ID   Q04762      PRELIMINARY;      PRT;   141 AA.
AC   Q04762;
DT   01-NOV-1996 (TrEMBLrel. 01, Created)
DT   01-NOV-1996 (TrEMBLrel. 01, Last sequence update)
DT   01-MAY-1999 (TrEMBLrel. 10, Last annotation update)
DE   CELL ADHESION REGULATORY PROTEIN (CAR).
GN   CAR.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=COLON CARCINOMA;
RX   MEDLINE=92220167; PubMed=1560826;
RA   Pullman W.E., Bodmer W.F.;
RT   "Cloning and characterization of a gene that regulates cell
RT   adhesion.";
RL   Nature 356:529-532(1992).
RN   [2]
RP   SEQUENCE OF 85-112 FROM N.A.
RX   MEDLINE=93252394; PubMed=8098008;
RA   Koyama K., Emi M., Nakamura Y.;
RT   "The cell adhesion regulator (CAR) gene, TaqI and insertion/deletion
RT   polymorphisms, and regional assignment to the peritelomeric region of
RT   16q by linkage analysis.";
RL   Genomics 16:264-265(1993).
CC   -!- FUNCTION: THIS IS A CELL ADHESION PROTEIN WHICH MAY PLAY A ROLE IN
CC       SIGNAL TRANSDUCTION, COUPLING THE CYTOPLASMIC PORTION OF ADHESION
CC       MOLECULES TO THE CYTOSKELETON AND ENABLING THE EXTERNAL
CC       ENVIRONMENT TO INFLUENCE THE CELL SHAPE AND BEHAVIOUR. IT MAY
CC       FUNCTION IN THE SUPPRESSION OF TUMOUR INVASION.
CC   -!- SUBCELLULAR LOCATION: CYTOPLASMIC.
DR   EMBL; X65784; CAA46667.1; -.
DR   EMBL; D14075; BAA03160.1; -.
KW   Cell adhesion; Phosphorylation; Myristylation; Polymorphism.
FT   INIT_MET      0      0       PROBABLE.
FT   LIPID         1      1       MYRISTATE.
FT   MOD_RES     141    141       PHOSPHORYLATION (BY TYR-KINASE)
FT                                (POTENTIAL).
FT   VARIANT      89    109       PVRPRHWAPEDSPLPPAAMWT ->
FT                                ASQAGTGLRRLTAPCC HVDWC (IN JV.1).
FT   VARIANT      89    112       PVRPRHWAPEDSPLPPAAMWTWCK -> ATQSGPGTGLRR
FT                                LTTAPCCHVDWC (IN JV.2).
FT   MUTAGEN     141    141       Y->*: ABOLISHES ENHANCEMENT OF
FT                                CELL-MATRIX ADHESION.
SQ   SEQUENCE   141 AA;  15604 MW;  A6299E9D79B71936 CRC64;
     GKVISASRVS MEHFEFQGYR QSFPVWLRPP RGSRAFRLQT DPCSCRCLHD RPSSCGSLGM
     LRGSDMKGPC EPIVLSPAAL SSSSLINGPV RPRHWAPEDS PLPPAAMWTW CKLRTSCWSS
     HACSVGDALV FTALRIVEIL Y
//