ID   POLG_HRV16     STANDARD;      PRT;  2153 AA.
AC   Q82122;
DT   15-JUL-1998 (Rel. 36, Created)
DT   15-DEC-1998 (Rel. 37, Last sequence update)
DT   15-DEC-1998 (Rel. 37, Last annotation update)
DE   GENOME POLYPROTEIN [CONTAINS: COAT PROTEINS VP1 TO VP4; CORE PROTEINS
DE   P2A TO P2C, P3A; GENOME-LINKED PROTEIN VPG; PICORNAIN 3C
DE   (EC 3.4.22.28) (PROTEASE 3C) (P3C); RNA-DIRECTED RNA POLYMERASE P3D
DE   (EC 2.7.7.48)].
OS   Human rhinovirus 16 (HRV-16).
OC   Viruses; ssRNA positive-strand viruses, no DNA stage; Picornaviridae;
OC   Rhinovirus.
OX   NCBI_TaxID=31708;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=95250310; PubMed=7732663;
RA   Lee W.M., Wang W., Rueckert R.R.;
RT   "Complete sequence of the RNA genome of human rhinovirus 16, a
RT   clinically useful common cold virus belonging to the ICAM-1 receptor
RT   group.";
RL   Virus Genes 9:177-181(1995).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 2-853.
RX   MEDLINE=94348864; PubMed=7915182;
RA   Oliveira M.A., Zhao R., Lee W.M., Kremer M.J., Minor I.,
RA   Rueckert R.R., Diana G.D., Pevear D.C., Dutko F.J., McKinlay M.A.,
RA   Rossmann M.G.;
RT   "The structure of human rhinovirus 16.";
RL   Structure 1:51-68(1993).
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 2-853, AND REV. TO 547-548.
RX   MEDLINE=97238938; PubMed=9083115;
RA   Hadfield A.T., Lee W.M., Zhao R., Oliveira M.A., Minor I.,
RA   Rueckert R.R., Rossmann M.G.;
RT   "The refined structure of human rhinovirus 16 at 2.15-A resolution:
RT   implications for the viral life cycle.";
RL   Structure 5:427-441(1997).
CC   -!- FUNCTION: P3C POLYPEPTIDE IS A PROTEASE THAT CLEAVES AT CERTAIN
CC       Q/G SITES IN THE POLYPROTEIN. IT MAY BE A CYSTEINE PROTEASE.
CC   -!- SUBUNIT: THE VIRUS CAPSID IS COMPOSED OF 60 ICOSAHEDRAL UNITS,
CC       EACH OF WHICH IS COMPOSED OF ONE COPY EACH OF PROTEINS VP1, VP2,
CC       VP3, AND VP4.
CC   -!- PTM: SPECIFIC ENZYMATIC CLEAVAGES IN VIVO YIELD MATURE PROTEINS.
CC   -!- SIMILARITY: THE PROTEASE BELONGS TO PEPTIDASE FAMILY C3.
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DR   EMBL; L24917; AAA69862.1; -.
DR   PDB; 1AYN; 21-JAN-98.
DR   PDB; 1AYM; 21-JAN-98.
DR   MEROPS; C03.007; -.
DR   INTERPRO; IPR000081; -.
DR   INTERPRO; IPR000199; -.
DR   INTERPRO; IPR000605; -.
DR   INTERPRO; IPR001205; -.
DR   INTERPRO; IPR001676; -.
DR   INTERPRO; IPR002527; -.
DR   PFAM; PF00548; Cys-protease-3C; 1.
DR   PFAM; PF00947; Pico_P2A; 1.
DR   PFAM; PF01552; Pico_P2B; 1.
DR   PFAM; PF00680; RNA_dep_RNA_pol; 1.
DR   PFAM; PF00910; RNA_helicase; 1.
DR   PFAM; PF00073; rhv; 3.
KW   Polyprotein; Coat protein; Core protein; Transferase;
KW   RNA-directed RNA polymerase; Hydrolase; Thiol protease; Myristate;
KW   3D-structure.
FT   CHAIN         2     69       COAT PROTEIN VP4 (P1A).
FT   CHAIN        70    330       COAT PROTEIN VP2 (P1B).
FT   CHAIN       331    568       COAT PROTEIN VP3 (P1C).
FT   CHAIN       569    853       COAT PROTEIN VP1 (P1D).
FT   CHAIN       854    995       CORE PROTEIN P2A.
FT   CHAIN       996   1090       CORE PROTEIN P2B.
FT   CHAIN      1091   1412       CORE PROTEIN P2C.
FT   CHAIN      1413   1489       CORE PROTEIN P3A.
FT   CHAIN      1490   1510       GENOME-LINKED PROTEIN VPG (P3B).
FT   CHAIN      1511   1693       PICORNAIN 3C.
FT   CHAIN      1694   2153       RNA-DIRECTED RNA POLYMERASE P3D.
FT   LIPID         2      2       MYRISTATE.
FT   ACT_SITE   1657   1657       PROTEASE (POTENTIAL).
FT   ACT_SITE   1671   1671       PROTEASE (POTENTIAL).
FT   CONFLICT    547    548       KD -> NH (IN REF. 1).
SQ   SEQUENCE   2153 AA;  242242 MW;  6B11D0D93DF11C04 CRC64;
     MGAQVSRQNV GTHSTQNMVS NGSSLNYFNI NYFKDAASSG ASRLDFSQDP SKFTDPVKDV
     LEKGIPTLQS PSVEACGYSD RIIQITRGDS TITSQDVANA VVGYGVWPHY LTPQDATAID
     KPTQPDTSSN RFYTLDSKMW NSTSKGWWWK LPDALKDMGI FGENMFYHFL GRSGYTVHVQ
     CNASKFHQGT LLVVMIPEHQ LATVNKGNVN AGYKYTHPGE AGREVGTQVE NEKQPSDDNW
     LNFDGTLLGN LLIFPHQFIN LRSNNSATLI VPYVNAVPMD SMVRHNNWSL VIIPVCQLQS
     NNISNIVPIT VSISPMCAEF SGARAKTVVQ GLPVYVTPGS GQFMTTDDMQ SPCALPWYHP
     TKEIFIPGEV KNLIEMCQVD TLIPINSTQS NIGNVSMYTV TLSPQTKLAE EIFAIKVDIA
     SHPLATTLIG EIASYFTHWT GSLRFSFMFC GTANTTLKVL LAYTPPGIGK PRSRKEAMLG
     THVVWDVGLQ STVSLVVPWI SASQYRFTTP DTYSSAGYIT CWYQTNFVVP PNTPNTAEML
     CFVSGCKDFC LRMARDTDLH KQTGPITQNP VERYVDEVLN EVLVVPNINQ SHPTTSNAAP
     VLDAAETGHT NKIQPEDTIE TRYVQSSQTL DEMSVESFLG RSGCIHESVL DIVDNYNDQS
     FTKWNINLQE MAQIRRKFEM FTYARFDSEI TMVPSVAAKD GHIGHIVMQY MYVPPGAPIP
     TTRDDYAWQS GTNASVFWQH GQPFPRFSLP FLSIASAYYM FYDGYDGDTY KSRYGTVVTN
     DMGTLCSRIV TSEQLHKVKV VTRIYHKAKH TKAWCPRPPR AVQYSHTHTT NYKLSSEVHN
     DVAIRPRTNL TTVGPSDMYV HVGNLIYRNL HLFNSDIHDS ILVSYSSDLI IYRTSTQGDG
     YIPTCNCTEA TYYCKHKNRY YPINVTPHDW YEIQESEYYP KHIQYNLLIG EGPCEPGDCG
     GKLLCKHGVI GIITAGGEGH VAFIDLRHFH CAEEQGITDY IHMLGEAFGS GFVDSVKDQI
     NSINPINNIS SKMVKWMLRI ISAMVIIIRN SSDPQTIIAT LTLIGCNGSP WRFLKEKFCK
     WTQLTYIHKE SDSWLKKFTE MCNAARGLEW IGNKISKFID WMKSMLPQAQ LKVKYLSELK
     KLNFLEKQVE NLRAADTNTQ EKIKCEIDTL HDLSCKFLPL YASEAKRIKV LYHKCTNIIK
     QKKRSEPVAV MIHGPPGTGK SITTSFLARM ITNESDIYSL PPDPKYFDGY DNQSVVIMDD
     IMQNPGGEDM TLFCQMVSSV TFIPPMADLP DKGKPFDSRF VLCSTNHSLL APPTISSLPA
     MNRRFYLDLD ILVHDNYKDN QGKLDVSRAF RLCDVDSKIG NAKCCPFVCG KAVTFKDRNT
     CRTYSLSQIY NQILEEDKRR RQVVDVMSAI FQGPISMDKP PPPAITDLLR SVRTPEVIKY
     CQDNKWIVPA DCQIERDLNI ANSIITIIAN IISIAGIIYI IYKLFCSLQG PYSGEPKPKT
     KVPERRVVAQ GPEEEFGMSI IKNNTCVVTT TNGKFTGLGI YDRILILPTH ADPGSEIQVN
     GIHTKVLDSY DLFNKEGVKL EITVLKLDRN EKFRDIRKYI PESEDDYPEC NLALVANQTE
     PTIIKVGDVV SYGNILLSGT QTARMLKYNY PTKSGYCGGV LYKIGQILGI HVGGNGRDGF
     SSMLLRSYFT EQQGQIQISK HVKDVGLPSI HTPTKTKLQP SVFYDIFPGS KEPAVLTEKD
     PRLKVDFDSA LFSKYKGNTE CSLNEHIQVA VAHYSAQLAT LDIDPQPIAM EDSVFGMDGL
     EALDLNTSAG YPYVTLGIKK KDLINNKTKD ISKLKLALDK YDVDLPMITF LKDELRKKDK
     IAAGKTRVIE ASSINDTILF RTVYGNLFSK FHLNPGVVTG CAVGCDPETF WSKIPLMLDG
     DCIMAFDYTN YDGSIHPIWF KALGMVLDNL SFNPTLINRL CNSKHIFKST YYEVEGGVPS
     GCSGTSIFNS MINNIIIRTL VLDAYKHIDL DKLKIIAYGD DVIFSYKYKL DMEAIAKEGQ
     KYGLTITPAD KSSEFKELDY GNVTFLKRGF RQDDKYKFLI HPTFPVEEIY ESIRWTKKPS
     QMQEHVLSLC HLMWHNGPEI YKDFETKIRS VSAGRALYIP PYELLRHEWY EKF
//