ID   NEF_HV1S1      STANDARD;      PRT;   208 AA.
AC   P19546;
DT   01-FEB-1991 (Rel. 17, Created)
DT   01-FEB-1991 (Rel. 17, Last sequence update)
DT   01-JUL-1993 (Rel. 26, Last annotation update)
DE   NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF).
GN   NEF.
OS   Human immunodeficiency virus type 1 (SF162 isolate) (HIV-1).
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=11691;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=90347835; PubMed=2384920;
RA   Cheng-Mayer C., Quiroga M., Tung J.W., Dina D., Levy J.;
RT   "Viral determinants of human immunodeficiency virus type 1 T-cell or
RT   macrophage tropism, cytopathogenicity, and CD4 antigen modulation.";
RL   J. Virol. 64:4390-4398(1990).
CC   -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING
CC       ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN.
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DR   EMBL; M65024; AAA45073.1; -.
DR   HSSP; P03406; 1EFN.
DR   HIV; M38428; NEF$SF162.
DR   INTERPRO; IPR001558; -.
DR   PFAM; PF00469; F-protein; 1.
KW   AIDS; Myristate; GTP-binding.
FT   LIPID         2      2       MYRISTATE (BY SIMILARITY).
SQ   SEQUENCE   208 AA;  23684 MW;  A0B1007D14E46E32 CRC64;
     MGGKWSKRMS GWSAVRERMK RAEPAEPAAD GVGAVSRDLE KHGAITSSNT AANNADCAWL
     EAQEDEDVGF PVRPQVPLRP MTYKAALDLS HFLKEKGGLE GLIYSQKRQD ILDLWIHHTQ
     GYFPDWQNYT PGPGIRYPLT FGWCFKLVPV DPDYVEEANA GENNSLLHPM SQHGMDDPEK
     EVLVWRFDSR LAFHHMAREL HPEYYKDC
//