ID   NEF_HV1ND      STANDARD;      PRT;   207 AA.
AC   P18801;
DT   01-NOV-1990 (Rel. 16, Created)
DT   01-NOV-1990 (Rel. 16, Last sequence update)
DT   01-JUL-1993 (Rel. 26, Last annotation update)
DE   NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF).
GN   NEF.
OS   Human immunodeficiency virus type 1 (NDK isolate) (HIV-1).
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=11695;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=90034200; PubMed=2806917;
RA   Spire B., Sire J., Zachar V., Rey F., Barre-Sinoussi F., Galibert F.,
RA   Hampe A., Chermann J.C.;
RT   "Nucleotide sequence of HIV1-NDK: a highly cytopathic strain of the
RT   human immunodeficiency virus.";
RL   Gene 81:275-284(1989).
CC   -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING
CC       ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN.
CC   -!- MISCELLANEOUS: NDK, ISOLATED FROM A ZAIRIAN PATIENT AFFECTED WITH
CC       AIDS, AND IS A HIGHLY CYTOPATHOGENIC STRAIN.
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DR   EMBL; M27323; AAA44874.1; -.
DR   PIR; JQ0068; QQLJND.
DR   HSSP; P03406; 1EFN.
DR   HIV; M27323; NEF$NDK.
DR   INTERPRO; IPR001558; -.
DR   PFAM; PF00469; F-protein; 1.
KW   AIDS; Myristate; GTP-binding.
FT   LIPID         2      2       MYRISTATE (BY SIMILARITY).
SQ   SEQUENCE   207 AA;  23748 MW;  09036C2F81D45D5E CRC64;
     MGGKWSKSSL VGWPAIRERI RKTDPAADGV GAVSRDLEKH GAITSSNTAS TNDTCAWLEA
     QEESEEVGFP VRPQVPLRPM TYKEAVDLSH FLKEKGGLEG LIWSKKRQEI LDLWVYNTQG
     IFPDWQNYTP GPGIRYPLTF GWCFQLVPVD PQEVEEATER EDNCLLHPMC QQGMEDPERQ
     VLMWRFNSRL ALEHKARELH PEFYKDC
//