ID   Q01119      PRELIMINARY;      PRT;   732 AA.
AC   Q01119;
DT   01-NOV-1996 (TrEMBLrel. 01, Created)
DT   01-NOV-1996 (TrEMBLrel. 01, Last sequence update)
DT   01-OCT-2000 (TrEMBLrel. 15, Last annotation update)
DE   GENOME POLYPROTEIN
DE   (NONSTRUCTURAL PROTEIN P20A; COAT PROTEINS VP1 TO VP4; CORE PROTEINS
DE   P12) (FRAGMENT).
GN   P1.
OS   foot and mouth disease virus C.
OC   Viruses; ssRNA positive-strand viruses, no DNA stage; Picornaviridae;
OC   Aphthovirus.
OX   NCBI_TaxID=12116;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=92260626; PubMed=1316467;
RA   Martinez M.A., Dopazo J., Hernandez J., Mateu M.G., Sobrino F.,
RA   Domingo E., Knowles N.J.;
RT   "Evolution of the capsid protein genes of foot-and-mouth disease
RT   virus: antigenic variation without accumulation of amino acid
RT   substitutions over six decades.";
RL   J. Virol. 66:3557-3565(1992).
CC   -!- SUBUNIT: THE VIRUS CAPSID IS COMPOSED OF 60 ICOSAHEDRAL UNITS,
CC       EACH OF WHICH IS COMPOSED OF ONE COPY EACH OF PROTEINS VP1, VP2,
CC       VP3, AND VP4.
CC   -!- MISCELLANEOUS: ALMOST THE ENTIRE GENOME CODES FOR A SINGLE
CC       POLYPROTEIN. SPECIFIC ENZYMATIC CLEAVAGES IN VIVO YIELD MATURE
CC       PROTEINS.
CC   -!- MISCELLANEOUS: THE COAT PROTEIN VP1 CONTAINS THE MAIN ANTIGENIC
CC       DETERMINANTS OF THE VIRION; THEREFORE, CHANGES IN ITS SEQUENCE
CC       MUST BE RESPONSIBLE FOR THE HIGH ANTIGENIC VARIABILITY OF THE
CC       VIRUS.
DR   EMBL; M90372; AAA91494.1; -.
DR   INTERPRO; IPR001676; -.
DR   PFAM; PF00073; rhv; 3.
KW   Polyprotein; Coat protein; Core protein; Myristylation.
FT   NON_TER       1      1
FT   CHAIN        <1     85       COAT PROTEIN VP4.
FT   CHAIN        86    303       COAT PROTEIN VP2.
FT   CHAIN       304    522       COAT PROTEIN VP3.
FT   CHAIN       523    732       COAT PROTEIN VP1.
FT   DOMAIN      655    678       ANTIGENIC A (BY SIMILARITY).
FT   DOMAIN      709    732       ANTIGENIC C (BY SIMILARITY).
FT   LIPID         1      1       MYRISTATE (BY SIMILARITY).
FT   NON_TER     732    732
SQ   SEQUENCE   732 AA;  79800 MW;  7F4939315B5A4362 CRC64;
     GTGQSSPATG SQNQSGNTAS IINNYYMQQY QNSMDTQLGD NAISAGSNEG STDTTSTHTT
     NTQNNDWFSK LASSAFSGLF GALLADKKTE ETTLLEDRIL TTRNGHTTST TQSSVGVTYG
     YATAEDSSSG PNTSGLETRV HQAERFFKMT LFDWDPSQKF GYMHKVVLPT EPKGIYGGLV
     KSYAYMRNGW DVEVTAVGNQ FNGGCXLVAL VPEMGDISDR EKYQLTLYPH QFINPRTNMT
     AHITVPYVGV NRYDQYNQHK PWTLVVMVLA PLTVNTAGAQ QIKVYANIAP TNVHVAGELP
     SKEGIXPVXC SDGXGNMVTT DPKTADPAYG KVYNPPRTAL PGXFTNYXDV AXAXPTFLMF
     ENVPYVSTRA DGQRLLAKFD VSLAAKHMSN TYLAGLAQYY TQYAGTINLH FMFTGPTDAK
     ARYMVAYVPP GMDAPDNPEE AAHCIHAEWD TXLNSKFTXS IPYISAAXYA YTASNEAETT
     CVQGWVCVYQ ITRGKASADA LVVSASAGKD FELRLPVDAR RQTTATGXSA DPVTTTVENY
     GGETQVQRRH HTDVAXVLDR FVKVKASGNQ HTLDVMQVHK DSIVGALLRA ATYYFSXLEI
     XXTXTGKLTW VPNGAPVSAL DNTSNPTAYH KGPLTRLALP YTAPHRVLAT TYTGTTTYTT
     SARRGDLAHL AATHAQRLPT SFNFGAVKAE TITELLVRMK RAELYCPRPI LPIQPAGDRH
     KQPLIAPEKQ LL
//