ID Q04022 PRELIMINARY; PRT; 263 AA. AC Q04022; DT 01-NOV-1996 (TrEMBLrel. 01, Created) DT 01-NOV-1996 (TrEMBLrel. 01, Last sequence update) DT 01-MAY-2000 (TrEMBLrel. 13, Last annotation update) DE NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN). GN NEF. OS Chimpanzee immunodeficiency virus (SIV(cpz)) (CIV). OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11723; RN [1] RP SEQUENCE FROM N.A. RA Benveniste R.E., Heidecker G., Greenwood J., Gonda M.A.; RL Unpublished observations (AUG-1990). CC -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING CC ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN. CC -!- MISCELLANEOUS: THIS IS A CAPTIVE MACAQUE NEMESTRINA ISOLATE. DR EMBL; M32741; AAA91938.1; -. DR INTERPRO; IPR001558; -. DR PFAM; PF00469; F-protein; 1. KW AIDS; Myristylation; GTP-binding. FT LIPID 2 2 MYRISTATE (BY SIMILARITY). SQ SEQUENCE 263 AA; 30370 MW; 079679276039947B CRC64; MGGATSKRRS KSPGDLRQRL LRARGETYGR LWEELEDGYS QSLGGSDKGS SLLSCEGQKY NQGQFMNTPW KNPAGEREKL AYRKQNIDDI DEEDNDLVGV PVRPRVPLRI ISYKLAVDMS HFIKEKGGLE GIYYSERRHK ILDMYLEKEE GIMPDWQNYT SGPGPRYPKT FGWLWKLVPV NVSDEAQEGE ENYLLHPAQT SQWDDPWGEV LVWKFDPTLA YTYEAYIRYP EEFGSKSGLS EEEVRRRLTA RGLLKMADKR ETS //