ID   NEF_SIVAG      STANDARD;      PRT;   229 AA.
AC   P27979;
DT   01-AUG-1992 (Rel. 23, Created)
DT   01-AUG-1992 (Rel. 23, Last sequence update)
DT   01-JUL-1993 (Rel. 26, Last annotation update)
DE   NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF).
GN   NEF.
OS   Simian immunodeficiency virus (AGM3 isolate) (SIV-AGM).
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=11730;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=90232731; PubMed=2158689;
RA   Baier M., Garber C., Mueller C., Cichutek K., Kurth R.;
RT   "Complete nucleotide sequence of a simian immunodeficiency virus from
RT   African green monkeys: a novel type of intragroup divergence.";
RL   Virology 176:216-221(1990).
CC   -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING
CC       ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN.
CC   -!- MISCELLANEOUS: THIS IS AN AFRICAN GREEN MONKEY ISOLATE.
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DR   EMBL; M30931; AAA91920.1; -.
DR   HSSP; P03406; 1EFN.
DR   INTERPRO; IPR001558; -.
DR   PFAM; PF00469; F-protein; 1.
KW   AIDS; Myristate; GTP-binding.
FT   LIPID         2      2       MYRISTATE (BY SIMILARITY).
SQ   SEQUENCE   229 AA;  26647 MW;  8812897790711203 CRC64;
     MGLGNSKPQH KKQLSLWHAL HKTRATRYGL LADPLIGQSS TLQEECDKAL KESLIRKRNG
     KMTPEGRKLQ EGDKWDEWSD EEDEVGFPVR PRVPLRQMTY KLAVDFSHFL KEKGGLDGIY
     YSDRRNQILN LYALNEWGII DDWNAWSEGP GIRYPRCFGF CFKLVPVDLH EEAETCERHC
     LVHPAQVRED PDGINHGEVL VWKFDPMLAV QYDPNRKYLT DMHDLGKRK
//