ID   NEF_HV1Z6      STANDARD;      PRT;   212 AA.
AC   P04602;
DT   13-AUG-1987 (Rel. 05, Created)
DT   13-AUG-1987 (Rel. 05, Last sequence update)
DT   01-JUL-1993 (Rel. 26, Last annotation update)
DE   NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF).
GN   NEF.
OS   Human immunodeficiency virus type 1 (Zaire 6 isolate) (HIV-1).
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=11708;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=87248097; PubMed=3036660;
RA   Srinivasan A., Anand R., York D., Ranganathan P., Feorino P.,
RA   Schochetman G., Curran J., Kalyanaraman V.S., Luciw P.A.,
RA   Sanchez-Pescador R.;
RT   "Molecular characterization of human immunodeficiency virus from
RT   Zaire: nucleotide sequence analysis identifies conserved and variable
RT   domains in the envelope gene.";
RL   Gene 52:71-82(1987).
RN   [2]
RP   POST-TRANSLATIONAL MODIFICATIONS, AND FUNCTION.
RX   MEDLINE=88039140; PubMed=3118220;
RA   Guy B., Kieny M.-P., Riviere Y., le Peuch C., Dott K., Girard M.,
RA   Montagnier L., Lecocq J.-P.;
RT   "HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling
RT   an oncogene product.";
RL   Nature 330:266-269(1987).
CC   -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING
CC       ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN.
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DR   EMBL; K03458; AAA45381.1; -.
DR   PIR; F26192; QQLJZR.
DR   HSSP; P03406; 1EFN.
DR   HIV; K03458; NEF$Z6.
DR   INTERPRO; IPR001558; -.
DR   PFAM; PF00469; F-protein; 1.
KW   AIDS; Myristate; GTP-binding.
FT   LIPID         2      2       MYRISTATE.
SQ   SEQUENCE   212 AA;  24415 MW;  EC095A1B263047CF CRC64;
     MGGRWSKSSI VGWPAIRERI RRTDPRRTDP AADGVGAASR DLEKHGAITS SNTRDTNADC
     AWLEAQEESE EVGFPVRPQV PLRPMTYKLA VDLSHFLKEK GGLEGLIWSK KRQEILDLWV
     YNTQGIFPDW QNYTPGPGIR YPLTFGWCFE LVPVDPREVE EATEGETNCL LHPVCQHGME
     DTEREVLKWR FNSRLAFEHK AREMHPEFYK DC
//