ID   NEF_SIVS4      STANDARD;      PRT;   309 AA.
AC   P12482;
DT   01-OCT-1989 (Rel. 12, Created)
DT   01-OCT-1989 (Rel. 12, Last sequence update)
DT   01-NOV-1990 (Rel. 16, Last annotation update)
DE   NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF).
GN   NEF.
OS   Simian immunodeficiency virus (F236/smH4 isolate) (sooty mangabey).
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=11737;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=89262053; PubMed=2786147;
RA   Hirsch V.M., Olmstead R.A., Murphey-Corb M., Purcell R.H.,
RA   Johnson P.R.;
RT   "An African primate lentivirus (SIVsm) closely related to HIV-2.";
RL   Nature 339:389-392(1989).
CC   -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING
CC       ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN.
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DR   EMBL; X14307; CAA32488.1; -.
DR   PIR; S07993; S07993.
DR   HSSP; P03406; 1EFN.
DR   HIV; X14307; NEF$SMMH4.
DR   INTERPRO; IPR001558; -.
DR   PFAM; PF00469; F-protein; 1.
KW   AIDS; Myristate; GTP-binding.
FT   LIPID         2      2       MYRISTATE (BY SIMILARITY).
SQ   SEQUENCE   309 AA;  35714 MW;  9E4686996909D99B CRC64;
     MGGAISKKQY KRGGNLRERL LQARGETYGR LWEGLEEGYS QSLGASGKGL SSLSCEPQKY
     SEGQYMNTPW RNPATERAKL GYRQQNMDDV DDEDDDLIGV SVHPRVPLRA MTYKLAIDMS
     HFIKEKGGLE GIYYNERRHR ILDMYLEKEE GIIPDWQNYT SGPGIRYPMH YGWLWKLVPV
     DVSDEAQEDE THCLVHPAQT YQWDDPWGEV LAWKFDPELA YSYKAFIKYP EEFGSKSGLS
     EEEVKRRLTA RGLLKWLTRR KQAETAGTFH KGLSWEVLGR SWLERPLILC INTTAFRSVF
     SRSAERLAD
//