ID NEF_HV1Y2 STANDARD; PRT; 214 AA. AC P35959; DT 01-JUN-1994 (Rel. 29, Created) DT 01-JUN-1994 (Rel. 29, Last sequence update) DT 01-JUN-1994 (Rel. 29, Last annotation update) DE NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF). GN NEF. OS Human immunodeficiency virus type 1 (YU-2 isolate) (HIV-1). OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=36377; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=93021387; PubMed=1404605; RA Li Y., Hui H., Burgess C.J., Price R.W., Sharp P.M., Hahn B.H., RA Shaw G.M.; RT "Complete nucleotide sequence, genome organization, and biological RT properties of human immunodeficiency virus type 1 in vivo: evidence RT for limited defectiveness and complementation."; RL J. Virol. 66:6587-6600(1992). CC -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING CC ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M93258; -; NOT_ANNOTATED_CDS. DR PIR; I44001; I44001. DR HSSP; P03406; 1EFN. DR INTERPRO; IPR001558; -. DR PFAM; PF00469; F-protein; 1. KW AIDS; Myristate; GTP-binding. FT LIPID 2 2 MYRISTATE (BY SIMILARITY). SQ SEQUENCE 214 AA; 24532 MW; E188D43D7B084D04 CRC64; MGGKWSKRSM AGWPTVRERM RRAEPAAERM RRAEPAADGV GAVSRDLERH GAITSSNTAA TNADCAWLEA QEEEEVGFPV RPQVPLRPMT HKAAMDLSHF LKEKGGLEGL IHSQQRQDIL DLWVYHTQGY FPDWQNYTPG GTRWPLTFGW CFKLVPVEPE KIEEANAGEN NCLLHPMSQH GMDDPEREGL EWRFDSRLAF HHVARELHPE YYKN //