ID   NEF_HV2NZ      STANDARD;      PRT;   180 AA.
AC   P05860;
DT   01-NOV-1988 (Rel. 09, Created)
DT   01-NOV-1988 (Rel. 09, Last sequence update)
DT   01-JUL-1993 (Rel. 26, Last annotation update)
DE   NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF).
GN   NEF.
OS   Human immunodeficiency virus type 2 (isolate NIH-Z) (HIV-2).
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=11719;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=88320359; PubMed=3261862;
RA   Zagury J.F., Franchini G., Reitz M.S. Jr., Collalti E., Starcich B.R.,
RA   Hall L., Fargnoli K., Jagodzinski L.L., Guo H.-G., Laure F.,
RA   Arya S.K., Josephs S.F., Zagury D., Wong-Staal F., Gallo R.C.;
RT   "Genetic variability between isolates of human immunodeficiency virus
RT   (HIV) type 2 is comparable to the variability among HIV type 1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 85:5941-5945(1988).
CC   -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING
CC       ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN.
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DR   EMBL; J03654; AAB00762.1; -.
DR   HSSP; P03406; 1EFN.
DR   HIV; J03654; NEF$2NIHZ.
DR   INTERPRO; IPR001558; -.
DR   PFAM; PF00469; F-protein; 1.
KW   AIDS; Myristate; GTP-binding.
FT   LIPID         2      2       MYRISTATE (BY SIMILARITY).
SQ   SEQUENCE   180 AA;  20409 MW;  C2DBE78AEC267887 CRC64;
     MGASGSKKRS KPLQGLQERL LQARGETCGG RCNESGGGYL QSHEGSGREQ NSPSCEGQRY
     QQGDFVNTPW RTPAAEREKE LYKQQNMDDV DLDDDDQVGF PVTPRVPLRP MTFKLAVDMS
     HFIKEKGGLE GLFYSQRRHR ILDLYLDKAF TLYPEEFGHN SGLPEKEWKA RLKARGIPFS
//