ID   NEF_HV1OY      STANDARD;      PRT;   211 AA.
AC   P20886;
DT   01-FEB-1991 (Rel. 17, Created)
DT   01-FEB-1991 (Rel. 17, Last sequence update)
DT   01-JUL-1993 (Rel. 26, Last annotation update)
DE   NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF).
GN   NEF.
OS   Human immunodeficiency virus type 1 (OYI isolate) (HIV-1).
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=11699;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=90148544; PubMed=2559749;
RA   Huet T., Dazza M.C., Brun-Vezinet F., Roelants G.E., Wain-Hobson S.;
RT   "A highly defective HIV-1 strain isolated from a healthy Gabonese
RT   individual presenting an atypical western blot.";
RL   AIDS 3:707-715(1989).
CC   -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING
CC       ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN.
CC   -!- MISCELLANEOUS: THE OYI ISOLATE WAS TAKEN FROM THE BLOOD OF A
CC       HEALTHY GABONESE INDIVIDUAL.
CC   --------------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use  by  non-profit  institutions as long  as its content  is  in  no  way
CC   modified and this statement is not removed.  Usage  by  and for commercial
CC   entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC   or send an email to license@isb-sib.ch).
CC   --------------------------------------------------------------------------
DR   EMBL; M26727; AAA83398.1; -.
DR   HSSP; P03406; 1EFN.
DR   HIV; M26727; NEF$OYI.
DR   INTERPRO; IPR001558; -.
DR   PFAM; PF00469; F-protein; 1.
KW   AIDS; Myristate; GTP-binding.
FT   LIPID         2      2       MYRISTATE.
SQ   SEQUENCE   211 AA;  24067 MW;  64D846EEC55DAB8C CRC64;
     MGGKWSKCSM KGWPTIRERM KRAELQPPEP AAEGVGAASR DLEKHGAITS SNTAATNADC
     AWLEAQEDEE VGFPVRPQVP LRPMTYKGAL DLSHFLKEKG GLEGLIYSQK RQDILDLWVY
     HTQGYFPDWQ NYTPGPGIRY PLCFGWCFKL VPMDPDQVEE ANEGENNSLL HPISLHGMDD
     PEKEVLVWKF DSRLAFRHMA REVHPEYYKD C
//