ID NEF_SIVML STANDARD; PRT; 263 AA. AC P11262; DT 01-JUL-1989 (Rel. 11, Created) DT 01-JUL-1989 (Rel. 11, Last sequence update) DT 01-OCT-1989 (Rel. 12, Last annotation update) DE NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF). GN NEF. OS Simian immunodeficiency virus (K78 isolate) (SIV-MAC). OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11736; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=87187627; PubMed=3646094; RA Hirsch V., Riedel N., Mullins J.I.; RT "The genome organization of STLV-3 is similar to that of the AIDS RT virus except for a truncated transmembrane protein."; RL Cell 49:307-319(1987). CC -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING CC ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN. CC -!- MISCELLANEOUS: THIS IS A MACAQUE ISOLATE. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M19499; AAB59912.1; ALT_SEQ. DR PIR; F26737; ASLJRT. DR HSSP; P03406; 1EFN. DR INTERPRO; IPR001558; -. DR PFAM; PF00469; F-protein; 1. KW AIDS; Myristate; GTP-binding. FT LIPID 2 2 MYRISTATE (BY SIMILARITY). SQ SEQUENCE 263 AA; 30245 MW; 4D349C6170E0BCA7 CRC64; MGGAISMRRS KPAGDLRQKL LRARGETYGR LLGEVEDGSS QSLGGLGKGL SSRSCEGQKY NQGQYMNTPW RNPAEEKEKL AYRKQNMDDI DEEDDDLVGV SVRPKVPLRA MTYKLAIDMS HFIKEKGGLE GIYYSARRHR ILDMYLEKEE GIIPDWQDYT SGPGIRYPKT FGWLWKLVPV NVSDEAQEDE RHYLMQPAQT SKWDDPWGEV LAWKFDPTPA YTYEAYVRYP EEFGSKSGLS EEEVRRRLTA RGLLNMADKK ETR //