ID   POLG_SVDVH     STANDARD;      PRT;  2185 AA.
AC   P16604;
DT   01-AUG-1990 (Rel. 15, Created)
DT   01-AUG-1990 (Rel. 15, Last sequence update)
DT   15-DEC-1998 (Rel. 37, Last annotation update)
DE   GENOME POLYPROTEIN [CONTAINS: COAT PROTEINS VP1 TO VP4; CORE PROTEINS
DE   P2A TO P2C, P3A; GENOME-LINKED PROTEIN VPG; PICORNAIN 3C
DE   (EC 3.4.22.28) (PROTEASE 3C) (P3C); RNA-DIRECTED RNA POLYMERASE P3D
DE   (EC 2.7.7.48)].
OS   Swine vesicular disease virus (strain H/3 '76).
OC   Viruses; ssRNA positive-strand viruses, no DNA stage; Picornaviridae;
OC   Enterovirus.
OX   NCBI_TaxID=12076;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=89279274; PubMed=2543767;
RA   Inoue T., Suzuki T., Sekiguchi K.;
RT   "The complete nucleotide sequence of swine vesicular disease virus.";
RL   J. Gen. Virol. 70:919-934(1989).
CC   -!- FUNCTION: IT IS THOUGHT THAT THE P2C PROTEIN ATTACHES TO VESICULAR
CC       MEMBRANES AND IS ASSOCIATED WITH VIRAL RNA SYNTHESIS.
CC   -!- FUNCTION: P3C POLYPEPTIDE IS A PROTEASE THAT CLEAVES AT CERTAIN
CC       Q/G SITES IN THE POLYPROTEIN. IT MAY BE A CYSTEINE PROTEASE.
CC   -!- SUBUNIT: THE VIRUS CAPSID IS COMPOSED OF 60 ICOSAHEDRAL UNITS,
CC       EACH OF WHICH IS COMPOSED OF ONE COPY EACH OF PROTEINS VP1, VP2,
CC       VP3, AND VP4.
CC   -!- PTM: SPECIFIC ENZYMATIC CLEAVAGES IN VIVO YIELD MATURE PROTEINS.
CC   -!- SIMILARITY: THE PROTEASE BELONGS TO PEPTIDASE FAMILY C3.
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DR   EMBL; D00435; BAA00337.1; -.
DR   PIR; A31331; GNNYSH.
DR   HSSP; P03313; 1COV.
DR   MEROPS; C03.001; -.
DR   MEROPS; C03.020; -.
DR   INTERPRO; IPR000081; -.
DR   INTERPRO; IPR000199; -.
DR   INTERPRO; IPR000605; -.
DR   INTERPRO; IPR001205; -.
DR   INTERPRO; IPR001676; -.
DR   INTERPRO; IPR002527; -.
DR   PFAM; PF00548; Cys-protease-3C; 1.
DR   PFAM; PF00947; Pico_P2A; 1.
DR   PFAM; PF01552; Pico_P2B; 1.
DR   PFAM; PF00680; RNA_dep_RNA_pol; 1.
DR   PFAM; PF00910; RNA_helicase; 1.
DR   PFAM; PF00073; rhv; 3.
KW   Polyprotein; Coat protein; Core protein; Transferase;
KW   RNA-directed RNA polymerase; Hydrolase; Thiol protease; Myristate.
FT   CHAIN         2     69       COAT PROTEIN VP4 (P1A).
FT   CHAIN        70    330       COAT PROTEIN VP2 (P1B).
FT   CHAIN       331    568       COAT PROTEIN VP3 (P1C).
FT   CHAIN       569    851       COAT PROTEIN VP1 (P1D).
FT   CHAIN       852   1001       CORE PROTEIN P2A (P2-3B).
FT   CHAIN      1002   1100       CORE PROTEIN P2B (P2-5B).
FT   CHAIN      1101   1429       CORE PROTEIN P2C (P2-X).
FT   CHAIN      1430   1518       CORE PROTEIN P3A (P3-1B).
FT   CHAIN      1519   1540       GENOME-LINKED PROTEIN VPG (P3B).
FT   CHAIN      1541   1723       PICORNAIN 3C.
FT   CHAIN      1724   2185       RNA-DEPENDENT RNA POLYMERASE P3D.
FT   LIPID         2      2       MYRISTATE (BY SIMILARITY).
FT   ACT_SITE   1687   1687       PROTEASE (POTENTIAL).
FT   ACT_SITE   1701   1701       PROTEASE (POTENTIAL).
SQ   SEQUENCE   2185 AA;  243164 MW;  5B2285DD94B2B3B6 CRC64;
     MGAQVSTQKT GAHETSLSAA GNSVIHYTNI NYYKDAASNS ANRQDFTQDP GKFTEPVKDI
     MVKSMPALNS PSAEECGYSD RVRSITLGNS TITTQECANV VVGYGVWPTY LKDEEATAED
     QPTQPDVATC RFYTLESVMW QQSSPGWWWK FPDALSNMGL FGQNMQYHYL GRAGYTIHVQ
     CNASKFHQGC LLVVCVPEAE MGCATLANKP DPKSLSKGEI ANMFESQNST GETAVQANVI
     NAGMGVGVGN LTIFPHQWIN LRTNNSATIV MPYINSVPMD NMFRHNNFTL MVIPFAPLSY
     STGATTYVPI TVTVAPMCAE YNGLRLAGKQ GLPTLSTPGS NQFLTSDDFQ SPSAMPQFDV
     TPEMDIPGQV NNLMEIAEVD SVVPVNNTEG KVMSIEAYQI PVQSNPTNGS QVFGFPLTPG
     ANSVLNRTLL GEILNYYAHW SGSIKLTFMF CGSAMATGKF LLAYSPPGAG APTTRKEAML
     GTHVIWDVGL QSSCVLCIPW ISQTHYRYVV MDEYTAGGYI TCWYQTNIVV PADAQSDCKI
     LCFASACNDF SVRMLKDTPF IKQDNFFQGP PGEVVERAIA RVADTIGSGP VNSESIPALT
     AAETGHTSQV VPSDTMQTRH VKNYHSRSES TVENFLCRSA CVFYTTYKNH DSDGDNFAYW
     VINTRQVAQL RRKLEMFTYA RFDLELTFVI TSTQEQPTVR GQDTPVLTHQ IMYVPPGGPV
     PTKVNSYSWQ TSTNPSVFWT EGSAPPRMSI PFIGIGNAYS MFYDGWARFD KQGTYGTSTL
     NNMGTLYMRH VNDGGPGPIV STVRIYFKPK HVKTWVPRPP RLCQYQKAGN VNFEPTGVTE
     GRTDITTMKT TGAFGQQSGA VYVGNYRVVN IHLATRADWQ NCVWEDYDRD LLVSTTTAHG
     CDTIARCDCT AGVYFCASRN KHYPVTFEGP GLVEVQESEY YPKKHQSHVL LAAGFAEPGD
     CGGILRCQHG VIGIVTMGGE GVVGFADVRD LLWLEDDAME QGVRDYVEQL GNAFGSGFTN
     QICEQVTLLK ESLIGQDSIL EKSLKALVKI VSALVIVVRN HDDLITVTAT LALIGCTTSP
     WRWLKQKVSQ YYGIPMAERQ NSGWLKKFTE MTNACKGMEW IAIKIQKFIE WLKVKILPEV
     KEKHEFLNRL KQLPLLESQI ATIEQSAPSQ SDQEQLFSNV QYFAHYCRKY APLYAAEAKR
     VFSLEKKMSN YIQFKSKCRI EPVCLLLHGS PGAGKSVATN LIGRSLAEKL NSSVYSLPPD
     PDHFDGYKQQ AVVIMDDLCQ NPDGKDVSLF CQMVSSVDFV PPMAALEEKG ILFTSPFVLA
     STNAGSVNAP TVSDSRALVR RFHFDMNIEV VSMYSQNGKI NMPMAVKTCD EECCPVNFKK
     CCPLVCGKAI QFIDRRTQVR YSLDMLVTEM FREYNHRHSV GATLEALFQG PPVYREIKIS
     VAPETPPPPA VADLLKSVDS EAVREYCKEK GWLIPEVDST LQIEKHVNRA FICLQALTTF
     VSVAGIIYII YKLFAGFQGA YTGMPNQKPK VPTLRQAKVQ GPAFEFAVAM MKRNASTVKT
     EYGEFTMLGI YDRWAVLPRH AKPGPTILMN DQVVGVLDAK ELVDKDGTNL ELTLLKLNRN
     EKFRDIRGFL AREEVEANEA VLAINTSKFP NMYIPVGRVT DYGFLNLGGT PTKRMLMYNF
     PTRAGQCGGV LMSTGKVLGI HVGGNGHQGF SAALLRHYFN EEQGEIEFVE SSKDAGFPVI
     NTPSKTKLEP SVFHHVFEGN KEPAVLRNGD PRLKANFEEA IFSKYIGNVN THVDEYMMEA
     VDYYAGQLAT LDISTEPMKL EDAVYGTEGL EALDLTTSAG YPYVALGIKK RDILSKKTRD
     LTKLKECMDK YGLNLPMVTY VKDELRSADK VAKGKSRLIE ASSLNDSVAM RQTFGNLYKT
     FHLNPGIVTG SAVGCDPDVF WSKIPVMLDG HLIAFDYSGY DASLSPVWFT CLKLLLEKLG
     YTNKETNYID YLCNSHHLYR DKHYFVRGGM PSGCSGTSIF NSMINNIIIR TLMLKVYKGI
     DLDQFRMIAY GDDVIASYPW PIDASLLAEA GKGYGLIMTP ADKGECFNEV TWTNVTFLKR
     YFRADEQYPF LVHPVMPMKD IHESIRWTKD PKNTQDHVRS LCLLAWHNGE HEYEEFIRKI
     RSVPVGRCLS LPAFSTLRRK WLDSF
//