ID   NEF_SIVMA      STANDARD;      PRT;   263 AA.
AC   P31818;
DT   01-JUL-1993 (Rel. 26, Created)
DT   01-JUL-1993 (Rel. 26, Last sequence update)
DT   01-JUL-1993 (Rel. 26, Last annotation update)
DE   NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF).
GN   NEF.
OS   Simian immunodeficiency virus (1A11 isolate) (SIV-MAC).
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=31682;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=92365133; PubMed=1501282;
RA   Unger R.E., Marthas M.L., Pratt-Lowe E., Padrid P.A., Luciw P.A.;
RT   "The nef gene of simian immunodeficiency virus SIVmac1A11.";
RL   J. Virol. 66:5432-5442(1992).
CC   -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING
CC       ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN.
CC   -!- MISCELLANEOUS: THIS IS A MACAQUE ISOLATE.
DR   PIR; A42747; ASLJMA.
DR   HSSP; P03406; 1EFN.
DR   INTERPRO; IPR001558; -.
DR   PFAM; PF00469; F-protein; 1.
KW   AIDS; Myristate; GTP-binding.
FT   LIPID         2      2       MYRISTATE (BY SIMILARITY).
SQ   SEQUENCE   263 AA;  30620 MW;  A46FAA79A47B0077 CRC64;
     MGGTISMRRS RSTGDLRQRL LRARGETYER LLGEVEDGSS QSLGELDKGL SSLSCEGQKY
     NQEQYMNTPW RNPAEEREKL AYRKQNMDDI DEEDDDLVGD TVRPKVPLRT MSYKLAIDMS
     HFIKEKGGLE GIYYSARRHR ILDIYLEKEE GIIPDWQDYT SGPGIRYPKT FGWLWKLVPV
     NVSDEAQEDE EHYLMHPAQT SQWDDPWGEV PAWKFDPTLA YTYEAYVRYP EEFGSKSGLS
     EEEVRRRLTA RGLLNMADKK ETR
//