ID   YES_XIPHE      STANDARD;      PRT;   544 AA.
AC   P27447;
DT   01-AUG-1992 (Rel. 23, Created)
DT   01-AUG-1992 (Rel. 23, Last sequence update)
DT   01-NOV-1995 (Rel. 32, Last annotation update)
DE   PROTO-ONCOGENE TYROSINE-PROTEIN KINASE YES (EC 2.7.1.112) (P61-YES)
DE   (C-YES).
GN   YES.
OS   Xiphophorus helleri.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei;
OC   Acanthomorpha; Acanthopterygii; Percomorpha; Atherinomorpha;
OC   Cyprinodontiformes; Poeciliidae; Xiphophorus.
OX   NCBI_TaxID=8084;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=RIO LANCETILLA;
RX   MEDLINE=91187435; PubMed=1707152;
RA   Hannig G., Ottilie S., Schartl M.;
RT   "Conservation of structure and expression of the c-yes and fyn genes
RT   in lower vertebrates.";
RL   Oncogene 6:361-369(1991).
CC   -!- CATALYTIC ACTIVITY: ATP + A PROTEIN TYROSINE = ADP +
CC       PROTEIN TYROSINE PHOSPHATE.
CC   -!- SIMILARITY: CONTAINS 1 SH2 DOMAIN.
CC   -!- SIMILARITY: CONTAINS 1 SH3 DOMAIN.
CC   -!- SIMILARITY: TO OTHER PROTEIN-TYROSINE KINASES IN THE CATALYTIC
CC       DOMAIN. BELONGS TO THE SRC SUBFAMILY.
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DR   EMBL; X54970; CAA38714.1; -.
DR   HSSP; P12931; 1FMK.
DR   INTERPRO; IPR000719; -.
DR   INTERPRO; IPR000980; -.
DR   INTERPRO; IPR001245; -.
DR   INTERPRO; IPR001452; -.
DR   PFAM; PF00017; SH2; 1.
DR   PFAM; PF00018; SH3; 1.
DR   PFAM; PF00069; pkinase; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50002; SH3; 1.
KW   Proto-oncogene; Tyrosine-protein kinase; Phosphorylation;
KW   Transferase; ATP-binding; Myristate; SH3 domain; SH2 domain.
FT   LIPID         2      2       MYRISTATE (BY SIMILARITY).
FT   DOMAIN       92    153       SH3 (BY SIMILARITY).
FT   DOMAIN      159    256       SH2.
FT   DOMAIN      278    531       PROTEIN KINASE.
FT   NP_BIND     284    292       ATP (BY SIMILARITY).
FT   BINDING     306    306       ATP (BY SIMILARITY).
FT   ACT_SITE    397    397       BY SIMILARITY.
FT   MOD_RES     427    427       PHOSPHORYLATION (AUTO-) (BY SIMILARITY).
SQ   SEQUENCE   544 AA;  61288 MW;  7D41818B3E7086EF CRC64;
     MGCVRSKEAK GPALKYQPDN SNVVPVSAHL GHYGPEPTIM GQSPAMKTQN NSHPTALSPF
     GGVSSPMTPF GGASTSFTSV TVNNPFPAVI TGGVTFFVAL YDYEARTSDD LSFRKGDRFQ
     IINNTEGDWW EARSINTGEN GYIPSNYVAP ADSIQSEEWY FGKLSRKDTE RLLLLPGNER
     GTFLIRESET TKGAYSLSLR DWDETKGDNC KHYKIRKLDN GGYYITTRTQ FMSLQMLVKH
     YTEHVDGLCY KLTTVCPQVK PQTQGIAKDA WEIPRESLRL DVRLGQGCFG EVWMGTWNGT
     TKVAIKTLKP GTMSPEAFLE EAQIMKKLRH DKLVPLYAVV SEEPIYIVTE FMGKGSLLDF
     LKEGDGKHLK LPQLVDMASQ IADGMAFIER MNYIHRDLRA ANILVADNLV CKIADFGLAR
     LIEDNEYTAR QGAKFPIKWT APEAALYGRF TIKSDVWSFG ILLTELVTKG RVPYPGMVNR
     EVLEQVDRGY RMPCPQGCPE SLHEMMRQCW KKEPDERPTF EYIQSFLEDY FTATEPQYQP
     GDNL
//