ID SIF1_DROME STANDARD; PRT; 2064 AA. AC P91621; DT 15-JUL-1999 (Rel. 38, Created) DT 15-JUL-1999 (Rel. 38, Last sequence update) DT 01-OCT-2000 (Rel. 40, Last annotation update) DE STILL LIFE PROTEIN TYPE 1 (SIF TYPE 1). GN SIF. OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Tracheata; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=HEAD; RX MEDLINE=97153054; PubMed=8999801; RA Sone M., Hoshino M., Suzuki E., Kuroda S., Kaibuchi K., Nakagoshi H., RA Saigo K., Nabeshima Y.-I., Hama C.; RT "Still life, a protein in synaptic terminals of Drosophila homologous RT to GDP-GTP exchangers."; RL Science 275:543-547(1997). RN [2] RP ERRATUM. RA Sone M., Hoshino M., Suzuki E., Kuroda S., Kaibuchi K., Nakagoshi H., RA Saigo K., Nabeshima Y.-I., Hama C.; RL Science 275:1405-1405(1997). CC -!- FUNCTION: REGULATES SYNAPTIC DIFFERENTIATION THROUGH THE CC ORGANIZATION OF ACTIN CYTOSKELETON POSSIBLY BY ACTIVATING RHO-LIKE CC GTPASES. IS LIKELY A FACTOR IN THE CASCADE OF RAC1 OR CDC42 IN THE CC NEURONS. CC -!- SUBCELLULAR LOCATION: LOCALIZES TO THE SUBMEMBRANOUS REGION OF CC SYNAPTIC TERMINALS. CC -!- ALTERNATIVE PRODUCTS: 2 ISOFORMS; SIF TYPE 1 (SHOWN HERE) AND SIF CC TYPE 2 (AC P91620); ARE PRODUCED BY ALTERNATIVE SPLICING. CC -!- DEVELOPMENTAL STAGE: AT STAGE 14, EXPRESSION OCCURS IN EACH CC SEGMENT OF THE CENTRAL NERVOUS SYSTEM. AT STAGE 17, EXPRESSION CC BECOMES RESTRICTED TO THE SYNAPTIC REGIONS OF THE BRAIN AND CC VENTRAL NERVE CORD, WHERE SYNAPSES UNDERGO MATURATION. CC -!- SIMILARITY: CONTAINS 1 DBL-HOMOLOGY DOMAIN (DH). CC -!- SIMILARITY: CONTAINS 2 PH DOMAINS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; D86547; BAA13109.1; -. DR FLYBASE; FBgn0019652; sif. DR INTERPRO; IPR000219; -. DR INTERPRO; IPR001331; -. DR INTERPRO; IPR001478; -. DR INTERPRO; IPR001849; -. DR PFAM; PF00595; PDZ; 1. DR PFAM; PF00169; PH; 2. DR PFAM; PF00621; RhoGEF; 1. DR PROSITE; PS00741; GDS_CDC24; 1. DR PROSITE; PS50003; PH_DOMAIN; 1. KW Guanine-nucleotide releasing factor; Developmental protein; KW Myristate; Synapse; Alternative splicing. FT LIPID 2 2 MYRISTATE (POTENTIAL). FT DOMAIN 839 957 PH. FT DOMAIN 1204 1293 PDZ. FT DOMAIN 1430 1693 DH. FT DOMAIN 1694 1787 PH. FT DOMAIN 445 453 POLY-GLY. FT DOMAIN 545 548 POLY-GLN. FT DOMAIN 1315 1318 POLY-PRO. FT DOMAIN 1918 1929 POLY-GLN. FT DOMAIN 1949 1953 POLY-PRO. SQ SEQUENCE 2064 AA; 230489 MW; D3BDCC10A94D9E6C CRC64; MGNKLSCSCA PLMRKAYRYE DSPWQSSRRR DGHLLSSFRL WAEVFHVSAS GAGTVKWQQV SEDLVPVNIT CIQDSPECIF HITAYNSQVD KILDVRLVQP GTRIGQASEC FVYWKDPMTN DTWGLNFTSP IDAKQFRECC SPSFKFSRKA SSSYSLKLDP PGKGKVKAKR KPLSTPASPS RVRQEPQCTC MSAEQYARLR TDPRVRGSST LPRNVGSHRI TDVDGQQQVG SGKVVSAVSS TSLYDNVASG GPGTNQGADT LPRQMKGGQQ DRQDVANSGV NTNTPGVIVT GVGNVGSDMC GQNHVGSQVG NDDPAACQMV MDLSKSEGTQ AGGGLHQSVG TCTSSSKGTG TRNKDFGDDM TRDAHSHDMH QHNVINNNTR RKTKSTEDMN VDTSTLKRML KPMPSTESPV TSPEMGRRRY NYYNANAAQT LGHPPHMHQH GMAMGMGGGG GGGHHIMNNN TMGRASSQSS RFSGSRSSHE IGRGYPPRNL YLELERERSC IEGSPPSDNV MFDNQCYATT PSSSNGNSDQ DQSYGQQQSS GQHPQQQQGP PQRSSRHQHH HQQAPNVTPT PGSPTSRLLL EYEMHLRNTL AKGMDAESYS LHTFEALLSQ SMENLANAKS STLPLPPHRP LSTIRDKERD RDRDGYYSDR NELIRERERE RDRGYLSDHN SSFSNSRCAS CIGESARAQW FRHSDGWRSG SSTIGSGSGH GMMTQQIPGS GHKRSPWDSL PSLRQDSSLN DSGYKSARAD SLEQRAEFIR QDSLRSEYLS DRESRYGIVQ QASIESTDSR MCYLTSSEIS DDDRMSLTTA VSDEDDGESV MASPYKAKAT GTAASSFNCT GAVRKAGFLS VKKWLLRKKH QIELARKRGW KGYWVCLKGT TLLFYPCDSR EGRSVEAAPK HLIIVDGAIM QPIPEHPKRD YIFCLSTAFG DAYLFQAPCQ VELENWVNSI HSACAAAFAR HRGKTGTLHL LQEEIFRLEK AIESDHKLKH MAELQQSVVT DQETRHQIQT QILQWEENLE RLHCEQFRLR CYMASLQSGE LPNPKSLLTH VSRPTKNTLN KLGVFTVSSF HAFICARSPS LLNNLLAGRG ATKRRPPMLS RSNSGSSRRS MQMNSRDEPE KTFKVAMPDN AYSTVYLRDA MSVEEFLASA CARRNLNPME HFVRVKKRRD MEDHNYFVPH RNDLIENYLH NHEFVEVCMK ILYQVELQRT TLEQMWGFSV EAELIENAER QDELCCYVSR VEDKSVAMHN GIIKGDEIMV INGAIVSDLD MMYLESVLQE EQSLSMMMRS SRTEPPDLVG IMRVTDDMID SLVCPPPPTD PPVMSEEMIT GLIVPAPGWN GTSKDLYSPE AESSPATSFV DPAAMAAQLA VGGLGVAKPT SRTSSFEIEN LLKTAEQETR KSSPTGSVTS SVSTTALTPS RQLTDAEKLR KVVMELVDTE RTYVKHLNNL LEHYLEPMKR ETFLSNAEIN ALFGNIHEIV TFQRQFLQNL EESLDLEPDF NKFEHCGQFR NVLFAIGSAF LYYVNHFKLY SSFCASHSKA QKVLHPNEGN HALQEFLAAR NPKQQHSSTL ESYLIKPIQR ILKYPLLLQQ MRNLTDTRAD EHVHLCEALK GMEKVAEHIN EMQRIHEEYG AIFDHLFRQH QKSCKQPIDL SPGDLLYYGG VEWLNISDFL GKIKKGLELH AMCFVFKSAV VFLCKERLRQ KKKLMGVSSK NATNEVEIIR YQVLIPVTEV QVRASSAKDM DSHFLWELIH LRSQLQRRSE KVYVLSNSTA DFRNAFLKTI RQIIRESVRN MSIPMKNFGG SSGSVSGHSS QGMGSMGYPG NSQTLERPKQ QITIVHGSHT LGKPKKKSGS QRHSAGNIDY DNLSGSQEAD DLPPSVGVVH YASGHTHGQQ MQPAGFRGRS KTVGDVTEIT CSSPEPHQQQ QQQQQQQQQL MQQGHAHAHP HPHPHPREPP PPPIRQPHLH HHSSDIERID PGTKSEGEED SQQGTIRPKA TLGRTPNHLT LSTTSTLSVG STGSQARLIQ SSHPPASYQP VLMKDLGSPV WKPRDMINLG TDPQSTTRKD DVKN //