ID   NEF_SIVM1      STANDARD;      PRT;   262 AA.
AC   P05862;
DT   01-NOV-1988 (Rel. 09, Created)
DT   01-NOV-1988 (Rel. 09, Last sequence update)
DT   01-OCT-1989 (Rel. 12, Last annotation update)
DE   NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF).
GN   NEF.
OS   Simian immunodeficiency virus (Mm142-83 isolate) (SIV-MAC).
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=11733;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=87287230; PubMed=3649576;
RA   Chakrabarti L., Guyader M., Alizon M., Daniel M.D., Desrosiers R.C.,
RA   Tiollais P., Sonigo P.;
RT   "Sequence of simian immunodeficiency virus from macaque and its
RT   relationship to other human and simian retroviruses.";
RL   Nature 328:543-547(1987).
CC   -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING
CC       ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN.
CC   -!- MISCELLANEOUS: THIS IS A MACAQUE ISOLATE.
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DR   EMBL; Y00277; CAA68389.1; -.
DR   PIR; I28887; ASLJM3.
DR   HSSP; P03406; 1EFN.
DR   HIV; M16403; NEF$MM142.
DR   INTERPRO; IPR001558; -.
DR   PFAM; PF00469; F-protein; 1.
KW   AIDS; Myristate; GTP-binding.
FT   LIPID         2      2       MYRISTATE (BY SIMILARITY).
SQ   SEQUENCE   262 AA;  30287 MW;  5A670495737C4553 CRC64;
     MGGAISKKRS KPPRDLRQRL LRARGENYGR LFKGVEDGSS QSLGGLDKGL SSLSCEGQKY
     NQGEYMNTPW RNPAEERKKL PYRKQNIDDI DEEDDDLVGI PVEARVPLRT MSYKLAIDMS
     HFIKEKGGLE GIYYSARRHR ILDIYLEKEE GIIPDWQIHS GPGIRYLKMF GWLWKLIPVN
     VSDEAQEDEE HYLVHPAQTS QWDDPWGEVL AWKFDPTLAY TYEAYIRYPE EFGSKSGLSE
     KEVKRRLAAR GLLEMADRKE TS
//