ID NEF_HV2KR STANDARD; PRT; 253 AA. AC Q74127; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 01-NOV-1997 (Rel. 35, Last annotation update) DE NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF). GN NEF. OS Human immunodeficiency virus type 2 (isolate KR) (HIV-2). OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=73484; RN [1] RP SEQUENCE FROM N.A. RA Kraus G.K., Talbott R., Leavitt M., Luznick L., Schmidt A., Badel P., RA Bartz C., Morton W., Wong-Staal F., Looney D.J.; RL Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING CC ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U22047; AAA64583.1; -. DR HSSP; P03406; 1EFN. DR INTERPRO; IPR001558; -. DR PFAM; PF00469; F-protein; 1. KW AIDS; Myristate; GTP-binding. FT LIPID 2 2 MYRISTATE (BY SIMILARITY). SQ SEQUENCE 253 AA; 28862 MW; 549DEFB328CD490A CRC64; MGASGSKKCS RSLQGLRERL LRARGETCGG QWDGSAGEYL QFQEGSGRGQ NLPSCEGQRY QQGDFMNTPW RTPAAGREGT LYKQQNMDDV DADNDNLIGV PVTPRVPLRA MTYKLAVDIS HFLNEKGGLD GMYYSERRHR ILDIYMEKEE GIIPDWQNYT HGPGVRYPKF FGWLWKLVPV DVPQGEEDHC LLHPAQTSGS DDPHGETLMW RFDPRLAYEY TAFNRYPEEF GYKSGLPEEE WKAKLKARGI PFS //