ID POLH_POL1M STANDARD; PRT; 2208 AA. AC P03300; Q84879; Q84880; Q89679; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 15-DEC-1998 (Rel. 37, Last annotation update) DE GENOME POLYPROTEIN [CONTAINS: COAT PROTEINS VP1 TO VP4; CORE PROTEINS DE P2A TO P2C, P3A; GENOME-LINKED PROTEIN VPG; PICORNAIN 3C DE (EC 3.4.22.28) (PROTEASE 3C) (P3C); RNA-DIRECTED RNA POLYMERASE P3D DE (EC 2.7.7.48)] (VERSION 2). OS Poliovirus type 1 (strain Mahoney). OC Viruses; ssRNA positive-strand viruses, no DNA stage; Picornaviridae; OC Enterovirus. OX NCBI_TaxID=12081; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=82060159; PubMed=6272282; RA Racaniello V.R., Baltimore D.; RT "Molecular cloning of poliovirus cDNA and determination of the RT complete nucleotide sequence of the viral genome."; RL Proc. Natl. Acad. Sci. U.S.A. 78:4887-4891(1981). RN [2] RP X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 1-880. RX MEDLINE=85300512; PubMed=2994218; RA Hogle J.M., Chow M., Filman D.J.; RT "Three-dimensional structure of poliovirus at 2.9-A resolution."; RL Science 229:1358-1365(1985). RN [3] RP X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 1-880. RX MEDLINE=95120467; PubMed=7820548; RA Grant R.A., Hiremath C.N., Filman D.J., Syed R., Andries K., RA Hogle J.M.; RT "Structures of poliovirus complexes with anti-viral drugs: RT implications for viral stability and drug design."; RL Curr. Biol. 4:784-797(1994). CC -!- FUNCTION: P3C POLYPEPTIDE IS A PROTEASE THAT CLEAVES AT CERTAIN CC Q/G SITES IN THE POLYPROTEIN. IT MAY BE A CYSTEINE PROTEASE. CC -!- SUBUNIT: THE VIRUS CAPSID IS COMPOSED OF 60 ICOSAHEDRAL UNITS, CC EACH OF WHICH IS COMPOSED OF ONE COPY EACH OF PROTEINS VP1, VP2, CC VP3, AND VP4. CC -!- PTM: SPECIFIC ENZYMATIC CLEAVAGES IN VIVO YIELD MATURE PROTEINS. CC -!- SIMILARITY: THE PROTEASE BELONGS TO PEPTIDASE FAMILY C3. CC -!- CAUTION: SEE ALSO VERSION 1 OF THIS PROTEIN. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; V01149; CAA24461.1; -. DR EMBL; V01149; CAA24462.1; ALT_SEQ. DR EMBL; V01149; CAA24463.1; ALT_SEQ. DR EMBL; V01149; CAA24464.1; ALT_SEQ. DR PIR; A03898; GNNY2P. DR PDB; 2PLV; 15-JUL-93. DR PDB; 1FPT; 31-MAR-95. DR PDB; 1POV; 07-DEC-95. DR PDB; 1VBD; 11-JUL-96. DR PDB; 1AL2; 19-NOV-97. DR PDB; 1AR6; 03-DEC-97. DR PDB; 1AR7; 03-DEC-97. DR PDB; 1AR8; 03-DEC-97. DR PDB; 1AR9; 03-DEC-97. DR PDB; 1ASJ; 03-DEC-97. DR PDB; 1PO1; 03-DEC-97. DR PDB; 1PO2; 03-DEC-97. DR MEROPS; C03.001; -. DR MEROPS; C03.020; -. DR INTERPRO; IPR000081; -. DR INTERPRO; IPR000199; -. DR INTERPRO; IPR000605; -. DR INTERPRO; IPR001205; -. DR INTERPRO; IPR001676; -. DR INTERPRO; IPR002527; -. DR PFAM; PF00548; Cys-protease-3C; 1. DR PFAM; PF00947; Pico_P2A; 1. DR PFAM; PF01552; Pico_P2B; 1. DR PFAM; PF00680; RNA_dep_RNA_pol; 1. DR PFAM; PF00910; RNA_helicase; 1. DR PFAM; PF00073; rhv; 3. KW Polyprotein; Coat protein; Core protein; Transferase; KW RNA-directed RNA polymerase; Hydrolase; Thiol protease; Myristate; KW 3D-structure. FT INIT_MET 0 0 FT CHAIN 1 68 COAT PROTEIN VP4. FT CHAIN 69 340 COAT PROTEIN VP2. FT CHAIN 341 578 COAT PROTEIN VP3. FT CHAIN 579 880 COAT PROTEIN VP1. FT CHAIN 881 1029 CORE PROTEIN P2A. FT CHAIN 1030 1126 CORE PROTEIN P2B. FT CHAIN 1127 1455 CORE PROTEIN P2C. FT CHAIN 1456 1542 CORE PROTEIN P3A. FT CHAIN 1543 1564 GENOME-LINKED PROTEIN VPG. FT CHAIN 1565 1746 PICORNAIN 3C. FT CHAIN 1747 2208 RNA-DIRECTED RNA POLYMERASE P3D. FT LIPID 1 1 MYRISTATE. FT ACT_SITE 1711 1711 PROTEASE (POTENTIAL). FT ACT_SITE 1725 1725 PROTEASE (POTENTIAL). FT STRAND 3 6 FT STRAND 25 28 FT HELIX 35 37 FT STRAND 45 45 FT TURN 49 49 FT HELIX 50 53 FT STRAND 56 56 FT TURN 62 63 FT TURN 74 75 FT TURN 79 80 FT STRAND 82 86 FT TURN 87 88 FT STRAND 89 93 FT STRAND 96 101 FT HELIX 102 104 FT TURN 112 114 FT STRAND 122 122 FT HELIX 125 127 FT TURN 128 128 FT STRAND 132 133 FT STRAND 137 140 FT TURN 141 142 FT STRAND 146 150 FT TURN 151 151 FT HELIX 152 154 FT TURN 155 156 FT HELIX 158 166 FT STRAND 167 179 FT TURN 184 185 FT STRAND 186 196 FT TURN 197 197 FT STRAND 202 202 FT HELIX 213 216 FT HELIX 219 221 FT STRAND 223 224 FT STRAND 226 226 FT TURN 235 236 FT STRAND 242 242 FT STRAND 245 245 FT HELIX 246 248 FT TURN 249 252 FT HELIX 255 260 FT STRAND 263 267 FT TURN 268 270 FT STRAND 273 278 FT STRAND 287 287 FT TURN 289 291 FT STRAND 292 292 FT STRAND 295 307 FT STRAND 314 331 FT STRAND 337 337 FT TURN 348 351 FT TURN 355 356 FT STRAND 363 363 FT TURN 366 367 FT STRAND 379 380 FT STRAND 382 382 FT HELIX 383 387 FT TURN 388 388 FT STRAND 391 392 FT STRAND 397 397 FT TURN 399 403 FT HELIX 405 408 FT STRAND 410 413 FT STRAND 423 426 FT TURN 429 431 FT TURN 433 437 FT HELIX 439 444 FT TURN 445 446 FT STRAND 447 451 FT STRAND 454 460 FT TURN 464 465 FT STRAND 467 467 FT STRAND 469 475 FT HELIX 485 489 FT TURN 490 490 FT STRAND 492 497 FT STRAND 503 508 FT STRAND 517 518 FT HELIX 523 525 FT STRAND 529 534 FT STRAND 539 539 FT TURN 542 543 FT STRAND 547 556 FT TURN 558 559 FT STRAND 561 565 FT STRAND 600 600 FT TURN 601 602 FT STRAND 604 604 FT STRAND 608 608 FT TURN 620 621 FT STRAND 622 623 FT HELIX 625 627 FT HELIX 635 637 FT TURN 638 638 FT STRAND 644 644 FT STRAND 649 649 FT HELIX 651 653 FT STRAND 654 654 FT HELIX 655 659 FT STRAND 663 672 FT TURN 675 676 FT STRAND 684 687 FT HELIX 695 700 FT TURN 701 702 FT STRAND 703 720 FT STRAND 732 738 FT TURN 740 741 FT TURN 748 749 FT HELIX 751 754 FT STRAND 760 764 FT TURN 765 766 FT STRAND 770 774 FT STRAND 783 784 FT STRAND 789 789 FT STRAND 795 795 FT TURN 796 797 FT HELIX 800 803 FT TURN 807 808 FT TURN 812 815 FT STRAND 817 822 FT STRAND 831 849 FT TURN 866 867 FT STRAND 875 875 FT TURN 877 878 SQ SEQUENCE 2208 AA; 246407 MW; 48C247FC45EE3270 CRC64; GAQVSSQKVG AHENSNRAYG GSTINYTTIN YYRDSASNAA SKQDFSQDPS KFTEPIKDVL IKTAPMLNSP NIEACGYSDR VLQLTLGNST ITTQEAANSV VAYGRWPEYL RDSEANPVDQ PTEPDVAACR FYTLDTVSWT KESRGWWWKL PDALRDMGLF GQNMYYHYLG RSGYTVHVQC NASKFHQGAL GVFAVPEMCL AGDSNTTTMH TSYQNANPGE KGGTFTGTFT PDNNQTSPAR RFCPVDYLLG NGTLLGNAFV FPHQIINLRT NNCATLVLPY VNSLSIDSMV KHNNWGIAIL PLAPLNFASE SSPEIPITLT IAPMCCEFNG LRNITLPRLQ GLPVMNTPGS NQYLTADNFQ SPCALPEFDV TPPIDIPGEV KNMMELAEID TMIPFDLSAT KKNTMEMYRV RLSDKPHTDD PILCLSLSPA SDPRLSHTML GEILNYYTHW AGSLKFTFLF CGFMMATGKL LVSYAPPGAD PPKKRKEAML GTHVIWDIGL QSSCTMVVPW ISNTTYRQTI DDSFTEGGYI SVFYQTRIVV PLSTPREMDI LGFVSACNDF SVRLLRDTTH IEQKALAQGL GQMLESMIDN TVRETVGAAT SRDALPNTEA SGPTHSKEIP ALTAVETGAT NPLVPSDTVQ TRHVVQHRSR SESSIESFFA RGACVTIMTV DNPASTTNKD KLFAVWKITY KDTVQLRRKL EFFTYSRFDM ELTFVVTANF TETNNGHALN QVYQIMYVPP GAPVPEKWDD YTWQTSSNPS IFYTYGTAPA RISVPYVGIS NAYSHFYDGF SKVPLKDQSA ALGDSLYGAA SLNDFGILAV RVVNDHNPTK VTSKIRVYLK PKHIRVWCPR PPRAVAYYGP GVDYKDGTLT PLSTKDLTTY GFGHQNKAVY TAGYKICNYH LATQDDLQNA VNVMWSRDLL VTESRAQGTD SIARCNCNAG VYYCESRRKY YPVSFVGPTF QYMEANNYYP ARYQSHMLIG HGFASPGDCG GILRCHHGVI GIITAGGEGL VAFSDIRDLY AYEEEAMEQG ITNYIESLGA AFGSGFTQQI SDKITELTNM VTSTITEKLL KNLIKIISSL VIITRNYEDT TTVLATLALL GCDASPWQWL RKKACDVLEI PYVIKQGDSW LKKFTEACNA AKGLEWVSNK ISKFIDWLKE KIIPQARDKL EFVTKLRQLE MLENQISTIH QSCPSQEHQE ILFNNVRWLS IQSKRFAPLY AVEAKRIQKL EHTINNYIQF KSKHRIEPVC LLVHGSPGTG KSVATNLIAR AIAERENTST YSLPPDPSHF DGYKQQGVVI MDDLNQNPDG ADMKLFCQMV STVEFIPPMA SLEEKGILFT SNYVLASTNS SRISPPTVAH SDALARRFAF DMDIQVMNEY SRDGKLNMAM ATEMCKNCHQ PANFKRCCPL VCGKAIQLMD KSSRVRYSID QITTMIINER NRRSNIGNCM EALFQGPLQY KDLKIDIKTS PPPECINDLL QAVDSQEVRD YCEKKGWIVN ITSQVQTERN INRAMTILQA VTTFAAVAGV VYVMYKLFAG HQGAYTGLPN KKPNVPTIRT AKVQGPGFDY AVAMAKRNIV TATTSKGEFT MLGVHDNVAI LPTHASPGES IVIDGKEVEI LDAKALEDQA GTNLEITIIT LKRNEKFRDI RPHIPTQITE TNDGVLIVNT SKYPNMYVPV GAVTEQGYLN LGGRQTARTL MYNFPTRAGQ CGGVITCTGK VIGMHVGGNG SHGFAAALKR SYFTQSQGEI QWMRPSKEVG YPIINAPSKT KLEPSAFHYV FEGVKEPAVL TKNDPRLKTD FEEAIFSKYV GNKITEVDEY MKEAVDHYAG QLMSLDINTE QMCLEDAMYG TDGLEALDLS TSAGYPYVAM GKKKRDILNK QTRDTKEMQK LLDTYGINLP LVTYVKDELR SKTKVEQGKS RLIEASSLND SVAMRMAFGN LYAAFHKNPG VITGSAVGCD PDLFWSKIPV LMEEKLFAFD YTGYDASLSP AWFEALKMVL EKIGFGDRVD YIDYLNHSHH LYKNKTYCVK GGMPSGCSGT SIFNSMINNL IIRTLLLKTY KGIDLDHLKM IAYGDDVIAS YPHEVDASLL AQSGKDYGLT MTPADKSATF ETVTWENVTF LKRFFRADEK YPFLIHPVMP MKEIHESIRW TKDPRNTQDH VRSLCLLAWH NGEEEYNKFL AKIRSVPIGR ALLLPEYSTL YRRWLDSF //