ID   POLG_HRV2      STANDARD;      PRT;  2150 AA.
AC   P04936;
DT   13-AUG-1987 (Rel. 05, Created)
DT   13-AUG-1987 (Rel. 05, Last sequence update)
DT   15-DEC-1998 (Rel. 37, Last annotation update)
DE   GENOME POLYPROTEIN [CONTAINS: COAT PROTEINS VP1 TO VP4; CORE PROTEINS
DE   P2A TO P2C, P3A; GENOME-LINKED PROTEIN VPG; PICORNAIN 3C
DE   (EC 3.4.22.28) (PROTEASE 3C) (P3C); RNA-DIRECTED RNA POLYMERASE P3D
DE   (EC 2.7.7.48)].
OS   Human rhinovirus 2 (HRV-2).
OC   Viruses; ssRNA positive-strand viruses, no DNA stage; Picornaviridae;
OC   Rhinovirus.
OX   NCBI_TaxID=12130;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=85215603; PubMed=2987843;
RA   Skern T., Sommergruber W., Blaas D., Gruendler P., Fraundorfer F.,
RA   Pieler C., Fogy I., Kuechler E.;
RT   "Human rhinovirus 2: complete nucleotide sequence and proteolytic
RT   processing signals in the capsid protein region.";
RL   Nucleic Acids Res. 13:2111-2126(1985).
RN   [2]
RP   REVISIONS.
RA   Kuechler E.;
RL   Submitted (FEB-1986) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: P3C POLYPEPTIDE IS A PROTEASE THAT CLEAVES AT CERTAIN
CC       Q/G SITES IN THE POLYPROTEIN. IT MAY BE A CYSTEINE PROTEASE.
CC   -!- SUBUNIT: THE VIRUS CAPSID IS COMPOSED OF 60 ICOSAHEDRAL UNITS,
CC       EACH OF WHICH IS COMPOSED OF ONE COPY EACH OF PROTEINS VP1, VP2,
CC       VP3, AND VP4.
CC   -!- PTM: SPECIFIC ENZYMATIC CLEAVAGES IN VIVO YIELD MATURE PROTEINS.
CC   -!- SIMILARITY: THE PROTEASE BELONGS TO PEPTIDASE FAMILY C3.
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DR   EMBL; X02316; CAA26181.1; -.
DR   PIR; A03902; GNNYH2.
DR   HSSP; Q82122; 1AYN.
DR   MEROPS; C03.007; -.
DR   MEROPS; C03.021; -.
DR   INTERPRO; IPR000081; -.
DR   INTERPRO; IPR000199; -.
DR   INTERPRO; IPR000605; -.
DR   INTERPRO; IPR001205; -.
DR   INTERPRO; IPR001676; -.
DR   INTERPRO; IPR002527; -.
DR   PFAM; PF00548; Cys-protease-3C; 2.
DR   PFAM; PF00947; Pico_P2A; 1.
DR   PFAM; PF01552; Pico_P2B; 1.
DR   PFAM; PF00680; RNA_dep_RNA_pol; 1.
DR   PFAM; PF00910; RNA_helicase; 1.
DR   PFAM; PF00073; rhv; 3.
KW   Polyprotein; Coat protein; Core protein; Transferase;
KW   RNA-directed RNA polymerase; Hydrolase; Thiol protease; Myristate.
FT   CHAIN         2     69       COAT PROTEIN VP4 (P1A).
FT   CHAIN        70    330       COAT PROTEIN VP2 (P1B).
FT   CHAIN       331    567       COAT PROTEIN VP3 (P1C).
FT   CHAIN       568    856       COAT PROTEIN VP1 (P1D).
FT   CHAIN       857    992       CORE PROTEIN P2A.
FT   CHAIN       993   1087       CORE PROTEIN P2B.
FT   CHAIN      1088   1409       CORE PROTEIN P2C.
FT   CHAIN      1410   1486       CORE PROTEIN P3A.
FT   CHAIN      1487   1507       GENOME-LINKED PROTEIN VPG (P3B).
FT   CHAIN      1508   1690       PICORNAIN 3C.
FT   CHAIN      1691   2150       RNA-DIRECTED RNA POLYMERASE P3D.
FT   LIPID         2      2       MYRISTATE (BY SIMILARITY).
FT   ACT_SITE   1654   1654       PROTEASE (POTENTIAL).
FT   ACT_SITE   1668   1668       PROTEASE (POTENTIAL).
SQ   SEQUENCE   2150 AA;  241975 MW;  6E0DF9F4945D9D0C CRC64;
     MGAQVSRQNV GTHSTQNSVS NGSSLNYFNI NYFKDAASNG ASKLEFTQDP SKFTDPVKDV
     LEKGIPTLQS PTVEACGYSD RIIQITRGDS TITSQDVANA IVAYGVWPHY LSSKDASAID
     KPSQPDTSSN RFYTLRSVTW SSSSKGWWWK LPDALKDMGI FGENMFYHYL GRSGYTIHVQ
     CNASKFHQGT LIVALIPEHQ IASALHGNVN VGYNYTHPGE TGREVKAETR LNPDLQPTEE
     YWLNFDGTLL GNITIFPHQF INLRSNNSAT IIAPYVNAVP MDSMRSHNNW SLVIIPICPL
     ETSSAINTIP ITISISPMCA EFSGARAKRQ GLPVFITPGS GQFLTTDDFQ SPCALPWYHP
     TKEISIPGEV KNLVEICQVD SLVPINNTDT YINSENMYSV VLQSSINAPD KIFSIRTDVA
     SQPLATTLIG EISSYFTHWT GSLRFSFMFC GTANTTVKLL LAYTPPGIAE PTTRKDAMLG
     THVIWDVGLQ STISMVVPWI SASHYRNTSP GRSTSGYITC WYQTRLVIPP QTPPTARLLC
     FVSGCKDFCL RMARDTNLHL QSGAIAQNPV ENYIDEVLNE VLVVPNINSS NPTTSNSAPA
     LDAAETGHTS SVQPEDVIET RYVQTSQTRD EMSLESFLGR SGCIHESKLE VTLANYNKEN
     FTVWAINLQE MAQIRRKFEL FTYTRFDSEI TLVPCISALS QDIGHITMQY MYVPPGAPVP
     NSRDDYAWQS GTNASVFWQH GQAYPRFSLP FLSVASAYYM FYDGYDEQDQ NYGTANTNNM
     GSLCSRIVTE KHIHKVHIMT RIYHKAKHVK AWCPRPPRAL EYTRAHRTNF KIEDRSIQTA
     IVTRPIITTA GPSDMYVHVG NLIYRNLHLF NSEMHESILV SYSSDLIIYR TNTVGDDYIP
     SCDCTQATYY CKHKNRYFPI TVTSHDWYEI QESEYYPKHI QYNLLIGEGP CEPGDCGGKL
     LCKHGVIGIV TAGGDNHVAF IDLRHFHCAE EQGVTDYIHM LGEAFGNGFV DSVKEHIHAI
     NPVGNISKKI IKWMLRIISA MVIIIRNSSD PQTILATLTL IGCSGSPWRF LKEKFCKWTQ
     LNYIHKESDS WLKKFTEACN AARGLEWIGN KISKFIEWMK SMLPQAQLKV KYLNELKKLN
     LYEKQVESLR VADMKTQEKI KMEIDTLHDL SRKFLPLYAS EAKRIKTLYI KCDNIIKQKK
     RCEPVAIVIH GPPGAGKSIT TNFLAKMITN DSDIYSLPPD PKYFDGYDQQ SVVIMDDIMQ
     NPAGDDMTLF CQMVSSVTFI PPMADLPDKG KAFDSRFVLC STNHSLLTPP TITSLPAMNR
     RFFLDLDIIV HDNFKDPQGK LNVAAAFRPC DVDNRIGNAR CCPFVCGKAV SFKDRNSCNK
     YSLAQVYNIM IEEDRRRRQV VDVMTAIFQG PIDMKNPPPP AITDLLQSVR TPEVIKYCEG
     NRWIIPAECK IEKELNLANT IITIIANVIG MARIIYVIYK LFCTLQGPYS GEPKPKTKIP
     ERRVVTQGPE EEFGMSLIKH NSCVITTENG KFTGLGVYDR FVVVPTHADP GKEIQVDGIT
     TKVIDSYDLY NKNGIKLEIT VLKLDRNEKF RDIRRYIPNN EDDYPNCNLA LLANQPEPTI
     INVGDVVSYG NILLSGNQTA RMLKYSYPTK SGYCGGVLYK IGQVLGIHVG GNGRDGFSAM
     LLRSYFTDVQ GQITLSKKTS ECNLPSIHTP CKTKLQPSVF YDVFPGSKEP AVLSEKDARL
     QVDFNEALFS KYKGNTDCSI NDHIRIASSH YAAQLITLDI DPKPITLEDS VFGTDGLEAL
     DLNTSAGFPY IAMGVKKRDL INNKTKDISK LKEAIDKYGV DLPMVTFLKD ELRKHEKVIK
     GKTRVIEASS VNDTLLFRTT FGNLFSKFHL NPGIVTGSAV GCDPEVFWSK IPAMLDDKCI
     MAFDYTNYDG SIHPIWFEAL KQVLVDLSFN PTLIDRLCKS KHIFKNTYYE VEGGVPSGCS
     GTSIFNTMIN NIIIRTLVLD AYKNIDLDKL KIIAYGDDVI FSYIHELDME AIAIEGVKYG
     LTITPADKSN TFVKLDYSNV TFLKRGFKQD EKYNFLIHPT FPEDEIFESI RWTKKPSQMH
     EHVLSLCHLM WHNGRDAYKK FVEKIRSVSA GRALYIPPYD LLLHEWYEKF
//