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Schematic presentation of different SMC/kleisin ring closure options

SMC/kleisin models

Figure legend: The process of opening and closing of the ring might involve several steps. (A) The SMC ring is closed by the interacting ATPase heads and the kleisin is attached via its C-terminal region to one of the SMCs. (B) Both kleisin globular domains are attached to the two SMC heads in tetramerized form. (C) Both kleisin globular domains are attached to the two SMC heads in the non-interacting form of the latter.
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