ID   POLG_FMDVA     STANDARD;      PRT;  2332 AA.
AC   P03308; P03312; Q65038; Q65039; Q65040; Q65041; Q65042; Q65043;
AC   Q65044; Q65045; Q65046; Q65047;
DT   21-JUL-1986 (Rel. 01, Created)
DT   01-JAN-1988 (Rel. 06, Last sequence update)
DT   30-MAY-2000 (Rel. 39, Last annotation update)
DE   GENOME POLYPROTEIN [CONTAINS: NONSTRUCTURAL PROTEIN P20A; COAT
DE   PROTEINS VP1 TO VP4; CORE PROTEINS X, P14, P41, P19; GENOME-LINKED
DE   PROTEINS VPG1 TO VPG3; PICORNAIN 3C (EC 3.4.22.28) (PROTEASE 3C)
DE   (P3C); RNA-DIRECTED RNA POLYMERASE (EC 2.7.7.48)].
OS   Foot-and-mouth disease virus (strain A12) (Aphthovirus A).
OC   Viruses; ssRNA positive-strand viruses, no DNA stage; Picornaviridae;
OC   Aphthovirus.
OX   NCBI_TaxID=12114;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=85211015; PubMed=2987518;
RA   Robertson B.H., Grubman M.J., Weddell G.N., Moore D.M., Welsh J.D.,
RA   Fischer T., Dowbenko D.J., Yansura D.G., Small B., Kleid D.G.;
RT   "Nucleotide and amino acid sequence coding for polypeptides of foot-
RT   and-mouth disease virus type A12.";
RL   J. Virol. 54:651-660(1985).
RN   [2]
RP   SEQUENCE OF 1863-2332 FROM N.A.
RX   MEDLINE=83225613; PubMed=6305004;
RA   Robertson B.H., Morgan D.O., Moore D.M., Grubman M.J., Card J.,
RA   Fischer T., Weddell G.N., Dowbenko D.J., Yansura D.G.;
RT   "Identification of amino acid and nucleotide sequence of the foot-and-
RT   mouth disease virus RNA polymerase.";
RL   Virology 126:614-623(1983).
RN   [3]
RP   SEQUENCE OF 715-955 FROM N.A.
RX   MEDLINE=82061853; PubMed=6272395;
RA   Kleid D.G., Yansura D.G., Small B., Dowbenko D.J., Moore D.M.,
RA   Grubman M.J., McKercher P.D., Morgan D.O., Robertson B.H.,
RA   Bachrach H.L.;
RT   "Cloned viral protein vaccine for foot-and-mouth disease: responses in
RT   cattle and swine.";
RL   Science 214:1125-1129(1981).
CC   -!- SUBUNIT: THE VIRUS CAPSID IS COMPOSED OF 60 ICOSAHEDRAL UNITS,
CC       EACH OF WHICH IS COMPOSED OF ONE COPY EACH OF PROTEINS VP1, VP2,
CC       VP3, AND VP4.
CC   -!- PTM: SPECIFIC ENZYMATIC CLEAVAGES IN VIVO YIELD MATURE PROTEINS.
CC   -!- SIMILARITY: THE PROTEASE BELONGS TO PEPTIDASE FAMILY C3.
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DR   EMBL; M10975; AAA42593.1; -.
DR   EMBL; J02187; AAA42670.1; -.
DR   PIR; A25794; GNNY4F.
DR   HSSP; P13899; 1TME.
DR   MEROPS; C03.008; -.
DR   MEROPS; U29.002; -.
DR   INTERPRO; IPR000605; -.
DR   INTERPRO; IPR001205; -.
DR   INTERPRO; IPR001676; -.
DR   PFAM; PF00680; RNA_dep_RNA_pol; 1.
DR   PFAM; PF00910; RNA_helicase; 1.
DR   PFAM; PF00073; rhv; 3.
KW   Polyprotein; Coat protein; Core protein; RNA-directed RNA polymerase;
KW   Transferase; Hydrolase; Thiol protease; Nonstructural protein;
KW   Myristate.
FT   CHAIN         1    200       NONSTRUCTURAL PROTEIN P20A.
FT   CHAIN       201    285       COAT PROTEIN VP4.
FT   CHAIN       286    503       COAT PROTEIN VP2.
FT   CHAIN       504    723       COAT PROTEIN VP3.
FT   CHAIN       724    937       COAT PROTEIN VP1.
FT   CHAIN       938    953       CORE PROTEIN X.
FT   CHAIN       954   1107       CORE PROTEIN P14.
FT   CHAIN      1108   1425       CORE PROTEIN P41.
FT   CHAIN      1426   1578       CORE PROTEIN P19.
FT   CHAIN      1579   1601       GENOME-LINKED PROTEIN VPG1.
FT   CHAIN      1602   1625       GENOME-LINKED PROTEIN VPG2.
FT   CHAIN      1626   1649       GENOME-LINKED PROTEIN VPG3.
FT   CHAIN      1650   1862       PROTEASE.
FT   CHAIN      1863   2332       RNA-DIRECTED RNA POLYMERASE.
FT   LIPID       201    201       MYRISTATE.
SQ   SEQUENCE   2332 AA;  259408 MW;  EE77DA739CBEDC6A CRC64;
     MNTTNCFIAL VHAIREIRAF FLSRATGKME FTLYNGERKT FYSRPNNHDN CWLNTILQLF
     RYVDEPFFDW VYNSPENLTL AAIKQLEELT GLELHEGGPP ALVIWNIKHL LQTGIGTASR
     PARCMVDGTN MCLADFHAGI FLKEQEHAVF ACVTSNGWYA IDDEDFYPWT PDPSDVLVFV
     PYDQEPLNGG WKANVQRKLK GAGQSSPATG SQNQSGNTGS IINNYYMQQY QNSMDTQLGD
     NAISGGSNEG STDTTSTHTT NTQNNDWFSK LASSAFTGLF GALLADKKTE ETTLLEDRIL
     TTRNGHTTST TQSSVGVTYG YSTEEDHVAG PNTSGLETRV VQAERFFKKF LFDWTPDKPF
     GHRTKLELPT DHHGVFGHLV DSYAYMRNGW DVEVSAVGNQ FNGGCLLVAM VPEWKTFDTR
     EEYQLTLFPH QFISPRTNMT AHITVPYLGV NRYDQYKKHK PWTLVIMVLS PLTVSNTAAT
     QIKVYANIAP TYVHVAGELP SKVGIFPVAC SDGYGGLVTT DPKTADPVYG KEYNPPKTNY
     PRRFTNLLDV AEACPTFLCF DDGKPYVVTR TDDTRLLAKF DVSLAAKHMS NTYLSGIAQY
     YTQYSGTINL HFMFTGSTDS KARYMVAYIP PGVETPPETP EGAAHCIHAE WDTGLNSKFT
     FSIPYVSAAD YAYTASDTAE TTNVQGWVCI YQITHGKAED DTLVVSASAG KDFELRLPID
     PRSQTTATGE SADPVTTTVE NYGGETQVQR RHHTDVSFIM DRFVKIKSLN PTHVIDLMQT
     HQHGLVGALL RAATYYFSDL EIVVRHDGNL TWVPNGAPEA ALSNTGNPTA YNKAPFTRLA
     LPYTAPHRVL ATVYNGTNKY SASGSGVRGD FGSLAPRVAR QLPASFNYGA IKAETIHELL
     VRMKRAELYC PRPLLAIEVS SQDRHKQKII APGKQLLNFD LLKLAGDVES NPRPFFFADV
     RSNFSKLVDT INQMQEDMST KHGPDFNRLV SAFEELATGV KAIRTGLDEA KPWYKLIKLL
     SRLSCMAAVA ARTKDPVLVA IMLADTGLEI LDSTFVVKKI SDSLSSLFHV PAPVFSFGAP
     VLLAGLVKVA SSFLRSTPED LERAEKQLKA RDINDIFAIL KNGEWLVKLI LAIRDWIKAW
     IASEEKFVTM TDLVLGILEK QRDLNDPSKY KEAKEWLDNA RQACLKSGNV HIANLCKVVA
     PAPSKSRPEP VVVCLRGKSG QGKSFLANVL AQAISTHFTG RTDSVWYCPP DPDHFDGYNQ
     QTVVVMDDLG QNPDGKDFKY FAQMVSTTGF IPPMASLEDK GKPFNSKVII ATTNLYSGFT
     PRTMVCPDAL NRRFHFDIDV SAKDGYKINN KLDIVKALED THTNPVAMFQ YDCALLNGMA
     VEMKRMQQDM FKPQPPLQNV YQLVQEVIER VELHEKVSSH PIFKQISIPS QKSVLYFLIE
     KGQHEAAIEF FEGMVHDSIK EELRPLIQQT SFVKRAFKRL KENFEIVALC LTLLANIVIM
     IRETRKRQKM VDDAVNEYIE KANITTDDTT LDEAEKNPLE TSGASTVGFR ERTLTGQRAC
     NDVNSEPARP AEEQPQAEGP YTGPLERQRP LKVRAKLPQQ EGPYAGPLER QKPLKVKAKA
     PVVKEGPYEG PVKKPVALKV KAKNLIVTES GAPPTDLQKM VMGNTKPVEL ILDGKTVAIC
     CATGVFGTAY LVPRHLFAEK YDKIMLDGRA MTDSDYRVFE FEIKVKGQDM LSDAALMVLH
     RGNRVRDITK HFRDTARMKK GTPVVGVVNN ADVGRLIFSG EALTYKDIVV CMDGDTMPSL
     FAYKAATKAG YCGGAVLAKD GADTFIVGTH SAGGNGVGYC SCVSKSMLLR MKAHVDPEPQ
     HEGLIVDTRD VEERVHVMRK TKLAPTVAHG VFNPEFGPAA LSNKDPRLNE GVVLDEVIFS
     KHKGDTKMSA EDKALFRACA ADYASRLHSV LGTANAPLSI YEAIKGVDGL DAMESDTAPG
     LPWAFQGKRR GALIDFENGT VGPEVEAALK LMEKREYKFV CQTFLKDEIR PMEKVRAGKT
     RIVDVLPVEH ILYTRMMIGR FCAQMHSNNG PQIGSAVGCN PDVDWQRFGT HFAQYRNVWD
     VDYSAFDTNH CSDAMNIMFE EVFRTDFGFH PNAEWILKTL VNTEHAYENK RITVEGGMPS
     DCSATGIINT ILNNIYVLYA LRRHYEGVEL DTYTMISYGD DIVVASDYDL DFEALKPHFK
     SLGQTITPAD KSDKGFVLGH SITDVTFLKR HFHIDYGTGF YKPVMASKTL EAILSFARRG
     TIQEKLTSVA GLAVHSGPDE YRRLFEPFQG LFEIPSYRSL YLRWVNAVCG DA
//