ID   NEF_HV2CA      STANDARD;      PRT;   260 AA.
AC   P24103;
DT   01-MAR-1992 (Rel. 21, Created)
DT   01-MAR-1992 (Rel. 21, Last sequence update)
DT   01-NOV-1995 (Rel. 32, Last annotation update)
DE   NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF).
GN   NEF.
OS   Human immunodeficiency virus type 2 (isolate CAM2) (HIV-2).
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=11715;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=91170959; PubMed=2005437;
RA   Tristem M., Hill F., Karpas A.;
RT   "Nucleotide sequence of a Guinea-Bissau-derived human immunodeficiency
RT   virus type 2 proviral clone (HIV-2CAM2).";
RL   J. Gen. Virol. 72:721-724(1991).
CC   -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING
CC       ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN.
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DR   EMBL; D00835; BAA00717.1; -.
DR   PIR; G38475; ASLJCZ.
DR   HSSP; P03406; 1EFN.
DR   INTERPRO; IPR001558; -.
DR   PFAM; PF00469; F-protein; 1.
KW   AIDS; Myristate; GTP-binding.
FT   LIPID         2      2       MYRISTATE (BY SIMILARITY).
SQ   SEQUENCE   260 AA;  29707 MW;  D8BCF5CAC7FCA9CA CRC64;
     MGASGSKKRS RPLQGLQERL LRARAGTCGE CYNALEGESL RSQEGSDREQ NSLSCEGQRY
     QQGDFMNTPW RAPAAEGKKN AYRQQNMDDI DSDDDDLVGV PATPRVPLRT MTYKLAVDMS
     HFIKEKGGLE GLFYSERRHR ILDIYLEKEE GIIADWQNYT SGPGVRYPMF FGWLWKLVPV
     DTSQEGEDTE TDTETHCLLH PAQTSRHDDM HGETLVWKFD SMLALKYEAF TRYPEEFGHK
     SGLPEDEWKA KLKARGIPFS
//