
Identities = 90/254 (35%), Positives = 134/254 (52%), Gaps = 5/254 (1%)
Query: 992 VYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLD 1051
+YWTD+ +I +A L+G ++ +L SP G+A+D + ++WTD + +RIEVA +
Sbjct: 967 IYWTDVERSTINKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTN 1026
Query: 1052 GTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLP 1111
G R +L L PR IV + + G ++W+DW D+P IE + MDG R + L P
Sbjct: 1027 GKMRTLLIWEKLYKPRDIVVNPIEGFMFWSDWG-DDPMIERANMDGHERVTITSKKLIYP 1085
Query: 1112 NGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMN 1171
NGL D S++ +VD GT E +N R+ L GL +PF + +++TDW
Sbjct: 1086 NGLAIDYEKSKIYFVDGGTKTLENMNFDGSGRQVILNGLGHPFGLDVNEGRVFWTDWDTK 1145
Query: 1172 SVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRT 1231
SV++ + K+T+ + T L I + N C NGGC+HLCL P S T
Sbjct: 1146 SVMSANKLTGKDTNVIIAN-STDLMDIRVFHRTRRRIFNACDKLNGGCSHLCLLNPTSYT 1204
Query: 1232 CRCPDNTLGVDCIE 1245
C C T+GV E
Sbjct: 1205 CAC---TVGVQLKE 1215
Score = 163 bits (408), Expect = 1e-38
Identities = 96/295 (32%), Positives = 142/295 (47%), Gaps = 5/295 (1%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
P ++LFA I ++ L+ + + P + L D +YW+D E
Sbjct: 1224 PTQYILFAHRIDIRQISLDFDHLIDVVLPL---PPISNAVALDVDRKTGYIYWSDTIENV 1280
Query: 1002 IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
I +S G I+ L +P+G+ VD +GR I+W D+ IEVA LDG+ R V+
Sbjct: 1281 IMSSSPDGLHVQKIVGDSLENPDGLVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYK 1340
Query: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSS 1121
DL +PRG+ D G L+WTDW KIE S++DG R +V +LG PNGL D S
Sbjct: 1341 DLESPRGLALDYEAGLLFWTDWGHYR-KIERSHLDGNERSRIVTANLGWPNGLSLDLKSK 1399
Query: 1122 QLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLA-I 1180
++ WVDA + + + R+ + L +P+A+ N+Y+TDWK ++ + I
Sbjct: 1400 RIYWVDARLKTIDSCDYTGNQRKLIMSSLHHPYALALSDDNIYWTDWKSKALHMTERRNI 1459
Query: 1181 SKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCP 1235
S + D I N C NNG C+HLCL P +C+CP
Sbjct: 1460 SAKRDIITNIDGLMDIKIIYQNQNQSTMKNACGNNNGNCSHLCLRNPSGYSCQCP 1514
Score = 147 bits (368), Expect = 6e-34
Identities = 82/252 (32%), Positives = 141/252 (55%), Gaps = 9/252 (3%)
Query: 991 MVYWTDITEPSIGRASLHG-GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAK 1049
++++ D+ I R +L E I+ D+ +P GIAVD + N++W+D++ IEV++
Sbjct: 1577 LLFFADVNLDVIRRVNLLNLTESKVIVGTDVLTPNGIAVDWIADNLYWSDTDRKLIEVSR 1636
Query: 1050 LDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLG 1109
LDG+ R+ + E +L +PR ++ + L+W+DW+ KIE SY+DG+NR +++ +G
Sbjct: 1637 LDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDWS-SPAKIERSYLDGSNRTVIITSGIG 1695
Query: 1110 LPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWK 1169
P GL D + +L W DA + ++ + R+ + +PF +T + ++++TDW
Sbjct: 1696 FPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQTIVPYAPHPFGLTLFENSIFWTDWY 1755
Query: 1170 MNSVV-ALDLAISKETDAFQPHKQTRLYGI----TTALSQCPQGHNYCSVNNGGCTHLCL 1224
SV + LA S + F+ + L G +LS+ P+ N+C+ +NGGCTHLCL
Sbjct: 1756 NKSVYRSQKLARSGYGNPFE--VRDALSGALDIRAVSLSRQPKSVNHCAQDNGGCTHLCL 1813
Query: 1225 ATPGSRTCRCPD 1236
C CPD
Sbjct: 1814 NRNVDYVCACPD 1825
Score = 49.2 bits (115), Expect = 3e-04
Identities = 42/169 (24%), Positives = 60/169 (34%), Gaps = 35/169 (20%)
Query: 672 CYIGTHGCDTNAACRPGP-RTQFTCECSIG--FRGDGRTCYDIDECSEQPSVCGSHTICN 728
C + T CD C G + +C +G + ++ C Q +C H C
Sbjct: 454 CILKTWLCDGYPDCAAGEDEVECHLQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECP 513
Query: 729 NHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCS 788
G +C + + S+ C + CI T S C+
Sbjct: 514 --AGEDEADCPKERKCSEPSPCEQL-----------------------CIETTAGSNECA 548
Query: 789 CLPGFSGDGQA--CQDVDECQ---PSRCHPDAFCYNTPGSFTCQCKPGY 832
C G+ D C D+DECQ C C+NT GSF C C+ GY
Sbjct: 549 CRLGYVMDKNKVNCTDIDECQYLTSPVCSQK--CHNTMGSFKCSCETGY 595
>gb|AAC34396.1| (AF056116) LRP1 [Takifugu rubripes]
Length = 1581
Score = 165 bits (414), Expect = 2e-39
Identities = 98/300 (32%), Positives = 154/300 (50%), Gaps = 14/300 (4%)
Query: 944 THLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS-- 1001
T+L+FA + +L L+G+ + + L F ++M+YWTD+T
Sbjct: 61 TYLIFANRYYLRKLNLDGSNY------TLIKQGLNNAVALDFHYAEQMIYWTDVTTQGSM 114
Query: 1002 IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
I R ++G + R L +P+G+AVD +G N++W D D IEV+KL+G R VL +
Sbjct: 115 IRRMRMNGSSMEVLHRTSLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVNS 174
Query: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSS 1121
L PR + D G LYW+DW D+P I MDGTNR ++V++ + PNGL D +
Sbjct: 175 GLREPRALAVDVRYGYLYWSDWG-DSPHIGRIGMDGTNRSVIVEEKITWPNGLTLDFIND 233
Query: 1122 QLCWVDAGTNRAECLNPSQPSRRKAL-EGLQYPFAVTSYGKNLYFTDWKMNSV--VALDL 1178
++ W DA + E + +R L + + FA+T + + +Y+TDW+ S+
Sbjct: 234 RIYWADAREDYIEFASLDGTNRHTVLNHDIPHIFAMTLFEEYIYWTDWETKSINRAHKTQ 293
Query: 1179 AISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATP-GSRTCRCPDN 1237
+K T H+ ++ I Q ++ C NNGGC++LCL +P G C CP N
Sbjct: 294 GTNKTTLISTLHRPMDVH-IYHPYRQPEVLNHPCQTNNGGCSNLCLLSPGGGYKCACPTN 352
Score = 113 bits (279), Expect = 2e-23
Identities = 74/246 (30%), Positives = 116/246 (47%), Gaps = 31/246 (12%)
Query: 1018 QDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGN 1077
++L P GIAVD + N++WTDS D IEVA++ G + L + P IV D RG
Sbjct: 991 KELKMPRGIAVDWVAGNLYWTDSGRDVIEVAQMSGQHCKTLISGMIDEPYAIVVDPQRGT 1050
Query: 1078 LYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLN 1137
+YW DW ++PKIET+ MDGT R+ LV +++ P GL D ++ +L W DA + +
Sbjct: 1051 MYWADWG-NHPKIETAAMDGTLRQTLVHENIQWPTGLAVDYYNERLYWADAKLSVIGSVR 1109
Query: 1138 PSQPSRRKALEGLQ----YPFAVTSYGKNLYFTDWKMNSVVA-----------LDLAISK 1182
A+ G++ +PF++ + +Y + N V L I+
Sbjct: 1110 LDGSDPVIAVSGIKNNLLHPFSIDIFEDYIYGVTYINNIVFRVNKFGKGTMENLTTGINH 1169
Query: 1183 ETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVD 1242
+D H+ + P+ N C + C LCL +P C CP+ + +
Sbjct: 1170 ASDIVLHHRYKQ-----------PEMTNPC--DRKKCEWLCLLSPSGPVCTCPNKYVADN 1216
Query: 1243 --CIER 1246
C+ER
Sbjct: 1217 GTCVER 1222
Score = 67.9 bits (163), Expect = 7e-10
Identities = 98/432 (22%), Positives = 154/432 (34%), Gaps = 77/432 (17%)
Query: 675 GTHGCDTNAACRPGPRTQFTCECSIGFR-GDGRTCYDIDECSEQPSVCGSHTI---CNNH 730
G C N+ P +F C + FR + R C + + + S CG ++ C
Sbjct: 706 GEDDCGDNSDENPEECRKFQCPPTRAFRCQNDRVCLQVSKRCDGVSNCGDNSDELNCQIP 765
Query: 731 PGTFRCE-----CVEGYQFSDEGTC-------------VAVVDQRPINYCETGLHNCDIP 772
P CE C S C + + C + C
Sbjct: 766 PAIPTCEKDEFLCANNRCISSTLRCNFFNDCEDFGSDEIGCKTDTKLTDCRSNRTQCGDG 825
Query: 773 QRAQCIYTGGSSYTCSCLPGFSGDG-QACQDVDEC-QPSRCHPDAFCYNTPGSFTCQCKP 830
A C+ G S+ CSC GF G + C D +EC Q C C NT GS+ C C
Sbjct: 826 DEAHCVTNGTDSF-CSCKAGFQKIGHRTCGDKNECLQFGVC--SHICNNTKGSYKCSCHK 882
Query: 831 GYQGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGL------FVPECDAHGHY 884
+ C + +R IL A + R + PG+ + DA
Sbjct: 883 YFTRISDTCKADNINSSR------QILYIADDNE-IRSLDPGMPDWRYEQTFQGDASVRI 935
Query: 885 APTQCHGSTG-YCWCVDRDGR----EVEGTRTRPGMTPPCLSTVAPPIH------QGPAV 933
H T W GR E++G P LS + H +G +
Sbjct: 936 DAMDVHVKTNRIFWTNWHTGRISTYELQG---------PSLSATSSNSHRNRRQSEGRVI 986
Query: 934 PTAV--IPLPPGT-------HLLFAQTGK--IERLPLEGNTMRKTEAKAFLHVPAKVIIG 982
+ + +P G +L + +G+ IE + G KT + P +++
Sbjct: 987 DLQIKELKMPRGIAVDWVAGNLYWTDSGRDVIEVAQMSGQHC-KTLISGMIDEPYAIVV- 1044
Query: 983 LAFDCVDKMVYWTDI-TEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSN 1041
D +YW D P I A++ G T++ +++ P G+AVD+ ++W D+
Sbjct: 1045 ---DPQRGTMYWADWGNHPKIETAAMDGTLRQTLVHENIQWPTGLAVDYYNERLYWADAK 1101
Query: 1042 LDRIEVAKLDGT 1053
L I +LDG+
Sbjct: 1102 LSVIGSVRLDGS 1113
Score = 46.9 bits (109), Expect = 0.001
Identities = 24/53 (45%), Positives = 30/53 (56%), Gaps = 5/53 (9%)
Query: 695 CECSIGF--RGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFS 745
C C GF + DGRTC DIDEC+ C C N G+F C CV+G++ S
Sbjct: 1 CRCHPGFQLKRDGRTCVDIDECT-TTYPCSQR--CINTHGSFHCLCVDGFELS 50
Score = 43.8 bits (101), Expect = 0.012
Identities = 22/50 (44%), Positives = 28/50 (56%), Gaps = 5/50 (10%)
Query: 787 CSCLPGFS--GDGQACQDVDECQPSRCHP-DAFCYNTPGSFTCQCKPGYQ 833
C C PGF DG+ C D+DEC + +P C NT GSF C C G++
Sbjct: 1 CRCHPGFQLKRDGRTCVDIDECTTT--YPCSQRCINTHGSFHCLCVDGFE 48
Score = 39.1 bits (89), Expect = 0.31
Identities = 44/186 (23%), Positives = 63/186 (33%), Gaps = 48/186 (25%)
Query: 665 PDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSH 724
P+ L +PC GC PG + C + D RTC + C+ VC +
Sbjct: 319 PEVLNHPCQTNNGGCSNLCLLSPGGGYKCACPTNFYLASDHRTC--MSNCTASQFVCKND 376
Query: 725 TICNNHPGTFRCECVEGY-QFSDEGTCVAVVDQRPINY-CETGL---------------- 766
P ++C+ + SDE RP + C TG+
Sbjct: 377 KCI---PFWWKCDTEDDCGDRSDEPADCPEFKCRPGQFQCGTGICTNPAYICDGDNDCQD 433
Query: 767 ----HNCDI----PQRAQCIYTGGSSYTCSCLPGF--------SGDGQACQDVDECQPSR 810
NCDI P + +C S+ C+PG GDG +D +C
Sbjct: 434 NSDEANCDIHVCLPSQFKC------SHPSRCIPGIFRCNGQDNCGDG---EDEKDCPEVT 484
Query: 811 CHPDAF 816
C P F
Sbjct: 485 CAPTQF 490
Score = 37.5 bits (85), Expect = 0.91
Identities = 47/182 (25%), Positives = 59/182 (31%), Gaps = 41/182 (22%)
Query: 668 LQNPCYIGTHGCDTNAACRP-GPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTI 726
+ NPC C+ P GP C C + D TC + + ++ P S
Sbjct: 1184 MTNPC--DRKKCEWLCLLSPSGP----VCTCPNKYVADNGTCVERPKPTQSPFSPPSEPC 1237
Query: 727 ---CNNHPGTF-------RCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQ 776
C N F +C C Y + D+ IN C N
Sbjct: 1238 DIQCLNGGSCFLNARQVAKCRCQPSY----------IGDRCDINQCRDYCKN-----GGT 1282
Query: 777 CIYTGGSSYTCSCLPGFSG---DGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQ 833
C + TC C GF+G Q CQD RC NT TC C YQ
Sbjct: 1283 CTASHAGVPTCRCPKGFTGPTCSRQTCQDYC-LNGGRCS-----VNTGNQPTCSCPSEYQ 1336
Query: 834 GD 835
GD
Sbjct: 1337 GD 1338
>sp|P98157|LRP1_CHICK LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1 PRECURSOR (LRP)
(ALPHA-2-MACROGLOBULIN RECEPTOR) (A2MR)
pir||A53102 alpha-2-macroglobulin receptor precursor - chicken
emb|CAA52870.1| (X74904) alpha-2-macroglobulin receptor [Gallus gallus]
Length = 4543
Score = 165 bits (413), Expect = 3e-39
Identities = 102/277 (36%), Positives = 144/277 (51%), Gaps = 19/277 (6%)
Query: 983 LAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNL 1042
L F +Y+ D T IGR + G E TI++ + + EGIAVD +G N++WTD
Sbjct: 566 LDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGIAVDWMGNNLYWTDDGP 625
Query: 1043 DR-IEVAKLD--GTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRD-----NPKIETSY 1094
+ I VA+L+ R+ L E + +PR IV D + G +YWTDW D KIE ++
Sbjct: 626 KKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSKRGKIERAW 685
Query: 1095 MDGTNRRILVQDDLGL-PNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG--LQ 1151
MDG+NR + + L PNGL D + L WVDA +R E + + R+ EG L
Sbjct: 686 MDGSNRNVFITSKTVLWPNGLSLDIPAKILYWVDAFYDRIEMVYLNGTERKIVYEGPELN 745
Query: 1152 YPFAVTSYGKNLYFTDWKMNSVVALD---LAISKETDAFQPHKQTRLYGITTALSQCPQG 1208
+ F + Y L++T+++ S+ LD A+S + P + R+Y Q G
Sbjct: 746 HAFGLCHYSSFLFWTEYRSGSIYRLDQSSKAVSLLRNERPPIFEIRMYD----AQQQQVG 801
Query: 1209 HNYCSVNNGGCTHLCLATPGSRTCRC-PDNTLGVDCI 1244
N C VNNGGC+ LCLATP R C C D LG D +
Sbjct: 802 SNKCRVNNGGCSSLCLATPRGRQCACAEDQILGADSV 838
Score = 163 bits (408), Expect = 1e-38
Identities = 149/562 (26%), Positives = 233/562 (40%), Gaps = 111/562 (19%)
Query: 708 CYDIDEC---SEQPSVCGSHTICNNHPGTFRC---ECVEGYQFSDEGT--CVAVVDQRPI 759
C D+C S++ C + C H FRC C+ Q+ +G C D+ P
Sbjct: 2835 CDHDDDCGDGSDESPEC-EYPTCGPHE--FRCANGRCLSNSQWECDGEFDCHDHSDEAPK 2891
Query: 760 NYCETGLHNCDIPQRAQCIYTGGSSYTCS---CLPG--FSGDGQACQD--------VDEC 806
N C P+ ++C S + C C+P + C D ++EC
Sbjct: 2892 N------PRCSSPE-SKC---NDSFFMCKNGKCIPEALLCDNNNDCADGSDELNCFINEC 2941
Query: 807 ---QPSRCHPDAFCYNTPGSFTCQCKPGYQ--GDGFRCVPGEVEKTRCQHEREHILGAAG 861
+ S C + C + + C+C+PG++ DG C+
Sbjct: 2942 LNKKLSGCSQE--CEDLKIGYKCRCRPGFRLKDDGKTCID-------------------- 2979
Query: 862 ATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLS 921
+ EC + +C + G C+ +EG + +P C
Sbjct: 2980 -------------IDECSTT-YPCSQKCINTLGSYKCLC-----IEGYKLKPDNPTSC-- 3018
Query: 922 TVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVII 981
AV P L+FA + +L L+G+ L +
Sbjct: 3019 -------------KAVTDEEP--FLIFANRYYLRKLNLDGSNY------TLLKQGLNNAV 3057
Query: 982 GLAFDCVDKMVYWTDITEPS--IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTD 1039
L FD ++M+YWTD+T I R ++G + R L +P+G+AVD +G N++W D
Sbjct: 3058 ALDFDYREQMIYWTDVTTQGSMIRRMHINGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCD 3117
Query: 1040 SNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTN 1099
D IEV+KL+G R VL + L PR +V D G LYWTDW D+ I MDGTN
Sbjct: 3118 KGRDTIEVSKLNGAYRTVLVNSGLREPRALVVDVQNGYLYWTDWG-DHSLIGKIGMDGTN 3176
Query: 1100 RRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL-EGLQYPFAVTS 1158
R ++V + PNGL D +S++ W DA + E + +R L + + + FA+T
Sbjct: 3177 RSVIVDTKITWPNGLTLDYINSRIYWADAREDYIEFASLDGSNRHTVLSQDIPHIFALTL 3236
Query: 1159 YGKNLYFTDWKMNSV--VALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNN 1216
+ +Y+TDW+ S+ +K H+ ++ I Q ++ C NN
Sbjct: 3237 FEDYIYWTDWETKSINRAHKTTGANKTLLISTLHRPMDIH-IYHPYRQPDVPNHPCKTNN 3295
Query: 1217 GGCTHLCLATP-GSRTCRCPDN 1237
GC++LCL +P G C CP N
Sbjct: 3296 AGCSNLCLLSPGGGHKCACPTN 3317
Score = 159 bits (399), Expect = 1e-37
Identities = 97/268 (36%), Positives = 137/268 (50%), Gaps = 14/268 (5%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASL-HGGEPTT---IIRQDLGSPEGIAVDHLGRNIF 1036
I L F +YWTD+ E I R L G T+ +I+ L +PEG+AVD + NI+
Sbjct: 1298 IALDFHLNQSSLYWTDVVEDKIYRGKLLENGALTSFEVVIQYGLATPEGLAVDWIAGNIY 1357
Query: 1037 WTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMD 1096
W +SNLD+IEVAKLDGT R L D+ +PR I D G L+WTDW+ P+IE + M
Sbjct: 1358 WVESNLDQIEVAKLDGTMRTTLLAGDIEHPRAIALDPRYGILFWTDWDASLPRIEAASMS 1417
Query: 1097 GTNRRILVQD--DLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---LQ 1151
G RR + ++ G PNGL D ++ W+DA ++ + L G L
Sbjct: 1418 GAGRRTIHKETGSGGWPNGLTVDYLEKRILWIDARSDAIYSALYDGTGHIEVLRGHEYLS 1477
Query: 1152 YPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT-ALSQCPQGHN 1210
+PFAVT YG +Y+TDW+ N++ + Q T+ + + S+ P N
Sbjct: 1478 HPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQ-RTNTQPFDLQVYHPSRQPLAPN 1536
Query: 1211 YCSVN--NGGCTHLCLATPG-SRTCRCP 1235
C N G C+HLCL + +C CP
Sbjct: 1537 PCEANGGKGPCSHLCLINYNRTLSCACP 1564
Score = 142 bits (355), Expect = 2e-32
Identities = 96/310 (30%), Positives = 150/310 (47%), Gaps = 14/310 (4%)
Query: 943 GTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPA-KVIIGLAFDCVDKMVYWTDITEPS 1001
G+ LL++ I +PL+ N ++ A + V + +G+ F + +YW D+ +
Sbjct: 1886 GSFLLYSVHEGIRGIPLDPND----KSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLST 1941
Query: 1002 IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
I RA ++ +G EGIAVD + NI+WTD D IEVA+L+G+ R V+
Sbjct: 1942 ISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQ 2001
Query: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSS 1121
L PR I +G L+WT+W + P+IE S +DGT R +LV + PNG+ D
Sbjct: 2002 GLDKPRAITVHPEKGYLFWTEWGQ-YPRIERSRLDGTERMVLVNVSISWPNGISVDYEDG 2060
Query: 1122 QLCWVDAGTNRAECLNPSQPSRRKAL--EGLQYPFAVTSYGKNLYFTD--WKMNSVVALD 1177
+L W DA T++ E ++ R+ + F+V+ + +Y++D S+
Sbjct: 2061 KLYWCDARTDKIERIDLETGENREVVLSSDNMDMFSVSVFEDYIYWSDRTHANGSIKRGS 2120
Query: 1178 LAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGS-RTCRCPD 1236
+ E+ + + +L I +G N C+ NNGGC LCL G RTC C
Sbjct: 2121 KDNATESVSLRTGIGVQLKDIKVFNRARQKGTNVCAQNNGGCQQLCLFRGGGRRTCACAH 2180
Query: 1237 NTL---GVDC 1243
L GV C
Sbjct: 2181 GMLSEDGVSC 2190
Score = 125 bits (310), Expect = 4e-27
Identities = 85/255 (33%), Positives = 121/255 (47%), Gaps = 33/255 (12%)
Query: 998 TEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRV 1057
T + R + GG T + L P GIAVD + NI+WTDS D IEVA++ G R+
Sbjct: 3935 TASNRNRRQIDGGV-THLNISGLKMPRGIAVDWVAGNIYWTDSGRDVIEVAQMKGENRKT 3993
Query: 1058 LFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFD 1117
L + P IV D +RG +YW+DW ++PKIET+ MDGT R LVQD++ P GL D
Sbjct: 3994 LISGMIDEPHAIVVDPLRGTMYWSDWG-NHPKIETAAMDGTLRETLVQDNIQWPTGLAVD 4052
Query: 1118 AFSSQLCWVDA-----GTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMN- 1171
+ +L W DA G+ R +P K +GL +PF++ + +Y + N
Sbjct: 4053 YHNERLYWADAKLSVIGSIRLNGTDPVVAIDNK--KGLSHPFSIDIFEDYIYGVTYINNR 4110
Query: 1172 ----------SVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTH 1221
SV L ++ TD H+ + P+ N C + C
Sbjct: 4111 IFKIHKFGHKSVTNLTSGLNHATDVVLYHQYKQ-----------PEVTNPC--DRKKCEW 4157
Query: 1222 LCLATPGSRTCRCPD 1236
LCL +P C CP+
Sbjct: 4158 LCLLSPSGPVCTCPN 4172
Score = 118 bits (294), Expect = 3e-25
Identities = 81/258 (31%), Positives = 123/258 (47%), Gaps = 16/258 (6%)
Query: 985 FDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWT--DSNL 1042
+D V++ +YW+D+ +I RA ++G T++ DL + G++VD + RN+FWT D+N
Sbjct: 1620 YDAVEQRIYWSDVRTQTIKRAFINGTGVETVVSADLPNAHGLSVDWVSRNLFWTSYDTNK 1679
Query: 1043 DRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRI 1102
+I VA+LDG+ + + + L P +V + G LYWT D I + MDG+NR +
Sbjct: 1680 KQINVARLDGSFKNAVIQ-GLDKPHCLVVHPLHGKLYWT----DGDNISVANMDGSNRTL 1734
Query: 1103 LVQDDLGLPNGLHFDAFSSQLCWVDAGT---NRAECLNPSQPSRRKALEGLQYPFAVTSY 1159
L + G P GL D S+L W+ +G NR L A+
Sbjct: 1735 LFTNQRG-PVGLAIDYPESKLYWISSGNGTINRCNLDGSDLEVIVAVKSQLSKATALAIM 1793
Query: 1160 GKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQ--GHNYCSVNNG 1217
G L++ D + + E + T L + + Q G N CSVNNG
Sbjct: 1794 GDKLWWADQASERMGTCNKKDGTEVTVLR--NSTTLVMLMKVYDESIQQAGSNPCSVNNG 1851
Query: 1218 GCTHLCLAT-PGSRTCRC 1234
C+ LCL T SR+C C
Sbjct: 1852 DCSQLCLPTSETSRSCMC 1869
Score = 105 bits (259), Expect = 4e-21
Identities = 83/311 (26%), Positives = 137/311 (43%), Gaps = 28/311 (9%)
Query: 945 HLLFAQTGKIERLPLEGNTMRKTEAKAFLHVP-AKVIIGLAFDCV-----DKMVYWTDIT 998
+LL+++ ++ + L K F K +I LAFD ++++DI
Sbjct: 2196 YLLYSERTILKSIHLSDENNLNAPIKPFEDAEHMKNVIALAFDYRYGTKGSNRIFYSDIH 2255
Query: 999 EPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVL 1058
+I + + G TI+ +++GS EG+A ++WT I +D + R
Sbjct: 2256 FGNIQQINDDGTGRRTIV-ENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQS-RLGA 2313
Query: 1059 FETDLV-------NPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLP 1111
FE + V +PR V D + ++WT+WN +P I + + G N I++ D+ P
Sbjct: 2314 FERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRATLSGANVLIIIDQDIRTP 2373
Query: 1112 NGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQ-YPFAVTSYGKNLYFTDW-- 1168
NGL D + ++ + DA ++ E R L+ +PF + YG +++TDW
Sbjct: 2374 NGLAIDHRAEKIYFSDATLDKIERCEYDGSHRHVILKSEPVHPFGLAVYGDYIFWTDWVR 2433
Query: 1169 ----KMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCL 1224
+ N V D+ + + QP + T + P C VNNGGC LCL
Sbjct: 2434 RAVQRANKYVGTDMKLLRVDIPQQPMGIIAVANDTDSCELSP-----CRVNNGGCQDLCL 2488
Query: 1225 ATP-GSRTCRC 1234
TP G C C
Sbjct: 2489 LTPKGHVNCSC 2499
Score = 87.8 bits (214), Expect = 7e-16
Identities = 119/491 (24%), Positives = 189/491 (38%), Gaps = 59/491 (12%)
Query: 792 GFSGDGQA-CQDVDECQP--------SRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPG 842
G+ DG+ C D + P SRC P+ +N G+ C C G
Sbjct: 46 GWRCDGEKDCPDGSDESPDICPQSKVSRCQPNE--HNCLGTELCIHMSKLCNGLHDCFDG 103
Query: 843 EVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRD 902
E C+ + L A Q P L P C + + + S C D D
Sbjct: 104 SDEGPHCREQ----LANCTALGCQHHCVPTLSGPACYCNNSFQLAEDRRS-----CKDFD 154
Query: 903 GREVEGT------RTRPGMTPPCLST-VAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIE 955
V GT T T C+ + P ++ + PP LL A + I
Sbjct: 155 ECTVYGTCSQTCTNTEGSYTCSCVEGYLLQPDNRSCKAKNEPVDRPPV--LLIANSQNIL 212
Query: 956 RLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRA-------SLH 1008
L G + + AK + F+ ++ V W + + + +L
Sbjct: 213 ATYLSGAPVPNITPTS-----AKQTTAMDFNYIEDTVCWVHVGDSASQTILKCAKIPNLK 267
Query: 1009 G--GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNP 1066
G E + I L E +A+D L N ++ D DRI V +G L + +L NP
Sbjct: 268 GFVEERSINISLSLHQVEQMAIDWLTGNFYFVDDIDDRIFVCNKNGLTCVTLLDLELYNP 327
Query: 1067 RGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWV 1126
+GI D G +++TD+ + PK+E MDG NR LV + P+G+ D S + W
Sbjct: 328 KGIALDPAMGKVFFTDYGQ-IPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWA 386
Query: 1127 DAGTNRAECLNPSQPSRRKALEG--LQYPFAVTSYGKNLYFTD------WKMNSVVALDL 1178
DA + E ++ +R ++G +++ + +T + LY T+ + SV+ ++
Sbjct: 387 DAYLDYIEVVDYEGKNRHTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNR 446
Query: 1179 AISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNN----GGCTHLCLA--TPGSRTC 1232
S E + I Q + C + GGC+ +CL + SRTC
Sbjct: 447 FNSTEYQVVTRVDKGGALHIYHQRRQPTVRSHACEPDQFGKPGGCSDICLLGNSHKSRTC 506
Query: 1233 RCPDN-TLGVD 1242
RC +LG D
Sbjct: 507 RCRSGFSLGSD 517
Score = 77.6 bits (188), Expect = 8e-13
Identities = 106/430 (24%), Positives = 165/430 (37%), Gaps = 76/430 (17%)
Query: 675 GTHGCDTNAACRPGPRTQFTCECSIGFRGD--------GRTCYDIDECSEQPSV--CGSH 724
G C N+ P +F C + FR GR C ID C + C S
Sbjct: 3672 GEDDCGDNSDENPEECLKFQCPPNRPFRCKNDRVCLWIGRQCDGIDNCGDNTDEKDCESP 3731
Query: 725 TI----CNNHPGTFRCE---CVEGY---QFSDEGTCVAVVDQRPINY------CETGLHN 768
T C+ F CE C+ F D+ C D++ ++ C T
Sbjct: 3732 TAKPKSCSQDKNEFLCENKKCISANLRCNFFDD--CGDGSDEKSCSHEHKSYDCMTNTTM 3789
Query: 769 CDIPQRAQCIYTGGSSYTCSCLPGFSG--DGQACQDVDEC-QPSRCHPDAFCYNTPGSFT 825
C AQCI S+Y C+C GF D +CQDV+EC + C C NT GS
Sbjct: 3790 CG--DEAQCIQAQSSTY-CTCRRGFQKVPDKNSCQDVNECLRFGTC--SQLCNNTKGSHV 3844
Query: 826 CQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPE---CDAHG 882
C C + C E ++ + + +P P E DA
Sbjct: 3845 CSCAKNFMKTDNMCKAEGSEHQILYIADDNKIRSMYPFNPNSAYEPAFQGDENVRIDAMD 3904
Query: 883 HYAP------TQCH-GSTGYC---------WCVDRDGREVEGTRTRPGMTPPCLSTVAPP 926
Y T H G YC +R+ R+++G G+T +S + P
Sbjct: 3905 IYVKGNKIYWTNWHTGRISYCELPASSAASTASNRNRRQIDG-----GVTHLNISGLKMP 3959
Query: 927 IHQGPAVPTAVIPLPPGTHLLFAQTGK--IERLPLEGNTMRKTEAKAFLHVPAKVIIGLA 984
+G AV ++ + +G+ IE ++G RKT + P +++
Sbjct: 3960 --RGIAVDWV------AGNIYWTDSGRDVIEVAQMKGEN-RKTLISGMIDEPHAIVV--- 4007
Query: 985 FDCVDKMVYWTDI-TEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLD 1043
D + +YW+D P I A++ G T+++ ++ P G+AVD+ ++W D+ L
Sbjct: 4008 -DPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLS 4066
Query: 1044 RIEVAKLDGT 1053
I +L+GT
Sbjct: 4067 VIGSIRLNGT 4076
Score = 55.8 bits (132), Expect = 3e-06
Identities = 28/70 (40%), Positives = 39/70 (55%), Gaps = 7/70 (10%)
Query: 693 FTCECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEG-- 748
+ C C GFR DG+TC DIDECS + C N G+++C C+EGY+ +
Sbjct: 2960 YKCRCRPGFRLKDDGKTCIDIDECS---TTYPCSQKCINTLGSYKCLCIEGYKLKPDNPT 3016
Query: 749 TCVAVVDQRP 758
+C AV D+ P
Sbjct: 3017 SCKAVTDEEP 3026
Score = 41.8 bits (96), Expect = 0.047
Identities = 26/71 (36%), Positives = 35/71 (48%), Gaps = 9/71 (12%)
Query: 695 CECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFS-DEGTCV 751
C C+ F+ D R+C D DEC+ C C N G++ C CVEGY D +C
Sbjct: 135 CYCNNSFQLAEDRRSCKDFDECTVY-GTCSQ--TCTNTEGSYTCSCVEGYLLQPDNRSCK 191
Query: 752 A---VVDQRPI 759
A VD+ P+
Sbjct: 192 AKNEPVDRPPV 202
Score = 40.2 bits (92), Expect = 0.14
Identities = 44/186 (23%), Positives = 63/186 (33%), Gaps = 48/186 (25%)
Query: 665 PDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSH 724
PD +PC GC PG + C + DG+TC + C+ VC +
Sbjct: 3284 PDVPNHPCKTNNAGCSNLCLLSPGGGHKCACPTNFYLGSDGKTC--VSNCTASQFVCKND 3341
Query: 725 TICNNHPGTFRCECVEGY-QFSDEGTCVAVVDQRPINY-CETGL---------------- 766
P ++C+ + SDE RP + C TG+
Sbjct: 3342 KCI---PFWWKCDTEDDCGDRSDEPEDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQD 3398
Query: 767 ----HNCDI----PQRAQCIYTGGSSYTCSCLPGF--------SGDGQACQDVDECQPSR 810
NCDI P + +C T C+PG GDG +D +C
Sbjct: 3399 NSDEANCDIHVCLPSQFKCTNTN------RCIPGIFRCNGQDNCGDG---EDEKDCPEVT 3449
Query: 811 CHPDAF 816
C P+ F
Sbjct: 3450 CAPNQF 3455
Score = 39.9 bits (91), Expect = 0.18
Identities = 40/159 (25%), Positives = 55/159 (34%), Gaps = 36/159 (22%)
Query: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCEC 738
C C P TC C GF G C +Q VC ++ C+N+ C
Sbjct: 4239 CQNGGLCTASPSGMPTCRCPTGFTG--------SRCDQQ--VCTNY--CHNNGS---CTV 4283
Query: 739 VEGYQFSDEGTCVAVVD----QRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFS 794
+G Q + + D Q+ NYCE C + C C P F
Sbjct: 4284 NQGNQPNCRCPPTFIGDRCQYQQCFNYCE---------NNGVCQMSRDGVKQCRCPPQF- 4333
Query: 795 GDGQACQD--VDECQPSRCHPDAFCYNTPGSFTCQCKPG 831
+G CQD CQ +C+ + G +C C G
Sbjct: 4334 -EGAQCQDNKCSRCQEGKCNIN----RQSGDVSCICPDG 4367
Score = 38.7 bits (88), Expect = 0.41
Identities = 22/79 (27%), Positives = 37/79 (45%), Gaps = 1/79 (1%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
+GLA D + +YW +I R +L G + I+ + A+ +G ++W D
Sbjct: 1743 VGLAIDYPESKLYWISSGNGTINRCNLDGSDLEVIVAVKSQLSKATALAIMGDKLWWADQ 1802
Query: 1041 NLDRIEVA-KLDGTQRRVL 1058
+R+ K DGT+ VL
Sbjct: 1803 ASERMGTCNKKDGTEVTVL 1821
Score = 37.1 bits (84), Expect = 1.2
Identities = 14/25 (56%), Positives = 16/25 (64%), Gaps = 1/25 (4%)
Query: 1212 CSVNNGGCTHLCLATPGSR-TCRCP 1235
CS+NNGGC+H C PG C CP
Sbjct: 1183 CSLNNGGCSHNCTVAPGEGIVCSCP 1207
Score = 36.7 bits (83), Expect = 1.6
Identities = 22/95 (23%), Positives = 35/95 (36%), Gaps = 4/95 (4%)
Query: 662 EGSPDA-LQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
+GS + L + C + GC N PG +C + D +TC C++
Sbjct: 1172 DGSDEGELCDQCSLNNGGCSHNCTVAPGEGIVCSCPLGMELGADNKTCQIQSYCAKHLK- 1230
Query: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVD 755
C C +C C EG+ +G +D
Sbjct: 1231 CSQK--CEQDKYNVKCSCYEGWMLEPDGESCRSLD 1263
>emb|CAA57882.1| (X82509) low-density lipoprotein receptor-related protein/alpha-2
macroglobulin receptor [Oryctolagus cuniculus]
Length = 309
Score = 159 bits (397), Expect = 2e-37
Identities = 95/269 (35%), Positives = 145/269 (53%), Gaps = 14/269 (5%)
Query: 983 LAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNL 1042
L F +Y+ D T IGR + G E TI++ + + EG+AVD +G N++WTD
Sbjct: 32 LDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGP 91
Query: 1043 DR-IEVAKLD--GTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRD-----NPKIETSY 1094
+ I VA+L+ R+ L E + +PR IV D + G +YWTDW D ++E ++
Sbjct: 92 KKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAW 151
Query: 1095 MDGTNRRILVQDDLGL-PNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG--LQ 1151
MDG++R I V L PNGL D + +L WVDA +R E + + R+ EG L
Sbjct: 152 MDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELN 211
Query: 1152 YPFAVTSYGKNLYFTDWKMNSVVALDLAI--SKETDAFQPHKQTRLYGITTALSQCPQ-G 1208
+ F + +G L++T+++ SV + + + T ++ ++ I +Q Q G
Sbjct: 212 HAFGLCHHGNYLFWTEYRSGSVYRXEXGVGXAPPTVTLLRSERPPIFEIRXYDAQQQQVG 271
Query: 1209 HNYCSVNNGGCTHLCLATPGSRTCRCPDN 1237
N C VNNGGC+ LCLATPGSR C C ++
Sbjct: 272 TNKCRVNNGGCSSLCLATPGSRQCACAED 300
>sp|Q99088|LDL2_XENLA LOW-DENSITY LIPOPROTEIN RECEPTOR 2 PRECURSOR (LDL RECEPTOR 2)
gb|AAA49898.1| (M62978) low density lipoprotein receptor-2 [Xenopus laevis]
Length = 892
Score = 157 bits (394), Expect = 5e-37
Identities = 96/315 (30%), Positives = 158/315 (49%), Gaps = 24/315 (7%)
Query: 945 HLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGR 1004
+L F ++ ++ L+ ++E +F+ K ++ L + +YW+D+T+ I
Sbjct: 398 YLFFTNRHEVRKMTLD-----RSEYTSFIP-RLKNVVALDMEIASNKIYWSDLTQRKIYS 451
Query: 1005 ASLHGGEPT----TIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFE 1060
AS+ + T T+I + +P+GIAVD + NI+WTDS I VA +G++R+ LF
Sbjct: 452 ASMDKADNTSHHETVISNQIQAPDGIAVDWIHGNIYWTDSKFSTISVANTEGSKRKTLFT 511
Query: 1061 TDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFS 1120
DL PR IV D +G +YWTDW KIE ++G +R LV D++ PNG+ D S
Sbjct: 512 DDLAKPRDIVVDPSQGFMYWTDWGLP-AKIEKGGLNGVDRYPLVTDNIEWPNGITLDLIS 570
Query: 1121 SQLCWVDAGTNRAECLNPSQPSRRKALEG---LQYPFAVTSYGKNLYFTDWKMNSVVALD 1177
+L WVD+ + C++ + +RR L L +PF +T + +++TD + ++ +
Sbjct: 571 QRLYWVDSKLHSLSCIDITGENRRTVLSDETHLAHPFGLTIFEDLVFWTDIENEAIFSAK 630
Query: 1178 LAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCS---VNNGGCTHLCLATPGSR---- 1230
+ H + + + P+ N+C + NGGC +LCL P
Sbjct: 631 RLTGENIMKVAEHLLSPEDIVLYHNLRQPKAENWCESHHLGNGGCGYLCLPAPHVNARSP 690
Query: 1231 --TCRCPDNT-LGVD 1242
TC CPD LG D
Sbjct: 691 KFTCACPDGMHLGTD 705
Score = 51.5 bits (121), Expect = 5e-05
Identities = 46/162 (28%), Positives = 67/162 (40%), Gaps = 22/162 (13%)
Query: 685 CRPGPRTQFTCECSIGFRGDGRTC---YDIDECSEQPSVCGSHTICNNHPGTFRC---EC 738
CRP QF C G R C YD + S++ C + T C P F+C EC
Sbjct: 234 CRPD---QFQCNDGTCIHGS-RQCDREYDCKDLSDEEG-CVNVTKCQG-PDVFKCRSGEC 287
Query: 739 VEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS---SYTCSCLPGFS- 794
+ + + PI C G + C + C + Y C C G+
Sbjct: 288 ITMDKVCHKKRDCRDWTDEPIKEC--GENEC-LRNNGGCSHICNDLKIGYECLCNEGYRL 344
Query: 795 GDGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGD 835
D + C+D++EC+ P+ C C N G + C+C+ GYQ D
Sbjct: 345 VDQKRCEDINECENPNTC--TQICINLHGGYKCECREGYQMD 384
Score = 47.6 bits (111), Expect = 8e-04
Identities = 29/76 (38%), Positives = 40/76 (52%), Gaps = 7/76 (9%)
Query: 669 QNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFR-GDGRTCYDIDECSEQPSVCGSHTIC 727
+N C GC + C + + C C+ G+R D + C DI+EC E P+ C IC
Sbjct: 313 ENECLRNNGGC--SHICND-LKIGYECLCNEGYRLVDQKRCEDINEC-ENPNTCTQ--IC 366
Query: 728 NNHPGTFRCECVEGYQ 743
N G ++CEC EGYQ
Sbjct: 367 INLHGGYKCECREGYQ 382
>pir||QRXLL2 LDL receptor 2 precursor - African clawed frog
Length = 909
Score = 157 bits (392), Expect = 9e-37
Identities = 97/320 (30%), Positives = 160/320 (49%), Gaps = 34/320 (10%)
Query: 945 HLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGR 1004
+L F ++ ++ L+ ++E +F+ K ++ L + +YW+D+T+ I
Sbjct: 398 YLFFTNRHEVRKMTLD-----RSEYTSFIP-RLKNVVALDMEIASNKIYWSDLTQRKIYS 451
Query: 1005 ASLHGGEPT----TIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFE 1060
AS+ + T T+I + +P+GIAVD + NI+WTDS I VA +G++R+ LF
Sbjct: 452 ASMDKADNTSHHETVISNQIQAPDGIAVDWIHGNIYWTDSKFSTISVANTEGSKRKTLFT 511
Query: 1061 TDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFS 1120
DL PR IV D +G +YWTDW KIE ++G +R LV D++ PNG+ D S
Sbjct: 512 DDLAKPRDIVVDPSQGFMYWTDWGLP-AKIEKGGLNGVDRYPLVTDNIEWPNGITLDLIS 570
Query: 1121 SQLCWVDAGTNRAECLNPSQPSRRKALEG---LQYPFAVTSYGKNLYFTDWKMNSVVAL- 1176
+L WVD+ + C++ + +RR L L +PF +T + +++TD + ++ +
Sbjct: 571 QRLYWVDSKLHSLSCIDITGENRRTVLSDETHLAHPFGLTIFEDLVFWTDIENEAIFSAK 630
Query: 1177 ----DLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCS---VNNGGCTHLCLATPGS 1229
+ + D P + + + P+ N+C + NGGC +LCL P
Sbjct: 631 RLTGENIMKVAEDLLSPEDIVLYHNL-----RQPKAENWCESHHLGNGGCGYLCLPAPHV 685
Query: 1230 R------TCRCPDNT-LGVD 1242
TC CPD LG D
Sbjct: 686 NARSPKFTCACPDGMHLGTD 705
Score = 55.0 bits (130), Expect = 5e-06
Identities = 47/162 (29%), Positives = 68/162 (41%), Gaps = 22/162 (13%)
Query: 685 CRPGPRTQFTCECSIGFRGDGRTC---YDIDECSEQPSVCGSHTICNNHPGTFRC---EC 738
CRP QF C G R C YD + S++ C + T C P F+C EC
Sbjct: 234 CRPD---QFQCNDGTCIHGS-RQCDREYDCKDLSDEEG-CVNVTKCEG-PDVFKCRSGEC 287
Query: 739 VEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS---SYTCSCLPGFS- 794
+ + D+ PI C G + C + C + Y C C G+
Sbjct: 288 ITMDKVCDKKRDCRDWTDEPIKEC--GENEC-LRNNGGCSHICNDLKIGYECLCNEGYRL 344
Query: 795 GDGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGD 835
D + C+D++EC+ P+ C C N G + C+C+ GYQ D
Sbjct: 345 VDQKRCEDINECENPNTC--SQICINLDGGYKCECREGYQMD 384
>gb|AAC14024.1| (AF053364) epidermal growth factor precursor [Sus scrofa]
Length = 574
Score = 153 bits (382), Expect = 1e-35
Identities = 89/299 (29%), Positives = 144/299 (47%), Gaps = 8/299 (2%)
Query: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
P LLFA + I + +G T+ + L+ +++ L D V+ VY+
Sbjct: 93 PPPFLLFANSQDIRHMHFDG-----TDYETLLNQQIGMVLALDHDPVENKVYFAHTALKW 147
Query: 1002 IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
I RA++ G + + + + PEG+A+D +GR +WTD IE + L+G R ++ +
Sbjct: 148 IERANMDGSQRERLFEEAVDVPEGLAIDWIGRKFYWTDRGRSLIEGSDLNGKYREIIIKE 207
Query: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSS 1121
D+ PRGI V L+WTD NP+IE+S + G RR++ DL P+G+ D +
Sbjct: 208 DISQPRGIAVHPVAKRLFWTDMG-TNPRIESSSLQGIGRRVIASSDLVWPSGITIDYLTD 266
Query: 1122 QLCWVDAGTNRAECLNPSQPSR-RKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAI 1180
+L W DA + E N R R A + +PFAV + +++F+DW M SV+ ++
Sbjct: 267 KLYWCDAKQSVIEMSNLDGSRRQRLAQNDVGHPFAVAVFEDHVWFSDWTMPSVIRVNKRT 326
Query: 1181 SKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTL 1239
K + + + G N C NGGC H+C + G+ C C + L
Sbjct: 327 GKNRVRLR-GSMLKPSSLVVVHPLAKPGTNPCLHQNGGCEHICKESFGTAQCLCHEGFL 384
Score = 79.2 bits (192), Expect = 3e-13
Identities = 50/129 (38%), Positives = 62/129 (47%), Gaps = 12/129 (9%)
Query: 675 GTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVC-GSHTICNNHPGT 733
G GC A C TC+C GF GDG C DIDEC SVC + + C N G
Sbjct: 448 GAAGCSAQARCVTEGEDA-TCQCLKGFAGDGNLCSDIDECELGTSVCPPTSSECINTEGG 506
Query: 734 FRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGF 793
C C EGYQ G + +D I+ C+ G+H C + A C T G +YTC+C
Sbjct: 507 HVCRCSEGYQ----GDGIHCLD---IDECQLGVHTCG--ENATCTNTEG-NYTCTCAGRP 556
Query: 794 SGDGQACQD 802
S G+ C D
Sbjct: 557 SEPGRICPD 565
Score = 75.7 bits (183), Expect = 3e-12
Identities = 34/70 (48%), Positives = 43/70 (60%), Gaps = 4/70 (5%)
Query: 774 RAQCIYTGGSSYTCSCLPGFSGDGQACQDVDECQ--PSRCHP-DAFCYNTPGSFTCQCKP 830
+A+C+ T G TC CL GF+GDG C D+DEC+ S C P + C NT G C+C
Sbjct: 455 QARCV-TEGEDATCQCLKGFAGDGNLCSDIDECELGTSVCPPTSSECINTEGGHVCRCSE 513
Query: 831 GYQGDGFRCV 840
GYQGDG C+
Sbjct: 514 GYQGDGIHCL 523
Score = 71.0 bits (171), Expect = 8e-11
Identities = 38/110 (34%), Positives = 55/110 (49%), Gaps = 11/110 (10%)
Query: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT 780
C + C C+C++G F+ +G + +D+ CE G C P ++CI T
Sbjct: 452 CSAQARCVTEGEDATCQCLKG--FAGDGNLCSDIDE-----CELGTSVCP-PTSSECINT 503
Query: 781 GGSSYTCSCLPGFSGDGQACQDVDECQ--PSRCHPDAFCYNTPGSFTCQC 828
G + C C G+ GDG C D+DECQ C +A C NT G++TC C
Sbjct: 504 EGG-HVCRCSEGYQGDGIHCLDIDECQLGVHTCGENATCTNTEGNYTCTC 552
Score = 56.2 bits (133), Expect = 2e-06
Identities = 24/67 (35%), Positives = 31/67 (45%)
Query: 672 CYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHP 731
C +GT C ++ C CS G++GDG C DIDEC CG + C N
Sbjct: 486 CELGTSVCPPTSSECINTEGGHVCRCSEGYQGDGIHCLDIDECQLGVHTCGENATCTNTE 545
Query: 732 GTFRCEC 738
G + C C
Sbjct: 546 GNYTCTC 552
>ref|NP_004516.1| low density lipoprotein-related protein 2; megalin [Homo sapiens]
sp|P98164|LRP2_HUMAN LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2 PRECURSOR
(MEGALIN) (GLYCOPROTEIN 330)
gb|AAB41649.1| (U33837) gp330 precursor [Homo sapiens]
Length = 4655
Score = 152 bits (381), Expect = 2e-35
Identities = 154/604 (25%), Positives = 230/604 (37%), Gaps = 128/604 (21%)
Query: 676 THGCDTNAAC--RPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGT 733
T G D N C R +FTC + C + C H C ++
Sbjct: 2979 TDGYDENQNCTRRTCSENEFTCGYGL--------------CIPKIFRCDRHNDCGDYSDE 3024
Query: 734 FRC---ECVEGYQFSDEGTCVA---VVDQRPINYCETG----LHNCDIPQ---------- 773
C C + G C++ V D+ N C G +H C P+
Sbjct: 3025 RGCLYQTCQQNQFTCQNGRCISKTFVCDED--NDCGDGSDELMHLCHTPEPTCPPHEFKC 3082
Query: 774 -RAQCIYTGG-SSYTCSCLPGFSGDGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKP 830
+CI ++ CL + D + C ++EC PS D C +T SF C C+P
Sbjct: 3083 DNGRCIEMMKLCNHLDDCLD--NSDEKGC-GINECHDPSISGCDHNCTDTLTSFYCSCRP 3139
Query: 831 GYQ--GDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQ 888
GY+ D CV + EC +
Sbjct: 3140 GYKLMSDKRTCVD---------------------------------IDECTEMPFVCSQK 3166
Query: 889 CHGSTG--YCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHL 946
C G C C RE +G R S + P +L
Sbjct: 3167 CENVIGSYICKCAPGYLREPDGKTCRQN------SNIEP-------------------YL 3201
Query: 947 LFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRAS 1006
+F+ + L ++G + + ++ L FD V+K +YW D I R
Sbjct: 3202 IFSNRYYLRNLTIDGYFY------SLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMF 3255
Query: 1007 LHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDL--- 1063
L+ TII L + E +AVD + R ++W D+ LD + V+ L+G RR+L + +
Sbjct: 3256 LNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDAN 3315
Query: 1064 -----VNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDA 1118
NPRG+ G LYW DW I MDGTN+ +++ L PNG+ D
Sbjct: 3316 NTFCFDNPRGLALHPQYGYLYWADWGH-RAYIGRVGMDGTNKSVIISTKLEWPNGITIDY 3374
Query: 1119 FSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNLYFTDWKMNSVVALD 1177
+ L W DA E + R +G L +PFA+T + +Y+TDW +V +
Sbjct: 3375 TNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGN 3434
Query: 1178 L--AISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSR--TCR 1233
+++T H+ ++ + Q P N C NNGGC+HLCL PG + TC
Sbjct: 3435 KYDGSNRQTLVNTTHRPFDIH-VYHPYRQ-PIVSNPCGTNNGGCSHLCLIKPGGKGFTCE 3492
Query: 1234 CPDN 1237
CPD+
Sbjct: 3493 CPDD 3496
Score = 140 bits (349), Expect = 1e-31
Identities = 149/602 (24%), Positives = 238/602 (38%), Gaps = 84/602 (13%)
Query: 678 GCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRC- 736
G D N C+ Q TC+ + + + +D C + IC ++ F C
Sbjct: 136 GADEND-CQYPTCEQLTCDNGACYNTSQKCDWKVD-CRDSSDEINCTEICLHNE--FSCG 191
Query: 737 --ECV-EGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCS----C 789
EC+ Y + C D+ NY G + P +CIY ++ C C
Sbjct: 192 NGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPS-GRCIY---QNWVCDGEDDC 247
Query: 790 LPGFSGDGQACQ----DVDECQPSR--CHPDAFCYNT----PGSFTCQCKPGYQGD---- 835
+GD C+ DV +C P C C + G C PG + +
Sbjct: 248 KD--NGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDC---PGREDENNTS 302
Query: 836 -GFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTG 894
G C CQ++ H GA PPG + D+ C G
Sbjct: 303 TGKYCSMTLCSALNCQYQC-HETPYGGACF----CPPGYIINHNDSRTCVEFDDCQ-IWG 356
Query: 895 YC--WCVDRDGREV----EGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLF 948
C C R GR + EG G + A I G LL
Sbjct: 357 ICDQKCESRPGRHLCHCEEGYILERGQY----------CKANDSFGEASIIFSNGRDLLI 406
Query: 949 AQT-GKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASL 1007
G+ R+ +E V +G+AF + V+WTD + + +
Sbjct: 407 GDIHGRSFRILVESQNRG-------------VAVGVAFHYHLQRVFWTDTVQNKVFSVDI 453
Query: 1008 HGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPR 1067
+G ++ + +PE +AVD + I+ ++ ++RI++ LDG+ R L +L +PR
Sbjct: 454 NGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPR 513
Query: 1068 GIVTDSVRGNLYWTDWN--RDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCW 1125
GI D G L+++DW PK+E ++MDG+NR+ LV+ LG P G+ D S ++ W
Sbjct: 514 GIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYW 573
Query: 1126 VDAGTNRAECLNPSQPSRRKALEG---LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISK 1182
VD+ + E + R+ + G + +PF V+ + ++FTDW +V+ +
Sbjct: 574 VDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTET 633
Query: 1183 ETDAFQPHKQTRLYGITTALS-QCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGV 1241
+ R YG+T S + P N C NNGGC +C+ + R ++ LG
Sbjct: 634 NPQVYY-QASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSH-----RTDNDGLGF 687
Query: 1242 DC 1243
C
Sbjct: 688 RC 689
Score = 131 bits (326), Expect = 5e-29
Identities = 76/264 (28%), Positives = 137/264 (51%), Gaps = 15/264 (5%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
+G+ FD D ++++D+++ I + + G + + + E +A D + +N++WTDS
Sbjct: 744 VGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDS 803
Query: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
+ I V +L RR + + L NPR +V G L++TDW R KI ++ DG++
Sbjct: 804 HYKSISVMRLADKTRRTVVQY-LNNPRSVVVHPFAGYLFFTDWFRP-AKIMRAWSDGSHL 861
Query: 1101 RILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKA--LEGLQYPFAVTS 1158
++ LG PNGL D +S+L WVDA ++ E RR+ +E + +PF +
Sbjct: 862 LPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAI 921
Query: 1159 YGKNLYFTDWKMNSVVAL------DLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC 1212
+G++L+FTDW++ +++ + ++ + + A+ H ++ I T + C N
Sbjct: 922 FGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNAC----NQP 977
Query: 1213 SVNNGGCTHLCLATPG-SRTCRCP 1235
+ NG C+H C P R C CP
Sbjct: 978 THPNGDCSHFCFPVPNFQRVCGCP 1001
Score = 130 bits (323), Expect = 1e-28
Identities = 78/264 (29%), Positives = 137/264 (51%), Gaps = 11/264 (4%)
Query: 980 IIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTD 1039
I+ + FD + ++W+D T+ A +G + + + E IA+D +GRN++WTD
Sbjct: 1468 IVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTD 1527
Query: 1040 SNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGN--LYWTDWNRDNPKIETSYMDG 1097
L+ IEV+K+DG+ R VL +L NPRG+ D L+W+DW +P+IE + MDG
Sbjct: 1528 YALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGH-HPRIERASMDG 1586
Query: 1098 TNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---LQYPF 1154
+ R ++VQD + P GL D + L ++D+ + + + + RR+ + +++P+
Sbjct: 1587 SMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPY 1646
Query: 1155 AVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSV 1214
A+T + ++Y+TD V+ + + Q L + S+ P N C+
Sbjct: 1647 ALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAF 1706
Query: 1215 NNGGCTHLCLAT---PGSRTCRCP 1235
+ C+HLCL + P +C CP
Sbjct: 1707 SR--CSHLCLLSSQGPHFYSCVCP 1728
Score = 124 bits (309), Expect = 5e-27
Identities = 80/263 (30%), Positives = 125/263 (47%), Gaps = 8/263 (3%)
Query: 978 KVIIGLAFDCVDKMVYWTDITEPSIGR---ASLHGGEPT-TIIRQDLGSPEGIAVDHLGR 1033
+ ++ L +D V +Y+T +G+ A+L G T T+I +G+ +GIA D + R
Sbjct: 2419 RTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITR 2478
Query: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
I+++D I DG+ R V+ PR IV D +G LYW DW+ + KIE +
Sbjct: 2479 RIYYSDYLNQMINSMAEDGSNRTVIARVP--KPRAIVLDPCQGYLYWADWDT-HAKIERA 2535
Query: 1094 YMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYP 1153
+ G R +V L +P+GL D L WVDA R E + R + +
Sbjct: 2536 TLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHA 2595
Query: 1154 FAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTAL-SQCPQGHNYC 1212
F +T YG+ +Y+TD + + A + ++ GI T + +Q Q +N C
Sbjct: 2596 FGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPC 2655
Query: 1213 SVNNGGCTHLCLATPGSRTCRCP 1235
NGGC+H+C P C+CP
Sbjct: 2656 EQFNGGCSHICAPGPNGAECQCP 2678
Score = 124 bits (309), Expect = 5e-27
Identities = 77/224 (34%), Positives = 113/224 (50%), Gaps = 18/224 (8%)
Query: 1023 PEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTD 1082
P+GIAVD +GR+I+W+D RIEVAKLDG R+ L TDL P I + G ++WTD
Sbjct: 4144 PDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTD 4203
Query: 1083 WNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSS-QLCWVDAGTNRAECLNPSQP 1141
W ++ PKIE+++M+G +R ILV +DLG P GL D ++ ++ W D + E +
Sbjct: 4204 WGKE-PKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGT 4262
Query: 1142 SRRKALEGLQYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPH-KQTR 1194
RR + P+++ + LY+ WK N ++T P Q R
Sbjct: 4263 DRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNK---FGQGKKEKTLVVNPWLTQVR 4319
Query: 1195 LYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNT 1238
++ P N C C+HLCL PG +C CP +
Sbjct: 4320 IFHQLRYNKSVP---NLCKQI---CSHLCLLRPGGYSCACPQGS 4357
Score = 110 bits (272), Expect = 1e-22
Identities = 82/281 (29%), Positives = 127/281 (45%), Gaps = 29/281 (10%)
Query: 986 DCVDKMVYWTDIT-----EPSIGRASLHGGEPTTIIRQDLGSP--EGIAVDHLGRNIFWT 1038
D +YW D + + +I R G I+ +G GIAVD + N+++T
Sbjct: 2103 DVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFT 2162
Query: 1039 DSNLDR--IEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMD 1096
++ + IEV +++ T RRVL + + PR IV D L+W D+ + PKIE S++D
Sbjct: 2163 NAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQ-RPKIERSFLD 2221
Query: 1097 GTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQY--PF 1154
TNR +LV + + P GL D + WVD + + + + G +Y P+
Sbjct: 2222 CTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPY 2281
Query: 1155 AVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTR-----LYGIT------TALS 1203
+T + ++ + D + + SKE + +P R L +T S
Sbjct: 2282 GITVFENSIIWVDRNLKKI----FQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRS 2337
Query: 1204 QCPQGHNYCSVNNGGCTHLCLATPGSRT--CRCPDNTLGVD 1242
+N C NNGGC+HLC A PG T C C TL D
Sbjct: 2338 PAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSD 2378
Score = 83.9 bits (204), Expect = 1e-14
Identities = 72/277 (25%), Positives = 111/277 (39%), Gaps = 22/277 (7%)
Query: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPE-GIAVDHLGRNIFWTD 1039
+ + FD ++ +YW + I R G T + P +A+D + RN++ T+
Sbjct: 1781 LDVEFDDAEQYIYWVE-NPGEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTN 1839
Query: 1040 SNLDRIEVAKLDGT--QRRVLFETD-----LVNPRGIVTDSVRGNLYWTDWNRDN---PK 1089
IEV L G R+ L D + P GI D RG LYW+D D+ K
Sbjct: 1840 PRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAK 1899
Query: 1090 IETSYMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG 1149
I ++ MDGT+ + L +L + D +L W G E N R +
Sbjct: 1900 IASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQ 1959
Query: 1150 LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT-ALSQCPQG 1208
L +P+ + + LY+TD + + +D A + + L G+ +
Sbjct: 1960 LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDN-VPNLRGLQVYHRRNAAES 2018
Query: 1209 HNYCSVNNGGCTHLCLATPGSR-TCRC-------PDN 1237
N CS N C +CL PG +C C PDN
Sbjct: 2019 SNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDN 2055
Score = 81.9 bits (199), Expect = 4e-14
Identities = 109/458 (23%), Positives = 167/458 (35%), Gaps = 95/458 (20%)
Query: 680 DTNAACR---PGPRTQFTCECSIGFR-GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFR 735
+T CR P P T++ +C G C D D+C + G CN
Sbjct: 3915 ETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELG----CNK------ 3964
Query: 736 CECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSG 795
E TC N CE C + CSC GF
Sbjct: 3965 ---------GKERTCAE-------NICEQN-----------CTQLNEGGFICSCTAGFET 3997
Query: 796 ---DGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHE 852
D +C D++EC+ P C NT GS+ C C G+ R PG+ RC
Sbjct: 3998 NVFDRTSCLDINECEQFGTCPQ-HCRNTKGSYECVCADGFTSMSDR--PGK----RC--- 4047
Query: 853 REHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDG--------- 903
AA + P +P + + + + Y VD D
Sbjct: 4048 ------AAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEE-YIQAVDYDWDPKDIGLSV 4100
Query: 904 --REVEGTRTRPGMTP----PCLSTVAPPIHQGPAVPTAVIPLPPG-------THLLFA- 949
V G +R G P + + Q + + P G H+ ++
Sbjct: 4101 VYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSD 4160
Query: 950 -QTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDI-TEPSIGRASL 1007
+ +IE L+G RK L PA + + +++WTD EP I A +
Sbjct: 4161 VKNKRIEVAKLDGR-YRKWLISTDLDQPAAIAVNPKLG----LMFWTDWGKEPKIESAWM 4215
Query: 1008 HGGEPTTIIRQDLGSPEGIAVDHLGRN-IFWTDSNLDRIEVAKLDGTQRRVLFETDLVNP 1066
+G + ++ +DLG P G+++D+L + I+W+D D IE K DGT RRV+ + + +NP
Sbjct: 4216 NGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAK-EAMNP 4274
Query: 1067 RGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 1104
+ D LYW + + + G + LV
Sbjct: 4275 YSL--DIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLV 4310
Score = 50.4 bits (118), Expect = 1e-04
Identities = 56/197 (28%), Positives = 75/197 (37%), Gaps = 38/197 (19%)
Query: 662 EGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVC 721
+G PD L +G D + AC P TC S F D C ++ + C
Sbjct: 1251 DGHPDCL--------YGSDEHNACVPK-----TCPSSY-FHCDNGNCIHRAWLCDRDNDC 1296
Query: 722 GSHTI---CNNHPGTFRCECVEGYQFSDEGTCVAV-VDQRPINYCETGLHNCDIPQRAQC 777
G + C P FRC + +Q CV + V I C G + C
Sbjct: 1297 GDMSDEKDCPTQP--FRCPSWQ-WQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSC 1353
Query: 778 I-YTGGSSYTCS---------CLPGF--SGDGQACQDVDECQP-SRCHPDAFCYNTPGSF 824
+ GG ++ C C GF + D + C+D+DEC C CYN GSF
Sbjct: 1354 SDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSC--SQHCYNMRGSF 1411
Query: 825 TCQCKPGY--QGDGFRC 839
C C GY + DG C
Sbjct: 1412 RCSCDTGYMLESDGRTC 1428
Score = 40.6 bits (93), Expect = 0.11
Identities = 54/205 (26%), Positives = 81/205 (39%), Gaps = 51/205 (24%)
Query: 668 LQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRG---DGRTCYDIDECSEQPSVCGSH 724
+ NPC GC +PG + FTCEC FR G T Y + CS +C ++
Sbjct: 3465 VSNPCGTNNGGCSHLCLIKPGGKG-FTCECPDDFRTLQLSGST-YCMPMCSSTQFLCANN 3522
Query: 725 TICNNHPGTFRC----ECVEGYQFSDEGTCVAVVDQRPINYCETGLH-----NCDIPQRA 775
C P ++C +C +G SDE +A+ QR +C G NC PQ
Sbjct: 3523 EKC--IPIWWKCDGQKDCSDG---SDE---LALCPQR---FCRLGQFQCSDGNCTSPQTL 3571
Query: 776 QCIYTGGSSYTCSCLPGFSGDGQACQDVD------ECQPSRCHPDAFCYNT--------- 820
+ +C G D C++ +C RC P+++ +T
Sbjct: 3572 CNAHQ-------NCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSD 3624
Query: 821 PGSFTC---QCKPG-YQGDGFRCVP 841
S C C+PG ++ RC+P
Sbjct: 3625 EDSSHCASRTCRPGQFRCANGRCIP 3649
Score = 40.2 bits (92), Expect = 0.14
Identities = 78/310 (25%), Positives = 105/310 (33%), Gaps = 90/310 (29%)
Query: 670 NPCYIGTH-GCDTNAACRPGPRTQFTCECSIGFR--GDGRTCYDIDECSEQPS-VCGSHT 725
N C TH D + C P P Q C C G R + TC + D +E P+ CG +
Sbjct: 972 NACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTC-EGDPTNEPPTEQCGLFS 1030
Query: 726 I-CNNH---PGTFRCECVEG-YQFSDE-------------------GTCVAV---VDQRP 758
C N P + C+ V+ + SDE G C+ D+R
Sbjct: 1031 FPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKR- 1089
Query: 759 INYCETGL--HNCDIPQRAQCIYTGGSSYTC---SCLP-----------GFSGDGQACQD 802
N C G HNC A C+ T YTC C+ G D + C
Sbjct: 1090 -NDCVDGSDEHNCPTHAPASCLDT---QYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNS 1145
Query: 803 VDECQPSR--------------CHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEV---E 845
+ CQPS+ C D C + GS C F+C G+
Sbjct: 1146 TETCQPSQFNCPNHRCIDLSFVCDGDKDCVD--GSDEVGCVLNCTASQFKCASGDKCIGV 1203
Query: 846 KTRCQHEREHILGAAGATDPQRP-----------IPPGLFVP---ECDAHGHYAPTQCHG 891
RC + + A P RP G+ +P ECD H P +G
Sbjct: 1204 TNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGH----PDCLYG 1259
Query: 892 STGYCWCVDR 901
S + CV +
Sbjct: 1260 SDEHNACVPK 1269
Score = 39.5 bits (90), Expect = 0.24
Identities = 30/113 (26%), Positives = 48/113 (41%), Gaps = 3/113 (2%)
Query: 933 VPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMV 992
+P ++ P +L +A G +R +E + + T + GLA D D V
Sbjct: 2191 MPRHIVVDPKNRYLFWADYG--QRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYV 2248
Query: 993 YWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRI 1045
YW D + I R ++ GE + +IR P + +I W D NL +I
Sbjct: 2249 YWVDDSLDIIARIRIN-GENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKI 2300
Score = 36.7 bits (83), Expect = 1.6
Identities = 17/46 (36%), Positives = 20/46 (42%), Gaps = 8/46 (17%)
Query: 1198 ITTALSQCPQGH--------NYCSVNNGGCTHLCLATPGSRTCRCP 1235
+ + CP G N CS NGGCTH C+ P C CP
Sbjct: 1331 VCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCP 1376
Score = 36.7 bits (83), Expect = 1.6
Identities = 48/190 (25%), Positives = 69/190 (36%), Gaps = 36/190 (18%)
Query: 672 CYIGTHGCDTNAACRPGPRT-----------QFTCECSIGFRGDGRTCYDIDECS----E 716
C + CD + C+ G QFTC + C D+C E
Sbjct: 195 CIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNW-VCDGEDDCKDNGDE 253
Query: 717 QPSVCGSHTICNNHPGTFRC----ECVEGYQFSDEGT-CVAVVDQRPIN---YCETGLHN 768
G H + P + C C+ Y+ D C D+ + YC L +
Sbjct: 254 DGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCS 313
Query: 769 CDIPQRAQCIYT--GGSSYTCSCLPGF---SGDGQACQDVDECQP-SRCHPDAFCYNTPG 822
+ + QC T GG+ C C PG+ D + C + D+CQ C D C + PG
Sbjct: 314 A-LNCQYQCHETPYGGA---CFCPPGYIINHNDSRTCVEFDDCQIWGIC--DQKCESRPG 367
Query: 823 SFTCQCKPGY 832
C C+ GY
Sbjct: 368 RHLCHCEEGY 377
>emb|CAA65729.1| (X97001) LR8B [Gallus gallus]
Length = 917
Score = 152 bits (380), Expect = 2e-35
Identities = 90/288 (31%), Positives = 147/288 (50%), Gaps = 30/288 (10%)
Query: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTT----IIRQDLGSPEGIAVDHLGR 1033
K ++ L + +YW D+ I A + T +I L SPEG+A+D + +
Sbjct: 464 KNVVALDVEVATNRIYWCDLFYRKIYSAYIDKASDTAEQVILIDSQLNSPEGVAIDWVHK 523
Query: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
NI+WTDS I VA DG++RR +F +DL PR I D R +YW+DW D KIE +
Sbjct: 524 NIYWTDSGNKTISVATADGSRRRTVFNSDLSEPRAIAVDPTRRFMYWSDWG-DKAKIEKA 582
Query: 1094 YMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRR---KALEGL 1150
++G R++LV D++ PNG+ D + +L WVD+ + C++ + +R +++ L
Sbjct: 583 GLNGVGRQVLVSDNIEWPNGITLDLLNQRLYWVDSKLHSLSCIDFNGSNREVLISSIDDL 642
Query: 1151 QYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQ 1204
+PF + + +++TD + N + LD+++ E + PH + + +
Sbjct: 643 SHPFGLAVFEDRVFWTDLENEAIFSANRLSGLDISVLAE-NLNNPHDIVVFHEL-----K 696
Query: 1205 CPQGHNYCSVN---NGGCTHLCLATP------GSRTCRCPDNT-LGVD 1242
P+ + C ++ NGGC +LCL P TC CPDN LG D
Sbjct: 697 QPKAPDSCELSPQPNGGCEYLCLPAPHISPRSPKFTCACPDNMWLGPD 744
Score = 58.2 bits (138), Expect = 6e-07
Identities = 46/169 (27%), Positives = 69/169 (40%), Gaps = 36/169 (21%)
Query: 685 CRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCG--SHTICNNHPGTFRC---ECV 739
CRP +F C G + C + +C + G + C + P F+C EC+
Sbjct: 273 CRPD---EFQCGDGTCIHG-AKQCDKVHDCPDNSDEAGCVQESACES-PSKFQCKSGECI 327
Query: 740 EGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSS---------YTCSCL 790
+G + D P+ C G++ C + GG S Y C C
Sbjct: 328 DGGKVCDLHRDCRDWSDEPLKEC--GINECSLNN-------GGCSHICKDLKIGYECECP 378
Query: 791 PGFSG-DGQACQDVDECQPSRCHPDA---FCYNTPGSFTCQCKPGYQGD 835
PG+ D + C D+DEC+ +PDA C N G + C+C GY+ D
Sbjct: 379 PGYKLLDKKTCGDIDECE----NPDACSQICINYKGDYKCECYEGYEMD 423
Score = 56.6 bits (134), Expect = 2e-06
Identities = 30/75 (40%), Positives = 42/75 (56%), Gaps = 7/75 (9%)
Query: 670 NPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRG-DGRTCYDIDECSEQPSVCGSHTICN 728
N C + GC + C+ + + CEC G++ D +TC DIDEC E P C IC
Sbjct: 353 NECSLNNGGC--SHICKD-LKIGYECECPPGYKLLDKKTCGDIDEC-ENPDACSQ--ICI 406
Query: 729 NHPGTFRCECVEGYQ 743
N+ G ++CEC EGY+
Sbjct: 407 NYKGDYKCECYEGYE 421
Score = 38.7 bits (88), Expect = 0.41
Identities = 16/34 (47%), Positives = 20/34 (58%), Gaps = 2/34 (5%)
Query: 1202 LSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCP 1235
L +C G N CS+NNGGC+H+C C CP
Sbjct: 347 LKEC--GINECSLNNGGCSHICKDLKIGYECECP 378
Score = 38.3 bits (87), Expect = 0.53
Identities = 41/136 (30%), Positives = 51/136 (37%), Gaps = 35/136 (25%)
Query: 678 GCDTNAACRPGPRTQFTCECSIGFRGDG-------RTCYD----------IDECSEQPSV 720
GC +AC + Q C G DG R C D I+ECS
Sbjct: 306 GCVQESACESPSKFQ----CKSGECIDGGKVCDLHRDCRDWSDEPLKECGINECSLNNGG 361
Query: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT 780
C SH IC + + CEC GY+ D+ TC I+ CE N D + Y
Sbjct: 362 C-SH-ICKDLKIGYECECPPGYKLLDKKTC------GDIDECE----NPDACSQICINYK 409
Query: 781 GGSSYTCSCLPGFSGD 796
G Y C C G+ D
Sbjct: 410 G--DYKCECYEGYEMD 423
>ref|NP_059992.1| apolipoprotein E receptor 2 [Homo sapiens]
emb|CAA99509.1| (Z75190) apolipoprotein E receptor 2 906 [Homo sapiens]
Length = 699
Score = 148 bits (370), Expect = 3e-34
Identities = 99/320 (30%), Positives = 158/320 (48%), Gaps = 37/320 (11%)
Query: 946 LLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRA 1005
L+F E P++ N R L K ++ L + +YW D++ I A
Sbjct: 295 LIFTNRTSAEDRPVKRNYSR-------LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSA 347
Query: 1006 SLHGG----EPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
+ E +I + L SPEG+AVD + ++I+WTDS I VA +DG +RR LF
Sbjct: 348 YMDKASDPKEREVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSR 407
Query: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSS 1121
+L PR I D +RG +YW+DW D KIE S ++G +R+ LV D++ PNG+ D S
Sbjct: 408 NLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQ 466
Query: 1122 QLCWVDAGTNRAECLNPSQPSRRKALEG---LQYPFAVTSYGKNLYFTD------WKMNS 1172
+L WVD+ ++ ++ S +R+ + L +PF + + +++TD + N
Sbjct: 467 RLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANR 526
Query: 1173 VVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVN---NGGCTHLCLATP-- 1227
+ L+++I E + PH + + + P+ + C ++ NGGC +LCL P
Sbjct: 527 LNGLEISILAE-NLNNPHDIVIFHEL-----KQPRAPDACELSVQPNGGCEYLCLPAPQI 580
Query: 1228 ----GSRTCRCPDNT-LGVD 1242
TC CPD LG D
Sbjct: 581 SSHSPKYTCACPDTMWLGPD 600
Score = 47.3 bits (110), Expect = 0.001
Identities = 52/194 (26%), Positives = 74/194 (37%), Gaps = 49/194 (25%)
Query: 654 SNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGF-RGDGRTCYDID 712
+ + P + S + C + CD C G + C S+G RGD C D
Sbjct: 123 TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGA-DEAGCATSLGTCRGDEFQCGD-- 179
Query: 713 ECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIP 772
G+ + H + +C +G SDE C+ + +N C LHN
Sbjct: 180 ---------GTCVLAIKHCNQEQ-DCPDG---SDEAGCL-----QGLNEC---LHN---- 214
Query: 773 QRAQCIYTGGSS---------YTCSCLPGFSG-DGQACQDVDECQ-PSRCHPDAFCYNTP 821
GG S + C+C GF D + C D+DEC+ P C C N
Sbjct: 215 -------NGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC--SQICVNYK 265
Query: 822 GSFTCQCKPGYQGD 835
G F C+C PG + D
Sbjct: 266 GYFKCECYPGCEMD 279
Score = 37.9 bits (86), Expect = 0.70
Identities = 15/31 (48%), Positives = 17/31 (54%)
Query: 1205 CPQGHNYCSVNNGGCTHLCLATPGSRTCRCP 1235
C QG N C NNGGC+H+C C CP
Sbjct: 204 CLQGLNECLHNNGGCSHICTDLKIGFECTCP 234
>pir||QRXLL1 LDL receptor 1 precursor - African clawed frog
Length = 909
Score = 148 bits (370), Expect = 3e-34
Identities = 88/287 (30%), Positives = 143/287 (49%), Gaps = 28/287 (9%)
Query: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPT----TIIRQDLGSPEGIAVDHLGR 1033
K ++ L + +YW+D+T+ I AS+ + T T+I + +P+GIAVD +
Sbjct: 425 KNVVALDMEIASNKIYWSDLTQRKIYSASMEKADNTSHHETVISNQIQAPDGIAVDWIHG 484
Query: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
NI+WTDS I VA +G++RR DL PR IV D +G +YWTDW KIE
Sbjct: 485 NIYWTDSKFSTISVANTEGSKRRTPPSDDLEKPRDIVVDPSQGFMYWTDWGLP-AKIEKG 543
Query: 1094 YMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---L 1150
++G +R LV +++ PNG+ D + +L WVD+ + C++ + +RR + L
Sbjct: 544 GLNGVDRYPLVTENIEWPNGITLDLINQRLYWVDSKLHSLSCIDVTGENRRTVISDETHL 603
Query: 1151 QYPFAVTSYGKNLYFTDWKMNSVVALDLAISKE-----TDAFQPHKQTRLYGITTALSQC 1205
+PF +T + +++TD + ++ + + + D P + + +
Sbjct: 604 AHPFGLTIFEDLVFWTDIENEAIFSANRLTGRNIMKVAEDLLSPEDIVLYHNL-----RQ 658
Query: 1206 PQGHNYCS---VNNGGCTHLCLATP------GSRTCRCPDNT-LGVD 1242
P+ N+C + NGGC +LCL P TC CPD LG D
Sbjct: 659 PKAENWCEAHHLGNGGCEYLCLPAPHITARSPKFTCACPDGMHLGAD 705
Score = 53.1 bits (125), Expect = 2e-05
Identities = 45/162 (27%), Positives = 68/162 (41%), Gaps = 22/162 (13%)
Query: 685 CRPGPRTQFTCECSIGFRGDGRTC---YDIDECSEQPSVCGSHTICNNHPGTFRC---EC 738
CRP QF C G R C YD + S++ C + T C P F+C EC
Sbjct: 234 CRPD---QFQCNTGTCIHGS-RQCDREYDCKDLSDEEG-CVNVTKCEG-PDVFKCRSGEC 287
Query: 739 VEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS---SYTCSCLPGFS- 794
+ + ++ P+ C G + C + C + Y C C G+
Sbjct: 288 ITMDKVCNKKRDCRDWSDEPLKEC--GENEC-LRNNGGCSHICNDLKIGYECLCNEGYRL 344
Query: 795 GDGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGD 835
D + C+D++EC+ P+ C C N G + C+C+ GYQ D
Sbjct: 345 VDQKRCEDINECENPNTC--SQICINLVGGYKCECREGYQMD 384
Score = 48.4 bits (113), Expect = 5e-04
Identities = 29/76 (38%), Positives = 40/76 (52%), Gaps = 7/76 (9%)
Query: 669 QNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFR-GDGRTCYDIDECSEQPSVCGSHTIC 727
+N C GC + C + + C C+ G+R D + C DI+EC E P+ C IC
Sbjct: 313 ENECLRNNGGC--SHICND-LKIGYECLCNEGYRLVDQKRCEDINEC-ENPNTCSQ--IC 366
Query: 728 NNHPGTFRCECVEGYQ 743
N G ++CEC EGYQ
Sbjct: 367 INLVGGYKCECREGYQ 382
>dbj|BAA21825.1| (D86407) ApoER2delta4-7 [Homo sapiens]
Length = 793
Score = 148 bits (369), Expect = 5e-34
Identities = 92/288 (31%), Positives = 148/288 (50%), Gaps = 30/288 (10%)
Query: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGG----EPTTIIRQDLGSPEGIAVDHLGR 1033
K ++ L + +YW D++ I A + E +I + L SPEG+AVD + +
Sbjct: 280 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 339
Query: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
+I+WTDS I VA +DG +RR LF +L PR I D +RG +YW+DW D KIE S
Sbjct: 340 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKS 398
Query: 1094 YMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---L 1150
++G +R+ LV D++ PNG+ D S +L WVD+ ++ ++ S +R+ + L
Sbjct: 399 GLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFL 458
Query: 1151 QYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQ 1204
+PF + + +++TD + N + L+++I E + PH + + +
Sbjct: 459 SHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAE-NLNNPHDIVIFHEL-----K 512
Query: 1205 CPQGHNYCSVN---NGGCTHLCLATP------GSRTCRCPDNT-LGVD 1242
P+ + C ++ NGGC +LCL P TC CPD LG D
Sbjct: 513 QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPD 560
Score = 51.9 bits (122), Expect = 4e-05
Identities = 25/52 (48%), Positives = 31/52 (59%), Gaps = 4/52 (7%)
Query: 693 FTCECSIGFRG-DGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQ 743
F C C GF+ D +TC DIDEC + P C IC N+ G F+CEC GY+
Sbjct: 188 FECTCPAGFQLLDQKTCGDIDECKD-PDACSQ--ICVNYKGYFKCECYPGYE 236
Score = 49.2 bits (115), Expect = 3e-04
Identities = 47/177 (26%), Positives = 64/177 (35%), Gaps = 25/177 (14%)
Query: 666 DALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCG--S 723
D + C CD + EC G TC C + CG S
Sbjct: 80 DCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK-QVCPAEKLSCGPTS 138
Query: 724 HTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS 783
H P ++RC+ E C D+ C T L+ C + C +
Sbjct: 139 HKCV---PASWRCD--------GEKDCEGGADEAG---CATWLNEC-LHNNGGCSHICTD 183
Query: 784 ---SYTCSCLPGFSG-DGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGD 835
+ C+C GF D + C D+DEC+ P C C N G F C+C PGY+ D
Sbjct: 184 LKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC--SQICVNYKGYFKCECYPGYEMD 238
>ref|NP_004622.1| low density lipoprotein receptor-related protein 8, apolipoprotein e
receptor; apolipoprotein E receptor 2 [Homo sapiens]
dbj|BAA09328.1| (D50678) apolipoprotein E receptor 2 precursor [Homo sapiens]
dbj|BAA21824.1| (D86407) ApoER2 [Homo sapiens]
Length = 963
Score = 148 bits (369), Expect = 5e-34
Identities = 92/288 (31%), Positives = 148/288 (50%), Gaps = 30/288 (10%)
Query: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGG----EPTTIIRQDLGSPEGIAVDHLGR 1033
K ++ L + +YW D++ I A + E +I + L SPEG+AVD + +
Sbjct: 450 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
Query: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
+I+WTDS I VA +DG +RR LF +L PR I D +RG +YW+DW D KIE S
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKS 568
Query: 1094 YMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---L 1150
++G +R+ LV D++ PNG+ D S +L WVD+ ++ ++ S +R+ + L
Sbjct: 569 GLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFL 628
Query: 1151 QYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQ 1204
+PF + + +++TD + N + L+++I E + PH + + +
Sbjct: 629 SHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAE-NLNNPHDIVIFHEL-----K 682
Query: 1205 CPQGHNYCSVN---NGGCTHLCLATP------GSRTCRCPDNT-LGVD 1242
P+ + C ++ NGGC +LCL P TC CPD LG D
Sbjct: 683 QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPD 730
Score = 53.1 bits (125), Expect = 2e-05
Identities = 58/191 (30%), Positives = 74/191 (38%), Gaps = 70/191 (36%)
Query: 686 RPGPR-----------TQFTC---EC-SIGFRGDG-RTCYD--------IDECSEQPSVC 721
RPGP +QF C EC +G+R DG R C D + C C
Sbjct: 247 RPGPGATSAPAACATVSQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQC 306
Query: 722 GSHTI------CNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRA 775
G T CN +C +G SDE C+ + +N C LHN
Sbjct: 307 GDGTCVLAIKHCNQEQ-----DCPDG---SDEAGCL-----QGLNEC---LHN------- 343
Query: 776 QCIYTGGSS---------YTCSCLPGFSG-DGQACQDVDECQ-PSRCHPDAFCYNTPGSF 824
GG S + C+C GF D + C D+DEC+ P C C N G F
Sbjct: 344 ----NGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC--SQICVNYKGYF 397
Query: 825 TCQCKPGYQGD 835
C+C PGY+ D
Sbjct: 398 KCECYPGYEMD 408
Score = 37.9 bits (86), Expect = 0.70
Identities = 15/31 (48%), Positives = 17/31 (54%)
Query: 1205 CPQGHNYCSVNNGGCTHLCLATPGSRTCRCP 1235
C QG N C NNGGC+H+C C CP
Sbjct: 333 CLQGLNECLHNNGGCSHICTDLKIGFECTCP 363
>sp|Q99087|LDL1_XENLA LOW-DENSITY LIPOPROTEIN RECEPTOR 1 PRECURSOR (LDL RECEPTOR 1)
gb|AAA49897.1| (M62976) low density lipoprotein receptor-1 [Xenopus laevis]
Length = 909
Score = 147 bits (367), Expect = 8e-34
Identities = 85/280 (30%), Positives = 140/280 (49%), Gaps = 27/280 (9%)
Query: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPT----TIIRQDLGSPEGIAVDHLGR 1033
K ++ L + +YW+D+T+ I AS+ + T T+I + +P+GIAVD +
Sbjct: 425 KNVVALDMEIASNKIYWSDLTQRKIYSASMEKADNTSHHETVISNQIQAPDGIAVDWIHG 484
Query: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
NI+WTDS I VA +G++RR DL PR IV D +G +YWTDW KIE
Sbjct: 485 NIYWTDSKFSTISVANTEGSKRRTPPSDDLEKPRDIVVDPSQGFMYWTDWGLP-AKIEKG 543
Query: 1094 YMDGTNRRILVQDDLGLPNGLHFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---L 1150
++G +R LV +++ PNG+ D + +L WVD+ + C++ + +RR + L
Sbjct: 544 GLNGVDRYPLVTENIEWPNGITLDLINQRLYWVDSKLHSLSCIDVTGENRRTVISDETHL 603
Query: 1151 QYPFAVTSYGKNLYFTDWKMNSVVALDLAISKE-----TDAFQPHKQTRLYGITTALSQC 1205
+PF +T + +++TD + ++ + + + D P + + +
Sbjct: 604 AHPFGLTIFEDLVFWTDIENEAIFSANRLTGRNIMKVAEDLLSPEDIVLYHNL-----RQ 658
Query: 1206 PQGHNYCS---VNNGGCTHLCLATP------GSRTCRCPD 1236
P+ N+C + NGGC +LCL P TC CPD
Sbjct: 659 PKAENWCEAHHLGNGGCEYLCLPAPHITARSPKFTCACPD 698
Score = 53.1 bits (125), Expect = 2e-05
Identities = 45/162 (27%), Positives = 68/162 (41%), Gaps = 22/162 (13%)
Query: 685 CRPGPRTQFTCECSIGFRGDGRTC---YDIDECSEQPSVCGSHTICNNHPGTFRC---EC 738
CRP QF C G R C YD + S++ C + T C P F+C EC
Sbjct: 234 CRPD---QFQCNTGTCIHGS-RQCDREYDCKDLSDEEG-CVNVTKCEG-PDVFKCRSGEC 287
Query: 739 VEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS---SYTCSCLPGFS- 794
+ + ++ P+ C G + C + C + Y C C G+
Sbjct: 288 ITMDKVCNKKRDCRDWSDEPLKEC--GENEC-LRNNGGCSHICNDLKIGYECLCNEGYRL 344
Query: 795 GDGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGD 835
D + C+D++EC+ P+ C C N G + C+C+ GYQ D
Sbjct: 345 VDQKRCEDINECENPNTC--SQICINLVGGYKCECREGYQMD 384
Score = 48.4 bits (113), Expect = 5e-04
Identities = 29/76 (38%), Positives = 40/76 (52%), Gaps = 7/76 (9%)
Query: 669 QNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFR-GDGRTCYDIDECSEQPSVCGSHTIC 727
+N C GC + C + + C C+ G+R D + C DI+EC E P+ C IC
Sbjct: 313 ENECLRNNGGC--SHICND-LKIGYECLCNEGYRLVDQKRCEDINEC-ENPNTCSQ--IC 366
Query: 728 NNHPGTFRCECVEGYQ 743
N G ++CEC EGYQ
Sbjct: 367 INLVGGYKCECREGYQ 382
>ref|NP_034830.1| low density lipoprotein receptor [Mus musculus]
sp|P35951|LDLR_MOUSE LOW-DENSITY LIPOPROTEIN RECEPTOR PRECURSOR (LDL RECEPTOR)
emb|CAA79581.1| (Z19521) low density lipoprotein receptor [Mus musculus]
Length = 864
Score = 145 bits (363), Expect = 2e-33
Identities = 96/317 (30%), Positives = 156/317 (48%), Gaps = 35/317 (11%)
Query: 945 HLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGR 1004
+LLF ++ ++ L+ ++E + L K ++ L + + +YW+D+++ I
Sbjct: 401 YLLFTNRHEVRKMTLD-----RSEYTSLLP-NLKNVVALDTEVTNNRIYWSDLSQKKIYS 454
Query: 1005 ASLHGGEPT---TIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
A + TII +DL +P+G+AVD + RNI+WTDS + VA G +RR LF+
Sbjct: 455 ALMDQAPNLSYDTIISEDLHAPDGLAVDWIHRNIYWTDSVPGSVSVADTKGVKRRTLFQE 514
Query: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSS 1121
PR IV D V G +YWTDW KI+ ++G + LV +++ PNG+ D S
Sbjct: 515 AGSRPRAIVVDPVHGFMYWTDWGTP-AKIKKGGLNGVDIHSLVTENIQWPNGITLDLSSG 573
Query: 1122 QLCWVDAGTNRAECLNPSQPSRRKALEG---LQYPFAVTSYGKNLYFTD------WKMNS 1172
+L WVD+ + ++ + +R+ LE L +PF++ Y +Y+TD + N
Sbjct: 574 RLYWVDSKLHSISSIDVNGGNRKTILEDENRLAHPFSLAIYEDKVYWTDVINEAIFSANR 633
Query: 1173 VVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVN----NGGCTHLCLATP- 1227
+ D+ + E + P + +T P+G N+C NGGC +LCL P
Sbjct: 634 LTGSDVNLVAE-NLLSPEDIVLFHKVTQ-----PRGVNWCETTALLPNGGCQYLCLPAPQ 687
Query: 1228 -----GSRTCRCPDNTL 1239
TC CPD L
Sbjct: 688 IGPHSPKFTCACPDGML 704
Score = 53.9 bits (127), Expect = 1e-05
Identities = 48/170 (28%), Positives = 66/170 (38%), Gaps = 34/170 (20%)
Query: 683 AACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV--CGSHTICNNHPGTFRC---E 737
A CRP +F C G R C +C + C + T C+ P F+C E
Sbjct: 235 ATCRPD---EFQCADGSCIHGS-RQCDREHDCKDMSDELGCVNVTQCDG-PNKFKCHSGE 289
Query: 738 CVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCI-YTGGSSYTCS-------- 788
C+ + D PI C+T +C+ GG S+ C
Sbjct: 290 CISLDKVCDSARDCQDWSDEPIKECKTN----------ECLDNNGGCSHICKDLKIGSEC 339
Query: 789 -CLPGFS-GDGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGD 835
C GF D C+D+DECQ P C C N GS+ C+C+ G+ D
Sbjct: 340 LCPSGFRLVDLHRCEDIDECQEPDTC--SQLCVNLEGSYKCECQAGFHMD 387
>pir||I48623 low density lipoprotein receptor - mouse
pir||QRMSLD LDL receptor precursor - mouse
emb|CAA45759.1| (X64414) low density lipoprotein receptor [Mus musculus]
Length = 862
Score = 145 bits (363), Expect = 2e-33
Identities = 96/317 (30%), Positives = 156/317 (48%), Gaps = 35/317 (11%)
Query: 945 HLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGR 1004
+LLF ++ ++ L+ ++E + L K ++ L + + +YW+D+++ I
Sbjct: 401 YLLFTNRHEVRKMTLD-----RSEYTSLLP-NLKNVVALDTEVTNNRIYWSDLSQKKIYS 454
Query: 1005 ASLHGGEPT---TIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
A + TII +DL +P+G+AVD + RNI+WTDS + VA G +RR LF+
Sbjct: 455 ALMDQAPNLSYDTIISEDLHAPDGLAVDWIHRNIYWTDSVPGSVSVADTKGVKRRTLFQE 514
Query: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLHFDAFSS 1121
PR IV D V G +YWTDW KI+ ++G + LV +++ PNG+ D S
Sbjct: 515 AGSRPRAIVVDPVHGFMYWTDWGTP-AKIKKGGLNGVDIHSLVTENIQWPNGITLDLSSG 573
Query: 1122 QLCWVDAGTNRAECLNPSQPSRRKALEG---LQYPFAVTSYGKNLYFTD------WKMNS 1172
+L WVD+ + ++ + +R+ LE L +PF++ Y +Y+TD + N
Sbjct: 574 RLYWVDSKLHSISSIDVNGGNRKTILEDENRLAHPFSLAIYEDKVYWTDVINEAIFSANR 633
Query: 1173 VVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVN----NGGCTHLCLATP- 1227
+ D+ + E + P + +T P+G N+C NGGC +LCL P
Sbjct: 634 LTGSDVNLVAE-NLLSPEDIVLFHKVTQ-----PRGVNWCETTALLPNGGCQYLCLPAPQ 687
Query: 1228 -----GSRTCRCPDNTL 1239
TC CPD L
Sbjct: 688 IGPHSPKFTCACPDGML 704
Score = 53.9 bits (127), Expect = 1e-05
Identities = 48/170 (28%), Positives = 66/170 (38%), Gaps = 34/170 (20%)
Query: 683 AACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV--CGSHTICNNHPGTFRC---E 737
A CRP +F C G R C +C + C + T C+ P F+C E
Sbjct: 235 ATCRPD---EFQCADGSCIHGS-RQCDREHDCKDMSDELGCVNVTQCDG-PNKFKCHSGE 289
Query: 738 CVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCI-YTGGSSYTCS-------- 788
C+ + D PI C+T +C+ GG S+ C
Sbjct: 290 CISLDKVCDSARDCQDWSDEPIKECKTN----------ECLDNNGGCSHICKDLKIGSEC 339
Query: 789 -CLPGFS-GDGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGD 835
C GF D C+D+DECQ P C C N GS+ C+C+ G+ D
Sbjct: 340 LCPSGFRLVDLHRCEDIDECQEPDTC--SQLCVNLEGSYKCECQAGFHMD 387
Database: nr
Number of letters in database: 182,691,300
Number of sequences in database: 580,189
Lambda K H
0.319 0.136 0.430
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 503775559
Number of Sequences: 580189
Number of extensions: 23721866
Number of successful extensions: 77642
Number of sequences better than 10.0: 1273
Number of HSP's better than 10.0 without gapping: 657
Number of HSP's successfully gapped in prelim test: 628
Number of HSP's that attempted gapping in prelim test: 54347
Number of HSP's gapped (non-prelim): 11884
length of query: 1247
length of database: 182,691,300
effective HSP length: 55
effective length of query: 1192
effective length of database: 150,780,905
effective search space: 179730838760
effective search space used: 179730838760
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 77 (34.4 bits)
