ID   NEF_HV1MA      STANDARD;      PRT;   209 AA.
AC   P04603;
DT   13-AUG-1987 (Rel. 05, Created)
DT   13-AUG-1987 (Rel. 05, Last sequence update)
DT   01-JUL-1993 (Rel. 26, Last annotation update)
DE   NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF).
GN   NEF.
OS   Human immunodeficiency virus type 1 (MAL isolate) (HIV-1).
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=11697;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=86245056; PubMed=2424612;
RA   Alizon M., Wain-Hobson S., Montagnier L., Sonigo P.;
RT   "Genetic variability of the AIDS virus: nucleotide sequence analysis
RT   of two isolates from African patients.";
RL   Cell 46:63-74(1986).
RN   [2]
RP   POST-TRANSLATIONAL MODIFICATIONS, AND FUNCTION.
RX   MEDLINE=88039140; PubMed=3118220;
RA   Guy B., Kieny M.-P., Riviere Y., le Peuch C., Dott K., Girard M.,
RA   Montagnier L., Lecocq J.-P.;
RT   "HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling
RT   an oncogene product.";
RL   Nature 330:266-269(1987).
CC   -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING
CC       ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN.
CC   --------------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use  by  non-profit  institutions as long  as its content  is  in  no  way
CC   modified and this statement is not removed.  Usage  by  and for commercial
CC   entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC   or send an email to license@isb-sib.ch).
CC   --------------------------------------------------------------------------
DR   EMBL; X04415; CAA28017.1; -.
DR   EMBL; A07116; CAA00624.1; -.
DR   HSSP; P03406; 1EFN.
DR   HIV; K03456; NEF$MAL.
DR   INTERPRO; IPR001558; -.
DR   PFAM; PF00469; F-protein; 1.
KW   AIDS; Myristate; GTP-binding.
FT   LIPID         2      2       MYRISTATE.
SQ   SEQUENCE   209 AA;  23644 MW;  D0B30A2442C8CC44 CRC64;
     MGGKWSKSSI VGWPKIRERI RRTPPTETGV GAVSQDAVSQ DLDKCGAAAS SSPAANNASC
     EPPEEEEEVG FPVRPQVPLR PMTYKGAFDL SHFLKEKGGL DGLVWSPKRQ EILDLWVYHT
     QGYFPDWQNY TPGPGIRFPL TFGWCFKLVP MSPEEVEEAN EGENNCLLHP ISQHGMEDAE
     REVLKWKFDS SLALRHRARE QHPEYYKDC
//